• Journal for History of Mathematics
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• v.25 no.4
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• pp.53-67
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• 2012

Today, it is necessary to calculate orbits with high accuracy in space flight. The key words of Poincar$\acute{e}$ in celestial mechanics are periodic solutions, invariant integrals, asymptotic solutions, characteristic exponents and the non existence of new single-valued integrals. Poincar$\acute{e}$ define an invariant integral of the system as the form which maintains a constant value at all time $t$, where the integration is taken over the arc of a curve and $Y_i$ are some functions of $x$, and extend 2 dimension and 3 dimension. Eigenvalues are classified as the form of trajectories, as corresponding to nodes, foci, saddle points and center. In periodic solutions, the stability of periodic solutions is dependent on the properties of their characteristic exponents. Poincar$\acute{e}$ called bifurcation that is the possibility of existence of chaotic orbit in planetary motion. Existence of near exceptional trajectories as Hadamard's accounts, says that there are probabilistic orbits. In this context we study the eigenvalue problem in early 20th century in three body problem by analyzing the works of Darwin, Bruns, Gyld$\acute{e}$n, Sundman, Hill, Lyapunov, Birkhoff, Painlev$\acute{e}$ and Hadamard.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.2
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• pp.802-809
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• 2021

To cope with the increasing maintenance costs due to aging, the maintenance cost was evaluated from the perspective of asset management. The maintenance cost can be predicted based on the condition of the bridge, and the life cycle cost is used as an index. In general, the condition of a bridge has a wide distribution characteristic depending on the deterioration, load, and material characteristics. In this paper, to evaluate the effect of the bridge conditions on the life cycle cost, condition prediction models were constructed considering the service life, deterioration rate, and inspection error, which are the main variables of the bridge condition and life cycle cost calculation. In addition, condition prediction models were constructed based on the distribution of the health index to estimate the upper and lower bounds of the life cycle costs that can occur in individual bridges. Life cycle cost analysis showed that the life cycle cost differed significantly according to the condition of the bridge. Accordingly, research will be needed to increase the reliability of predicting the life cycle cost of individual bridges.

• Journal of Life Science
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• v.25 no.1
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• pp.1-7
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• 2015

Cyclin D is a member of the cyclin protein family, which plays a critical role as a core member of the mammalian cell cycle machinery. D-type cyclins (D1, D2, and D3) bind to and activate the cyclin-dependent kinases 4 and 6, which can then phosphorylate the retinoblastoma tumor suppressor gene products. This phosphorylation in turn leads to release or derepression of E2F transcription factors that promote progression from the G1 to S phase of the cell cycle. Among the D-type cyclins, cyclin D3 encoded by the CCND3 gene is one of the least well studied. In the present study, we have investigated the biochemistry of the proteolytic mechanism that leads to loss of cyclin D3 protein. Treatment of human prostate carcinoma PC-3-M cells with lovastatin and actinomycin D resulted in a loss of cyclin D3 protein that was completely reversible by the peptide aldehyde calpain inhibitor, LLnL. Additionally, using inhibitors for various proteolytic systems, we show that degradation of cyclin D3 protein involves the $Ca^{2+}$-activated neutral protease calpain. Moreover, the half-life of cyclin D3 protein half-life increased by at least 10-fold in PC-3M cells in response to the calpain inhibitor. We have also demonstrated that the transient expression of the calpain inhibitor calpastatin increased cyclin D3 protein in serum-starved NIH 3T3 cells. These data suggested that the function of cyclin D3 is regulated by $Ca^{2+}$-dependent protease calpain.

• Journal of Life Science
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• v.16 no.4
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• pp.598-604
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• 2006

The $Ca^{2+}-activated$ neutral protease calpain induced proteolysis has been suggested to play a role in certain cell growth regulatory proteins. Cyclin proteolysis is essential for cell cycle progression. D-type cyclins, which form an assembly with cyclin-dependent kinases (cdk4 and cdk6), are synthesized earlier in G1 of the cell cycle and seem to be induced in response to external signals that promote entry into the cell cycle. Here we show that cyclin D3 protein levels are regulated at the posttranscriptional level by calpain protease. Treatment of human breast carcinoma MDA-MB-231 cells with lovastatin and actinomycin D resulted in a loss of cyclin D3 protein that was completely reversible by the peptide aldehyde calpain inhibitor, LLnL. The specific inhibitor of the 26S proteasome, lactacystin, the lysosome inhibitors, ammonium chloride and chloroquine, and the serine protease inhibitor, phenylmethylsulfonylfluoride (PMSF), did not block the degradation of cyclin D3 by lovastatin and actinomycin D. Results of in vitro degradation of cyclin D3 by purified calpain showed that cyclin D3 protein is degraded in a $Ca^{2+}-dependent$ manner, and the half-life of cyclin D3 protein was dramatically increased in LLnL treated cells. These data suggested that cyclin D3 protein is regulated by the $Ca^{2+}-activated$ protease calpain.

