• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.14 no.1
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• pp.3-11
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• 2003

Attention-deficit/Hyperactivity disorder(ADHD) is the most common psychiatric disorder of childhood and among the most prevalent chronic health conditions affecting school-aged children. Children with ADHD experience significant functional problems, such as school difficulties, academic underachievement, troublesome interpersonal relationships with family members and peers, and low self-esteem. The most widely used pharmacological treatments for ADHD are psychostimulants, such as methylphenidate and amphetamine salts. These medications provide clinical efficacy by increasing the availability of catecholamines, primarily dopamine, in the frontal lobe of the brain. immediate-release(IR) formulations of sychostimulants were among the most effective psychotrophic medications in the psychopharmacological treatment. However, there are some limitations of IR formulations：the short half-life and duration of efficacy, which result in the need for multiple daily dosing and the poor compliance. These limitations have led to the development of once-daily, extended-release(ER) formulations of methylphenidate and amphetamine salts. However, these ER formulations may not be as immediately helpful to ADHD children due to delayed onset of action and the acute tolerance which is the failure to sustain the efficacy with the same concentration of drug as the initial stage of medication. OROS-methylphenidate(Concerta$^{\circledR}$) given once a day produces an ascending-pattern plasma drug level generated by the osmotically released, timed drug-delivery system. These new formulations of the psychostimulants have been shown to be a useful alternative to old stimulant medications through the evidence by the clinical trials.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.10 no.5
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• pp.219-231
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• 2015

Open innovation is known to have a significant impact on the performance of enterprise innovation. The role of open innovation is more critical due to small scale and limitation on the available resources for the venture company. This study focused on the relationship among Entrepreneurship(ENT), Innovation Capability(IC), and External Cooperation(EC), which affect Technological Innovation Performance(TIP) to maximize TIP. Empirical study was proceeded to analyze the relationships among ENT, IC, EC, and TIP for venture companies in Busan. ENT was verified to have a positive impact on IC, EC, and TIP. IC was done on EC and TIP. EC was done on TIP. Each of IC and EC showed positive mediating role in the relationship between ENT and TIP. Finally, IC and EC together performed positive mediating role in the relationship between ENT and TIC.

• Journal of the Korean Chemical Society
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• v.59 no.5
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• pp.445-453
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• 2015

In 2005, descriptive assessment was introduced to increase students’ higher mental ability like problem-solving ability and creativity. Every year the ratio of descriptive assessment increases and it is regarded as an alternative evaluation to a multiple-choice item which measures simplicity knowledge. Externally the descriptive assessment took a root in school, but we can’t say definitely that it meets its original goal. In this paper, science descriptive assessment items of 5 middle schools in Gyeonggi-do were analysed; examiners was interviewed about how well they understood the characteristic of the assessment items. According to the analysis, characteristic of the items are ① unequal distribution of unit, ② difference of item’s type by unit, and ③ disappearance of measuring higher mental ability. It is considered that there are several factors of these characteristic - the lack of teachers’ ability to make assessment item; understanding of assessment instrument. These factors can be explained by the lack of assessment expertise. So the society’s effort is needed to raise teacher’s ability for the descriptive assessment.

• Journal of Convergence for Information Technology
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• v.12 no.4
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• pp.166-176
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• 2022

The purpose of this study was to investigate the construct of Korean Version of Mental Toughness through Open-ended Questionnaire for soccer Players and coach. Data collection was inductively analyzed by distributing open questionnaires to 100 soccer players belonging to the Korean Football Association and 100 soccer coaches who participated in the training for obtaining a soccer coach's license. The resulting results are as follows. First, as a result of the inductive content analysis of korean version soccer players mental toughness, 11 factors were derived in the detailed area and 6 factors in the general area. Secondly, in the results on the mental toughness of Korean version soccer players according to soccer players and coaches, both players and coaches were found to be the highest factor, kkangdagu. I hope that the results of this study will be used as basic data for efforts to reduce the improving performance for soccer players and coaches.

• Korean Journal of Psychosomatic Medicine
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• v.27 no.1
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• pp.50-59
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• 2019

Objectives : Many of the patients with type 2 diabetes are associated with sleep problems, and the rate of insomnia is known to be higher in the general population. The aims of this study were to know the frequency and clnical characteristics of insomnia, and related variables to insomnia in patients diagnosed with type 2 diabetes. Methods : For 99 patients from 18 to 80 years of age (65 males and 34 females) with type 2 diabetes, interviews were performed. Total sleep time and sleep latency was evaluated. Insomnia was evaluated using the Korean Version of the Insomnia Severity Index (ISI-K). Severity of depressive symptoms were evaluted using the Korean version of the Hamilton Depression Scale (K-HDRM). According to the cutoff score of 15.5 on the ISI-K, subjects were divided into the group of type 2 diabetics with insomnia (N=34) and those without insomnia (N=65) at first, and then statistically analyzed. Results : TInsomnia could be found in 34.34% of type 2 diabetics. Type 2 diabetics with insomnia had significantly more single or divorced (respectively 11.8%, p<0.05), higher total scores of the K-HDRS ($11.76{\pm}5.52$, p<0.001), shorter total sleep time ($5.35{\pm}2.00hours$, p<0.001), and longer sleep latency ($50.29{\pm}33.80minutes$, p<0.001). The all item scores of the ISI-K in type 2 diabetics with insomnia were significantly higher than those in type 2 diabetics without insomnia, that is, total ($18.38{\pm}2.69$), A1 (Initial insomnia) ($2.97{\pm}0.76$), A2 (Middle insomnia) ($3.06{\pm}0.69$), A3 (Terminal insomnia) ($2.76{\pm}0.61$), B (Satisfaction) ($3.18{\pm}0.72$), C (Interference) ($2.09{\pm}0.97$), D (Noticeability) ($2.12{\pm}1.09$) and E (Distress) ($2.21{\pm}0.81$) (respectively p<0.001). Variables associated with insomnia in type 2 diabetics were as following. Age had significant negative correlation with A3 items of the ISI-K (${\beta}=-0.241$, p<0.05). Total scores of the K-HDRS had significant positive correlation, while total sleep time had significant negative correlation with all items of the ISI-K (respectively p<0.05). Sleep latency had significant positive correlation with total,, A1, B and E item scores of the ISI-K (respectively p<0.05). Conclusions : Insomnia was found in about 1/3 of type 2 diabetics. According to the presence of insomnia, clinical characteristics including sleep quality as well as quantity seemed to be different. Because depression seemed to be correlated with insomnia, clinicians should pay attention to early detection and intervention of depression among type 2 diabetics.

