• Journal of the Korean Society for Marine Environment & Energy
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• v.9 no.4
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• pp.243-252
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• 2006

Influence of the increasing carbon dioxide concentration in seawater on various marine organisms is assessed in this article with regard to the impacts of anthropogenic $CO_2$ introduced into surface or deep oceans. Recent proposals to sequester $CO_2$ in deep oceans arouse the concerns of adverse effects of increased $CO_2$ concentration on deep-sea organisms. Atmospheric introduction of $CO_2$ into the ocean can also acidify the surface water, thereby the population of some sensitive organisms including coral reefs, cocolithophorids and sea urchins will be reduced considerably in near future (e.g. in 2100 unless the increasing trend of $CO_2$ emission is actively regulated). We exposed bioluminescent bacteria and benthic amphipods to varying concentrations of $CO_2$ and also pH for a short period. The ${\sim}l.5$ unit decrease of pH adversely affected test organisms. However, amphipods were not influenced by decreasing pH when HCl was used for the seawater acidification. In this article, we reviewed the biological adverse effects of $CO_2$ on various marine organisms studied so for. Theses results will be useful to predict the potential risks of the increase of $CO_2$ concentrations in seawater due to the increase of atmospheric $CO_2$ emission and/or sequestration of $CO_2$ in deep oceans.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.33 no.5
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• pp.431-438
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• 2000

To clarify the annual reproductive cycle in a rockfish, Sebastes schlegeli, monthly changes in gonadosomatic index (GSI), hepatosomatic index (HSI) and histological feature of gonads and plasma levels of sex steroid hormones ($estradiol-l7{\beta},\;17{\alpha},\;20{\beta}-dihydroxy-4-pregnen-3-one,\;testosterone\;and\;11-ketotestosterone$) were investigated. The annual reproductive cycle in females could be divided into 5 periods as follows: 1) recovery period (June to September): serum level of $estradiol-l7{\beta}$ increased gradually; 2) vitellogenesis period (Septemer to february) : vitellogenic oocytes were obsewed, GSI sustained high value, and serum level of $estradiol-l7{\beta}$ increased; 3) gestation period (February-April): developing larva showed in the ovary, and serum levels of $17{\alpha},\;20{\beta}-dihydroxy-4-pregnen-3-one$ and testosterone increased; 4) partrition period (April to May) : larva were delivered, and value of GSI and serum levels of hormones decreased rapidly; 5) resting period (May to June) : value of GSI and serum levels of $estradiol-l7{\beta}$ and testosterone remained low. The annual reproductive cycle in males could be divided into 6 periods; 1) early maturation period (April to June): value of GSI and serum levels of hormones incresed gradually, cyst of spermatogonia incresed in number, and a small number of cyst of spermatocyte was observed; 2) mid-maturation perid (June to September); value of GSI and serum levels of hormones increased, and germ cells in many cysts were undergoing active sperrnatogenesis; 3) late maturation period (September to November) : value of GSI and serum levels of hormones remained high and spermatozoa were released into the lumina of the seminal lobules; 3) spermatozoa dischaging period (Nobember to December) : the lumina of the seminal lobules were enlarged and filled with mature spermatozoa; 4) degeneration period (December to Februauy)i value of GSI decresed and cyst of spermatocyte were decresed in number; 5) resting period (December to April) : no histological changes of testes were observed, and value of GSI and serum levels of hormones remained low. In November, the lumina of the seminal lobules were filled with mature spermatozoa and sperm masses were present in the ovarian cavity. Thus, copulation in this species occurred in November and December.

