• Korean Journal of Plant Taxonomy
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• v.47 no.4
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• pp.328-335
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• 2017

The Korean medicinal plant name written in Chinese script, Jingyo, is somewhat confusingly used in the Korean modern literature. This name was assigned to at least three species, with examples being Gentiana macrophylla, Aconitum pseudolaeve, and Justicia procumbens. To clarify the taxonomic identity of Jingyo, these names were examined based on the Chinese classics and Korean classics and compared them with the modern flora of both China and Korea. In China, Jingyo was considered as Justicia gendarussa or Gentiana macrophylla. In Korea, Jingyo was considered as A. pseudolaeve or J. procumbens. However, it was concluded that Jingyo is not distributed on the Korean Peninsula. In addition, although the Hangeul name Jinbeom was the result of the misreading of the Chinese script Jinbong, another Chinese term for Jingyo, this name is used in many modern studies related plant taxonomy. Hence, we also propose Jinbeom as the conserved Hangeul name of A. pseudolaeve.

• Korean Journal of Pharmacognosy
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• v.32 no.4 s.127
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• pp.287-291
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• 2001

The Radix of Gentiana macrophylla (Gentianaceae) has been used for dispelling wind-damp, relaxing the sinews, and clearing heat from deficiency. In order to evaluate its quality, the method for the quantitative determination of gentiopicroside as standard compound has been developed. Gentiopicroside was a major compound of Gentianae Macrophyllae Radix. It was analyzed by HPLC using 30% MeOH as a solvent system. The amount of gentiopicroside from Gentianae Macrophyllae Radix was in the range of $2.22{\pm}1.22%\;(n=18)$.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.22 no.3
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• pp.63-70
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• 2009

Objectives : The present study was examined to evaluate the anti-inflammatory effects of the Gentianae Macrophyllae Radix MeOH extracts (GMR) in vivo. Methods : The effects of GMR on anti-inflammation were measured by production of NO, TNF-$\alpha$ (Tumor Necrosis Factor-alpha) and IL-$1{\beta}$ (Interleukin-$1{\beta}$), IL-6 in Raw 264.7 macrophage cells stimulated with LPS. Results : 1. All concentrations of GMR(0.10 mg/ml) had no significant cytotoxicity in Raw 264.7 cell during the entire experimental period. 2. The level of NO and iNOS in culture medium was dramatically increased by LPS application. However, these increases were dose-dependently(0.03 and 0.10 mg/ml) attenuated by treatment with GMR. 3. All concentrations of GMR significantly inhibited the production of IL-$1{\beta}$ in Raw 264.7 macrophage cells stimulated with LPS. Conclusions : These results provide evidences that therapeutic effect of GMR on heat syndrome, especially due to the acute inflammation, are partly due to the reduction of some of inflammatory factors by inhibiting iNOS and COX-2 through the suppression of $p-I{\kappa}B{\alpha}$. Moreover, it suggests that the mechanism of action of GMR comes from the suppression of inflammatory mediators, such as NO, PGE2 and pro-inflammatory cytokines.

• Journal of Navigation and Port Research
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• v.28 no.5
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• pp.449-454
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• 2004

These days ships medical treatment is under unfavorable circumstances, because there is no professional doctor who can diagnose and treat the patients accurately on the ships. Therefore, ship's telemedicine should be urgently actualized to elevate the crew's my of boarding life and welfare. A purpose of this research is to develope the telemedicine system which can acquire the patient's informations like ECG and phonocardiogram used for the diagnosis and transmit those to the doctors of shore medical center. In this paper, we designed the communication part which could transmit the bio-signals acquired from the developed ship's digital ECG and stethoscope based on personal computer by the INMARSAT Also we inspected data errors through the comparison between the sent and received data And we confirmed the possibility and compatibility of the telemedicine using ship's communication system.

