• Food Science and Industry
• /
• v.40 no.2
• /
• pp.46-58
• /
• 2007

제2형 당뇨병은 대사성 질환으로 간, 근육 그리고 지방 조직 세포에서 인슐린 작용의 장애로 나타나는 인슐린 저항성으로 혈당의 이용이 감소하여 혈당이 높아짐에도 불구하고 췌장의 베타세포에서 인슐린 분비가 충분하지 못할 때 유발된다. 서구에서는 비만 등으로 인해 인슐린 저항성이 증가하면 인슐린 분비가 높은 고인슐린혈증을 나타내어 당뇨병으로의 진전은 늦다. 하지만 우리나라를 비롯한 아시아의 사람들은 인슐린 저항성이 증가할 때 인슐린 분비가 충분치 못해 혈청 인슐린 농도가 정상인과 비슷하거나 더 낮은 상태에서 당뇨병으로 진전된다. 이러한 차이는 우리나라를 비롯한 아시아 사람들에게서 제2형 당뇨병의 발생이 급격하게 증가할 것이라는 보고되었다. 결국 당뇨병은 간, 근육 및 지방조직에서의 인슐린 작용의 장애와 췌장의 베타세포에서 인슐린 분비의 부족의 복합적인 장애에 의해서 나타나고 이것은 공통적으로 각 조직에서의 인슐린/insulin growth factor (IGF)-1 신호전달의 장애와 관련이 있다. 베타세포에서의 인슐린분비 자체는 인슐린/IGF-1 신호전달과 관계가 없지만 간접적으로 관련이 있다. 인슐린 분비능은 베타세포의 증식과 생존에 의한 베타세포의 양과 밀접한 관련이 있는데 인슐린/IGF-1 신호전달은 베타세포의 증식과 생존을 조절한다. 그러므로 혈당 조절에 관여하는 기능성 식품은 인슐린 작용을 향상시키는 인슐린 민감성 특성을 가지거나, 혈당이 높아질 때 인슐린 분비를 촉진시키는 insulinotropic 작용을 하는 성질을 가지고 있어야 하겠다. 전자의 대표적인 약은 1999년에 미국 FDA에서 승인 받은 peroxisome proliferator-activated receptor $(PPAR)-{\gamma}$ agonist 인 thiazolidinedione 계통의 약물인 troglitazone, pioglitazone, rosiglitazone 등이 있고, 후자는 2007년에 승인 받은 Exenatide는 glucagon like peptide (GLP)-1 agonist이다. 이 두 가지 약은 모두 자연계에 존재하는 동식물에서 유래된 것으로 식품에도 많이 다양한 종류의 인슐린 민감성 물질이나 insulinotropic 작용을 하는 물질이 함유되어 있을 것이다. 이러한 기능 이외에 혈당조절 약이나 식품으로 사용되는 것은 탄수화물의 소화를 방해하는 것으로 탄수화물 소화효소인 a-amylase 또는 maltase의 활성을 억제하여 식후 혈당의 급격한 상승을 방지하는 것이 있다. 우리나라 사람들은 탄수화물의 섭취가 너무 많아서 실제로 이러한 식품이나 약의 효능이 높지 않을 것이다. 혈당을 조절하는 기능성 식품은 이 세 가지 효능 중 일부를 가지고 있는 것이 될 수 있다. 이러한 기능을 스크리닝하기 위해서 3가지 단계를 거쳐야 한다. 먼저 시험관에서 또는 세포 실험을 통해서 앞서 언급한 3가지 기능을 가지고 있는 지 여부를 각각 조사한다. 이중에서 효과가 있는 것은 당뇨 동물 모델을 사용하여 in vivo에서 혈당 강하기능과 혈당 강하기전을 조사하는 실험을 한다. 효과가 있는 식품이 우리가 전통적으로 식품으로 섭취해 왔다면 독성 검사를 거쳐야 할 필요가 없지만 한약재이거나 특수 식품의 경우에는 in vivo 실험 전에 GLP 기관에서 반드시 독성 실험을 거쳐 독성 유무를 확인할 필요가 있다. 동물 실험에서 효과적인 것은 인체 실험을 거쳐 혈당 조절 기능성 식품으로 식약청에서 허가를 받을 수 있겠다. 결론적으로 식품에는 항당뇨 특성을 가진 물질들이 함유되어 있는 것들이 상당히 많다. 혈당 조절기능이 있는 기능성 식품으로 개발할 때 고려해야 할 것은 1) 그 양이 혈당 강하 기능성 식품으로 지정받을 수 있을 정도로 충분히 함유되어 있느냐, 2) 혈당을 강하시키는 기전이 단순히 당의 배설을 촉진시켜서 혈당을 저하시키는 것이 아니라, 인슐린 작용을 촉진시키거나, 포도당 자극에 의한 인슐린 분비를 촉진시키거나 탄수화물의 소화 흡수를 억제시킴으로 혈당을 강하시키는 지 등을 파악하는 것이다. 이러한 조건을 만족시키는 식품은 지속적으로 섭취할 때 당뇨병을 예방하거나 진전을 지연시킬 수 있는 혈당조절기능이 있는 기능성 식품으로 개발 가능성이 있겠다.

