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Effect of Celecoxib on Lung Injury Improvement by Controlling Epithelial-Mesenchymal Transition(EMT) in Chronic Obstructive Pulmonary Disease(COPD) (만성폐쇄성폐질환에서 상피중간엽이행 조절을 통한 Celecoxib의 폐 손상 개선효과)

  • Lee, Sun-Kyung
    • Journal of Convergence for Information Technology
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    • v.11 no.11
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    • pp.248-255
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    • 2021
  • This study confirmed the effects of improving lung damage of celecoxib using an animal model of chronic obstructive pulmonary disease(COPD). It was induced in models LPS + CSE and performed in vitro and in vivo. MTT assay and real-time PCR were performed in MRC5 cells as in vitro, and mRNA expression, BALF, collagen content, and protein expression were confirmed as in vivo. Celecoxib reduced the number of inflammatory cells, cytokine and soluble protein accumulation in BALF, decreased body weight and lung weight in animal models, and improved lung collagen deposition. In addition, the reduction of EMT markers was confirmed through Western blotting and real-time PCR. Consequently, celecoxib is thought to improve lung damage of COPD induced to LPS+CSE by regulating EMT.

PHYSIOLOGIC DRIFT OF THE MANDIBULAR DENTITION FOLLOWING THE EXTRACTION OF FOUR FIRST PREMOLARS (상, 하악 제1소구치 발치 후 하악치열의 생리적 치아이동에 관한 연구)

  • Chun, Youn-Sic
    • The korean journal of orthodontics
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    • v.26 no.1 s.54
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    • pp.33-41
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    • 1996
  • Retrostpective study of two groups of patients was conducted to evaluate the physiologic drift of the mandibular teeth following the extraction of four first premolars. The concept of physiologic drift, commonly referred to as 'driftodontics', following first premolar extractions has been gaining acceptance in the orthodontic community, the exact nature and amount of drift has not been adequately documented. There were also no guide lines as to when drift should be allowed to now. The purpose of this study was to quantify physiologic drift of the untreated mandibular dentition following extraction of the four first premolars during the early permanent and late permanent dentition stages. The early permanent dentition extraction sample(Group 1) included 26 Patients and the mean age at pretreatment was approximately 13.5 years. The observation period following extraction was approximately 6.96 months. The late permanent dentition extraction sample(Group 2) included 31 patients. The mean age at pretreatment was 21.3 years, followed by a observation period of 7.26 months. During the observation period, except for the extractions, no other mandibular therapy was rendered. Pre-and post-treatment lateral cephalograms and dental casts were analyzed. The obtained results were as follows 1. Group 2 showed marked changes in movements of the mandibular incisors and canines but minimal changes in molars. 2. The amount of changes in movements of the mandibular incisors and canines were significantly greater in Group 1 than in Group 2. The results showed no differences in rates of molar movements between groups. 3. Physiologic drift of the dentition produced desirable changes such as decreased Incisor Irregularity.

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Effect of Isopropanol on CO2 Absorption by Diethylenetriamine Aqueous Solutions (이소프로판올을 포함한 디에틸렌트리아민 상분리 흡수제의 CO2 흡수 특성)

  • Lee, Hwa Young;Seok, Chang Hwan;Hong, Yeon Ki
    • Clean Technology
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    • v.27 no.3
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    • pp.255-260
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    • 2021
  • A drawback in the CO2 capture process using an aqueous amine solution is the high energy requirement for the regeneration process. In order to overcome this disadvantage, this study investigated CO2 capture characteristics using a biphasic absorbent in which isopropanol (IPA) was introduced into an aqueous solution of diethylenetriamine (DETA). When the IPA composition exceeded 20 wt% in 20 wt% DETA aqueous solution, the absorbent phase was liquid-liquid separated into a CO2-rich phase and a CO2-lean phase because of the low solubility of the salt formed by the reaction of CO2 with DETA in isopropanol. When the isopropanol composition in the DETA aqueous solution increased, the phase volume ratio of the CO2-rich phase to the volume of the CO2-lean phase increased; and, accordingly, the CO2 in the CO2-rich phase was more concentrated. The results of absorbing CO2 in a packed tower using 20 wt% DETA + IPA + water absorbent confirmed that both the CO2 absorption capacity and the absorption rate were higher than that of the 20 wt% DETA aqueous solution. When a biphasic absorbent composed of DETA + IPA + water is applied to CO2 capture, it can be expected to concentrate CO2 because of phase separation and thereby reduce regeneration energy owing to volume reduction of the CO2-rich phase.

