• Title/Summary/Keyword: 증명완화

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Protective Effect of Citrus unshiu Peel Extract on Ethanol-Induced Fatty Liver in Rats (흰쥐에서 감귤과피 추출물의 알코올성 지방간 개선 작용)

  • Kim, Juyeon;Choi, In-Wook;Noh, Sang Kyu
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.43 no.2
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    • pp.187-193
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    • 2014
  • This study investigated whether or not Citrus unshiu peel extract (CPE) affects fat accumulation in livers of rats fed an ethanol-containing liquid diet. Initially, male Sprague-Dawley rats were housed individually in stainless steel, wire-bottomed cages with free access to a Lieber-Decarli control liquid diet. Rats were divided by body weight into three groups of eight each: one group of rats was fed the Lieber-Decarli control liquid diet devoid of ethanol (control), another was fed the Lieber-Decarli ethanol diet (ethanol), and third was fed the same ethanol diet except containing CPE. All three groups were fed their respective diets for 6 weeks. Serum and liver lipids were analyzed and liver histology performed. Body weight did not differ among the groups over the 6-wk duration. Histology images showed that CPE administration significantly improved fat accumulation in livers, which was induced by ethanol diet. Serum levels of transaminases and lipids also were reduced by CPE consumption. Taken together, the results indicate that CPE may protect ethanol-induced fatty liver by lowering fat accumulation in both the liver and blood. The protective effects of CPE appear to be due to its phenolic contents.

B-site Cationic Ordering Structures of Donor-Doped Relaxor Ferroelectric $Pb({Mg_{1/3}}{Nb_{2/3})}O_3$ (전자 주게가 첨가된 완화형 강유전체 $Pb({Mg_{1/3}}{Nb_{2/3})}O_2$의 B자리 양이온 질서배열구조)

  • Cha, Seok-Bae;Kim, Byeong-Guk;Je, Hae-Jun
    • Korean Journal of Materials Research
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    • v.10 no.7
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    • pp.478-481
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    • 2000
  • Single phase $Pb(Mg_{1/3}Nb_{2/3})O_3$ ceramics doped by 10 mol% of electron donors such as $La^3,\; Pr^{3+,4+},\; Nd^{3+},\; Sm^{3+}$, were synthesized and their B-site cationic ordering structures were investigated by XRD and TEM. In the XRD patterns, only fundamental reflections were observed for the undoped $Pb(Mg_{1/3}Nb_{2/3})O_3$, while the (h/2 $\textsc{k}$/2ι/2)(h,$\textsc{k}$,ι all odd) superlattice reflections resulting from the 1:1 ordering induced unit cell doubling were also observed for the donor-doped $Pb(Mg_{1/3}Nb_{2/3})O_3$. In the TEM selected area diffraction patterns, the (h/2 k/2 l/2)(h,k,l all odd) superlattice reflection spots as well as the fundamental reflection spots were observed for all the samples, but the relative intensities of the superlattice reflection spots to the fundamental reflection spots were significantly enhanced by the donor-doping. In the TEM dark-field images, antiphase boundaries were observed only for the donor-doped $Pb(Mg_{1/3}Nb_{2/3})O_3$. It was therefore experimentally verified that doping by electron donors such as $La^3,\; Pr^{3+,4+},\; Nd^{3+},\; Sm^{3+}$, enhances the B-site cationic 1:1 ordering in $Pb(Mg_{1/3}Nb_{2/3})O_3$. These experimental results were interpreted in terms of the charge compensation mechanism.

