• Title/Summary/Keyword: 지표상태인자

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Evaluation of Parameters of Gas Exchange During Partial Liquid Ventilation in Normal Rabbit Lung (토끼의 정상 폐 모델에서 부분액체환기 시 가스교환에 영향을 주는 인자들에 대한 연구)

  • An, Chang-Hyeok;Koh, Young-Min;Park, Chong-Wung;Suh, Gee-Young;Koh, Won-Jung;Lim, Sung-Yong;Kim, Cheol-Hong;Ahn, Young-Mee;Chung, Man-Pyo;Kim, Ho-Joong;Kwon, O-Jung
    • Tuberculosis and Respiratory Diseases
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    • v.52 no.1
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    • pp.14-23
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    • 2002
  • Background: The opitmal ventilator setting during partial liquid ventilation(PLV) is controversial. This study investigated the effects of various gas exchange parameters during PLV in normal rabbit lungs in order to aid in the development of an optimal ventilator setting during PLV. Methods: Seven New-Zealand white rabbits were ventilated in pressure-controlled mode with the following settings; tidal volume($V_T$) 8 mL/kg, positive end-expiratory pressure(PEEP) 4 $cmH_2O$, inspiratory-to-expiratory ratio(I:E ratio) 1:2, fraction of inspired oxygen($F_TO_2$) 1.0. The respiration rate(RR) was adjusted to keep $PaCO_2$ between 35~45 mmHg. The ventilator settings were changed every 30 min in the following sequence : (1) Baseline, as the basal ventilator setting, (2) Inverse ratio, I:E ratio 2:1, (3) high PEEP, adjust PEEP to achieve the same mean inspiratory pressure (MIP) as in the inverse ratio, (4) High $V_T$, $V_T$ 15 mL/kg, (5) high RR, the same minute ventilation (MV) as in the High $V_T$. Subsequently, the same protocol was repeated after instilling 18 mL/kg of perfluorodecalin for PLV. The parameters of gas exchange, lung mechanics, and hemodynamics were examined. Results: (1) The gas ventilation(GV) group showed no significant changes in the $PaO_2$ at all phases. The $PaCO_2$ was lower and the pH was higher at the high $V_T$ and high RR phases(p<0.05). No significant changes in the lung mechanics and hemodynamics parameters were observed. (2) The baseline $PaO_2$ for the PLV was $312{\pm}$ mmHg. This was significantly lower when decreased compared to the baseline $PaO_2$ for GV which was $504{\pm}81$ mmHg(p=0.001). During PLV, the $PaO_2$, was significantly higher at the high PEEP($452{\pm}38$ mmHg) and high $V_T$ ($461{\pm}53$ mmHg) phases compared with the baseline phase. However, it did not change significantly during the inverse I:E ratio or the high RR phases. (3) The $PaCO_2$ was significantly lower at high $V_T$ and RR phases for both the GV and PLV. During the PLV, $PaCO_2$ were significantly higher compared to the GV (p<0.05). (4) There were no important or significant changes in of baseline and high RR phases lung mechanics and hemodynamics parameters during the PLV. Conclusion: During PLV in the normal lung, adequate $V_T$ and PEEP are important for optimal oxygenation.

Development and Application of Hydrological Safety Evaluation Guidelines for Agricultural Reservoir with AHP (AHP를 이용한 농업용저수지 수문학적 안전성평가 방법 개발 및 적용)

  • Lee, Jae Ju;Park, Jong Seok;Rhee, Kyoung Hoon
    • Journal of Wetlands Research
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    • v.16 no.2
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    • pp.235-243
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    • 2014
  • According to the "Safety Evaluation Detailed Instructions (Dam)", precise safety inspection is carried out for dams that exceed a certain scale. However, as the Hydrological Safety Evaluation from various evaluation standards is designed to evaluate the safety of existing dams considering PMF, the evaluation is much less applicable for most agricultural reservoirs. Therefore, the Hydrological Safety Guidelines for agricultural reservoirs are expected to be re-evaluated considering the diverse risk factors with the coefficient model and AHP in this study. The coefficient model has been developed by selecting the hydrological safety superordinate subordinate evaluation factors to reflect diverse risk factors of agricultural reservoirs. After calculating the sum of indicators score for each evaluation factors, validation procedures were performed for the questionnaire which a panel answered. The practical coefficient has eventually been estimated for the hydrological safety evaluation considering the diverse risk factors. The conclusions acquired based on the study done are that both most agricultural reservoirs were classified as flood defense capability is insufficient and agricultural reservoirs which meet embankment-freeboard standards considering PMF was overestimated.

