• Proceedings of the Acoustical Society of Korea Conference
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• autumn
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• pp.369-370
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• 2004

초음파의 조차에 의한 인체내부의 온도상승의 측도로 열지수(thermal index)가 사용되고 있으며, 이는 주파수 및 음향파워에 의존한다. 초음파 조사에 의한 인체내부의 온도상승을 평가하는데 사용되는 재료를 조직 모사 물질이라 한다. 본 논문아사는 단위 음향파워에 대한 온도 변화인 열 감도(thermal sensitivity)를 새로이 정의하였으며, 이 물리량으로 조직모사물질의 성능을 평가 할 수 있다는 것을 제안하고자 한다.

• The Journal of the Acoustical Society of Korea
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• v.23 no.7
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• pp.503-513
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• 2004

In this paper, the thermal sensitivity, i .e. the temperature rise per unit acoustic power, was newly defined and proposed as a performance parameter of a tissue mimicking material. Eatable tofu (bean curd) manufactured by a factory was selected as a sample material for the experiment. The temperature changes were measured not only with the variation of ultrasonic irradiation time, acoustic power, depth from the sample surface. and the distance from the source transducer while adjusting the frequency to 8 MHz but also with the variation of frequency while acoustic power. depth from the sample surface. and the distance from the source transducer keeping constant. As a result of a consideration for the transformation of the measured temperature changes to thermal sensitivities. the thermal sensitivity was found to be sufficient to use as a Performance parameter for tissue mimicking material. The tofu as a tissue mimicking material showed the maximum thermal sensitivity at 10 MHz, as is a significant result to imply the possibility that the thermal sensitivity of real human tissue strong1y depends on the frequency.

• Journal of radiological science and technology
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• v.33 no.3
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• pp.245-252
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• 2010

This study analyzed speed of sound, impedance, attenuation coefficient in accordance with acoustic characteristic standard of body soft tissue corresponding with Annex DD of IEC standard 60601-2-37(2007) which is about tissue mimicking materials (TMM) synthesized by polyurethane as a main material and new type of n-type scatter materials. This study reached the following conclusion after analyzing and evaluating image characteristic with SONOACE 9900 c PRIME (MEDESON Co.) and brightness, maximum penetration with convex probe (2.5~5.0 MHz). When n-type scatter materials are increasingly synthesised 0~8% with prepolymer as a main material and polyol mixture as a catalyst, 1. The more scatter materials are increased, the more sound speed of TMM becomes closely similar to soft tissue. 2. The more scatter materials are decreased, the more acoustic impedance becomes closely similar to soft tissue. 3. The more scatter materials are increased, the more attenuation coefficient is increased. 4. The more scatter materials are increased, the more average brightness of images is increased, but there is threshold. 5. The maximum penetration becomes closely similar to soft tissue at the 6% TMM as a scatter material.

• Journal of Adhesion and Interface
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• v.24 no.4
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• pp.113-119
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• 2023

Since it was reported that the unusual amino acid DOPA in synergy with lysine and histidine residues found in mussel adhesive proteins plays a pivotal role in mussel adhesion in underwater environments, there has been a burgeoning development of various catecholamines-based adhesives for biomedical applications. Among these, catechol-conjugated chitosan, containing catecholamine, featuring multiple catechol groups within its aminerich chitosan backbone, has found versatile utility in fields, such as tissue adhesion, wound dressing, tissue healing, hemostats, drug delivery systems, and tissue engineering scaffolds. Significantly, chitosan-catechol is a mussel-inspired material approved by both US Food and Drug Administration (FDA) and KR Ministry of Food and Drug Safety (MFDS) for its effectiveness in hemostasis. This review focuses on 1) general aspects of catechol-conjugated chitosan, highlighting catechol group integration into chitosan backbones, 2) examination of proposed mechanisms of hemostasis, and 3) exploration of diverse physical forms, including solution, hydrogels, patches, and thin films with practical applications inapplicable to hemostasis.

• The Journal of the Acoustical Society of Korea
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• v.40 no.6
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• pp.587-592
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• 2021

Change in the cortical thickness of long bones occurring with aging and osteoporosis is known to be a risk factor for fracture. The present study aims to investigate the dependencies of phase velocities of ultrasonic guided waves on the cortical thickness in 7 soft tissue-bone mimicking phantoms consisting of acrylic plates covered by a 2 mm-thick silicone rubber layer by using the axial transmission technique with a pair of transducers with a center frequency of 200 kHz and a diameter of 12.7 mm. Two distinct propagating waves with different velocities, the First Arriving Signal (FAS) and the Slow Guided Waved (SGW), were consistently observed for all the soft tissue-bone mimicking phantoms. The FAS velocity decreased slightly with increasing thickness, whereas the SGW velocity increased strongly with increasing thickness. The FAS and the SGW velocities were found to be closely consistent with the S0 and the A0 Lamb mode velocities for a free acrylic plate, respectively, suggesting that the presence of the soft tissue mimicking material (2 mm-thick silicone rubber layer) covering the acrylic plates does not influence significantly the velocity measurements.