A Study on Measures to Improve Smoke Control Performance in Case of Fire in a Clean room as an LCD Manufacturing Process (LCD 제조공정 클린룸의 화재시 CFD를 이용한 제연성능 개선대책에 관한 연구)

  • Son, Bong-Sei;Jang, Chan-Hee
    • Fire Science and Engineering
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    • v.26 no.5
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    • pp.41-47
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    • 2012
  • As a core process in the manufacture of state-of-the-art industrial technologies such as semiconductor and LCD, a clean room is the most important process which can affect the performance and quality of products drastically. Nevertheless, scientific research on comprehensive safety measures from a fire protection standpoint is not being carried out in Korea. This study aims to derive measures to improve smoke control systems by identifying performance and problems of smoke systems installed in clean rooms as an LCD manufacturing process and analyzing fire and evacuation simulations considering several scenarios. As a result of analysis of fires and smoke in a clean roomas an LCD manufacturing process, it is found to be necessary to stop air handling units through interlocking in case of a fire and exhaust smoke out of the room through the top of FAB in consideration of buoyancy of smoke. It is also found to be necessary to install quick response sprinkler heads and accessories to accelerate the response time, because the heat-accumulating performance of sprinkler heads decreases in this application. Despite its low density of dwelling due to the automation process, clean room is characterized by an array of complex production equipment and working environment requiring dustproof clothes, which makes it difficult to acquire evacuation safety performance. Thus, thorough control of danger factors in processes and periodic education and training are required. It is also necessary to establish a level of domestic technologies equivalent to the level of standards of advanced countries in fire protection.

A Guidance Methodology Using Ubiquitous Sensor Network Information in Large-Sized Underground Facilities in Fire (대형 지하시설물에서 화재발생 시 USN정보를 이용한 피난 유도 방안)

  • Seo, Yonghee;Lee, Changju;Jung, Jumlae;Shin, Seongil
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.28 no.4D
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    • pp.459-467
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    • 2008
  • Because of the insufficiency of ground space, the utilization of underground is getting more and more in these days. Moreover, underground space is being used not only buildings but multipurpose space for movement, storage and shopping. However, ground space has vital weakness for fire compared to ground space. Especially in case of underground shopping center, there are various stuffs to burn and poisonous gas can be exposed on this count when the space is burned. A large number of casualties can be also occurred from conflagration as underground space has closed structures that prevent rapid evacuation and access. Therefore, this research proposes the guidance methodology for evacuation from conflagration in large-sized underground facilities. In addition, suggested methodology uses high technology wireless sensor information from up-to-date ubiquitous sensor networks. Fire information collected by sensors is integrated with existing underground facilities information and this is sent to guidance systems by inducing process. In the end, this information is used for minimum time paths finding algorithm considering the passageway capacity and distance. Also, usefulness and inadequacies of proposed methodology is verified by a case study.

Combustion Gas-emission of Medium Density Fibreboard (MDF) Treated with Alkylenediaminialkyl-bis-phosphonic Acids and Bis-(dimethylaminomethyl) Phosphinic Acid (알킬렌디아미노알킬-비스-포스폰산과 비스-디메틸아미노메틸 포스핀산으로 처리된 중질섬유판의 연소가스 발생)