A Study on the Change of Gait Temporal Parameter and Ankle Joint Moment in Patients with Achilles Tendinitis (아킬레스 건염 환자의 보행 시 고관절, 슬관절 및 족관절 모멘트의 변화에 대한 연구)

  • Yu, Jae-Ho;Lee, Gyu-Chang;Lee, Dong-Yeop
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.12 no.12
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    • pp.5766-5772
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    • 2011
  • This study was to investigate the change of gait temporal parameter and ankle joint moment between patients with achilles tendinitis and healthy people. Thus, the purpose of this study is to clarify biomechanical change of gait in patients with achilles tendinitis and to find risk factor for prevention of achilles tendinitis. We recruited 20 patients with an achilles tendinitis and 20 healthy people. While subjects shuttled 5 times on 13 m distance with comfortable pace, we examined gait function marker with three-dimensional gait analysis system. All subject outstepped center of forceplate during gait and calculated ankle joint moment using software. Obtained data was analyzed using SPSS 12.0 software. In results, we confirmed that patients with achilles tendinitis showed reduction of extension moment in early initial phase and reduction of flexion moment in mid-stance on hip joint. and reduction of flexion moment in early initial phase and reduction of extension moment in late phase on knee joint. And we identified that patients with achilles tendinitis showed reduction of dorsiflexion moment in early stance phase, maximal plantarflexion moment in mid stance phase, and dorsiflexion moment in late stance phase. Thus, there are biomechanical changes on gait in patients with achilles tendinitis compared to healthy people. And, in clinical settings, they should focus on changes of gait in patients with achilles tendinitis. Further study will be undertaken for the biomechanical changes of patietns with achilles tendinitis.

Evaluation of Temporal and Spatial Variations of Water Quality at the Streams Flowing into the Suncheon Bay (순천만 유입수계의 시.공간적 수질환경 평가)

  • Park, Sang-Jin;Cheong, Cheong-Jo
    • Journal of Wetlands Research
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    • v.15 no.3
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    • pp.329-337
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    • 2013
  • This study was performed to evaluate the temporal and spatial variations of the water quality at stream flowing into the Suncheon bay in Suncheon city from October 2008 to August 2009 and to estimate the pollutant sources from the streams using multivariate analysis. Water qualities from Seo stream, Dong stream, Ok stream were evaluated as I grade(very good) that compared to the Water Quality Standard. But Haeryong stream and inlet site of Suncheon Bay in BOD were evaluated as a little bad and fair. Water quality at the stream flowing into the Suncheon Bay was could be explained up to 92.8% by three factors which were included in loading of nutrients, organic matter and total coliform group by the allochthonous matters(53.7%), Topographic Factors(25.0%), seasonal variation(14.2%). The concentrations of total nitrogen and phosphorus at sewage treatment plant and organic matters at Haeryong stream were higher than that of others, respectively. From principal component analysis and factor analysis, it could be suggested that it is very important to make an effort to reduce the nutrients and organic matters from sewage treatment plant and Haeryong stream to be in good conservation of the Suncheon bay.

