• The Korean Journal of Nuclear Medicine
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• v.27 no.2
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• pp.155-160
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• 1993

The identification of viable myocardium in patients with coronary artery disease and left ventricular dysfunction is an issue of increasing clinical relavance in the current era of myocardial revascularization. There are at least two forms of reversible myocardial dysfunction. Early reperfusion does not always lead to immediate functional improvement; rather, the return of contractility in tissue salvaged by reperfusion is delayed for hours, days or even weeks, a phenomenon that has been termed "stunned myocardium". Some patients with coronary artery disease show myocardial dysfunction at rest which are associated with reduced perfusion, and which disappear after revascularization; this phenomenon has been termed "hibernating myocardium". Recently, cardiac imaging techniques that evaluate myocardial viability on the basis of perfusion-contraction mismatch and inotropic reserve have gained substantial popularity and clinical success. This review focus on the application of $^{201}TI$ and $^{99m}Tc-MIBI$ to address myocardial viability in patients with hibernating and stunned myocardium. It is clear that 4-hour redistribution images of $^{201}TI$ underestimate ischemia and overestimate scar. Delayed imaging and reinjection imaging have been developed for the assessment of viability. Among many protocols suggested, stress-redistribution-reinjection imaging gained most popularity. Although $^{99m}Tc-MIBI$ could identify myocardial viability, $^{201}TI$ reinjection technique was regarded as superior to it. In conclusion, $^{201}TI$ stress, 4-hr rest redistribution, and reinjection imaging technique may be the most preferable method for evaluation of myocardial viability.

• The Korean Journal of Cytopathology
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• v.7 no.1
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• pp.1-11
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• 1996

From the concepts of cellular pathology and of exfoliative cytology, as elucidated by Virchow and Papanicolaou respectively in the late 19th and early 20th century, have evolved the primary methods for the diagnosis of cancer today. From Papanicolaou's concept of exfoliative cytology developed fine needle aspiration biopsy in the early 1960's, this has become a major diagnostic procedure and has contributed to a significant reduction in open biopsies and, therefore, to medical cost-effectiveness immunobiochemical techniques provided us with a supplement to cancer diagnosis in the 1980's. The immunoperoxidase method, using monoclonal antibodies, is applied primarily as an ancillary measure to elucidate the nature of cancers The availability of specific monoclonal antibodies has greatly facilitated the identification of cell products or surface markers. For example, antibodies directed against intermediate filaments have proved to be of value in determining the histogenesis oi poorly differentiated neoplasms. Tumor markers may serve as biochemical indicators of the presence of a neoplasm. They can be detected In plasma and other body fluids. Their concentration can be applied as a diagnostic test, for monitoring the clinical course of known cancer, and as a screening measure to detect certain cancers in a population at risk. Flow cytometry is a useful tool for distinguishing several cell characteristics, such as the immunophenotype of leukemia-lymphoma cells, the DNA content of neoplastic cells, and cell proliferation rate. Molecular biologic techniques provided a giant step for the management of cancer patients encompassing diagnosis, prognostic evaluation, and therapy. Nucleic acid hybridization techniques are utilized as Southern, Northern, and dot blots and in situ hybridization. Molecular biology and its techniques may bring a blight new horizon for understanding cancer biology and in designing therapy on the basis of gene manipulation.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.17 no.4
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• pp.419-427
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• 2019

The application of ion crystallization technology was considered as a way to increase the operating efficiency and improve the operating performance of a liquid waste management system (LWMS) in the Advanced Power Reactor 1400 (APR 1400). Although ion crystallization technology has not been practically applied to Nuclear Power Plants (NPPs) until now, a previous experimental study demonstrated that it is possible to selectively remove at least 95% of various nuclide ions present in the liquid radioactive waste of NPPs. We reviewed the possibility of applying ion crystallization technology to the existing LWMS by applying the nuclide removal rate of ion crystallization technology and prepared a way to improve the existing LWMS in the APR 1400. Furthermore, we determined the optimized application location of ion crystallization technology in the existing LWMS by considering decontamination characteristics of the ion crystallization technology and the existing LWMS design features and operating experiences. The application of ion crystallization technology to the liquid waste collection tank, where liquid radioactive materials are collected, will have the least impact on the existing design while providing the greatest improvement. It is expected that the application of ion crystallization technology to the current APR 1400 or new NPPs would increase the operating efficiency of the LWMS and result in an improvement of system performance.

• Proceedings of the Korea Contents Association Conference
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• 2009.05a
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• pp.306-311
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• 2009

We initially obtained human diseases-related proteins dataset from the OMIM and the SWISS PROT and then constructed disease-related protein-protein interaction network. The protein network contains 40 hub proteins such as CALM1, ACTB and ABL2. The protein network can be derived the map of the relationship between different disease proteins, denoted disease interaction network. We demonstrate that the associations between diseases are directly correlated to their underlying protein-protein interaction networks. From constructed the disease-protein bipartite network, we derived 38 diseasomal proteins, including APP, ABL1 and STAT1. We previously demonstrated that hub proteins in the network tend to be diseasomal proteins in the disease-related protein sub-networks. However, we found that 18% hubs are only diseasomal proteins in the whole disease network. At this point, we could not elucidate difference in the hub-diseasomal proteins tendency between sub0network and whole network. In spite of we still have unsolved problems, our results elucidate that the discovery of protein interaction networks assigned by diseases will provide insight into the underlying molecular mechanisms and biological processes in complex human disease system.