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Development of Continuous Indirect Connectivity Model for Evaluation of Hub Operations at Airport (공항의 허브화 평가를 위한 연속연결성지수모형 개발)

  • Lee, Sang-Yong;Yu, Gwang-Ui;Park, Yong-Hwa
    • Journal of Korean Society of Transportation
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    • v.27 no.4
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    • pp.195-206
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    • 2009
  • The deregulation of aviation markets in Europe and the United Sates had led airlines to reconfigure their networks into hub-and-spoke systems. Recent trends of "Open Skies" in the Asian aviation market are also expected to prompt the reformation of airlines' networks in the region. A significant connectivity index is a crucial tool for airlines and airport authorities to estimate the degree of hub-and-spoke operations. Therefore, this paper suggests a new index, Continuous Indirect Connectivity Index (CICI), for measuring the coordination of airlines' flight schedules, applying it to the Asian, European and the American aviation markets. CICI consists of three components:(i) temporal connectivity to identify the attractiveness between connection flights, (ii) spatial connectivity to differentiate the attractiveness by de-routing distance with continuous linear function, and (iii) relative intensity to reflect the effect of direct flight frequency on transfer routes. CICI is evaluated to examine a casual relationship through regression analyses with two dependent variables of the number of transfer passengers and transfer rates. Compared with Danesi's index and Doganis' index through evaluation processes, CICI has a higher coefficient value of determination, implying that it explains the relationship between connectivity and transfer passengers more precisely.

The effect of aroma foot spa on stress (아로마풋스파가 스트레스에 미치는 영향)

  • Lee, Yeon-Hee;Jong, Seo-Woo
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.13 no.5
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    • pp.2206-2211
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    • 2012
  • To identify the effect of the aroma foot spa on the stress, 12 university students with stress were divided into control group (6 subjects) and aroma foot spa group (6 subjects). Control group was not subjected to any kind of intervention while aroma foot spa group was subjected to 10 minutes of foot bath using 5% Juniper, lavender and lemon essential oil and 10 minutes of foot massage using massage cream during four weeks, two times per week. As for the evaluation method, brain wave was studied to measure the amount of change in stress. After measuring the change in the brain wave before and after the experiment, it was proven that the aroma foot spa group s Alpha wave (Z=-2.364, p<.05) and SMR wave (Z=-1.981, p<.05) were higher than those of the control group. Moreover, when the pre and post experiment results of the aroma foot spa group were measured, it was proven that the Theta wave (Z=-2.366, p<.05) decreased while Alpha wave (Z=-2.371, p<.05) increased. In other words, aroma foot spa that included foot bath using essential oil and foot massage increased Alpha wave which in turn influenced the brain wave due to increased blood circulation resulting from muscle relaxation. Moreover, SMR wave increase was closely related to the change in Alpha wave, which demonstrates that SMR wave increased due to stress alleviation. Accordingly, it may be possible to assume that aroma foot spa is effective in relieving stress.

Immunoregulatory Effects of Saengshik on DSS-Induced Inflammatory Bowel Disease in Mouse Model System (DSS로 유도된 염증성 장 질환 마우스 동물모델에서 생식이 장관 임파조직내 면역조절 기능에 미치는 영향)

  • Lim, Beong-Ou;Jeong, Yong-Jun;Park, Mi-Hyoun;Kim, Jong-Dai;Hwang, Sung-Joo;Yu, Byung-Pal
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.36 no.1
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    • pp.32-42
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    • 2007
  • This study was conducted on the immunoregulatory effect of Saengshik on gut-associated lymphoid tissue with inflammatory bowel disease. Although the contents of IgA increased in mesenteric lymph node, IgE content was suppressed by Saengshik. The same results were found in spleen, but IgA and IgE responses were very weak. Concentration of fecal IgA was high from the first day through the third day in Saengshik group. In DSS + Saengshik group, concentration of IgA was high till the 2nd day and it maintained the highest level among the test groups on 5th day. Concentration of IFN-gamma and IL-2 was the highest in the Saengshik group, but the concentration of TNF-alpha was lower in DSS + Saengshik compared to DSS. The expressions of STAT1 in Saengshik group were high, while those of STAT6 were low According to these findings, Saengshik exhibited effectiveness via increasing the IgA production, suppressing the IgE production, followed by inhibiting the production of IL-4 and IL-10. Saengshik also strengthened the immune system and alleviated injury in DSS -induced inflammation.