The Relationship of Plasma Visfatin Level and Anorexia in Terminal Cancer Patients (말기암환자의 혈중 Visfatin 농도와 식욕부진의 관계)

  • Lee, So Jin;Lee, Joon Yong;Choi, Youn Seon;Lee, June Young
    • Journal of Hospice and Palliative Care
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    • v.17 no.1
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    • pp.18-26
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    • 2014
  • Purpose: Anorexia is a common symptom in terminal cancer patients. Some data have suggested a role of visfatin in regulating feeding behavior. We studied the relationship of a serum visfatin level and anorexia in cancer patients provided with hospice care. Methods: After informed consent was obtained, 69 cancer patients over 20 years old at a hospice center were enrolled in the study from July 2009 to July 2010. We characterized patients by age, sex, body mass index, primary cancer site, and Eastern Cooperative Oncology Group (ECOG) performance status, etc. Also, blood tests were performed to measure the level of hemoglobin, white blood cell (WBC), C-reactive protein (CRP), total cholesterol, albumin, lymphocyte count, glucose, blood urea nitrogen (BUN), creatinine, tumor necrosis factor-alpha (TNF-${\alpha}$), interukin-6, leptin and visfatin. Results: The mean age of subjects was 65.5 years old, According to univariate analysis, pulse, ECOG performance scale, opioid use and visfatin level were different between the anorexia and non-anorexic group (P<0.05). The median visfatin level was higher in the anorexia group than the good appetite group (P=0.0323). Serum visfatin concentrations were not related with either body mass index or serum leptin or total cholesterol levels, but it was negatively correlated with serum albumin levels (P=0.0198) and lymphocyte counts (P=0.0013). Conclusion: This study did not identify a novel link between visfatin levels and anorexia in cancer patients at a hospice.

Bio-mediated Flocculation by Extracellular Polymeric Substances in Cohesive Sediment Suspensions: Experimental Study (생체고분자물질이 부유사 응집에 미치는 영향 연구)

  • Baek, Seung-Ryong;Kim, Jae-In;O, Min-Ji;Lee, Byeong-Jun
    • Proceedings of the Korea Water Resources Association Conference
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    • 2015.05a
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    • pp.107-107
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    • 2015
  • 최근 기후변화로 인한 강우강도 증대, 산업화에 따른 토지개발 등으로 인하여 다량의 점착성 부유사(Cohesive Sediments)가 하천, 호소 등 수자원 환경으로 유입되고 있다. 점착성 부유사는 하천, 호소의 난류 조건에 따라 부유하거나 혹은 응집, 침전하여 하상 저니층을 형성한다. 부유사, 미생물 및 각종 유기입자가 포함된 하상 저니층은 검은색으로 외관상 보기 좋지 않을 뿐 아니라, 혐기성상태에서 부패하여 수생태계의 건강성을 해치게 된다. 또한 미세 부유사 및 미생물 입자는 각종 중금속, 유기오염물질을 흡착하고, 조건에 따라 재용출할 수 있는 저장매체로 작용하기 때문에 수자원환경에 미치는 영향이 아주 크다. 특히, 수중 미생물(조류) 작용에 의해 생성되는 EPS (Extracellular Polymeric Substances)는 부유사 및 미생물 입자들을 서로 엉겨 붙게 하여, 부유사-미생물 혼합 응집체 및 저니층 형성을 가속화하게 된다. 본 연구에서는 EPS가 부유사 응집에 미치는 영향을 파악하기 위하여, Xanthan Gum (Sigma-Aldrich, USA)을 EPS의 지표 물질로 사용하고, Kaolinite(Sigma-Aldrich, USA)를 수자원환경에 존재하는 대표적인 부유사로 사용하여 응집실험(Jar Test)을 수행하였다. 이온농도가 응집에 미치는 영향을 파악하기 위하여 수체 이온농도를 0.0001M NaCl, 0.001M NaCl, 0.01M NaCl, 그리고 0.001M NaCl + 0.1mg/L $Ca^{2+}$, 0.001M NaCl + 0.5mg/L $Ca^{2+}$, 0.001M NaCl + 1.0 mg/L $Ca^{2+}$으로 보정하여 응집실험을 수행하였다. 250 rpm 급속 교반 1븐, 50 rpm 완속교반 5시간, 침잔 1시간 후 응집체를 채취하여 응집체 이미지 분석을 통해 응집체 크기 및 형상을 측정하였고, 수표면 2 cm 지점에서 상등액을 채수하여 잔류 고형물 농도 분석을 실시하였다. 응집실험을 통하여 다음과 같은 결과를 도출하였다.. 낮은 이온농도의 경우, EPS가 큰 고분자 구조체에 부유 입자들이 엮어 응집되는 Sweeping Flocculation의 특징을 나타내었다. 하지만, 이온농도가 높아질수록 경우, EPS 고분자 구조체 내부 반발력이 감소하여 크기가 축소되고, 이에 따라 부유 입자 표면에 패치 형태로 흡착되었다. EPS가 패치형태로 입자에 흡착한 경우, 응집제 농도 증가에 따라 응집능 최적점이 형성되고, 이후 표면하전 역전이나 Steric Stabilization에 의해 응집능이 저감되는 형태를 나타낸다. 따라서,수중이온농도가 EPS의 사슬형 고분자 응집제의 크기, 형태(Morphology)를 결정하고, 더 나아가 응집능을 결정하는 중요한 인자로 나타났다. 따라서, 후속 연구를 통하여 생체고분자물질의 크기 및 형태 변화, 이에 따른 응집능변화를 면밀히 연구하고자 한다.