• Economic and Environmental Geology
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• v.26 no.4
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• pp.519-539
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• 1993

A total of 264 independently oriented core samples were collected from 26 sites in the southwestern part (the Naktong Trough) of the Cretaceous $Ky{\check{o}}ngsang$ Basin in south Korea. The sampled formations comprise the sedimentary Shindong and the Hayang Groups of the Lower Cretaceous age. Alternating field and thermal demagnetizations were conducted. Characteristic remanent magnetization (ChRM) was relatively easily isolated in each formation except in the Chinju formation, from which only remagnetization circles were observed. Even though an extensive use of the fold test was not possible due to the nearly homoclinal nature of the strata in the area, we believe that the ChRM of each formation is of primary origin based on the following grounds: The in-situ ChRM direction of each formation is different from the present geomagnetic field direction. Fisherian precision parameter becomes enhanced through the tilt correction in all formations, closely to the values required for a positive fold test. Three out of the five studied formations pass the reversal test. The mean palaeomagnetic pole position from the studied area is found to be statistically different from the contemporary pole from the Chinese block exclusive of the Shandong area. The difference in magnetic declination suggests a $14.5^{\circ}$ (${\pm}10.5^{\circ}$) clockwise rotation of the studied area relative to the Chinese block comprising the west of the Tan-Lu fault. On the other hand, any significant difference in magnetic inclination and concurrent palaeolatitude is not observed between the studied area and China as well as the other area (Taegu-Andong area) in the $Ky{\check{o}}ngsang$ Basin. The dual nature of the magnetic polarity confirmed in all formations suggests an older than 124 Ma (Neocomian or older) age of the studied sedimentary strata.

• Korean Journal of Food Science and Technology
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• v.29 no.4
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• pp.808-816
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• 1997

Fifty six kinds of medicinal herbs were extracted by 75% ethanol and antimicrobial activity of the extracts were tested against food-born bacteria, Listeria monocytogenes ATCC 15313, 19111, 19112, 19113, 19114, Bacillus cereus YUFE 2004, Staphylococcus aureus KFCC 11764, Pseudomons fluorescens KCTC 1645, 2344 and Leuconostoc mesenteroides KFCC 12031. Ethanol extracts of Terminalia chebula Rets, Rosa laevaigate Michx, Caesalpinia sappan L and Myristica fragrans Houtt showed inhibitory effects on the growth of most of the strains tested. In particular, the extract of Terminalia chebula Rets showed obvious growth inhibition in proportion to the concentration and Caesalpinia sappan L stopped the growth in the concentration of 100 ppm on several strains. Also, ethylacetate fractionates of Terminalia chebula Rets, Rosa laevaigate Michx, and Caesalpinia sappan L and chloroform fractionate of Myristica fragrans Houtt showed more effective inhibitory action on the growth of most of the strains tested.

• Journal of Korean Medicine Rehabilitation
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• v.18 no.1
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• pp.75-94
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• 2008

Objectives : This study was to investigate the effects of GCP treatment on the monosodium iodoacetate-induced osteoarthritis in rats. Methods : Arthritis was induced by injection of Monosodium lodoacetate(0.5mg) into knee joints of rats. Arthritic rats were divided into control(n=8) and treated(n=8) group. Control group was taken distilled water for 20 days. Treated group was taken extracts of GCP by oraly for same duration. Normal group(n=8) was injected with normal saline and was taken distilled water for 20 days. Body weight was measured at 0, 5, 10, 15, 20 days after injection. Macroscopic examination and histopathological study on articular cartilage of knee joint were operated at 20 days after injection. Proteoglycan(PG) content of articular cartilages of knee joint was represented by safranine O staining, was measured at 20 days injection. Tumor necrosis $factor-{\alpha}$, $Interleukin-1{\beta}$, Interleukin-6 in synovial fluid were measured with ELISA kit at 20 days after injection. Immunohistochemical staining of COX-2, iNOS in knee joints were observed at 20 days after injection. Results : 1. Body weight of the treated group increased compare with control group at 20 days after injection. 2. Macroscopically, degree of osteoarthritis in the treated group were evaluated compared with the control group. 3. PG content in articular cartilage of the treated group was significantly increased compared with the control group. 4. Histopathologically, osteoarthritic scores of the treated group was significantly decreased compared with the control group. 5. $TNF-{\alpha}$ content in synovial fluid of the treated group was decreased compared with the control group. 6. $IL-1{\beta}$ content in synovial fluid of the treated group was significantly decreased compared with the control group. 7. Positive reaction of COX-2 in chondrocytes and synovial membrane of the treated group was faint compared with the control group. Conclusions : On the basis of these results, we concluded that GCP has inhibiting effects on the $IL-1{\beta}$ and COX-2 secretion of chondrocytes and synovial membrane in Monosodium lodoacetate-Induced osteoarthritis model of rats.