The Performance Improvement of U-Net Model for Landcover Semantic Segmentation through Data Augmentation (데이터 확장을 통한 토지피복분류 U-Net 모델의 성능 개선)

  • Baek, Won-Kyung;Lee, Moung-Jin;Jung, Hyung-Sup
    • Korean Journal of Remote Sensing
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    • v.38 no.6_2
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    • pp.1663-1676
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    • 2022
  • Recently, a number of deep-learning based land cover segmentation studies have been introduced. Some studies denoted that the performance of land cover segmentation deteriorated due to insufficient training data. In this study, we verified the improvement of land cover segmentation performance through data augmentation. U-Net was implemented for the segmentation model. And 2020 satellite-derived landcover dataset was utilized for the study data. The pixel accuracies were 0.905 and 0.923 for U-Net trained by original and augmented data respectively. And the mean F1 scores of those models were 0.720 and 0.775 respectively, indicating the better performance of data augmentation. In addition, F1 scores for building, road, paddy field, upland field, forest, and unclassified area class were 0.770, 0.568, 0.433, 0.455, 0.964, and 0.830 for the U-Net trained by original data. It is verified that data augmentation is effective in that the F1 scores of every class were improved to 0.838, 0.660, 0.791, 0.530, 0.969, and 0.860 respectively. Although, we applied data augmentation without considering class balances, we find that data augmentation can mitigate biased segmentation performance caused by data imbalance problems from the comparisons between the performances of two models. It is expected that this study would help to prove the importance and effectiveness of data augmentation in various image processing fields.

A Comparative Study on the Burden of proof between Korea and the USA under the Product Liability (제조물책임법상 입증책임에 관한 한·미 간 비교연구)

  • Ha, Choong-Lyong;Kim, Eun-Bin
    • Korea Trade Review
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    • v.43 no.3
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    • pp.101-124
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    • 2018
  • After the establishment of the Korean Product Liability Act, a new clause on the burden of proof has been added and is being revised to meet the purpose of consumer protection. Article 3(2) of the new clause stipulates a provision for estimating a causal relationship when proving indirect facts to alleviate burden of proof. While consumer rights are increasing and public attention is drawn to consumer issues, problems are still emerging. In order to solve the problem, the U.S. Product Liability Act, which has strong consumer rights, was examined to describe the direction in which Korea's Product Liability Act should proceed in terms of consumer protection. The results of the comparative analysis show that the US has expanded the concept of strict liability in terms of rigorous liability, consumer dispute resolution, provable possibility, and litigation accessibility, The consumer dispute settlement system has thoroughly protected consumers by operating educational and systemic consumer ADR system. As for the possibility of proving, Korea has three provenances, and the United States has one. In the United States, where consumer lawsuits are frequent, lawsuits are more accessible than those in Korea, where the party responsible for proving is turned into a manufacturer and responsible for proving the case. This study focuses on consumer protection and provides implications for Korean product liability law.

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The Association of Life Event Stress, Family Function and Cancer (암과 생활사건스트레스 및 가족기능의 연관성)

  • Choi, Youn-Seon;Lee, Young-Mee;Hong, Myung-Ho;Chun, Byung-Chul
    • Journal of Hospice and Palliative Care
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    • v.2 no.2
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    • pp.114-124
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    • 1999
  • Purpose : To clarify the relation between psychosocial variables and cancer in Korea. Methods : Case-control study. Participants: 239 subjects in 2 university hospitals in Seoul completed a series of psychometric instruments(the Olson's FACES III and the Lee's 98-items life event scale). Results : In bivariable analysis, there were statistically significant difference in age and economic status(income): marginal significance in education status and marital status between the cases and controls. The family function type and stress score were not significantly different. The result of multivariable logistic regression, analysis showed that the risk of cancer was associated with economic status and marital status, but neither the family function nor the life event stress. Conclusion : In this study, we cannot prove the statistical association between the family function, life event stress and cancer. It is necessary to persevere in our efforts to clarify the relation between stress and disease and to develop the useful tools to measure the Korean family function and life event stress.

