• The Monthly Diabetes
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• s.189
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• pp.14-17
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• 2005

소변이 오랜 시간 방광에 머물면 방광염이 생길 가능성도 많고, 또한 방광의 확장으로 방광근육의 손상이 생기기 쉽다. 그러므로 당뇨병환자에서는 혈당조절이나 식이 요법 등의 자기관리가 필요한데, 남성에서는 전립선도 자기관리 항목에 추가하는 것이 좋을 것으로 생각한다.

• Journal of Korean Academic Society of Home Health Care Nursing
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• v.23 no.1
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• pp.45-52
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• 2016

Purpose: This study aimed to investigate the effects of providing prostatic hypertrophy patients with information about an upcoming prostate biopsy procedure on their anxiety, depression, and sleep quality. Methods: Sixty-two participants were divided equally into an experimental and control group. Experiments were conducted from July 31, 2015, to March 30, 2016. After providing information, we evaluated anxiety, depression, and sleep quality using structured questionnaires. Data were analyzed using chi-square tests, Fisher's exact tests, t-tests, and ANCOVA using SPSS. Results: The experimental group demonstrated significantly lower levels of anxiety and depression than the control group. The experimental group also demonstrated significantly higher sleep quality. Conclusion: Information on an upcoming prostate biopsy improved psychological outcomes in patients with prostatic hypertrophy. This education should be incorporated into nursing practice.

• Journal of Yeungnam Medical Science
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• v.23 no.1
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• pp.62-70
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• 2006

Background: Benign prostatic hyperplasia (BPH) is the most common benign tumor in older men; the etiology of this disease remains poorly understood. Testosterone and dihydrotestosterone (DHT) both act as androgen via a single androgen receptor. Testosterone is converted to DHT by $5{\alpha}$-reductase in prostatic stromal cells. Progesterone has been reported to inhibit DHT conversion; howevwe, its effect on prostatic stromal cells remains to be elucidated. Materials and Methods: In this experiment, we investigated the effect of progesterone on androgen receptor expression induced by DHT. We also tested the effect of progesterone on cyclooxygenase-2 (COX-2) expression, as well as prostate stromal cell proliferation using the cell count kit-8. Results: Progesterone did not cause an increase of prostate stromal cell proliferation. The mRNA expression of the androgen receptor and COX-2 were not changed by progesterone; the expressions of androgen receptor and COX-2 proteins were decreased by progesterone in prostate stromal cells. Conclusion: These results suggest that in prostate stromal cells, progesterone decreases androgen receptor protein expression, which results in decrement of COX-2 protein expression. This effect might be mediated by post-transcriptional regulation.

• Proceedings of the Korea Contents Association Conference
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• 2015.05a
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• pp.191-192
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• 2015

전립선비대증(Benign Prostatic Hyperplasia, BPH)은 전립선조직중에 이행구역의 결절성증식과 요도 주위의 과증식(Hyperplasia)이 특징이다. 경직장초음파(TRUS: transrectal ultrasonography)검사를 이용한 진단에 있어 정상조직과 비대되어 있는 조직의 영상 차이를 비교하고 수량화로 나타내었다, 영상분석에는 GLCM 통계적 파라미터 중에서 Autocorrelation, Cluster Prominence, Entropy, Sum average를 4개의 파라미터에서 병변 인식이 가능하였고 인식 효율은 92-98%가 나왔다. 전립선비대증식에 대한 초음파영상을 가지고 컴퓨터영상처리분석을 제안하여 진단시 참고 자료가 될 것으로 기대한다.

• Journal of Life Science
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• v.29 no.6
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• pp.705-711
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• 2019

Benign prostatic hyperplasia (BPH) is the most common urogenital disorder in men, benign tumor and is a typical disease deteriorating the quality of old men's lives, and its prevalence increases with age. Though the molecular pathogenesis of BPH has not yet been clearly revealed, it is known that the variation and aging of the endocrine including sex hormone may cause BPH. Especially the hypertrophy of the prostate cell by the formation of the excessive dihydrotestosterone (DHT) is estimated to cause BPH. If testosterone exists excessively in blood, a lot of DHT is produced in prostate by $5{\alpha}-reductase$. Thus, in this study we tried to analyze haematological change and histopathological change by using the model rat with BPH caused by hypodermic injection of testosterone to prove the effect of Houttuynia cordata extracts on BPH. Rats were divided into four experimental groups: no treatment group (N), the testosterone injection and D.W treatment group (DO), the testosterone injection and Houttuynia cordata treatment group (HO) and testosterone injection and finasteride treatment group (FO). Prostate weight, volume and weight ratio in the HO and FO groups were significantly lower than the DO group. Testosterone and DHT levels in the HO group were significantly lower than the DO group. The HO and FO groups showed trophic symptoms and were lined by flattened epithelial cells, thus, the stromal proliferation is relatively low as compared to the DO group. These results suggest that Houttuynia cordata may control benign prostatic hyperplasia.

