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http://dx.doi.org/10.3746/jkfn.2011.40.11.1548

Effect of Sweet Persimmon Wine on Alcoholic Fatty Livers in Rats  

Nam, Kyung-Sook (Dept. of Food and Nutrition, Changwon National University)
Kim, Ju-Youn (Dept. of Food and Nutrition, Changwon National University)
Noh, Sang-K. (Dept. of Food and Nutrition, Changwon National University)
Park, Joong-Hyeop (MalGeun Naeil Co.)
Sung, Eon-Gi (Dept. of Anatomy, Youngnam University Medical School)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.40, no.11, 2011 , pp. 1548-1555 More about this Journal
Abstract
Persimmons are shown to contain high levels of phenolics. The present study was designed to investigate if a sweet persimmon wine (SPW) would affect the development of alcoholic fatty liver in rats. Initially, male Sprague-Dawley rats were housed singly in stainless steel wire-bottomed cages in a room of controlled temperature and lighting. The rats had free access to a nutritionally adequate AIN-93G diet and deionized water. After the acclimatization period, rats were weight-matched and assigned to the following three groups: two groups were fed 6.7% ethanol or the caloric equivalent of maltose-dextrin in a Lieber-DeCarli diet and the other group was fed the isocaloric Lieber-DeCarli diet containing SPW at the same ethanol level. All three groups were fed their respective diets for 6 weeks. Serum transaminase, cholesterol, and triglyceride levels were measured. Liver lipids and histology were assessed at 6 weeks. The total phenolic content and the antioxidant and free radical scavenging activities of SPW were determined. SPW significantly increased antioxidant and free radical scavenging activities. As markers of liver injury, serum alanine and aspartate transminases were markedly lowered by SPW at 6 weeks. SPW significantly reduced the serum levels of serum cholesterol and triglyceride compared to ethanol treatment. SPW delayed the development of an alcoholic fatty liver by reversing fat accumulation in the liver, as evidenced in histological observations. Taken together, SPW seems to protect the liver from becoming fatty by alleviating fatty liver symptoms and lowering hepatic and serum lipid levels. Such a protective effect of SPW appears to be in part due to its phenolics.
Keywords
sweet persimmon wine; alcoholic fatty liver; rats;
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1 Yoon OH, Kang BT, Lee JW, Kim KO. 2008. Effect of plum wine on the lipid metabolism and lipid peroxidation of rats. J Korean Soc Food Sci Nutr 37: 422-427.   과학기술학회마을   DOI
2 Shin CS, Rho SN. 2006. Effect of powder of small waterdropwort (Oenanthe javanica DC) and Brewer's yeast (Saccharomyces cerevisiae) on the liver function and serum lipid metabolism in alcohol-consumed rats. J East Asian Soc Dietary Life 16: 281-291.
3 Harata J, Nageta M, Sasaki E, Ishiguro I, Ohta Y, Yamazaki M, Hoshino T. 1982. Changes in activities of various enzyme and GOT isoenzyme in serum and liver of prolonged alcohol administered rats. Jpn J Alcol & Drug Dependence 17: 237-244.
4 Dakeishi M, Iwate T, Ishil N, Murata K. 2004. Effects of alcohol consumption on hepatocellular injury in Japanese men. Tohoku J Exp Med 202: 31-39.   DOI
5 Kammerer D, Claus A, Carle R, Schieber A. 2004. Polyphenol screening of pomace from red and white grape varieties (Vitis vinifera L.) by HPLC-DAD-MS/MS. J Agric Food Chem 52: 4360-4367.   DOI
6 Lieber CS. 1994. Alcohol and the liver. Gastroenterology 106: 1085-1105.   DOI
7 Anila L, Vijayalakshmi NR. 2002. Flavonoids from Emblica officinalis and Mongifera indica-effectiveness for dyslipidemia. J Ethnopharmacol 79: 81-87.   DOI
8 Seo HJ, Jeong KS, Lee MK, Park YB, Jung UJ, Kim HJ, Choi MS. 2003. Role of naringin supplement in regulation of lipid and ethanol metabolism in rats. Life Sci 73: 933-946.   DOI
9 Lee SH, Bae KH, Lee HJ, Eun JB, Kim MK. 1999. Effect of hesperidin extracted from tangerine peel on Cd and lipid metabolism, and antioxidative capacity in rats. Korean J Nutr 32: 137-149.   과학기술학회마을
10 Pikaar NA, Wedel M, van der Beek EJ, van Dokkum W, Kempen HJ, Kluft C, Ockhuizen T, Hermus RJ. 1987. Effects of moderate alcohol consumption on the platelet aggregation fibrinolysis, and blood lipids. Metabolism 36: 538-543.   DOI
11 Zeman FJ. 1991. Liver disease and alcoholism. In Clinicalnutrition and Dietetics. 2nd ed. Macmillan Publ., New York, NY, USA. p 517-553.
