• Journal of Periodontal and Implant Science
• /
• v.30 no.2
• /
• pp.241-257
• /
• 2000

Autogenous periosteal grafts are an attractive alternative to existing barrier membrane materials since they meet the reqiurements of an ideal material. But no histological data are available on the effectiveness of periosteal membranes in the treatment of periodontal defects. The purpose of this study was to evaluate effect of autogenous periosteal graft on periodontal regeneration histologically. Class II furcation defects were surgically created on the second, third and the fourth premolars bilaterally in the mandibules of six mongrel dogs. The experimental sites were divided into three groups according to the treatment modalities; control group - surgical debridement only; Group I- autogenous periosteal membrane placement after surgical debridement; Group II-autogenous periosteal membrane placement after surgical debridement and bone grafting. The animals were sacrificed at 2, 4 and 12 weeks after periodontal surgery and the decalcified and undecalcified specimens were prepared for histological and histometrical analysis. Clinically all treated groups healed without significant problems. Under light microscope, at 2 weeks, control group showed significant apical epithelial migration and bone remodelling only below the notch area. But for the group I, II with autogenous periosteal graft, less apical migration of epithelium appeared and large amount of osteoid tissue showed above the notch area. Grafted periosteal membrane was indiscernable at 4 weeks, so periosteal membrane might be organized to surrounding tissues. Histometrically, at 4 and 12 weeks, all the test and control groups didn't show significant change of epithelial zone but new attachment level tended to be gained in the test groups than control group. These results suggest that autogenous periosteal grafts should be a good alternative for guided tissue regeneration.

• Journal of Chest Surgery
• /
• v.30 no.9
• /
• pp.899-907
• /
• 1997

Recently, primary lung cancer has increased markedly in incidence & prevalence in korea. Prom July 1979 to June 1996, 183 patients were diagnosed and operated for primary non-small cell lung cancer, and evaluated clinically. 1. There were 164 males and 19 females(M:P=8.6: 1), and the peak incidence of age was 50th and 60th decade of life(73.7%). 2. Most of symptoms were respiratory, whitch were cough(44.8%), chest pain(30.1%), dyspnea(20.8%), hemoptysis or blood tinged sputum(19.7%), sputum(15.3%), and asymptomatic cases were 12.0%. 3. Histopathologically, sguamous cell carcinoma was 68.9%, adenocarcinoma 19.7%, bronchioloalveol r cell carcinoma 2.2%, adenosguamous cell carcinoma 1.6%, and large cell carcinoma 7.7%. 4. In the operation, pneumonectomy was 41.0%, lobectomy 42.1%, bilobectomy 13.1%, stagmentectomy or wedge resection 1.6%, and explore tharacotomy 2.2%, and the overall resectability was 97.8%. 5. Postoperative complications were developed in 31.9%, and operative mortality was 1.6%. 6. In postoperative stagings, stage I was 38.3%, stage H 14.8%, stage llla 31.1%, and stage IIIb 15.8%. 7. The overall cumulative survival rates were 1 year 77.8%, 3 year 42.7%, and 5 year 39.5%. The 5 year survival rate according to stage were stage 153.0%, stage H 46.5%, stage I[la 28.2%, and stage IIIb 13.8%(p<0.05), according to operation method were lobectomy 45.0%, and pneumonectomy 30.3%(p<0.05), and according to mediastinal involvement were Nl 32.0%, and N2 11.1%(p<0.05). The 5 year survival rate according to histologic type were squamous cell carcinoma 43.1%, adenocarcinoma 23.3%, and large cell carcinoma 30.3 (p>0.05).

• Journal of the Korean Arthroscopy Society
• /
• v.3 no.2
• /
• pp.85-90
• /
• 1999

Purpose : The purpose of this study is to evaluate the clinical and histological results of the osteoarthritic patients who had second look arthroscopy after microfracture surgery. Materials and Methods : From Oct. 1997 to Dec. 1998, 46 patients, 48 knees were treated by microfracture technique. In the 22 patients, 24 knees, 'second-look' arthroscopies and biopsies were performed at 6 months following microfracture. Three patients were men and 19 patients were women. Average age of the patients were 58 years (range, 40-75 years). The average follow up period was 12 months(7-20 months). We analysed clinical results according to the nine-point scale. Also we observed type II collagen formation with immunohistochemical staining. Results : Clinical results were excellent in 83% and good in 17%. Among the 24 knees, more than 80% areas of chondral defect were covered with regenerated cartilage in 21 knees. Histologically, the regenerated tissue appears to be a hybrid of hyaline cartilage and fibrocartilage. Regenerated cartilage contains variable amount of type II collagen with immunohistochemical staining. Conclusion : Most of the patients had significant improvement clinically. 'Second-look' showed that the chondral defect areas were covered with newly grown grayish white tissue. Microfracture in the full thickness chondral defect provides and enriched environment for cartilaginous tissue regeneration.