• Korean Journal of Heritage: History & Science
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• v.52 no.4
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• pp.18-37
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• 2019

This study derived a method for establishing the chronology of cloud patterns by examining the arrangement of the treasure motifs in the cloud pattern used in the relevant pattern-decorated book covers of 89 Oegyujanggak Uigwe books, which are currently housed in the National Museum of Korea. The cloud pattern with a treasure motif was used in the covers of a total of 89 books from King Hyojong Gukjangdogam Uigwe (1659) to Sadoseja Garyedogam Uigwe (1744), spanning 86 years. First, to analyze the cloud pattern, it should be broken down into smaller parts to the extent that the different shapes of treasure motifs can be recognized. Secondly, the method of decoding the pattern is as follows: First, check whether the pattern is arranged in one or two directions from the vertex of the cloud's head, and determine the direction of the cloud tail. Then, decode the treasure motif's arrangement starting from the vertex of the cloud's head toward the direction the tail of manja is headed. Record the findings of this decoding process by categorizing them. Thirdly, as a result of the analysis, a total of 28 types of cloud patterns with treasure motifs were identified in 89 books. There were 45 types of treasure motifs used in such patterns. Finally, we have concluded that applying the method of decoding the treasure motif in the cloud pattern to portraits, excavated costumes, and various relics can be useful to establish the chronology of cloud patterns in the late Joseon period. The method suggested in this study is called 'The Reading Method of Chronology in Cloud Pattern with Treasure Motifs' (also 'Jeung-ha Cloud Pattern Reading Method').

• Journal of Life Science
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• v.26 no.9
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• pp.1056-1062
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• 2016

Lung cancer is currently the most common malignant disease and the leading cause of mortality in the world and non-small cell lung cancer (NSCLC) accounts for 75-80% of lung cancer cases. miR-155 gene was found to be over expressed in several solid tumors, such as thyroid carcinoma, breast cancer, colon cancer, cervical cancer, pancreatic ductal adenocarcinoma (PDAC) and lung cancer. The aims of this study were to define the expression of miR-155 in lung cancer and its associated clinic-pathologic characteristics. Total RNA was purified from formalin-fixed, paraffin-embedded NSCLC tissues and benign lung tissues. Expression of miR-155 in human lung cancer tissues were evaluated as mean fold changes of miR-155 in cancer tissues compared to benign lung tissues by quantitative real-time reverse transcriptase polymerase chain reaction (real-time qRT-PCR) and associations of miR-155 expression with clinic-pathologic findings of cancer. Compared with the benign control group, miR-155 expression was significantly overexpressed in NSCLCs (p=<0.001). miR-155 was more overexpressed in squamous cell carcinoma than in adenocarcinoma. Poorly differentiated tumors showed significantly overexpression of miR-155 than well-differentiated tumors (p=<0.001). Overexpression of miR-155 was significantly associated with lymph node metastasis (p=<0.05). In survival analysis for all NSCLC patients, high miR-155 expression was significantly correlated with worse overall survival (p=<0.05). These results suggested that miR-155 might play an important role in lung cancer progression and metastasis.

• The Korean Journal of Food And Nutrition
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• v.10 no.4
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• pp.514-520
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• 1997

The study was carried out to investigate the changes of quality and to determine the optimal shelf-life of fried soybean curd under low temperature(8$\pm$2$^{\circ}C$) and room temperature(25-3$0^{\circ}C$), respectively. The quality criteria for fried soybean were acid value, peroxide value, fatty acid composition and microbial concentration, et al. The initial moisture content of fried soybean curd was 41.9%, it was rapidly decreased to 29.6% until the second days under low temperature. The pH value was 5.7 and 5.8 at the ninth days under 8$\pm$2$^{\circ}C$ and the sixth days under 25-3$0^{\circ}C$, respectively. Also, the acid value rised remarkly to 10.65 at the fifth days and the peroxide value was 12.20 at the sixth days under room temperature. The viable cell counts were 1.0$\times$1.0 at the initial storage, but they were increased to 6.1$\times$105 over at the second days of room temperature. Moreover, the mold colony counts were in 2.0$\times$10-6.0$\times$103 and 2.0$\times$10=8.5$\times$107 during all storage days under 8$\pm$2$^{\circ}C$ and 25-3$0^{\circ}C$, respectively.