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Effect of Semisulcospira libertina Extract on Hepatic Injury Induced by D-galactosamine (다슬기 추출물이 D-galactosamine에 의해 손상된 간에 미치는 효과)

  • Park, Young Mi;Lee, Jong Eun;Seo, Eul Won
    • Korean Journal of Environmental Biology
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    • v.36 no.4
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    • pp.498-506
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    • 2018
  • The purpose of this study is to examine the restorative effect of Semisulcospira libertina extract, on damaged liver cells induced by D-galactosamine in rats. Treatment of damaged liver cells with S. libertina extract significantly reduced local fatty degeneration, and inflammatory cell necrosis, to levels similar with the undamaged control group. In addition, S. libertina extracts were found to reduce plasma levels of liver damage indicator enzymes, such as AST, ALT, LDH and ALP, to control levels. It also reduced lipid peroxides, and lipid contents within damaged liver tissues. This suggests that S. libertina extract has a restorative effect on liver cells, thus reducing release of damage-associated liver enzymes, and oxidative degradation of lipids. Also, S. libertina extracts were found to be involved in recovery of damaged cells from inflammatory response by suppressing expression of $TNF-{\alpha}$, which leads to tissue injury and necrosis, whereas inducing expression of HO-1 that protects cells during inflammation. Thus, S. libertina extract restores liver tissue from necrosis and fibrosis, as well modulates expression of inflammation-related genes against liver damage. Our findings suggest that S. libertina extract is an effective medicinal resource, for improving and recovering liver cells from hepatic injury.

Reliability Evaluation of the Estimation of Suspended Sediment Dispersion (부유사 확산예측 모형의 신뢰도 평가에 관한 연구)

  • Tac, Dae-Ho;Chung, Younjin;Jun, Eun-Ju;Yang, Joon-Yong
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.28 no.6
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    • pp.890-898
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    • 2022
  • Dispersion of suspended sediment, caused by coastal and marine development, is a key item in assessing marine environmental impact as it adversely affects marine life by increasing the level of turbidity and decreasing the amount of sunlight in seawater. However, its estimation has not been reliable because of the absence of a standard for the data measurement and divergent approaches to the impact assessment. In this study, we examined the estimation models from 58 Marine Environmental Impact Statements (MEISs, 2012-2014) to identify the gaps in the assessment and devise ways of improving the estimation. We developed four index items-grid system; unit load, particle size, and settling velocit-to evaluate their reliability in the estimation. The mean reliability score of each index was overall low-25 for grid system, 60 for unit load, 34 for particle size, and 17 for settling velocity. To ensure high reliability, it is important to develop a standard guideline that defines precise measurement of suspended sediment for unit load and settling velocity by particle size, followed by a grid system with compatible size for modelling. This can improve the estimation and thus underlie coherent impact assessment of suspended sediment dispersion on marine environment.

