• Proceedings of the Korea Association of Information Systems Conference
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• 2003.11a
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• pp.276-287
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• 2003

21세기에 접어들면서 기업의 경영환경은 급속한 속도로 변화하고 있다. 이러한 급격한 환경변화 속에서 기업이 핵심역량에 집중하고 기업의 경쟁력을 극대화하기 위해 기업의 정보관련 시스템 및 어플리케이션을 아웃소싱하기 위해 사용하는 개념이 ASP 서비스이다. ASP 서비스는 기업내부에 정보시스템 전담 조직을 갖추지 않고서도 각종 소프트웨어를 저렴한 값에 사용할 수 있고, 기업 자체의 전산시스템 및 운영 전담인력이 필요없으며, 하드웨어 및 소프트웨어를 구입할 필요성이 없는 등 여러 가지 이점을 가지고 있어 최근들어 기업들로 하여금 큰 논의와 함께 많은 투자가 이루어지고 있다. 하지만 ASP 서비스의 개념이 비교적 최근에 등장한 개념이기 때문에 관련 연구들이 개념정립이나 도입 의사결정 요인에 관한 연구에 머무르고 있는 실정이다. 이러한 배경하에서 본 연구는 첫째, ASP 서비스에 대한 체계적인 연구를 통해 ASP 서비스의 개념에 대한 명확한 이해를 제공하고, 기업의 정보화 추진 방법으로서 ASP 서비스가 가지는 가능성을 분석해 보고 둘째, 기업이 ASP 서비스를 도입하고 운영함에 있어서 성공적인 수행에 어떠한 요인들이 중요한 영향을 미치는지 살펴보기 위해 개념적인 모형을 도출해 보고자 한다.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.4 no.1
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• pp.18-27
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• 2001

Purpose: The aims of this study are to investigate the effect of the eradication of H. pylori on histological change of gastric mucosa in children with H. pylori gastritis and to determine whether the histological grading by the Sydney system is valuable in predicting the effect of treatment. Methods: 1) Histological scores by the Sydney system and the endoscopic characteristics were assessed before and at least four weeks after anti-H. pylori therapy in 42 children with H. pylori gastritis. 2) In 32 children treated with omeprazole, amoxicillin and clarithromycin (OAC), pretreatment histological scores and endoscopic findings were compared between the eradicated and the noneradicated to evaluate their predictive value for the successful eradication. Results: 1) In the eradicated (27 cases), nodular gastritis significantly decreased from 89% to 63% (p<0.05). There was an significant improvement in the mean activity score from 2.06 before treatment to 0.24 after treatment (p<0.01). The mean inflammatory score also improved from 2.61 before treatment to 1.89 after treatment (p<0.05). Lymphoid follicles significantly decreased from 48% to 15% (p<0.05). Epithelial damage improved in all 4 cases. But in the noneradicated (15 cases), there was no significant change in the frequency of nodular gastritis, the mean activity score, the mean inflammatory score and the frequency of the lymphoid follicles. 2) In 32 children treated with OAC, there was a tendency that the higher was the pretreatment score of the bacterial density, the lower was the eradication rate of H. pylori (p=0.072). Conclusion: The loss of the polymorphonuclear cell infiltration is the most prominent histological change after successful eradication. There may be negative correlation of the grade of the bacterial density with the success rate of the anti-H. pylori therapy.

• Proceedings of the Korean System Dynamics Society
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• 2003.02a
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• pp.29-55
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• 2003