• Korean Journal of Social Welfare Studies
• /
• v.47 no.1
• /
• pp.93-121
• /
• 2016

The aim of this study is to reveal development processes of mothers with disabled children as active human agents utilizing social welfare institutions. Many social welfare studies have generally described welfare service users as passive subjects alienated from welfare information and subordinate to dominant welfare system. However, this investigation indicates that they do not merely remain as passive policy targets. They also perform as active actors who seek for useful information, strategically acquire profits in the given system despite institutional constraints, and create new welfare institutions. Through in-depth interviews with 11 mothers of disabled children with brain lesions, this study has derived a grounded theory on the mothers' maturation processes in interaction with social welfare institutions, which consist 6 stages(entering, awakening, exploring, struggling, resigning and utilizing period). This substantive analysis on the survival processes of mothers with disabled children in the social welfare system provides empirical knowledge and evidence about relationship between the structure and agents. It also suggests a practical policy proposal for disabled people and their families based on these stages.

• Proceedings of the Korea Water Resources Association Conference
• /
• 2016.05a
• /
• pp.74-74
• /
• 2016

복잡한 지형에서 컴퓨터를 이용한 물리적 기반 수치모의는 합리적인 시간내에 연산을 완료하기 위해 대개 큰 연산장비 들을 요구한다. 더욱이 모의되는 현상이 시간단계마다 갱신되어지는 동역학적 현상에 기반된 비정상상태일 때 연산성능은 고려되어지는 가장 중요한 주제가 될 수 있다. 연산 시간을 줄이기 위한 가장 널리 이용되는 전략중의 하나는 적절한 수의 프로세서를 이용하는 병렬 기법이다. 최근 들어 연산속도를 가속화하기 위해 다수의 코어를 이용한 OpenMP 와 MPI 기법들이 병렬해석기법으로 대두되었고 그래픽 연산장치를 이용한 병렬처리 해석기법도 소개되고 있다. 본 연구에서는 중앙연산장치를 이용한 병렬 해석기법을 이용하여 제내지 침수해석의 적용성을 검토하고 그 결과을 비교하였다. 본 연구를 위해 OpenMP 병렬기법을 이용하여 확산파 침수해석 프로그램의 원시코드를 재작성하여 가상 및 실제 유역에 적용하였다. 해석결과는 분산메모리 병렬해석 기법인 MPI를 도입한 모형의 결과와 비교되었다. OpenMP를 도입한 모형과 MPI를 도입한 경우 유량 및 수심의 경우 오차 허용 한계내에 수렴되어 만족되었으나 그러나 연산 속도의 경우 두 기법간의 자료의 저장 방법 차이로 인해 차이를 나타내었다. 가상 유역에 적용된 결과로 검토된 각 기법의 증속(speedup) 효과는 MPI의 경우 4 코어를 이용하였을 때 최고 2.62 배 정도에 도달하는 것으로 나타났다. OpenMP 를 적용한 경우 2.87 배 정도로 나타나 OpenMP 를 이용하였을 때 증속효과가 조금 더 뛰어났다. 이는 두 기법의 메모리 저장방식의 차이로 인해 자료의 전송량과 전송 시간이 적은 OpenMP 를 도입한 모형에서 MPI 모형 보다 상대적으로 뛰어난 결과를 나타내었다. 실제 유역의 적용을 위해 상대적으로 우수한 증속결과를 나타낸 OpenMP를 도입한 모형을 Malpasset 댐 붕괴 유역에 적용하였다. 적용된 요소의 수는 각각 45254, 11352 개로 비교적 많은 요소를 가진 하류지역에 적용하여 병렬효과를 극대화하고자 하였다. 적용결과 두 경우 모두 병렬 해석 기법을 도입한 모형에서 유속과 침수심 등은 순차적 모형과 동일한 값을 나타내었으나 증속효과로 인한 연산시간은 순차적 모형에서 8.57 배로 나타나 병렬 모형의 상대적으로 빠른 연산속도를 판단할 있었다. 위의 적용결과를 통해 계산 요소들이 많은 2 차원 해석의 경우 기존의 단일 코어를 이용한 순차적 해석은 장시간에 걸치 연산시간으로 인해 작업효율이 낮아지는 결과를 발생시킬 수 있으며 병렬 해석을 도입할 경우 주어진 컴퓨터 자원를 효율적으로 이용가능하여 합리적인 연산시간으로 연산결과를 얻는 것이 가능하여 반복적 통계 기법/Ensemble 해석 등을 이용한 종합적 해석이 좀 더 실용적으로 이루어 질 수 있을 것이라고 판단되었다.

