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http://dx.doi.org/10.3807/KJOP.2019.30.2.059

Real-time Highly Sensitive Measurement of Myocardial Infarction Biomarkers Using Silicon-based Ellipsometric Biosensors  

Min, Yoon Gi (Department of Photonics and Sensors / Department of Computer, Communication and Unmanned Technology, Graduate School, Hannam University)
Cho, Hyun Mo (Semiconductor Integrated Metrology Team, Korea Research Institute of Standards and Science)
Jo, Jae Heung (Department of Photonics and Sensors / Department of Computer, Communication and Unmanned Technology, Graduate School, Hannam University)
Publication Information
Korean Journal of Optics and Photonics / v.30, no.2, 2019 , pp. 59-66 More about this Journal
Abstract
We report highly sensitive detection of myocardial infarction biomarkers, such as myoglobin and cTnI, within several hundred seconds using a rotating-analyzer ellipsometer and a biosensor with biochips fabricated on a $SiO_2$-coated tilted silicon substrate. We choose the running buffer to be pure phosphate-buffered saline (PBS) or 10% mixed human serum. When we choose the running buffer to be pure PBS, we obtain diagnostic densities of pure myocardial infarction biomarkers of up to 1 ng/ml and 5 pg/ml respectively. Meanwhile, when we use PBS with 10% human serum, the measured densities of myoglobin and cTnI were up to 1 ng/mL and 1 pg/mL respectively. The measured diagnostic densities are less than 1/15 and 1/80 (in cases of myoglobin and cTnI respectively) of those referenced by the World Health Organization.
Keywords
Ellipsometer; Biosensor; Myocardial infarction biomarker;
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Times Cited By KSCI : 1  (Citation Analysis)
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