최근의 통신서비스 시장은 경쟁의 도입과 기술의 발전이라는 두 축에 힘입어 양질의 서비스를 보다 저렴한 요금으로 소비자들에게 제공하고자 노력하여 왔다. 그러나 이러한 통신서비스의 질적 향상 노력에도 불구하고 여전히 통신서비스의 품질은 소비자들의 기대수준에는 미치지 못하고 있다는 지적이 있다 더욱이 문제가 되는 것은 소비자가 인지하고 있는 통신 서비스 품질의 기대수준은 시간의 흐름에 따라 동태적으로 변화하는 것이어서 한 시점에서의 통신 서비스 품질 수준의 측정으로는 정책적으로 큰 의미를 설명하기 어려운 실정이다. 이와 관련하여 많은 선행 연구들이 다양한 측면에서 시행되어져 왔지만 이제까지의 많은 선행 연구들은 대부분이 통신서비스의 특성을 제대로 고려하지 않고, 고객만족의 향상과 불일치를 가져오고 있는 성능품질만을 측정한다거나, 시간의 흐름에 따라 변화해 가는 소비자가 서비스에 대해 인지하고 있는 중요도나 기대수준을 고려하지 않고 있으며, 각 구성요소간의 동태적 인과고리에 대한 고려 없이 연구가 이루어져 전반적인 통신 서비스의 고객만족을 전체적인 시각에서 평가한 연구는 극히 드물다. 따라서 본 연구는 통신서비스의 고객만족을 피드백 관점, 동태적 관점, 사실적 관점의 시스템 다이내믹스 방법론을 적용하여 전반적인 동태적 고객만족 모형을 구현하고 이를 정책적으로 활용할 수 있는가에 대한 접근을 시도하였다. 고객만족은 결코 한순간에 머물러 있는 것이 아니며 체감품질 및 기대수준의 영향을 받아 지속적으로 변화해간다 따라서 어떻게 기대수준을 관리하고 고객의 기대에 부응하는 체감품질을 관리하는 것이 지속적인 고객만족을 획득할 수 있는 가를 시뮬레이션 모형을 통해 가시적으로 시스템의 행태를 구현함으로써 그 이해의 폭을 넓히고자 시도하였다.으로써 웹에서의 혁신적이며 크로스 사이트, 크로스 장르적인 컨텐츠 플래닝의 가능성을 시사하는데 의의가 있다고 하겠다.y used to some of interactive storytelling through hyper text in CD-ROM and web sites. More complicated and different structured models were born through games that offered graphics, virtual spaces and interactivity. When drawn onto a structural graph, few attributes and similarities seem to occur. This paper will try to outline and discuss structural graphs of interactive storytelling methods and suggest some ways for better storytelling design.eal sales volume, but the case study could verified that this method is effective to the evaluation of marketability in case of completely new product got on the typical category and the product category could be set up the population clearly.의 무게와 부피는 24주간 다소 감소하는 경향을 보였으나 통계적인 유의차는 없었다. 냉동저장 감자의 무게와 부피 변화는 48주간 전혀 없었다. 상온 냉장저장 감자의 조직의 강도(hardness)는 24주

• Journal of Oral Medicine and Pain
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• v.26 no.3
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• pp.205-214
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• 2001

오늘날 스트레스라는 단어는 모든 현대인과 방송, 언론매체에서도 매일 거론되어질 정도로그 중요성이 대두되고 있다. 의학계에서도 스트레스를 단순한 심리적 문제로 국한시키지 않고 과도한 스트레스가 지속될 경우 신경계와 내분비계, 면역계의 변화를 초래해 인체의 항상성에 영향을 미쳐 질병을 일으킨다는 것을 인식하고 있으며 이에 대한 연구가 진행되고 있다. 이러한 질병의 발생과정에서 생체의 일부조직이 파괴됨으로써 기능과 형태변화가 초래될 때 apoptosis가 관여하고 있으며 이에 본 저자는 스트레스와 구강악안면영역에서 발생할 수 있는 질병과의 상관관계를 규명하기 위해 이종의 한냉 스트레스와 다소의 굴신을 허용한 중등도의 구속 스트레스를 부여한 후 측두하악관절 활막의 변화를 전자현미경관찰을 통해 밝혀내고자 한다. Sprague-Dawley계 웅성 백서(200-230 g/bw) 33마리를 구속스트레스부여군 (12마리), 한냉스트레스부여군 (12마리) 및 정상군 (3마리)으로 나누고 이들을 각각 구속장치에 구속한 후 1, 3, 5, 7일에 각각 희생시켰으며 측두하악관절 활막의 변화를 전자현미경으로 관찰하였다. 그 결과는 다음과 같다. 1. 중등도의 구속스트레스군에서 사립체는 부분적으로 농축된 소견을 보였으며 수와 크기에 있어 시간이 지남에 따라 점차 감소하는 소견을 보였다. 2. 중등도의 구속스트레스군에서 과립내형질망은 점점 확장되었으며 불규칙한 형태를 나타내었다. 3. 중등도의 구속스트레스군에서 물결모양의 핵막의 이중구조가 7일군에서 관찰되었다. 4. 한냉 스트레스군에서 사립체는 1일, 3일군에서 약간 부푼 형태를 가지고 그 수가 다소 감소되었으나 시간이 지남에 따라 5일, 7일군에서 건강한 모양으로 점차 증가되었다. 5. 한냉 스트레스군에서 과립내형질망은 1일, 3일군에서 불규칙하게 확장된 소견을 보였으나 5일, 7일군에서는 잘 발달된 형태로 핵 주위에서 다수 관찰되었다. 6. 한냉 스트레스군에서 핵은 전 기간에 걸쳐 큰 변화를 보이지 않았다. 이와 같은 결과를 토대로 측두하악관절 활막조직은 한냉 스트레스 및 중등도의 구속 스트레스에 대하여 중등도의 저항성을 가지고 있는 것으로 생각되며 생리적 적응한계를 넘는 과도하고 지속적인 스트레스에 의하여 활막조직이 apoptosis되어 측두하악관절에 병리적 변화를 초래할 가능성이 있다고 사료되어 이후 지속적인 연구가 요구된다.