• 월간산업보건
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• s.347
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• pp.56-65
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• 2017

• Korean Journal of Psychosomatic Medicine
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• v.31 no.2
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• pp.165-172
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• 2023

Objectives : The purpose of this study is to determine whether there is a significant difference in the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio according to the history of suicide attempt in patients with psychiatric diseases. Methods : A medical record review was conducted on patients who had been hospitalized in Konyang University Hospital since 2021-03-01 to 2023-02-28 to collect demographic and clinical characteristics. T-test for continuous variables and Chi-square test for categorical variables were performed to determine demographic differences according to the history of suicide attempt, and the ANCOVA test was performed to compare the average value of peripheral inflammatory marker according to the history of suicide attempt with gender and age as covariates. One-way variance analysis was performed to determine whether the number of suicide attempt causes significant difference of the peripheral inflammatory marker. Results : The final analysis target of this study was 266 patients, 101 had history of suicide attempt, and 165 had no history of suicide attempt. The neutrophil-to-lymphocyte ratio (p<0.001) and platelet-to-lymphocyte ratio (p<0.001) were higher in patients with the history of suicide attempt than patients without the history of suicide attempt, but the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio were not significantly increased depending on the serial increase of number of suicide attempts. Conclusions : This study suggests that peripheral inflammatory markers are meaningful and easily accessible indicators for predicting the risk of suicide attempt in psychiatric patients. We expect that prospective follow-up study will be conducted with more subjects and controlled potential confounding variables.

• Korean Journal of Psychosomatic Medicine
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• v.23 no.2
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• pp.114-120
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• 2015

Objectives : This study aimed to investigate the risk factors of depression for patients with tuberculosis(TB). Methods : A total of 57 patients with TB were recruited. All participants completed the Becks Depression Inventory-II for evaluating depressive symptoms. The risk factor for depression was analyzed by binary logistic regression analysis. Nomogram was performed for probability of depression. Results : Low body mass index(BMI, OR 0.801, 95% CI 0.65, 0.98), interruption of treatment for TB(OR 5.908, 95% CI 1.19, 29.41), past history of depression(OR 24.653, 95% CI 1.99, 308.44) were associated with increased risk for depression. The calibration curve for predicting probability of survival showed a good agreement between the nomogram and actual observation(Original C-index=0.789, bias corrected C-index=0.754). Conclusions : The result of the present study indicate that low BMI, interruption of treatment for TB, and past history of depression were risk factors for depression in patients with TB. The psychiatric intervention may be needed to prevent depression if the patients with TB have risk factor during treatment for TB.

• 한국벤처창업학회:학술대회논문집
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• 2018.04a
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• pp.57-59
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• 2018

최근 대학 내 창업 친화적 학사제도 활성화 등의 정책적 노력과 지원에 따라 다양한 형태의 창업교과 및 비교과 활동이 이뤄지고 있으며 그 유형에 따라 수강생의 참여도 및 교육효과가 다르게 나타날 수 있음을 많은 연구에서 주목하고 있다. 이에 본 연구는 이론과 정보 전달 중심의 일반적 창업 강좌와 창업실습 등을 중심으로 한 체험형 창업 강좌 수강생을 대상으로 창업동기, 기업가정신 및 창업의지에 대한 인식 차이가 있는지, 그리고 창업동기와 기업가정신이 창업의지에 미치는 영향력에 있어서 두 집단간의 차이가 있는지를 비교하기 위해 자료를 수집, 실증분석을 실시하였다. 본 연구결과는 향후 체험중심의 창업교육(experiential entrepreneurship education) 활성화를 위한 정책적 시사점을 제공할 뿐만 아니라, 창업교육 효과에 대한 연구 확산에도 기여할 수 있을 것이라고 판단된다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.2 no.1
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• pp.76-86
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• 1991

Plasma $dopamine-{\beta}-hydroxylase(DBH)$ activity was measured in 37 autistic disorders, 26 atypical pervasive developmental disorders and 23 controls, to elucidate the biological etiology in pervasive developmental disorders. The results are summarized as follows : 1) In the autistic group, the mean plasma DBH activity was significantly elevated compared to the atypical and control groups. The mean plasma DBH activity was also significantly elevated in pervasive developmental disorders(autistic disorder+atypical developmental disorder) compared to control group. 2) In the atypical and control groups, the DBH activity significantly increased with age, but in the autistic group, the DBH activity was not significantly correlated with age. 3) No significant correlation was found between the DBH activity and the severity of psychopathology. These findings support the hypothesis of a possible involvement of brain catecholamine dysfunction in the production of autistic symptoms, and this dysfunction might be due to the abnormal ontogenetic process of DBH activity in autistic disorders.