12 Park JY, Park EM, Lee MK, Jang JY, Kim MJ, Cho SY. 2000. Effect of persimmon leaves (Diospyros kaki folium) extract on serum and liver lipid concentrations in hypercholesterolemic rats. J Korean Soc Food Sci Nutr 29: 537-542.   과학기술학회마을
13 Noh SK, Koo SI. 2004. Milk sphingomyelin is more potent inhibitor than egg sphingomyelin of intestinal absorption of cholesterol and $\alpha$-tocopherol in rats. J Nutr 134: 2611-2616
14 Noh SK, Koo SI. 2003. Egg sphingomyelin lowers the lymphatic absorption of cholesterol in rats. J Nutr 133: 3571-3576.
15 Nuria MC, Isabel G, Jose AL, Alejandra GA, Fulgencia SC. 1999. Reduction in serum total and LDL cholesterol concentrations by a dietary fiber and polyphenol-rich grape product in hypercholesterolemic rats. Nutr Res 9: 1371-1381.
16 Yugarani T, Tan BK, Das NP. 1993. The effect of tannic acid on serum lipid parameters and tissue lipid peroxides in the spontaneously hypertensive and Wistar Kyoto rats. Planta Med 59: 28-31.   DOI
17 Yugarani T, Tan BK, Das NP. 1993. The effects of tannic acid on serum and liver lipids of RAIF and Rkco rats fed on high fat diet. Comp Biochem Physiol Comp Physiol 104: 339-343.   DOI
18 Shin HK, Seo YJ, Kim JY, Kim CS, Noh SK. 2007. Onion favorably affects serum markers of ethanol-induced fatty liver in rats. Korean J Food Preserv 14: 662-668.   과학기술학회마을
19 Noh SK, Koo SI, Jeon IJ. 1999. Estrogen replacement in ovariectomized rats increases the hepatic concentration and biliary secretion of alpha-tocopherol and polyunsaturated fatty acids. J Nutr Biochem 10: 110-117.   DOI
20 Slover HT, Lanze E. 1979. Quantitative analysis of food fatty acids by capillary gas chromatography. J Am Oil Chem Soc 56: 933-943.   DOI
21 Achiwa Y, Hibasmi H, Katsuzaki H, lami K, Komiya T. 1997. Inhibitory effects of persimmon (Diospyros kaki) extract and related polyphenol compounds on growth of human lymphoid leukemicells. Biosci Biotechnol Biochem 61: 1099-1101.   DOI
22 Lee SO, Kim MJ, Kim DG, Choi HJ. 2005. Antioxidative activities of temperature-stepwise water extracts from Inonotus obliquus. J Korean Soc Food Sci Nutr 34: 139-147.   과학기술학회마을   DOI
23 Seo HK, Jang SY, Kim HJ Park HR. 2010. Antioxidant activity and neuroprotective effect of concentrates from commercial sweet persimmon wine. Korean J Food Cookery Sci 26: 13-17.   과학기술학회마을
24 Chol Y, Yu KW, Han NS, Koh JH, Lee JS. 2006. Antioxidant activities and antioxidant compounds of commercial red wines. J Korean Soc Food Sci Nutr 35: 1286-1290.   과학기술학회마을   DOI
25 Moon YG, Choi KS, Lee KJ, Kim KY, Heo MS. 2006. Screening of antioxidative and antibacterial activity from hot water extracts of indigenous plants, Jeju-Island. Korean J Biotechnol Bioeng 21: 164-169.   과학기술학회마을
26 Choi JH, Oh SK. 1985. Studies on the anti-aging action of Korean ginseng. J Korean Food Sci Technol 17: 506-515.   과학기술학회마을
27 Lieber CS, DeCarli LM. 1974. An experimental model of alcohol feeding and liver injury in the baboon. J Med Prim 3: 153-163.   DOI
28 Singleton VL, Orthofer R, Lamuela-Raventos RM. 1999. Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent. Methods Enzymol 299: 152-178.   DOI
29 Hibashmi H, Achiwa Y, Fujikawa T, Komiya T. 1996. Induction of programmed cell death (apoptosis) in human lymphoid leukemia cells by catechin compounds. Anticancer Res 16: 1943-1946.
