• Journal of Ginseng Research
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• v.28 no.2
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• pp.111-119
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• 2004

The renoprotective effects of Korean Red Ginseng were examined in STZ-induced diabetic spontaneously hypertensive rats (SHR). After 3 day administration of streptozotocin (STZ), animals were divided into four groups : Group 1, hypertensive rats (H); Group 2, hypertensive rats with diabetes (HD); Group 3, hypertensive rats with diabetes administered with 100 mg/kg of ginseng total saponin(GTS); Group 4, hypertensive rats with diabetes administered with 600 mg/kg of ginseng non-saponin (GNS). After 2 weeks oral administraions of GTS and GNS, body weight, kidney weight, plasma glucose, urinary albumin excretion, serum creatinine, urea nitrogen and blood pressure were examined. After 3,7 and 21 day of STZ administration, expressions of TGF-${\beta}$1 and fibronectin in kidney were analyzed by immunoblotting and/or immunohistochemistry. GTS and GNS treatments slightly decreased blood pressure when compared to H and HD groups. Also, GTS and GNS treatments ameliorated kidney hypertrophy without affecting plasma glucose levels. Meanwhile, GNS treatment increased Cu/Zn-SOD activity in kidney and generally showed more efficient renoprotective effects than GTS. We suggest that the renoprotective effects of ginseng partially result from downregulations of TGF-${\beta}$1, fibronectin expressions and anti-oxidative activity of ginseng non-saponin.

• The Journal of the Petrological Society of Korea
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• v.14 no.3 s.41
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• pp.141-148
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• 2005

Lead isotopic compositions are analyzed from the sulfide minerals of the Yeonhwa, Janggun and Uljin deposits and from host limestone, intrusives, and basement rocks to reveal the source of Pb in these deposits. In the $^{206}Pb/^{204}Pb$ vs $^{207}Pb/^{204}Pb$ plot, Galenas from the Yeonhwa mine display relatively well defined positive linear array, similar to the Precambrian basement rocks of the Korean peninsula. A galena sample from the Uljin mine, Janggun limestone and the basement rocks also follow the variation of Yeonhwa mine. However, ore minerals from the Janggun mine, having relatively low $^{206}Pb/^{204}Pb$ values, reveal offset from such trend toward lower $^{207}Pb/^{204}Pb$ values. Considering the fact that Mesozoic igneous rocks and ores within the Gyeongsang basin display considerably lower $^{207}Pb/^{204}Pb$ values than basement rocks of the Korean peninsula, the deviation of Janggun ore minerals can be interpreted as to reflect mixing between leads from old continental crustal materials and from Mesozoic igneous rocks with more mantle signature. The lead of the Yeonhwa and Uljin mine, following trend of Precambrian basement rather well, seems to have been originated mostly from such basement. However, regarding that they occupy low $^{207}Pb/^{204}Pb$ side of the variation trend of the basement, the possibility of having some leads derived from the Mesozoic igneous rocks cannot be excluded.

• Korean Journal of Food Science and Technology
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• v.45 no.2
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• pp.199-205
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• 2013

We investigated the anti-obesity effects of Ishige okamurae extract (IOE) on body weight, epididymal adipose tissue weight, plasma lipid levels, and leptin levels in high-fat diet (HFD)-induced obese mice. After inducing obesity by feeding 45% HFD for 4 weeks, C57BL/6J mice were randomly assigned to HFD or HFD containing 5% IOE, and then fed for 6 weeks. The body weight and epididymal adipose tissue weight were increased by HFD, but they were significantly less in animals fed HFD containing 5% IOE than in those fed HFD. Levels of plasma triglyceride, total cholesterol, and LDL-cholesterol were significantly lower, but the HDL-cholesterol level was significantly higher in animals fed HFD containing 5% IOE compared with the HFD group. The plasma leptin level was significantly lower in animals fed HFD containing 5% IOE. The diet containing 5% IOE did not show any adverse effects on liver and kidney functions. These results suggest that IOE has a potential as anti-obesity agent by reducing body weight and lowering the levels of obesity-related factors in plasma.