• Journal of the Korean Geotechnical Society
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• v.38 no.11
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• pp.69-86
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• 2022

The railway is widely used to transport passengers and freight due to its punctuality and large transport capacity. The recent remarkable development in construction technology enables various subsea railway tunnels for continent-continent or continent-island connectivity. In Korea, design and construction experience is primarily based on the successful completion of the Boryeong subsea tunnel (2021) and the Gadeok subsea tunnel (2010). However, frequent earthquakes with diverse magnitudes, globally induced and continuously increased the awareness of seismic risks and the frequency of domestic earthquakes. The effect of an earthquake on the subsea tunnel is very complicated. However, ground conditions and seismic waves are considered the main factors. This study simulated four ground types of 3-dimensional numerical models, such as soil, rock, composite, and fractured zone, to analyze the effect of ground type and seismic wave. A virtual subsea railway shield tunnel considering external water pressure was modeled. Further, three different seismic waves with long-term, short-term, and both periods were studied. The dynamic analyses by finite difference method were performed to investigate the displacement and stress characteristics. Consequently, the long-term period wave exhibited a predominant lateral displacement response in soil and the short-term period wave in rock. The artificial wave, which had both periodic characteristics, demonstrated predominant in the fractured zone. The effect of an earthquake is more noticeable in the stress of the tunnel segment than in displacement because of confining effect of ground and structural elements in the shield tunnel. 

• Proceedings of the Korean Vacuum Society Conference
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• 2012.08a
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• pp.338-338
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• 2012

사파이어 ($Al_2O_3$)는 높은 밴드갭 에너지 (~19.5 eV)를 가진 물질로서 우수한 내마모성, 강도, 전기 절연성 및 안정한 화학적 특성을 갖고 발광다이오드 기판, 보석재료 등 각종 산업 및 기술적 분야에서 널리 사용되고 있다. 특히, 플립칩 발광다이오드 구조의 경우 광추출효율을 향상시키기 위해 높은 투과도를 갖는 사파이어 기판이 요구되어 왔으며, 지금까지 건식/습식식각방법을 이용한 사파이어 표면에 마이크로 크기의 심한 거칠기 또는 요철이 형성된 나노크기의 격자구조를 형성시키는 연구가 진행되어 오고 있다. 그 중, 나노 크기의 격자구조는 공기에서 반도체 기판까지 선형적인 유효굴절률 분포를 갖기 때문에 표면에서 생기는 Fresnel 반사 손실을 줄일 수 있다. 이러한 구조를 형성하기 위해서는 식각 마스크가 필요한데, 형성 방법으로 레이저 간섭 리소그래피, 전자빔 리소그래피, 나노임프린트 리소그래피 등이 있으나, 비싼 가격과 복잡한 공정 절차 등의 단점을 지니고 있다. 따라서 본 연구에서는 식각 마스크 패턴을 위해, 보다 저렴하고 간단한 실리카 나노구 및 열적응집 금 나노 입자를 이용하였다. 양면 폴리싱 c-plane 사파이어 기판을 사용하였고, 단일 층의 주기적인 실리카 나노구를 기판 표면에 스핀코팅에 의해 도포한 후 유도결합플라즈마 식각 장비를 이용하여 식각하여 주기적인 패턴을 갖는 렌즈모양의 격자구조를 형성하였다. 그리고 주기적으로 형성된 격자 위에 열 증착기를 이용하여 금 박막을 증착한 후 급속열적어닐닝(rapid thermal annealing)을 이용하여 열처리함으로써 비주기적인 금 나노입자를 형성시켰다. 형성된 금 나노패턴을 이용하여 동일한 조건으로 식각함으로써 광대역 및 전방향성 높은 투과도를 갖는 원뿔 모양의 사파이어 나노구조를 제작하였다. 제작된 샘플의 패턴 및 식각 형상은 전자현미경을 사용하여 관찰하였으며, UV-vis-NIR 분광광도계 (spectrophotometer)를 사용하여 투과율을 측정하였다. 렌즈 모양 표면 위에 원뿔모양의 나노구조를 갖는 사파이어 기판은 일반적인 사파이어 기판보다 향상된 투과율 특성을 보였다.