Virus Inactivation Processes for the Manufacture of Human Acellular Dermal Matrix (인체이식용 무세포 진피 제조를 위한 바이러스 불활화 공정)

  • Bae, Jung-Eun;Kim, Jin-Young;Ahn, Jae-Hyoung;Choi, Da-Mi;Jeong, Hyo-Sun;Lee, Dong-Hyuck;Kim, In-Seop
    • Microbiology and Biotechnology Letters
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    • v.38 no.2
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    • pp.168-176
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    • 2010
  • Acellular dermal matrix (ADM), produced by decellularization from human cadaveric skin, has been used for various biomedical applications. A manufacturing process for ADM ($SureDerm^{TM}$) using tri-n-butyl phospahate (TnBP) and deoxycholic acids as the decellularization solution has been developed. The manufacturing process for $SureDerm^{TM}$ has 70% ethanol treatment and ethylene oxide gas sterilization for inactivating infectious microorganisms. The purpose of this study was to examine the efficacy of the 70% ethanol treatment, decellularization process using 0.1% TnBP and 2% deoxycholic acids, and EO gas sterilization process in the inactivation of viruses. A variety of experimental model viruses for human pathogens, including the human immunodeficiency virus type 1 (HIV-1), bovine herpes virus (BHV), bovine viral diarrhoea virus (BVDV), hepatitis A virus (HAV), and porcine parvovirus (PPV) were all selected for this study. Enveloped viruses such as HIV-1, BHV, and BVDV were effectively inactivated to undetectable levels by 70% ethanol treatment. However HAV and PPV showed high resistance to 70% ethanol treatment with the log reduction factors of 1.85 and 1.15, respectively. HIV-1, BHV, and BVDV were effectively inactivated to undetectable levels by decellularization process. All the viruses tested were completely inactivated to undetectable levels by EO gas treatment. The cumulative log reduction factors of HIV-1, BHV, BVDV, HAV, and PPV were $\geq12.71$, $\geq18.08$, $\geq14.92$, $\geq6.57$, and $\geq7.18$, respectively. These results indicate that the production process for $SureDerm^{TM}$ has a sufficient virus-reducing capacity to achieve a high margin of the virus safety.

The Prognostic Role of B-type Natriuretic Peptide in Acute Exacerbation of Chronic Obstructive Pulmonary Disease (만성폐쇄성폐질환의 급성 악화시 예후 인자로서의 혈중 B-type Natriuretic Peptide의 역할)

  • Lee, Ji Hyun;Oh, So Yeon;Hwang, Iljun;Kim, Okjun;Kim, Hyun Kuk;Kim, Eun Kyung;Lee, Ji-Hyun
    • Tuberculosis and Respiratory Diseases
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    • v.56 no.6
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    • pp.600-610
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    • 2004
  • Background : The plasma B-type natriuretic peptide(BNP) concentration increases with the degree of pulmonary hypertension in patients with chronic respiratory disease. The aim of this study was to examine the prognostic role of BNP in the acute exacerbation of chronic obstructive lung disease (COPD). Method : We selected 67 patients who were admitted our hospital because of an acute exacerbation of COPD. Their BNP levels were checked on admission at the Emergency Department. Their medical records were analyzed retrospectively. The patients were divided into two groups according to their in-hospital mortality. The patients' medical history, comobidity, exacerbation type, blood gas analysis, pulmonary function, APACHE II severity score and plasma BNP level were compared. Results : Multiple logistic regression analysis identified three independent predictors of mortality: $FEV_1$, APACHE II score and plasma BNP level. The decedents group showed a lower $FEV_1$($28{\pm}7$ vs. $37{\pm}15%$, p=0.005), a higher APACHE II score($22.4{\pm}6.1$ vs. $15.8{\pm}4.7$, p=0.000) and a higher BNP level ($201{\pm}116$ vs. $77{\pm}80pg/mL$, p=0.000) than the sSurvivors group. When the BNP cut-off level was set to 88pg/mL using the receiver operating characteristic curve, the sensitivity was 90% and the specificity was 75% in differentiating between the survivors and decedents. On Fisher's exact test, the odds ratio for mortality was 21.2 (95% CI 2.49 to 180.4) in the patients with a BNP level > 88pg/mL. Conclusion : The plasma BNP level might be a predictor of mortality in an acute exacerbation of COPD as well as the $FEV_1$ and APACHE II score.