• Journal of Digital Convergence
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• v.11 no.4
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• pp.221-227
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• 2013

RFID is an automatic identification technology that can control a range of information via IC chips and radio communication. Also known as electronic tags, smart tags or electronic labels, RFID technology enables embedding the overall process from production to sales in an ultra-small IC chip and tracking down such information using radio frequencies. Currently, RFID-based application and development is in progress in such fields as health care, national defense, logistics and security. RFID structure consists of a reader that reads tag information, a tag that provides information and the database that manages data. Yet, the wireless section between the reader and the tag is vulnerable to security issues. To sort out the vulnerability, studies on security protocols have been conducted actively. However, due to difficulties in implementation, most suggestions are concerned with theorem proving, which is prone to vulnerability found by other investigators later on, ending up in many troubles with applicability in practice. To experimentally test the security of the protocol proposed here, the formal verification tool, CasperFDR was used. To sum up, the proposed protocol was found to be secure against diverse attacks. That is, the proposed protocol meets the safety standard against new types of attacks and ensures security when applied to real tags in the future.

• Geophysics and Geophysical Exploration
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• v.10 no.1
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• pp.29-36
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• 2007

Recent seismic surveys have shown that the presence of methane hydrate (MH) in sediments has significant influence on seismic attenuation. I have used vertical seismic profile (VSP) data from a Nankai Trough exploratory well, offshore Tokai in central Japan, to estimate compressional attenuation in MH-bearing sediments at seismic frequencies of 30-110 Hz. The use of two different measurement methods (spectral ratio and centroid frequency shift methods) provides an opportunity to validate the attenuation measurements. The sensitivity of attenuation analyses to different depth intervals, borehole irregularities, and different frequency ranges was also examined to validate the stability of attenuation estimation. I found no significant compressional attenuation in MH-bearing sediments at seismic frequencies. Macroscopically, the peaks of highest attenuation in the seismic frequency range correspond to low-saturation gas zones. In contrast, high compressional attenuation zones in the sonic frequency range (10-20 kHz) are associated with the presence of methane hydrates at the same well locations. Thus, this study demonstrated the frequency-dependence of attenuation in MH-bearing sediments; MH-bearing sediments cause attenuation in the sonic frequency range rather than the seismic frequency range As a possible reason why seismic frequencies in the 30-110 Hz range were not affected in MH-bearing sediments, I point out the effect of thin layering of MH-bearing zones.

• Journal of the Korean Institute of Intelligent Systems
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• v.14 no.3
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• pp.253-261
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• 2004

Game theory is mathematical analysis developed to study involved in making decisions. In 1928, Von Neumann proved that every two-person, zero-sum game with finitely many pure strategies for each player is deterministic. As well, in the early 50's, Nash presented another concept as the basis for a generalization of Von Neumann's theorem. Another central achievement of game theory is the introduction of evolutionary game theory, by which agents can play optimal strategies in the absence of rationality. Not the rationality but through the process of Darwinian selection, a population of agents can evolve to an Evolutionary Stable Strategy (ESS) introduced by Maynard Smith. Keeping pace with these game theoretical studies, the first computer simulation of co-evolution was tried out by Hillis in 1991. Moreover, Kauffman proposed NK model to analyze co-evolutionary dynamics between different species. He showed how co-evolutionary phenomenon reaches static states and that these states are Nash equilibrium or ESS introduced in game theory. Since the studies about co-evolutionary phenomenon were started, however many other researchers have developed co-evolutionary algorithms, in this paper we propose Game theory based Co-Evolutionary Algorithm (GCEA) and confirm that this algorithm can be a solution of evolutionary problems by searching the ESS.To evaluate newly designed GCEA approach, we solve several test Multi-objective Optimization Problems (MOPs). From the results of these evaluations, we confirm that evolutionary game can be embodied by co-evolutionary algorithm and analyze optimization performance of GCEA by comparing experimental results using GCEA with the results using other evolutionary optimization algorithms.

• 한국HCI학회:학술대회논문집
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• 2008.02b
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• pp.109-114
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• 2008

We have long kept our Cartesian tradition in which Mind privileges over Body; the invention of printing technology has accelerated the tradition in which the intelligence and legibility of media were considered as a higher human value. However, the development of media and technology are supporting the multisensory mechanisms of the body as it was in preliterate era when we communicated with our whole bodily experiences. The development and spread of mass-media and new technologies have broaden the boundary of human sensory that are largely dominated by visual information and expanded it to auditory, olfactory and even gustatory sensation. Since 1960's, some philosophers and artists have recognized the human body as a subjective matter, starting the movement in which the body plays a role as an essential factor in study of human perception and cognition, aesthetics in art, and sociology, and the changed perspectives are practiced vigorously in the field of new media art; the theory of Maurice Merleau-Ponty who clarified the body as a general means for the body's possession of world, so that recognize the importance of cognition of one's body and approved the embodiment could be applied and practiced here. Therefore, we discuss how Merleau-Ponty's philosophical theory can be practiced and how McLuhan's perspective could be applied on the notion of body's extension in media by analysing some new media art cases.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2003.05a
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• pp.608-611
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• 2003