• Journal of Sericultural and Entomological Science
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• v.41 no.1
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• pp.41-47
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• 1999

Silk fibroin dissolved in highly concentrated calcium chloride and ethanol mixture aqueous solution turned into gel under suitable conditions. Preparation conditions and properties of gel were investigated as a function of parameters such as pH of solution, fibroin concentration, glycerol concentration and molecular weight. When pH of silk fibroin aqueous solution was near the isoelectronic point(pH 3.9~4.0), gelation occurred rapidly and strength of gel was stonger than that of pH-unadjusted due to electrostatic repulsion decrease between silk fibroin macromolecules. As concentration of silk fibroin and glycerol was higher, gelation occurred more rapid. FT Infra-red spectra of freeze-dried fibroin gel showed that gelation was derived by intermolecular anti-parallel ${\beta}$-sheet structure formation. In addition to, it was found that white-precipitate occurred instead of gelation when aqueous silk fibroin was treated by enzyme(flavouzyme), however, after flavouzyme-treated silk fibroin aqueous solution was centrifugated gelation occurred instantly. The results of differential scanning thermal analysis and infra-red spectroscopy showed that thermal stability and crystallinity of enzyme-hydrolyzed fibroin are superior to those of unhydrolyzed fibroin.

• Journal of Yeungnam Medical Science
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• v.19 no.1
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• pp.39-48
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• 2002

Background: The treatment of rheumatoid arthritis still depend on conserve therapy in major. Recent studies report that n-3 polyunsaturated fatty acids(PUFA) could modulate the incidence and progress of arthritis. The purpose of this study was to investigate the effects of n-3 PUFA on the development of collagen-induced arthritis in rats. Materials and Methods: Female Louvain rats were used for this experiment. Rats were randomly assigned into either normal (n=8) or collagen-immunized groups, and collagen immunized groups were divided into control(n=8, normal diet) and n-3 PUFA(n=8, 5% n-3 PUFA in diet) groups. One week after feeding n-3 PUFA to rats, they were immunized with type II collagen emulsified in incomplete Freund's adjuvant into tail and back. Development of arthritis was confirmed by x-ray and microscopic examination. Results: Incidence of arthritis at the 5th week after immunization was 38% in control and 0% in n-3 PUFA. Rats with arthritis showed edema in hind paws and inflammation in synovial membrane of the knee joint. Plasma glucose and insulin were not changed by both of immunization and diet. Plasma triglycerides and cholesterol concentrations were decreased by n-3 PUFA. Conclusion: n-3 PUFA may prevent or treat collagen-induced arthritis m rats. Further studies are needed for action mechanism of it.

• Journal of the Korean Society of Food Science and Nutrition
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• v.26 no.1
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• pp.103-108
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• 1997

It has been known that garlic, one of the essential ingredients of spices in Korean food, has a hypotensive effect. The following experiments were done to compare the effect of heat treatment of garlic on change in blood pressure. We selected SHR(Spontaneously Hypertension Rat) for experimental animals since, in the case of human beings, 85~90% of high blood pressure is in hereditary origin. Animals were divided into 3 groups, control group(no garlic), 3% raw garlic group and 3% heated garlic group. Serum was analyzed for lipid concentration, and plasma for prothrombin time and fi-brinogen concentration. The effects of heat treatment of garlic were as follow. There was no significant differences in body weight gain and feed efficiency ratio except that feed intake of 3% heated garlic-fed group was significantly lower than that of control group and 3% raw garlic-fed group. Garlic-fed groups, in contrast to the control group, showed significant difference in cholesterol content in pro-thrombin time and in fibrinogen concentration. Taken together, hypotensive effects of garlic on high blood pressure were significant. Regardless of heat treatment both heated garlic and raw garlic showed hypotensive effects.

• Journal of the Korean Society of Food Science and Nutrition
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• v.24 no.6
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• pp.829-836
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• 1995