• Applied Microscopy
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• v.31 no.1
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• pp.37-47
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• 2001

In order to investigate a pathogenesis of liver damage induced by skin burn, thermal injury was induced by scald burn on entirely dorsal surface in rats (total burn surface area $20\sim25\%$) except for inhalated injury. At 5 and 24 h after scald burn, biochemical assay and morphological changes in serum and liver tissue were examined. Skin burn increased liver weight (% of body weight, p<0.05) and the activity of serum aniline amino-transferase (ALT, p<0.05), in addition, the activity of xanthine oxidase (XO), an enzyme of oxygen free radical generating system, was elevated (p<0.01) in serum, but not in skin and in liver. Postburn treatment of allopurinol intraperitoneally decreased liver weight, serum ALT activity and serum XO activity. Scald burn induced ultrastructurally swelling of endoplasmic reticulum, ribosome detachment, accumulation of lipid, dilatation of bile canaliculi and intercellular space, neutrophil infiltration, activation of Kupffer's cells and degeneration of hepatocytic microvilli. Futhermore , thermal injury decreased not only the protein concentration in plasma but also the number of intravascular leukocytes, that indicates induction of edema formation with protein exudation and inflammation by neutrophil infiltration into the internal organs. However allopurinol injection after burn inhibited post burn ultrastructural changes. These data suggest that acute dermal scald burn injury leads to liver damage, that is related to elevation of xanthine oxidase activity in serum. Xanthine oxidase may be a key role in the pathogenesis of liver damage induced by skin burn.

• Journal of Chest Surgery
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• v.40 no.1 s.270
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• pp.1-7
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• 2007

Backgound: It has been shown that the endothelium of cardiac valves and adjacent great vessels have a reduced immune reaction compared to other vessels. We investigated the clinical feasibility of using immunologically untreated xenogenic valves, in a pig-to-goat pulmonary valve conduit implantation model. Material and Method: Porcine pulmonary valve conduits were prepared without specific immunologic treatment and implanted into the right ventricular outflow tract of goats while undergoing cardiopulmonary bypass. Two goats each were assigned to the following observation time intervals: one day, one week, three months, six months and twelve months. Echo-cardiographic examinations were performed prior to sacrifice of the goat to evaluate pulmonary valve function. After the xenograft specimens were retrieved, histological changes were evaluated microscopically. Result: Ten of the twelve animals survived the predetermined observation time intervals. Aneurysmal dilatations, of the anterior wall of the implanted pulmonary artery, were observed at each of three and twelve month-survival animals. A variable degree of pulmonary valve regurgitation was observed on echocardiography. However, valve stenosis, thrombotic occlusion and vegetation were not seen. Microscopically, the nuclei of the donor tissue disappeared as a result of pyknosis and karyolysis; however the three components of the implanted xenografts (the pulmonary artery, the valve and the infundibulum) were gradually replaced by host cells over time, while maintaining their structural integrity. Conclusion: Immunologically untreated xenogenic pulmonary valve conduits were replaced by host cells with few observed clinical problems in a pig to goat pulmonary valve implantation model. Therefore, they might be an alternative bioprosthesis option.