선진국입을 목전에 둔 한국경제의 발전을 위해서 지식과 기술을 기반으로 한 벤처기업의 생성과 발전은 매우 중요한 요소라 할 수 있다. 민과 관의 적절한 벤처 투자는 미래의 기업가들에게 신지식 창조의 동기를 부여하고 성장, 발전단계에 있는 기업들에게 자본을 공급함으로써 미래의 산업을 창조하는 매우 중요한 활동이다. 국내외적으로 벤처 투자자본에 대한 연구가 활발히 진행되어 왔으나 재무론을 바탕으로 한 벤처투자에 관한 연구와 다양한 벤처투자자본들의 유형과 투자행태 등을 설문지를 통해 밝혀내는 탐색적 연구들에 국한되어 연구, 발표되고 있는 실정이다. 본 연구에서는 벤처자본시장의 대표적 투자자본인 사적 창업투자회사와 정부 벤처정책투자 간의 전략적 상호작용을 가격모델을 통해 고찰하였다. Bertrand paradox의 가정에서 기술한 바와 같이 정부 벤처정책투자간 민간 창업투자회사들과 같은 투자전략을 구사하면 민간 창업투자회사들은 시장에서 살아남기 어렵고 결과적으로 정부는 벤처기업의 생성 및 발전지원이라는 목적에 부합되지 않은 투자를 한 것이 된다. Hotelling(1929)의 위치차별모델이 역설하는 바와 같이 정부 벤처정책투자는 사적 창업투자회사가 지향하는 투자와는 다른 투자정책을 구사할 때만 벤처기업 육성이라는 목표를 효율적으로 수행할 수가 있을 것이다. 이 연구 논문에서는 다양한 투자변수에 대한 Nash Equibrium이 존재함을 증명함으로써 사적 창업투자회사와 정부의 벤처정책투자가 벤처기업의 육성이라는 목적에 맞는 효율적 투자를 하기 위해 취해야 할 투자 전략들을 밝혀내었다.가 있는 것 같다. 따라서 본 연구에서는 웹기반 쇼핑시스템의 확산에 관련된 균형된 분석을 수행하기 위하여 경영(management)과 기술 (technology)을 조화롭게 고려한 관점에서 연구를 수행하고자 한다. 즉, 본 논문에서는 기술적 측면(technical aspect)과 경영적 측면(management aspect)을 동시에 고려하여 웹기반 쇼핑시스템의 주요만 특성을 살펴보고, 향후 정보통신 기술(ICT)의 확산에 관한 연구에서 두 가지 관점의 통합적 중요성에 대하여 강조하고자 한다. 그에 덧붙여 웹기반 쇼핑시스템과 다른 정보시스템을 비교하여 전자상거래 환경에서 웹기반 쇼핑시스템의 주요만 특성들이 두가지 연구관점에서 어떻게 개념화 될 수 있는지를 고찰하고자 한다. 이러만 분석에 기반하여 본 연구에서는 기술적 측면과 경영적인 측면을 동시에 고려한 웹기반 쇼핑시스템의 특성을 제시하고자 한다. 결론적으로 본 연구의 목적은 본 논문에서 적용한 기술(technical)과 경영(management)의 조화로운 연구관점이 향후 정보통신 기술이나 시스템, 그리고 전자상거래에 관련된 일련의 연구에 적응되어 보다 균형잡힌 논의와 분석이 이루어 질 수 있는 시발점이 되길 기대한다.생된 $CH_{4}$를 회수하여 이용하면 대체에너지원으로 활용 가치가 높은 것으로 판단된다./207), $99.2\%$(238/240), $98.5\%$(133/135) 및 $100\%$ (313)였다. 각각 두 개의 요골동맥과 우내흉동맥에서 부

• Journal of the Institute of Electronics and Information Engineers
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• v.50 no.8
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• pp.83-93
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• 2013

By comparing Wiener's MMSE on stochastic signal transmission with Shannon's mutual information first proved by C.E. Shannon in terms of information theory, connections between two approaches were investigated. What Wiener wanted to see in signal transmission in noisy channel is to try to capture fundamental limits for signal quality in signal estimation. On the other hands, Shannon was interested in finding fundamental limits of signal quantity that maximize the uncertainty in mutual information using the entropy concept in noisy channel. First concern of this paper is to show that in deriving limits of Shannon's point to point fundamental channel capacity, Shannon's mutual information obtained by exploiting MMSE combiner and Wiener filter's MMSE are interelated by integro-differential equantion. Then, At the meeting point of Wiener's MMSE and Shannon's mutual information the upper bound of spectral efficiency and the lower bound of energy efficiency were computed. Choosing a proper lattice-type code of a mod-${\Lambda}$AWGN channel model and MMSE estimation of ${\alpha}$ confirmed to lead to the fundamental Shannon capacity limits.