• Journal of Environmental Policy
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• v.12 no.1
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• pp.59-74
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• 2013

The weakness of current water quality monitoring system was reviewed to manage Nakdong river's water quality. The current monitoring system has sampling periods lasting for a week to 10 days, but these-SAMpling periods may not accurately measure the real level of water quality. Therefore, daily sampling and analysis of water samples for nine factors was performed from May 1st 2011 to Sep. 30st 2011 to check the water quality changes at three-SAMpling points, Munsanri (the upper side of Kangjung-Koryung weir), Kangchang (the outlet of the Kumho River) and Samunjin (the lower side of Kangjung-Koryung weir). As demonstrated by the results, concentrations of all nine factors dramatically changed on a daily basis, so daily sampling and analysis of water quality samples may be needed instead of weekly sampling and analysis of water quality samples to ensure the proper management of the Nakdong River's water quality. However, daily observations for all water sampling points are not possible because costs and labors are limited, so that new methods which could support the current monitoring system should be developed.

• Journal of Physiology & Pathology in Korean Medicine
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• v.21 no.6
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• pp.1483-1490
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• 2007

This study was carried out to investigate the effects of GCP treatment on the expression of NOS, c-fos, serotonin and substance P in central nerve system of monosodium iodoacetate(MIA)-induced osteoarthritic pain model. Arthritis was induced by injection of MIA(0.5 mg) into knee joint cavities of rats. Arthritic rats were divided into control(n=8) and treated(n=8) group. Control group was taken distilled water for 20 days. Treated group was taken extracts of GCP by oraly for same duration. Normal group(n=8) was infected with normal saline and was taken distilled water for 20 days. The numbers of NADPH-d positive cells in superficial dorsal horn of spinal cord of treated group($21{\pm}5$) was significantly (p<0.01) decreased compared with control($33{\pm}5$). The numbers of NADPH-d positive cell in dorsolateral periaqueductal gray matter of treated group($111{\pm}16$) was significantly(p<0.01) decreased compared with control($143{\pm}14$). The numbers of c-fos positive cells in dorsal periaqueductal gray matter of treated group($57{\pm}16$) was significantly(p<0.01) decreased compared with control($78{\pm}13$). The numbers of c-fos positive cells in paraventricular thalamic nucleus of treated group($60{\pm}15$) was significantly decreased compared with control($88{\pm}27$). The numbers of serotonin positive cells in median raphe nucleus of treated group($171{\pm}31$) was significantly(p<0.05) decreased compared with control($217{\pm}48$). On the basis of these results, we concluded that GCP treatment has inhibiting effects on the pain transmission in monosodium iodoacetate-induced osteoarthritic pain model in rat.

• The Journal of the Korea Contents Association
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• v.19 no.1
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• pp.242-255
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• 2019

In this study, we examined the antimicroboal effect against Actinobacillus actinomycetemcomitans and Prevotella intermedia which were the bacteria causing the Periodontopathic by using 34 types of natural plant extracts. Therefore, this study measures growth inhibition activity and Minimum Inhibition Concentration (MIC) of a sample extract with the use of organic solvent extracts in order to analyze the antibacterial effect of natural plant extracts on periodontopathic bacteria. Each of the 34 types of natural plant extracts were extracted by using the ethanol, and subsequently, the size of growth inhibition zone(clear zone, ㎜) of respective extracts were measured through the disk diffusion method. As a result, it was found that the growth inhibitory activity was found for A. actinomycetemcomitans, which is the bacteria causing the Periodontitis, in 13 types of natural plant extracts such as Raphanus sativus, Akebia quinata, Paeonia lactiflora, Belamcanda chinensis, Inula britannics, Houttuynia cordata, Forsythia saxatilis, Gentiana macrophylla, Melia azedarach, Scutellaria baicalensis, Coptis chinensis, Phellodendron amurense, Kalopanax Pictus, etc. In the case of P. intermedia, the growth inhibitory activity was found in 13 types of natural plant extracts such as Raphanus sativus, Angelica acutiloba, Akebia quinata, Belamcanda chinensis, Inula britannics, Houttuynia cordata, Cinnamomum cassia, Aster tataricus, Melia azedarach, Scutellaria baicalensis, Coptis chinensis, Phellodendron amurense, Kalopanax Pictus etc. For A. actinomycetemcomitans, anti-bacterial effect was exhibited in Belamcanda chinensis, Cinnamomum cassia, Kalopanax Pictus, Phellodendron amurense, Coptis chinensis. The Coptis chinensis showed the most excellent growth inhibitory activity in all organic solvent fragment, while P. intermedia showed the growth inhibitory activity in Belamcanda chinensis, Cinnamomum cassia, Meliaazedarach, Phellodendron amurense, and Coptis chinensis.