• Korean Journal of Remote Sensing
• /
• v.37 no.5_1
• /
• pp.871-884
• /
• 2021

The purpose of this study was to determine ways to increase efficiency in constructing and verifying artificial intelligence learning data on land cover using aerial and satellite images, and in applying the data to AI learning algorithms. To this end, multi-resolution datasets of 0.51 m and 10 m each for 8 categories of land cover were constructed using high-resolution aerial images and satellite images obtained from Sentinel-2 satellites. Furthermore, fine data (a total of 17,000 pieces) and coarse data (a total of 33,000 pieces) were simultaneously constructed to achieve the following two goals: precise detection of land cover changes and the establishment of large-scale learning datasets. To secure the accuracy of the learning data, the verification was performed in three steps, which included data refining, annotation, and sampling. The learning data that wasfinally verified was applied to the semantic segmentation algorithms U-Net and DeeplabV3+, and the results were analyzed. Based on the analysis, the average accuracy for land cover based on aerial imagery was 77.8% for U-Net and 76.3% for Deeplab V3+, while for land cover based on satellite imagery it was 91.4% for U-Net and 85.8% for Deeplab V3+. The artificial intelligence learning datasets on land cover constructed using high-resolution aerial and satellite images in this study can be used as reference data to help classify land cover and identify relevant changes. Therefore, it is expected that this study's findings can be used in the future in various fields of artificial intelligence studying land cover in constructing an artificial intelligence learning dataset on land cover of the whole of Korea.

• Korean Journal of Construction Engineering and Management
• /
• v.22 no.6
• /
• pp.55-63
• /
• 2021

Recently, as the problem of the traditional on-site labor-intensive construction production method has been raised due to changes in construction work labor and site conditions, the OSC method is gradually spreading as an alternative to this. Even in apartment houses, the application of the PC method is expanding centered on the underground parking lot, but the high cost structure is a problem compared to the conventional formwork method. In this study, factors affecting the calculation of construction cost in the economic evaluation, which are the core of determining the construction method for apartment buildings, are derived through domestic and foreign literature review and expert advice, the importance was analyzed through an opinion survey targeting industry experts. The measures to reduce construction cost were mainly derived from the improvement of the design and manufacturing process. It is expected that the factors affecting the construction cost and improvement measures of the PC method derived from this study will serve as a direction for technology development to spread the application of the PC method for apartment houses in the future.

• (The) Research of the performance art and culture
• /
• no.18
• /
• pp.449-480
• /
• 2009

In this paper, I tried to study the change of the Chinese performing arts market during the 10th 5year development plan, from year 2001 to year 2005 by both of the quantitative and qualitative analysis, because it's really the time when we need to understand the growing market of chinese culture along with the development of the Chinese cultural industry. During that period, the Chinese government developed the policy to establish a healthy cultural market and strengthen it's cultural power; the parts who product the piece of performing arts including the performing troupes, the theatres and the production companies were consolidated and became familiar to market through the reformation of the organization; and the audience who consume the performing arts and entertainments still shows very Chinese characteristics in the cities and villages. In the village, the audiences invite the troupe to play their local theatre in many occasions of their life according to their traditional beliefs, also somehow to show their wealth. The fact that the local governments and the companies are very important consumer groups in China is also very 'Chinese' characteristics. It means that Chinese performing arts are still more or less under the influence of the political ideas. Nonetheless it is worthy of notice that Chinese performing arts not only develope the new contents in very creative way and also try to learn the knowhow of the excellent items of foreign countries by inviting them to the festivals or organize a co-productions on the basis of the upgraded cultural power through the 10th 5 year development plan.