  • Park, Myung-Ho;Chung, Yeong-Jin
    • Applied Chemistry for Engineering
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    • v.28 no.1
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    • pp.112-117
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    • 2017
  • This study demonstrated the emission of combustion gases of medium density fibreboard (MDF)s coated with piperazinomethyl-bis-phosphonic acid (PIPEABP), methylpiperazinomethyl-bis-phosphonic acid (MPIPEABP), N,N-dimethylethylenediaminomethyl-bis-phosphonic acid (MDEDAP), or bis-(dimethylaminomethyl) phosphinic acid (DMDAP). Each MDFs were coated in three times with a brush with 15 wt% aqueous solution of the phosphorus-nitrogen acid additives. After the specimens were dried at room temperature, the emission of combustion gases was tested using a cone calorimeter (ISO 5660-1, 2). The peak smoke production rate ($SPR_{peak}$) of the specimens coated with phosphorus-nitrogen acids was 18.5 to 41.5%, which is lower than that of using the virgin plate. However, the production of peak carbon monoxide ($CO_{peak}$) was 6.7 to 24.2% higher than that of using the virgin plate. Also, the peak carbon dioxide ($CO_{2peak}$) was 4.2 to 24.4% lower than that of using virgin plate. While the peak oxygen depletion rate was much higher than the level of 15%, which can be fatal to humans and the resulting risk could thus be eliminated. Overall, the combustibility of coated specimens was partially suppressed, but showed a negative effect on the reduction of carbon monoxide.

Selective Removal of Acetic Acid for the Effective Production of Succinic Acid using the Various Amino Extractants and Solvents (효율적 숙신산 생산을 위한 다양한 아민추출제와 용매를 이용한 아세트산의 선택적 추출제거)

  • Huh Yun Suk;Hong Yeon Ki;Jun Young-Si;Hong Won Hi
    • KSBB Journal
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    • v.20 no.3
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    • pp.238-243
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    • 2005
  • Succinic acid has recently been drawing much interest as a raw material for biodegradable polymer. In this study acetic acid was removed by reactive extraction with various amines dissolved in various diluents. Distribution coefficients were determined as the kind of amines, diluents, and pHs of continuous phase. The extraction capacity increased with the polarity of diluent and the decrease of pH from the artificial binary solution. Based on the different extractability for succinic acid and acetic acid from the artificial binary solution, the removal of acetic acid from fermentation broth was investigated using various amines and diluents. In addition, the extractability and selectivity of CLA for succinic acid and acetic acid from fermentation broth were higher than that of straight solvent extraction.

Kinetics of CO2 Absorption in Aqueous DETA and DEEA Solutions by Wetted-Wall Column (젖은 벽탑을 이용한 디에틸렌트리아민과 디에틸에탄올아민 수용액의 CO2 흡수속도 측정)

  • You, Jong Kyun;Lee, Jun;Hong, Yeon Ki
    • Korean Chemical Engineering Research
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    • v.60 no.4
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    • pp.582-587
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    • 2022
  • Biphasic solvents are attracting attention as energy-reducing solvents for capturing CO2 from flue gas in combustion process. In this study, considering diethylenetriamine (DETA) and diethylethanolamine (DEEA) mixed solvents, one of the biphasic solvents by blending of two types of amines, the CO2 absorption rates of DETA and DEEA was measured by wetted wall column. The effects of DETA and DEEA concentrations and operating temperature on the overall mass transfer coefficient were investigated. As a result, the overall mass transfer coefficient was proportional to the DETA concentration. However, in the case of the DEEA concentration, the effect was small and when the concentration was exceeded, the overall mass transfer coefficient decreased. The DETA aqueous solution showed little change in the overall mass transfer coefficient with the operating temperature, whereas the DEEA aqueous solution increased the overall mass transfer coefficient with the operating temperature. As a result of obtaining the observed reaction rate constant under the pseudo-first-order reaction assumption, it was found that the observed reaction rate constant in DETA aqueous solution was proportional to the DETA concentration, but DEEA did not fit the pseudo-first-order reaction assumption.

A study on the effect of air velocity through a damper on smoke extraction performance in case of fire in road tunnels (도로터널 화재 시 집중배기방식의 배기포트 통과풍속이 배연성능에 미치는 영향에 관한 연구)