• Journal of Periodontal and Implant Science
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• v.29 no.3
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• pp.593-607
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• 1999

치주인대세포는 치주인대의 유지와 개조에 있어서 중요한 역할을 담당하는 섬유아세포성 세포로서, 세포에 가해진 여러가지 조건에 따라 다양한 표현형의 변화를 나타내는 것으로 알려져 있다. 기계적 응력은 치주인대세포의 세포증 식과 밀접히 연관되어 있는 것으로 알려져 있으며, 이는 세포주기 조절인자들의 발현을 증가 시킴으로써 이루어질 것으로 생각되나 그 자세 한 작용기전은 알려져 있지 않다. 그러므로 이 연구의 목적은 기계적 응력이 사람 치주인대세 포의 세포증식과 세포주기 조절인자의 발현에 미치는 영향을 연구하기 위하여 사람 치주인대 세포에 기계적 응력을 가한 후 세포증식을 관찰하고 , 세포주기조절인자들인 p 53 , $p21^{WAF1/CIP1}$ cyclin-dependent kinases(cdks), cyclins 및 proliferating cell nuclear antigen(PCNA)의 단백질 발현 변화를 연구하였다. 본 연구에 사용한 사람 치주인 대세포는 교정치료를 목적으로 발거한 건전한 사람 소구치의 치주인대로부터 explantation culture하여 얻은 후 계대배양을 시행하여 제6 계대의 세포를 사용하였다. 배양한 사람 치주인 대세포를 55-mm Petriperm dish당 $1{\times}10^4$ 개를 분주하고, dish당 1kg의 기계적 응력을 가하면서 12일동안 세포배양을 시행하였다. 사람 치주인대세포의 세포증식은 기계적 응력을 가한 후 8-12일 사이에 현저히 증가하였으며, PCNA 단백질의 발현은 기계적 응력을 가한 후 6-10일 사이에 현저히 증가하였다. 또한 기계적 응력은 사람 치주 대세포의 cdk4, cdk6, cdk2 및 cyclin D1 단백질의 발현을 다소 증가 시켰으나, p53 및 $p21^{WAF1/CIP1}$ 단백질의 발현은 큰 변화가 없었다. 이상의 결과 서 기계적 응력은 사람 치주인대세포 의 p53 및 $p21^{WAF1/CIP1}$ 단백질 발현의 변화 없이 cdks 단백질 발현을 증가시킴으로써 세포증식을 증가시키는 것으로 생각된다.

• Journal of the Korea Concrete Institute
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• v.23 no.5
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• pp.569-579
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• 2011

Reinforced concrete walls subjected to cyclic loading show complicated inelastic behaviors varying with aspect ratio, re-bar detail, and loading condition. In the present study, a macro model for nonlinear analysis of reinforced concrete walls was developed. For exact prediction of inelastic flexure-compression and shear behaviors, the macro model of the wall was idealized with longitudinal and diagonal uniaxial elements. The uniaxial elements consist of concrete and re-bars. Simplified cyclic models for concrete and re-bars under uniaxial loading was used. For verification, the proposed model was applied to slender, lowrise, and coupled walls subjected to cyclic loading. The results showed that the proposed method predicted the nonlinear behaviors of the walls with reasonable precision.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.33 no.5
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• pp.1887-1895
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• 2013

In this study, physical experiments were performed in a two-dimensional wave flume to investigate the hydraulic and structural performance of a SFT model. The experiments were made by generating regular waves of different heights and periods under various conditions of buoyancy to weight ratio (BWR) and water depth as well. Through the analysis of the experimental data, it was clarified that the sway and heave motions of the tunnel body linearly increased with wave height and period. In contrast, the roll motion was rather insignificant unless wave height and period were comparatively large as the design wave. Similarly proportional relationship with respect to wave height and period was obtained in case of the maximum tensile force acting on the tension legs and the wave loads on the tunnel body. Regarding the change of water depth or BWR conditions, generally decreasing trend was obtained according to increase of water depth but decrease of BWR for both of the magnitudes of structural behaviors or wave loadings on the SFT structure.

• Journal of Korean Society of Steel Construction
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• v.18 no.6
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• pp.677-686
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• 2006

In this paper, a more practical and realistic method is proposed to establish the lifetime optimum maintenance strategies of the deteriorating bridges considering the life-cycle performance as well as life-cycle cost. The genetic algorithm is applied to generate the set of maintenance scenarios that is the multi-objective combinatorial optimization problem related to lifetime performance and cost as separate objective functions, and the technique to select optimum tradeoff maintenance scenario is presented. Optimum maintenance scenarios could be generated not only at the individual member level but also at the system level of the bridge. Through the analytical results of applying the proposed methodology to the existing bridge, it is expected that the methodology will be effectively used to determine the optimum maintenance strategy for introducing a real preventive maintenance system and overcoming the limits of existing maintenance methods.