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http://dx.doi.org/10.5142/JGR.2004.28.2.111

Renoprotective Effects of Korean Red Ginseng  

Kim, Young-Lim (College of Pharmacy, Kyung Hee University)
Chung, Sung-Hyun (College of Pharmacy, Kyung Hee University)
Publication Information
Journal of Ginseng Research / v.28, no.2, 2004 , pp. 111-119 More about this Journal
Abstract
The renoprotective effects of Korean Red Ginseng were examined in STZ-induced diabetic spontaneously hypertensive rats (SHR). After 3 day administration of streptozotocin (STZ), animals were divided into four groups : Group 1, hypertensive rats (H); Group 2, hypertensive rats with diabetes (HD); Group 3, hypertensive rats with diabetes administered with 100 mg/kg of ginseng total saponin(GTS); Group 4, hypertensive rats with diabetes administered with 600 mg/kg of ginseng non-saponin (GNS). After 2 weeks oral administraions of GTS and GNS, body weight, kidney weight, plasma glucose, urinary albumin excretion, serum creatinine, urea nitrogen and blood pressure were examined. After 3,7 and 21 day of STZ administration, expressions of TGF-${\beta}$1 and fibronectin in kidney were analyzed by immunoblotting and/or immunohistochemistry. GTS and GNS treatments slightly decreased blood pressure when compared to H and HD groups. Also, GTS and GNS treatments ameliorated kidney hypertrophy without affecting plasma glucose levels. Meanwhile, GNS treatment increased Cu/Zn-SOD activity in kidney and generally showed more efficient renoprotective effects than GTS. We suggest that the renoprotective effects of ginseng partially result from downregulations of TGF-${\beta}$1, fibronectin expressions and anti-oxidative activity of ginseng non-saponin.
Keywords
Korean red ginseng; spontaneously hypertensive rat; streptozotocin; ginseng total saponin; ginseng non-saponin; TGF-${\beta}$1; fibronectin; SOD;
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