• Journal of Wetlands Research
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• v.16 no.1
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• pp.41-50
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• 2014

The purpose of this study is to evaluate the High Rate Spiral Clarifier(HRSC) availability for the improvement of polluted retention pond water quality. A lab scale and a pilot scale test was performed for this. The fluid flow patterns in a HRSC were studied using Fluent which is one of the computational fluid dynamic(CFD) programs, with inlet velocity and inlet diameter, length of body($L_B$) and length of lower cone(Lc), angle and gap between the inverted sloping cone, the lower exit hole installed or not installed. A pilot scale experimental apparatus was made on the basis of the results from the fluid flow analysis and lab scale test, then a field test was executed for the retention pond. In the study of inside fluid flow for the experimental apparatus, we found out that the inlet velocity had a greater effect on forming spiral flow than inlet flow rate and inlet diameter. There was no observable effect on forming spiral flow LB in the range of 1.2 to $1.6D_B$(body diameter) and Lc in the range of 0.35 to $0.5L_B$, but decreased the spiral flow with a high ratio of $L_B/D_B$ 2.0, $Lc/L_B$ 0.75. As increased the angle of the inverted sloping cone, velocity gradually dropped and evenly distributed in the inverted sloping cone. The better condition was a 10cm distance of the inverted sloping cone compared to 20cm to prevent turbulent flow. The condition that excludes the lower exit hole was better to prevent channeling and to distribute effluent flow rate evenly. From the pilot scale field test it was confirmed that particulate matters were effectively removed, therefore, this apparatus could be used for one of the plans to improve water quality for a large water body such as retention ponds.

• Clinical and Experimental Pediatrics
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• v.45 no.10
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• pp.1263-1272
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• 2002

Purpose : Rett syndrome(RTT) is an X-linked dominant neurodevelopmental disorder affecting 1 per 10,000-15,000 female births worldwide. It was initially described by Andreas Rett in 1966. RTT involves developmental regression characterized stereotypic hand movements, tremors, gait apraxia, seizures, deceleration of head growth after the age of 6-18 months. The disease-causing gene was identified as MECP2 on chromosome Xq28. We carried out mutational analysis of MECP2 genes in RTT patients. Methods : Whole blood(5 cc) of 34 sporadic RTT patients was collected in EDTA-anticoagulated tubes. Genomic DNA was extracted from peripheral blood using the E.Z.N.A. blood DNA kit. Four exons of the MECP2 gene were amplified by PCR in 34 Korean with RTT. We carried out PCR divided the exon three into two parts and the exon four into five parts. Primer sequences designed by Amir et al. in 1999 were almost used(AF030876). Sequencing primers used were the same as PCR. DNA sequencing reactions were performed using an ABI 377 DNA sequencer and ABI PRISM dye terminator cycle sequencing reaction kit(Perkin-elmer). The results were compared with the normal DNA sequence(X99686). To confirm the change of sequence on novel mutations, RFLP analysis was performed. Results : The MECP2 mutations were detected in 23(67.6%) of the 34 patients. The mutations consisted of 12 different types including nine missense and three nonsense mutations. Of these, three (L100V, G161E and T311M) mutations were newly identified. Most of the mutations discovered are located within MBD(39.1%) and TRD(39.1%). In this study, three(T158M, R270X, R306C) mutations were identified high frequency. Conclusion : MECP2 gene was also an important cause of Korean RTT patients. MECP2 gene study is an important tool for diagnosis of Korean RTT patients.