• Journal of the Korea Convergence Society
• /
• v.10 no.3
• /
• pp.275-290
• /
• 2019

The present study aimed to develop a sports psychological skill training program and to test its applicability to improve the performance of national wheelchair curling players. A total of 4 participants completed the study. Subjects have been to 12 sessions of 6 different psychological skills training programs (routine training, attentional focus training, writing practice training in diary, relation training, self-control training, and positive self-talk training). The effectiveness of psychological skills training has been evaluated with 6 questionnaires and EEG measurement. The result was that psychological skills training had improved coping with adversity, peaking under pressure, and concentration, self-management and reduced anxiety of Korean national wheelchair curling player. The result was that the EEG inter-hemispheric asymmetry index showed negative emotional states before psychological skill training but positive emotional states after. The result implies that psychological skill training plays an important mediating role in bringing about positive effects in the psychological elements and competitiveness in national wheelchair curling players.

• Journal of The Korean Association For Science Education
• /
• v.39 no.3
• /
• pp.321-335
• /
• 2019

This study aims to explore the influencing factors and the process of enhancing science self-efficacy (SSE) and to lay the foundation in understanding science self-efficacy of students. The ten categories related to the science self-efficacy were derived through the coding of the interview data based on the grounded theory and paradigm analysis to develop a process model of science self-efficacy improvement. Through the process analysis, four cyclical phases were found in the process of enhancing SSE: 'Entering into learning science' phase, 'enhancing SSE' phase, 'adjustment' phase, and 'result' phase. More specifically, the phase of 'entering into learning science' is where students choose science track and stimulated to construct SSE. The phase of 'enhancing SSE' is where students taking a science track actively learn science and perform science activities. In the phase of 'adjustment', students come to have successful performance about learning science and performing science activities by using diverse strategies. Finally, 'result' phase indicates different appearances of students depending on SSE levels. The phases were non-linear and periodically repeat depending on situation. The core category in the selective coding was indicated to be 'enhancing science self-efficacy.' Students' SSE form by learning science and performing science activities. These finding may help better understand the behavior of students who are taking a science track by facilitating effective science learning through the increase of their SSE levels.

• Journal of Life Science
• /
• v.29 no.7
• /
• pp.824-835
• /
• 2019

In recent decades, oncolytic viruses (OVs) have extensively been investigated as a potential cancer drug. Oncolytic viruses have primarily the unique advantage in the fact that they can only infect and destroy cancer cells. Secondary, oncolytic viruses induce the activation of specific adaptive immunity which targets tumor-associated antigens that were hidden during the initial cancer progression. In 2015, one genetically modified oncolytic virus, talimogene laherparepvec (T-VEC), was approved by the American Food and Drug Administration (FDA) for the treatment of melanoma. Currently, various oncolytic viruses are being investigated in clinical trials as monotherapy or in combination with preexistent cancer therapies like immunotherapy, radiotherapy or chemotherapy. The efficacy of oncolytic virotherapy relies on the balance between the induced anti-tumor immunity and the anti-viral response. Despite the revolutionary outcome, the development of oncolytic viruses for the treatment of cancer faces a number of obstacles such as delivery method, neutralizing antibodies and induction of antiviral immunity due to the complexity, variability and reactivity of tumors. Intratumoral administration has been successful reducing considerably solid tumors with no notable side effects unfortunately some tumors are not accessible (brain) and require a systemic administration of the oncolytic viruses. In order to overcome these hurdles, various strategies to enhance the efficacy of oncolytic viruses have been developed which include the insertion of transgenes or combination with immune-modulatory substances.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
• /
• v.17 no.2
• /
• pp.213-226
• /
• 2019

Regulatory agency and licensee are preparing for the site restoration of Kori unit 1, the first commercial NPP in Korea, scheduled for 2031. Developing regulatory guidelines and strategies is essential for effective restoration work. Unfortunately, Korea does not have experience of site restoration of commercial NPPs. Therefore, it is important to review cases from experienced countries to establish a strategy and regulatory standards. The U.S. has had numerous soil remediation experiences using RESRAD and MARSSIM. However, formalized evaluation methodologies for subsurface soil have not yet been established in MARSSIM. This survey focused on subsurface soil remediation by reviewing the five decommissioned NPPs under regulation of the US NRC. Overall process of remediating a contaminated subsurface soil and groundwater was reviewed to identify considerations and lessons that could be applicable in Korea. In addition, an applied methodology for evaluation of contaminated subsurface soil and related major issues between regulatory agency and licensees were reviewed in detail to support establishment of remediation strategy for Kori unit 1.