• Journal of Life Science
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• v.15 no.6 s.73
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• pp.1022-1027
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• 2005

The aim of this study was to evaluate effects of mulberry cultivars extracts on the collagen content of the connective tissues in ovariectomized rats. From day 2 until day 37 after ovariectomy, Sprague-Dawley female rats were randomly assigned to the following groups : sham-operated rats (Sham), ovariectomized control rats (OVX-control), and ovariectomized rats supplemented with $80\%$ ethyl alcohol extracts from various kinds of Tajikistan mulberry, Korea mulberry and China mulberry at 200 mg/kg bw/day, respectively. The mulberry extracts were orally administrated at 1 mL per day. The OVX rats were significantly heavier than the sham-operated rats were at all time points, but supplementation with the mulberry extracts tended to gain weight less than OVX-control did. The ovariectomy caused a decreasing in the levels of collagen content in bone and cartilage tissues. However, supplementation with mulberry extracts prevented the decrease in the collagen level in bone and cartilage tissues. Therefore, it may be used to possibly improve the quality of life in menopausal women.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.19 no.2
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• pp.1-11
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• 2024

In the midst of the current turbulent global economy, traditional investment metrics are undergoing a metamorphosis, signaling the onset of what's often referred to as an "Investment cold season". Early-stage startups, despite their boundless potential, grapple with immediate revenue constraints, intensifying their pursuit of critical investments. While financial indicators once took center stage in investment evaluations, a notable paradigm shift is underway. Organizational culture, once relegated to the sidelines, has now emerged as a linchpin in forecasting a startup's resilience and enduring trajectory. Our comprehensive research, integrating insights from CVF and OCAI, unveils the intricate relationship between organizational culture and its magnetic appeal to investors. The results indicate that startups with a pronounced external focus, expertly balanced with flexibility and stability, hold particular allure for investment consideration. Furthermore, the study underscores the pivotal role of adhocracy and market-driven mindsets in shaping investment desirability. A significant observation emerges from the study: startups, whether they secured investment or failed to do so, consistently display strong clan culture, highlighting the widespread importance of nurturing a positive employee environment. Leadership deeply anchored in market culture, combined with an unwavering commitment to innovation and harmonious organizational practices, emerges as a potent recipe for attracting investor attention. Our model, with an impressive 88.3% predictive accuracy, serves as a guiding light for startups and astute investors, illuminating the intricate interplay of culture and investment success in today's economic landscape.

• Journal of Conservation Science
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• v.24
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• pp.57-66
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• 2008

It is reported that excavated carbonized wooden objects tend to have more peeling and deformation stemming from the coexisting of different types of parts of objects. However, there is little research results on this. In this experiment, the sugar alcohol method was used and then compared with the results of the PEG4000 method which widely uses. This research targets: prediction of strength by weight increase, investigation of the dimensional stabilization effects by measuring the rate of shrinkage change, condition of drug penetration and change of wood texture by using a scanning electron microscope. As the results, the PEG4000 method needs a phased approach over 80% impregnation. On the other hand, the S A method remains steady from over 40% impregnation. The Deformation of carbonized wooden objects used in this experiment is considered as the phenomenon by shrinkage of non-carbonized parts. The PEG4000 method is verified the shrinkage in the samples treated with 20%, 40% and 60%; the S A method is verified the shrinkage in the samples treated with 20%.

• Korean Journal of Optics and Photonics
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• v.33 no.6
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• pp.331-337
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• 2022

Raman spectroscopy is an optical technique that can identify molecules in a label-free manner, and is therefore heavily investigated in various areas ranging from biomedical engineering to materials science. Probe-based Raman spectroscopy can perform minimally invasive chemical analysis, and thus has potential as a real-time diagnostic tool during surgery. In this study, Raman experimentation was calibrated by examining the Raman shifts with respect to the concentrations of chemical substances. Raman signal characteristics, targeted for normal mice and cerebral tissues of the 5xFAD dementia mutant model with accumulated amyloid beta plaques, were measured and analyzed to explore the possibility of diagnosis of Alzheimer's disease. The application to the diagnosis of dementia was cross-validated by measuring Raman signals of amyloid beta. The results suggest the potential of Raman spectroscopy as a diagnostic tool that may be useful in various areas of application.