• Clinical and Experimental Pediatrics
• /
• v.50 no.5
• /
• pp.476-483
• /
• 2007

Purpose : The objective of this study was to assess ventricular function by tissue Doppler imaging (TDI) in children with congenital heart disease (CHD) who have been undergoing open heart surgery (OHS) using cardiopulmonary bypass. We tried to compare the parameters of tissue Doppler imaging before and after OHS in patients with congenital heart disease. Methods : This study was conducted on 32 patients with CHD after OHS from January 2005 to December 2005 at Kyungpook National University hospital. Patients who underwent 2-D echocardiography before and after their OHS. All patients were divided into three groups, left ventricular volume overloading group (group 1), and right ventricular volume overloading group (group 2), and right ventricular pressure overloading group (group 3). The TDIs were examined before and 1 to 3 months after OHS. Peak early diastolic (E), and peak late diastolic (A) velocity of transmitral flow were measured by pulsed wave Doppler examination. Peak systolic (Sm), peak early diastolic (Em), and peak late diastolic (Am) velocity in apical 4-chamber and 2-chamber views were measured by TDI. The author calculated E/Em ratio. Results : The patients were 14 boys and 18 girls and the average age of patients was 2 years and 3 months. The congenital heart diseases which have to get OHS were ventricular septal defect (13 cases), atrial septal defect (7), atrioventricular septal defect (3), isolated pulmonary stenosis (2) and tetralogy of Fallot (7). There were significant decrease of Sm, Em, Am measured on tricuspid annulus and E/Em measured on mitral annulus in apical 4 chamber view (P<0.05). Conclusion : This study showed significant decrease of Sm, Em, Am measured on tricuspid annulus and E/Em measured on mitral annulus in apical 4 chamber view after OHS. These changes might be due to the effects of cardiopulmonary bypass in OHS and/or hemodynamic changes after correction of congenital heart disease. To clarify these changes, further study on more patients is needed.

• Journal of Periodontal and Implant Science
• /
• v.27 no.2
• /
• pp.395-409
• /
• 1997

성견의 2면 골내낭에서 calcium sulfate 이식이 치조골 및 백악질 재생 능력과 접합상피의 근단이동에 미치는 영향에 대해 알아보고자 3마리 성견의 상하악 제3대구치 근심면을 연결하는 깊이 4mm, 너비 4mm의 2면 골내낭을 외과적으로 형성하고 calcium sulfate를 이식한 군을 시험군으로, 치은박리술만을 실시한 군을 대조군으로 설정하였다. 술후 8주후에 치유결과를 접합상피의 길이, 백악질 형성, 치조골 형성, 결합조직 유착으로 나누어 조직학적으로 비교 관찰하여 다음과 같은 결과를 얻었다. 1. 접합상피의 길이는 대조군에서 2.28mm, 실험군에서 0.51mm로 나타났으며, 대조군과 실험군간에 유의성 있는 차이가 있었다(p<0.05). 2. 백악질 형성은 대조군에서 1.33mm, 실험군에서 2.59mm로 나타났으며, 대조군과 실험군간에 유의성 있는 차이가 있었다(p<0.05). 3.치조골 형성은 대조군에서 1.02mm, 실험군에서 2.30mm로 나타났으며, 대조군과 실험군간에 유의성 있는 차이가 있었다(p<0.05). 4. 결합조직 유착은 대조군에서 0.50mm, 실험군에서 1.14mm로 나타났으며, 대조군과 실험군간에 유의성 있는 차이가 있었다(p<0.05). 이상의 결과를 본 실험상의 한계내에서 고려하여 볼 때, calcium sulfate는 2면 골내낭의 치주치료에 치조골 및 백악질 재생 효과가 있으며 안전하고 경제적인 골 이식재 재료로 사용될 수 있으리라 사료된다.

• Proceedings of the Materials Research Society of Korea Conference
• /
• 2009.05a
• /
• pp.49.1-49.1
• /
• 2009

최근 손상된 생체조직의 재생 또는 대체를 위하여 다공성의 지지체(scaffold)를 이용하는 연구가 활발히 이루어져 왔다. 지지체 재료는 조직 재생을 목적으로 하는 경우에는 생분해성 고분자, 생흡수성 세라믹스 또는 이들의 복합재료가 사용되고, 조직 대체를 목적으로 하는 경우에는 금속 또는 세라믹스 재료가 단독으로 사용된다. 현재 경조직 대체를 위한 임플란트 재료로 사용되고 있는 금속재료 중 대부분이 타이타늄 또는 타이타늄 합금이다. 타이타늄은 비강도, 내식성이 우수하며, 생체 내 환경에서 부동태피막 재생 속도가 빠르고, 섬유상 결체조직 형성 두께가 얇아 생체의료용 소재로서 각광을 받고 있다. 다공성 타이타늄은 기존 타이타늄 소재의 장점에 다공체의 구조적인 특성을 부가하여 하중을 받는 골 결손부에 사용될 경우 뼈와의 탄성계수 차이에서 기인하는 응력차폐(stress shielding) 효과를 최소화할 수 있고, 다공체 내부로 골조직 성장을 유도할 수 있어 지지체와 골조직이 일체화되는 골융합 효과의 극대화를 기대할 수 있다. 본 연구에서는 기공 구조를 다양하게 제어할 수 있고, 3차원적 연결 기공구조를 만들 수 있는 적층조형(layer manufacturing) 기술을 이용하여 3차원 다공성 타이타늄 지지체를 제조하였으며, 이에 대한 세포독성, 조골세포 증식능 등 in vitro 생체적합성을 평가하고, Rat model 을 이용한 in vivo 생체적합성을 평가하였다. 또한 지지체의 골조직 재생 유도성의 증대를 위한 생체활성처리 영향도 분석 평가하였다.