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The Effect of Corticosteroid on the Treatment of Endobronchial Tuberculosis (기관지 결핵 환자에서 부산피질 스테로이드 투여가 기관지 협착의 완화에 미치는 영향)

  • Mo, Eun-Kyung;Kim, Ho-Joong;Kim, Dong-Gyn;Choi, Jung-Eun;Park, Myung-Jae;Hyun, In-Gyu;Lee, Myung-Koo;Jung, Ki-Suck
    • Tuberculosis and Respiratory Diseases
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    • v.44 no.2
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    • pp.409-418
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    • 1997
  • Objective : Appropriate antituberculosis chemotherapy may not prevent occurrence or progression of tracheobronchial stenosis and obstruction in the patients with endobronchial tuberculosis. The effect of corticosteroid treatment combined with antituberculosis chemotherapy was inconclusive. We evaluated prospectively the effect of corticosteroid treatment. Methods : We diagnosed endobronchial tuberculosis by bronchoscopic examination and bronchial biopsy in the patients of tuberculosis within one month of antituberculosis chemotherapy. After randomization, we prescribed isoniazid, rifampin, ethambutol, and pyrazinamide with or without prednisolone 40 mg for 4 weeks. We carried out bronchoscopy in second month and ninth month of treatment. Results : Edematous endobronchial tuberculosis showed significant improvement of bronchial stenosis after corticosteroid treatment(p < 0.05). Corticosteroid treatment did not have advantage of improvement of bronchial stenosis in the patients with infiltrative endobronchial tuberculosis. Conclusion : Corticosteroid is effective in the treatment of bronchial stenosis when endobronchial tuberculosis is edematous type, in the early period of antituberculosis chemotherapy.

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Effect of Sweet Persimmon Wine on Alcoholic Fatty Livers in Rats (흰쥐에서 단감발효주가 알코올성 지방간 형성에 미치는 영향)

  • Nam, Kyung-Sook;Kim, Ju-Youn;Noh, Sang-K.;Park, Joong-Hyeop;Sung, Eon-Gi
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.40 no.11
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    • pp.1548-1555
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    • 2011
  • Persimmons are shown to contain high levels of phenolics. The present study was designed to investigate if a sweet persimmon wine (SPW) would affect the development of alcoholic fatty liver in rats. Initially, male Sprague-Dawley rats were housed singly in stainless steel wire-bottomed cages in a room of controlled temperature and lighting. The rats had free access to a nutritionally adequate AIN-93G diet and deionized water. After the acclimatization period, rats were weight-matched and assigned to the following three groups: two groups were fed 6.7% ethanol or the caloric equivalent of maltose-dextrin in a Lieber-DeCarli diet and the other group was fed the isocaloric Lieber-DeCarli diet containing SPW at the same ethanol level. All three groups were fed their respective diets for 6 weeks. Serum transaminase, cholesterol, and triglyceride levels were measured. Liver lipids and histology were assessed at 6 weeks. The total phenolic content and the antioxidant and free radical scavenging activities of SPW were determined. SPW significantly increased antioxidant and free radical scavenging activities. As markers of liver injury, serum alanine and aspartate transminases were markedly lowered by SPW at 6 weeks. SPW significantly reduced the serum levels of serum cholesterol and triglyceride compared to ethanol treatment. SPW delayed the development of an alcoholic fatty liver by reversing fat accumulation in the liver, as evidenced in histological observations. Taken together, SPW seems to protect the liver from becoming fatty by alleviating fatty liver symptoms and lowering hepatic and serum lipid levels. Such a protective effect of SPW appears to be in part due to its phenolics.