• Journal of the Korean Society of Hazard Mitigation
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• v.9 no.4
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• pp.81-89
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• 2009

The seepage should be analyzed to design or reinforce the levees. The steady seepage analysis is an usual application in USA and European countries where the large scaled dams and levees are existed. However, Korea and Japan, where the reaching time is short, the excessive forces are applied on the levees at the short reaching time if the seepages are analyzed in steady condition. Accordingly, the unsteady analysis based on the variation of time is necessitated. In the unsteady analysis, the flood wave type is necessary. No criteria and standards, however, are derived for the unsteady seepage in Korea. In the study, the flood wave type is derived for the unsteady seepage. The major reliable flood surface data are collected in 5 stations including Jindong of the Nakdong river basin. The data are sorted in duration, and they are non-dimensionalized. The statistical method is also applied to derive the waves. To verify the study, the seepage is analyzed by the derived wave and applied to the prototype. The results are also compared with the Japanese Method. The errors between the hydraulic gradient and critical velocity method are $0{\sim}0.7%$, $0{\sim}0.7%$ at the Jindong, $1.6{\sim}4.0%$, $1.7{\sim}4.1%$ at the Hyunpoong, $0.6{\sim}3.6%$, $0.6{\sim}3.7%$ at the Waegwan, $2.0{\sim}8.1%$, $2.0{\sim}8.1%$ at the Nakdong, and $1.2{\sim}9.8%$, $1.3{\sim}9.9%$ at the Jeongam, respectively. The relationship($R^2$) between each method is relatively high as $0.983{\sim}0.999$. This means the results are more logical than the Japanese method, and the study is applicable to the design of hydraulic structures.

• Journal of Radiation Protection and Research
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• v.40 no.2
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• pp.79-86
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• 2015

$^3He$ gas has been used for neutron monitors as the neutron converter owing to its advantages such as high sensitivity, good ${\gamma}$-discrimination capability, and long-term stability. However, $^3He$ is becoming more difficult to obtain in last few years due to a global shortage of $^3He$ gas. Accordingly, the cost of a neutron monitor using $^3He$ gas as a neutron converter is becoming more expensive. Demand on a neutron monitor using an alternative neutron conversion material is widely increased. $^{10}B$ has many advantages among various $^3He$ alternative materials, as a neutron converter. In order to develop a neutron converter using $^{10}B$ (actually $B_4C$), we calculated the optimal thickness of a neutron converter with a Monte Carlo simulation using MCNP6. In addition, a neutron converter was fabricated by the Ar sputtering method and the neutron signal detection efficiencies were measured with respect to various thicknesses of fabricated a neutron converter. Also, we developed a 2-dimensional multi-wire proportional chamber (MWPC) for neutron beam profile monitoring using the fabricated a neutron converter, and performed experiments for neutron response of the neutron monitor at the 30 MW research reactor HANARO at the Korea Atomic Energy Research Institute. The 2-dimensional MWPC with boron ($B_4C$) neutron converter was proved to be useful for neutron beam monitoring, and can be applied to other types of neutron imaging.

• Culinary science and hospitality research
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• v.21 no.4
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• pp.101-120
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• 2015

This study was conducted to examine the relation between a mother's LOHAS lifestyle propensity, healthy dietary life, and nutrient intake perceived by Chinese university students. The subjects consisted of 376 Chinese university students. The research results are summarized below. The mother's LOHAS attitude index was 76.02 points out of a perfect score of 100 points. High LOHAS attitude factors of mothers were 'health', whereas 'social welfare' scored low. The highest LOHAS attitude items of mothers that Chinese university students perceived was 'My mother uses health food, organic food, clean food'(4.26 points). Males who lived on their own in a large city and have normal BMI ($18.5{\sim}22.9kg/m^2$) perceived a high mother's LOHAS score. The highest food habit variables are 'eating without spilling food' 'cleaning up after meals around' and 'washing my hands before meals'. The highest healthy dietary life item is 'I try to maintain a pleasant and enjoyable life'(3.83 points). The highest nutrient intake attitude score is 'I tend to eat yellowish-green vegetables every day.'(3.92 points). According to mother's LOHAS lifestyle score, it was verified that the higher mother's LOHAS lifestyle score, the higher children's food habit, healthy dietary life, and nutrient intake score are. Mother's environment-friendly LOHAS attitude index has a meaningful impact on the child's food habits, healthy dietary life, and nutrient intake.