• Journal of Periodontal and Implant Science
• /
• v.34 no.1
• /
• pp.223-241
• /
• 2004

The purpose of this present study evaluated the osseous response around Ca-P coated xenogenic bone and compared osteogenic potential of Ca-P coated xenogenic bone to that of combination with type I collagen derived from bovine tendon as a biocompatible binder to prevent migration of bone particle on the repair of calvarial defects in rabbits. To study the effects of Ca-P coated xenogenic bone and collagen on bone healing, four 5-mm-diameter skull defect were made in calvaria with trephine filled with an autogenous bone chip or Ca-P coated xenogenic bone or Ca-P coated xenogenic bone and type I collagen (1:1 mixture by volume) or left empty. The defects were evaluated histologically at 1, 2, 4 and 8 weeks following implantation. Ca-P coated xenogenic bone at the calvarial defects of rabbits showed osteoconductivity at the margin of defect in the early stage of bony healing, but no direct contact with new bone was observed. With time passed by, it was resorbed slowly and showed consistent inflammatory reaction. An additional use of type I collagen derived from bovine tendon improved clinical handling, but no new bone formation was observed histologically. Above all, autogenous bone graft showed most prominent healing in quantity and density of new bone formation. According to this study, the use of Ca-P coated xenogenic bone alone and combination with type I collagen did not showed effective healing in quantity and density of new bone formation.

• Journal of the korean academy of Pediatric Dentistry
• /
• v.34 no.4
• /
• pp.679-684
• /
• 2007

Odontoma is the most common benign odontogenic tumors, and have been defined as mixed odontogenic tumor composed of epithelial and mesenchymal cells. Odontoma is believed to be hamartomatous rather than neoplastic in nature. The classification by WHO divides odontoma into 2 groups such as complex odontoma and compound odontoma. Compound odontoma comprises dental tissues, resembling the morphology of a tooth and has predilection for the anterior maxilla. In contrast, complex odontoma has unorganized mass, not resembling the normal tooth and has predilection for the posterior mandible. Odontoma is almost asymptomatic, so it is usually found on routine radiographic examination. Common presenting symptom is impacted or unerupted permanent teeth and retained primary teeth, but coexistent odontoma and congenital missing of permanent teeth is a very rare condition. The recommended treatment for an odontoma is conservative surgical excision, with care taken to remove the surrounding soft tissue. This report presents 2 patients with compound odontoma of the mandible who have congenital missing of the permanent teeth.

• The Journal of Korean Academy of Prosthodontics
• /
• v.58 no.1
• /
• pp.30-34
• /
• 2020

Maxillectomy is performed to remove the tumor in the palate, maxillary sinus, buccal mucosa or nasal cavity. The resection range depends on the size and the extent of the tumor and it affects speech production or cause nasal regurgitation during feeding. Obturator can occlude an opening such as an oro-nasal fistula and protect the defect area. Successful reconstrucion of the patient's oral cavity who have gone over the maxillectomy is a difficult task. The condition and number of teeth, the remaining support area, and the extent of the defect area have a great influence on manufacturing the obturator. If these factors are disadvantageous, the prognosis of the prosthesis is uncertain. The final obturator must have a sufficient retention in the patient's oral cavity and must not irritate the surrounding tissue and support area where the resection was performed.In this case, a 55 year old female went through the maxillectomy and the only 3 teeth remained. And the retention of the maxillary prosthesis seems to be poor. So that, we fabricated the closed hollow obturator which has reduced weight compared to the conventional obturator. Consequently the closed hollow obturator can give better sealing and the adaptation.

• The Journal of Korean Academy of Prosthodontics
• /
• v.57 no.4
• /
• pp.356-363
• /
• 2019

A patient who went through maxillectomy can have soft palate defects including oronasal fistulas and suffer from dysphagia and dysarthria due to velopharyngeal insufficiency. This defect causes the food to enter nasal cavity and creates hypernasal sound which debilitates a quality of life. An obturator can rehabilitate the substantial oral tissue defects. The maxillary obturator separates the nasopharynx from the oropharynx during speech and deglutition by closing of the defect. For edentulous obturator patient, it is difficult to obtain proper retention due to reduced peripheral sealing. Therefore, the contours of the defects must be used to maximize the retention, stability, and support. Hollow type obturator can improve physiologic function by reducing weight than the traditional obturator. This case report describes a patient with hemi-maxillectomy who recovers mastication, speech, deglutition, and appearance with a maxillary obturator using physiological border molding of the velopharyngeal area and double-processing method.