• Proceedings of the Materials Research Society of Korea Conference
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• 2011.05a
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• pp.241.2-241.2
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• 2011

다공 소재는 큰 비표면적과 규칙적으로 정렬된 구조의 특성으로 인해 자성메모리 소자용 재료, 나노 와이어 제작용 템플릿, 마이크로 반응기, 메타물질용 소재 등으로 각광을 받고 있다. 자기조립 수직배열 다공구조 재료를 제작하는 방법으로 흔히 알루미늄의 양극산화 방법과 이원공정계의 상분리 방법이 등이 있다. 본 연구에서는 상변태를 비롯한 패턴형성과 계면 운동을 가장 정확하게 다루는 이론적 모델로 알려진 상장모델(Phase Field model)을 이용하여 이원공정계의 박막성장과정 동안의 자발적 상분리에 의한 수직배열 자기조립 다공구조 형성을 시뮬레이션 한다. 상장모델을 기초로 하여 상분리 메커니즘에 의해 발현된 미세조직을 해석하고 다양한 공정변수가 미세조직 발현에 미치는 영향에 대해 연구한다. 또한 상장모델을 통해 얻은 결과는 기존에 발표된 연구들의 결과와 비교를 통해 유효성을 입증한다.

• Journal of the Korean Society of Radiology
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• v.12 no.3
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• pp.427-433
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• 2018

Because of the expectation of the non-invasive treatment effect, Various studies on the treatment of varicose veins using focused ultrasound are reported. In this study, the bio-tissue phantom and tissue equivalent phantom that can be applied to estimation of ultrasonic varicose veins treatment effect. Each phantom was evaluated for its usefulness by evaluating the acoustic characteristics and the shrinkage rate according to the ultrasonic irradiation. A multi-layer structure phantom with three layers of skin, fat, and muscle was constructed considering the structure of the tissue where the varicose veins occurred. The materials constituting each layer were made to have characteristics similar to human body. In addition, the multi-layered phantoms with blood vessel mimic tube, with bovine blood vessel, and with animal tissue were fabricated. The degree of shrinkage of blood vessel mimic material and vascular tissue according to ultrasonic irradiation was evaluated using B-mode image. As the results of this study, it was thought that the proposed phantom could be used effectively in the evaluation of ultrasonic varicose veins treatment. In addition, it is thought that these phantoms could be applied to the development of varicose vein treatment device using the focused ultrasound and the verification of the therapeutic effect.

• Journal of Radiation Protection and Research
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• v.41 no.1
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• pp.41-47
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• 2016

Background: For the accurate dose assessment in radiation therapy, energy spectrum of the photon beam generated from the linac head is essential. The aim of this study is to develop the technique to accurately unfolding the energy spectrum with the transmission analysis method. Materials and Methods: Clinical linear accelerator and Monet Carlo method was employed to evaluate the transmission signals according to the thickness of the observer material, and then the response function of the ion chamber response was determined with the mono energy beam. Finally the energy spectrum was unfolded with HEPROW program. Elekta Synergy Flatform and Geant4 tool kits was used in this study. Results and Discussion: In the comparison between calculated and measured transmission signals using aluminum alloy as an attenuator, root mean squared error was 0.43%. In the comparison between unfolded spectrum using HEPROW program and calculated spectrum using Geant4, the difference of peak and mean energy were 0.066 and 0.03 MeV, respectively. However, for the accurate prediction of the energy spectrum, additional experiment with various type of material and improvement of the unfolding program is required. Conclusion: In this research, it is demonstrated that unfolding spectra technique could be used in megavoltage photon beam with aluminum alloy and HEPROW program.

• Journal of the Korean Society of Radiology
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• v.15 no.4
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• pp.401-408
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• 2021

Proton therapy using the Bragg peak is one of the radiation therapies and can deliver its maximum energy to the tumor with giving least energy for normal tissue. A cross-sectional image of the human body taken with the computed tomography (CT) has been used for radiation therapy planning. The HU values change according to the tube voltage, which lead to the change in the boundary and thickness of the anatomical structure on the CT image. This study examined the changes in the Bragg peak of the brain region according to the thickness variation in the head phantom composed of several materials using the Geant4. In the phantom composed of a single material, the Bragg peak according to the type of media and the incident energy of the proton beams were calculated, and the reliability of Geant4 code was verified by the Bragg peak. The variation of the peak in the brain region was examined when each thickness of the head phantom was changed. When the thickness of the soft tissue was changed, there was no change in the peak position, and for the skin the change in the peak was small. The change of the peak position was mainly changed when the bone thickness. In particular, when the bone was changed only or the bone was changed together with other tissues, the amount of change in the peak position was the same. It is considered that measurement of the accurate bone thickness in CT images is one of the key factors in depth-dose distribution of the radiation therapy planning.

• The Korean Journal of Rheology
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• v.7 no.1
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• pp.19-27
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• 1995

정밀사출성형품을 생산하기 위해서는 성형조건의 변화가 최종 사출품에 어떠한 영 향을 미치는 가에 대한 연구가 필요하다. 본논문에서는 성형조건을 조직적으로 변화시키며 가장 간단한 원반형상의 사출품에 남는 복굴절의 분포를 측정함으로써 성형조건의 변화가 최종 사출품의 광학적 이방성의 구조에 어떠한 영향을 미치는 가에 초점을 맞추었다. 광탄 성적 성질이 많이 다른 폴리스틸렌과 폴리카보네이트를 재료로 지름이 10.16cm 이고 두께 가 2mm인 금형을 사용하였다. 두께 방향의 복굴절양과 광학 주축각의 분포를 통해 보압크 기가 최종사출품의 광학적 이방성, 특히 내측의 두 개의 정점값에 미치는 영향을 알수 있었 다. 한편 서로 다른 두 물질의 광학적, 물리적 성질의 차이점에 기인한 복굴절 분포의 구조 적 차이점도 발견할수 있었다. 이 실험 데이터는 컴퓨터 모사에의한 최종사출품의 잔류 응 력과 광학적 이방성 예측에도 중요한 자료가 되리라 믿는다.