30 Kim SG, Lee YC, Suh KG, Choi HS. 2001. Acetaldehyde dehydrogenase activator from persimmon and its processed foods. Korean J Food Sci Technol 30: 954-958.   과학기술학회마을
31 Dewanto V, Wu X, Adom KK, Liu RH. 2002. Thermal processing enhance the nutritional value of tomatoes by increasing total antioxidant activity. J Agric Food Chem 50: 3010-3014.   DOI
32 Blois MS. 1958. Antioxidant determination by the use of a stable free radical. Nature 181: 1199-1200.   DOI
33 Marklund S, Marklund G. 1974. Involvement of superoxide anion radical in the oxidation of pyrogallo and a convenient assay for superoxide dismutase. Eur J Biochem 47: 467-474.
34 Lieber CS, DeCarli LM. 1986. The feeding of ethanol in liquid diets. Alcohol Clin Exp Res 10: 550-553.   DOI
35 Loest HB, Noh SK, Koo SI. 2002. Green tea extract inhibits the lymphatic absorption of cholesterol and $\alpha$-tocopherol in ovariectomized rats. J Nutr 132: 1282-1288.
36 Folch PJ, Lees M, Sloane-Stanley GM. 1957. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226: 497-509.
37 Agren JJ, Julkunen A, Penttilä I. 1992. Rapid separation of serum lipids for fatty acid analysis by a single aminopropyl column. J Lipid Res 33: 1871-1876.
38 Seo JH, Jeong YJ, Shin SR, Kim KS. Effects of tannins from astringent persimmons in alcohol fermentation for persimmon vinegars. J Korean Soc Food Sci Nutr 29: 407-411.   과학기술학회마을
39 Lee YH. 2001. Effect of Ligularia stenocephala extract on lipid metabolism and liver function of rat administered with ethanol. MS Thesis. Dong-A University, Busan, Korea.
40 Rehm J, Mathers C, Popova S, Thavorncharoensap M, Teerawattananon Y, Patra J. 2009. Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders. Lancet 373: 2223-2233.   DOI   ScienceOn
41 Lee JB. 2003. A study on the alcohol fermentation of sweet persimmon (Diospyros kaki) juice. MS Thesis. Chinju University, Gyeongnam, Korea.
42 Emile A, Celine M, Gisele HA, Annelise L, Robert A, Alain B, Jean CS, Ramaroson A. 1998. Natural dietary polyphenolic compounds cause endothelium-dependent vasorelaxationin rat thoracic aorta 1. J Nutr 12: 2324-2333.
43 Kawase M, Motohashi N, Satoh K, Sakagami H, Nakashima H, Tani S, Shirataki Y, Kurihara T, Spengler G, Wolfard K, Molnar J. 2003. Biological activity of persimmon (Diospyros kaki ) peel extracts. Phytother Res 17: 495-500.   DOI
44 Gorinstein S, Kulasek GW, Bartnikowska E, Leontowicz M, Zemser M, Morawiec M, Trakhtenberg S. 2000. The effects of diets, supplemented with either whole persimmon or phenol-free persimmon, on rats fed cholesterol. Food Chem 70: 303-308.   DOI