  • Ryu, Ji-Oh;Na, Kwang-Hoon
    • Journal of Korean Tunnelling and Underground Space Association
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    • v.22 no.4
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    • pp.347-365
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    • 2020
  • In order to resolve traffic problems in urban areas and to increase the area of green spaces, tunnels in downtown areas are being increased. Additionally, the application of large port smoke extraction ventilation systems is increasing as a countermeasure to smoke extraction ventilation for tunnels with high potential for traffic congestion. It is known that the smoke extraction performance of the large port smoke extraction system is influenced not only by the amount of the extraction flow rate, but also by various factors such as the shape of the extraction port (damper) and the extraction air velocity through a damper. Therefore, in this study, the design standards and installation status of each country were investigated. When the extraction air flow rate was the same, the smoke extraction performance according to the size of the damper was numerically simulated in terms of smoke propagation distance, compared and evaluated, and the following results were obtained. As the cross-sectional area of the smoke damper increases, the extraction flow rate is concentrated in the damper close to the extraction fan, and the smoke extraction rate of the damper in downstream decreases, thereby increasing the smoke propagation distance on the downstream side. In order to prevent such a phenomenon, it is necessary to reduce the cross-sectional area of the smoke damper and increase the velocity of passing air through the damper so that the pressure loss passing through the damper increases, thereby reducing the non-uniformity of smoke extraction flow rate in the extraction section. In this analysis, it was found that when the interval distance of the extraction damper was 50 m, the air velocity passing through damper was 4.4 m/s or more, and when the interval distance of the extraction dampers was 100 m, the air velocity passing through damper was greater than 4.84 m/s, it was found to be advantageous to ensure smoke extraction performance.

Truth of Mahāyāna Thought -The Controversy Between The Madhyamaka and The Yogācāra on Sunya and The two truth theories of Nāgārjuna (대승불교의 진리관 -용수(龍樹)의 공(空)과 이체설(二諦說)에 대한 중관학파(中觀學派)와 유지학파(唯識學派)의 논쟁을 중심으로)

  • Yun, Jong-gab
    • Journal of Korean Philosophical Society
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    • v.116
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    • pp.225-256
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    • 2010
  • The two school $M{\bar{a}}dhyamika$ and $Yog{\bar{a}}c{\bar{a}}ra$ act as a representative of $Mah{\bar{a}}y{\bar{a}}na$ Buddhism in India. But the two school disputed with each other insisting ${\acute{s}}{\bar{u}}nyat{\bar{a}}-v{\bar{a}}da$ and $vij{\tilde{n}}aptim{\bar{a}}trav{\bar{a}}da$ separately. To introduce the disputation shortly is as follow. $N{\bar{a}}g{\bar{a}}rjuna$ explained the world and truth by two truth theories(二諦說) which carry out truth of a word and the dimension(spiritual enlightenment) which is absolute(ultimate) to it being lokasaṁvṛtisatya(世俗諦) about the truth which can be expressed verbally, and which is phenomenon-like (everyday) at paramaarthasatya(勝義諦). By the way, lokasaṁvṛtisatya and paramaarthasatya are actually distinction of the recognition which is not an ontological distinction. That is, lokasaṁvṛti(世俗) is paramaartha(勝義) as it is the time of seeing by the eyes of those who have realized. The two truth theories of $N{\bar{a}}g{\bar{a}}rjuna$ was developed logical more precisely by his successors. With an everyday language, the position of Candrakīrti(月稱) that it cannot be expressed as the position of $Bh{\bar{a}}vaviveka$(淸辨) that paramaarthasatya can be expressed logically is opposed to each other, and dissociates by $Sv{\bar{a}}tantrika$(自立論證派) and $P{\bar{a}}rsagika$(歸謬論證派). Confrontation of $Sv{\bar{a}}tantrika$ and $P{\bar{a}}rsagika$ is the dispute about the ability of s which is the highest truth to be proved logically. The $P{\bar{a}}rsaga$ of Candrakirti thinks that people exist truly, and is because it claims not existing in the world where a favorite thing is actually actual. However, $Bh{\bar{a}}vaviveka$ proved Sunyata(空性)을 positively based on the reliance to language and logic. Also the mokṣa of $M{\bar{a}}dhyamika$ is not recovery of original condition of $vij{\tilde{n}}apti$ which is pure in itself as $Yog{\bar{a}}c{\bar{a}}ra$ saying, as well as obtaining a thing which is dravya-sat as $Sarv{\bar{a}}stiv{\bar{a}}din$ saying. The mokṣa of $M{\bar{a}}dhyamika$ means a condition of liberated from karma and pains through extinction of $prapa{\tilde{n}}ca$ and discrimination by realizing the real aspect of all dharma which is said by pratītyasamutpāda, $praj{\tilde{n}}apti$, niḥsvabhāva, ${\acute{s}}{\bar{u}}nya$, $madhyam{\bar{a}}pratipad$.