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http://dx.doi.org/10.5352/JLS.2018.28.4.465

Beneficial Effects of Nano-sized Bee Pollen on Testosterone-induced Benign Prostatic Hyperplasia in Rodents  

Bak, Jia (Department of Pharmacy, Kyungsung University)
Pyeon, Hae-In (Department of Pharmacy, Kyungsung University)
So, Soojeong (Research Center, Natural Science Biotechnology Co., Ltd.)
Lee, Seunghyun (Department of Biotechnology, Daegu Catholic University)
Lee, Seungmin (Research Center, Natural Science Biotechnology Co., Ltd.)
Suh, Hwa-Jin (Research Center, Natural Science Biotechnology Co., Ltd.)
Kang, Jae Seon (Department of Pharmacy, Kyungsung University)
Choi, Yun-Sik (Department of Pharmacy, Kyungsung University)
Chung, Il Kyung (Department of Biotechnology, Daegu Catholic University)
Publication Information
Journal of Life Science / v.28, no.4, 2018 , pp. 465-471 More about this Journal
Abstract
Bee pollen is one of many types of alternative remedies, and it has been used for a long time throughout the world. It has numerous health effects, including antifungal, antibacterial, and antioxidant properties, immune modulation, enhanced cell proliferation, and even anti-carcinogenic effects. This study was designed to elucidate the effects of bee pollen on benign prostatic hyperplasia in rodents. For this experiment, we used nano-sized bee pollen produced through wet-grinding technology, thereby the extraction efficiency of the active ingredients in the bee pollen was significantly enhanced. First, We found that nano-sized bee pollen significantly reduced the size of prostates enlarged by chronic testosterone administration. In addition, nano-sized bee pollen significantly reduced the plasma concentration of the prostate-specific antigen (PSA). Interestingly, nano-sized bee pollen did not reduce the testosterone-induced increase in the plasma concentration of prostaglandin $E_2$ ($PGE_2$). The beneficial effects of nano-sized bee pollen in reducing both the size of the prostate and the plasma concentration of PSA was comparable to that of dutasteride. Finally, nano-sized bee pollen did not cause damage in LNCaP cells which are androgen-sensitive human prostate adenocarcinoma cells. Together, these data indicate that nano-sized bee pollen may be able to be used as a good alternative remedy for the treatment of benign prostatic hyperplasia.
Keywords
Bee pollen; benign prostatic hyperplasia; dutasteride; prostate specific antigen; prostaglandin $E_2$;
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