This study was performed to evaluate the relationship between dietary, blood and urinary levels of lead and blood pressure and serum lipids in 30 healthy adult living in rural area of Korea. Analysis for the nutritional status of subjects were performed by 3-day dietary intake record, duplicated diet collection, 24-hour urine collection, and venous blood sampling before anthropometry. The mean daily intakes of lead estimated for 3 days was $120.1{\pm}22.0\mu\textrm{g}$. The blood levels and 24-hour urinary excretion of lead were $10.8{\pm}3.6\mu\textrm{g}/dl\;and\;36.5{\pm}9.5\mu\textrm{g}$, respectively. The systolic and diastolic blood pressure were $113.0{\pm}16.9mmHg\;and\;76.7{\pm}12.1\;mmHg$. The serum levels of total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol and ${\beta}-lipoprotein$ were $158.8{\pm}32.9mg/dl,\;104.6{\pm}48.8mg/dl,\;45.7{\pm}9.9mg/dl,\;92.2{\pm}28.5mg/dl\;and\;426.4{\pm}141.5mg/dl$, respectively. There was no significance in the relation between lead and blood pressure. In the relation between lead and serum lipids, it showed negative correlation with lead intake and HDL-choleterol at the level of significance of p<0.01. But there was no significance in the relation between lead and serum levels of otehr lipids.

• Journal of the Korean Society of Food Science and Nutrition
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• v.41 no.7
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• pp.895-900
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• 2012

The effects of three fractions, hexane (BHHH), chloroform (BHHC), and ethyl acetate (BHHE), from water extract of Benincasa hispida on the underlying mechanisms of adipogenesis were investigated in 3T3-L1 cells. Intracellular lipid droplets were stained with Oil Red O dye and quantified. Compared to control, lipid accumulation significantly decreased by 11% and 13% upon treatment with BHHC and BHHE, respectively at a concentration of 50 ${\mu}g/mL$. Intracellular triglyceride (TG) levels were also reduced by 21% and 16%, respectively, at the same concentration. To determine the mechanism behind the reductions in TG content and lipid accumulation, glycerol release and expression levels of adipogenic marker genes were measured. The levels of free glycerol released into culture medium increased by 13% and 17% upon treatment with BHHC and BHHE, respectively. In subsequent measurements using real-time polymerization chain reaction, the mRNA levels of $PPAR{\gamma}$, C/$EBP{\alpha}$, and leptin significantly decreased upon treatment with BHHE (45%, 67%, and 35%) in comparison with non-treated control. These results suggest that BHHE inhibits adipocyte differentiation by blocking $PPAR{\gamma}$, C/$EBP{\alpha}$, and leptin gene expression in 3T3-L1 cells, resulting in reduced lipid accumulation, increased glycerol release, and intracellular triglycerides.

• Journal of Navigation and Port Research
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• v.26 no.1
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• pp.22-27
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• 2002

The 25 Watt hybrid MIC SSPA has been developed in the frequency rang from 1.6265 GHz to 1.6465 GHz for uplink of INMARST's earth station. To simplify the fabrication process, the whole system is designed of two parts composed of a friving amplifier and a power amplifier. The Motorolas MRF-6401 is used for driving part, the Motorolas MRF-16006 and MRF-16030 is used the power amplifier. We reduced weight and volume of high power amplifier through arranging the bias circuits in the same housing. The realized SSPA has more than 30 dB for gain within 20 MHz bandwidth, and the voltage standing wave ratios(VSWR) of input and output port are less than 1.7, respectively. The output power of 44 dBm is achieved at the 1 dB gain compression point of 106365 GHz These results reveal a high power amplifier of 25 Watt which is the design target. The Proposed SSPA manufacture techniques in this paper can be applied to the implementation of high power amplifiers for some radars and SCPC.

• Korean Chemical Engineering Research
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• v.44 no.4
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• pp.350-355
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• 2006

Growth curves of microbes were examined to evaluate decomposition of metal-working fluids and decomposition properties of metal-working fluids were experimented using controled microbes such as E. coli and K. pnemoniae. According to the results of growth curve of microbes, the growth period depended on species of microbes, 2 h of E. coli, 3 h of K. pneumoniae, 4 h of P. aeruginosa and 3 h of P. oleovarans after incubation. The colony count of E. coli and K. pneumoniae controled to OD of 0.5 ranged from $4.4{\sim}10.0{\times}10^5CFU/mL$ and $1.8{\sim}9.5{\times}10^7CFU/mL$, respectively. The decomposition of metal-working fluids was excellently progressed in the range of pH 6~8 than below pH 4 and above pH 10. In the case of controled fluids to pH 6~8, the decomposition of the fluid containing ester group was more accelerated than that of the fluid containing ethylene glycol.