• 대한예방의학회:학술대회논문집
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• 2004.10a
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• pp.63.1-63.1
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• 2004

• Journal of Korean Academy of Nursing
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• v.40 no.2
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• pp.287-297
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• 2010

Purpose: This study was done to examine the relationship of low urinary tract symptoms (LUTS), depression, sexual function, and health-related quality of life (HRQoL), and to identify factors influencing HRQoL in patients with benign prostatic hyperplasia (BPH) living in the community. Methods: A total of 218 patients with BPH were recruited into the study. The data were collected by personal interviews using questionnaires and were analyzed with SPSS (version 17.0) computer program, and included descriptive statistics, one-way ANOVA, Pearson's correlation coefficient, and stepwise multiple regression analysis. Results: The relationship between HRQoL and LUTS with depression had a significant negative correlation, whereas the relationship between HRQoL and sexual function had a significant positive correlation. Depression, age, LUTS, number of chronic disease, and excercise were found to be significant predictors (35.6%) of the Physical Component Summary of HRQoL. Depression, stress, smoking, LUTS, and sexual function were found to be significant predictors (48.2%) of the Mental Component Summary of HRQoL. Conclusion: To improve HRQoL of patients with BPH, nurses should focus on the factors identified in this study when doing nursing assessments, and should develop nursing intervention programs for BPH prevention and symptoms management in primary care settings.

• Journal of Life Science
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• v.28 no.4
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• pp.465-471
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• 2018

Bee pollen is one of many types of alternative remedies, and it has been used for a long time throughout the world. It has numerous health effects, including antifungal, antibacterial, and antioxidant properties, immune modulation, enhanced cell proliferation, and even anti-carcinogenic effects. This study was designed to elucidate the effects of bee pollen on benign prostatic hyperplasia in rodents. For this experiment, we used nano-sized bee pollen produced through wet-grinding technology, thereby the extraction efficiency of the active ingredients in the bee pollen was significantly enhanced. First, We found that nano-sized bee pollen significantly reduced the size of prostates enlarged by chronic testosterone administration. In addition, nano-sized bee pollen significantly reduced the plasma concentration of the prostate-specific antigen (PSA). Interestingly, nano-sized bee pollen did not reduce the testosterone-induced increase in the plasma concentration of prostaglandin $E_2$ ($PGE_2$). The beneficial effects of nano-sized bee pollen in reducing both the size of the prostate and the plasma concentration of PSA was comparable to that of dutasteride. Finally, nano-sized bee pollen did not cause damage in LNCaP cells which are androgen-sensitive human prostate adenocarcinoma cells. Together, these data indicate that nano-sized bee pollen may be able to be used as a good alternative remedy for the treatment of benign prostatic hyperplasia.

• The Korean Chronic Disease News
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• no.312
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• pp.1-18
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• 2007

서울 마포구 보건소 하현성 소장/65세 이상 서울시민 무료 치매 검진/‘건강투자’보건의료전략 제시/국산약 해외진출,“ 현지화가 급선무”/‘의약품정책협의회’공식 출범/서방형 성장호르몬 상품화 성공/“다 함께 건강증진, 안전한 마포 건설”/지역자원역량강화 통합적 서비스 체계 구축/전립선비대증‘녹차’예방 효과 커/건강검진 수검자 비만율 30.64%/“식품첨가물, 아토피피부염과 상관없다”/허리둘레 크면 당뇨위험 2.2배 증가/발의 구조가 무너지면 인체의 구조가 무너진다/고령친화 모델지역 기본구상/

• Journal of Korean Biological Nursing Science
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• v.18 no.3
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• pp.127-134
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• 2016

Purpose: The purpose of this study was to investigate the physiological index, anxiety and depression by the severity of lower urinary tract symptoms in patients with benign prostatic hyperplasia. Methods: This research was conducted from the 4th to the 27th of May in 2016 on112 patients with benign prostatic hyperplasia. The data were analyzed using a chi-square test, ANOVA, and Pearson Correlation Coefficients. Results: The results demonstrated a difference depending on the dysuria period of each lower urinary tract symptom, marital status, occupation and perceived health state of the patient. The physiological index by lower urinary tract symptoms showed a difference in the maximum flow rate, amount of post-void residual urine and Prostate-Specific Antigen (PSA), and anxiety and depression factors also revealed a difference. Lower urinary tract symptoms showed a positive correlation to the amount of post voided residual urine and PSA, a negative correlation to the maximum flow rate and also indicated a positive correlation to depression. Conclusion: The results of the study belonging to the moderate and severe categories were high when the result was based on the categorization of subjects with benign prostatic hyperplasia with lower urinary tract symptoms. Considering that depression levels increase as the symptom intensifies and the anxiety score is also high with mild symptoms, psychological support intervention is needed when a pattern of benign prostatic hyperplasia appears.