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Association Study between Porcine LEPR-derived Microsatellite Polymorphisms and Economic Traits (돼지 leptin receptor내 초위성체 다형성과 경제형질과의 연관성 구명)

  • Choi, B.H.;Kim, T.H.;Cho, Y.M.;Lee, H.Y.;Jeon, J.T.;Cheong, I.C.
    • Journal of Animal Science and Technology
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    • v.45 no.5
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    • pp.679-688
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    • 2003
  • The leptin receptor gene(LEPR) produces a high affinity receptor that mediates the regulation of the leptin gene. Leptin secreted from adipose tissue plays an important role in regulating feed intake and energy balance. In this study, a microsatellite marker within LEPR was selected and genotyped for the F2 population composed of 354 individuals from an intercross between Korean Native boars and Landrace sows. Totally, six alleles (255, 259, 261, 263, 265 and 267bp) and nineteen genotypes were detected in the population, of which the CE (261/265), CC (261/261) and EE (265/265) types were observed by 20.0%, 10.1% and 9.6%, respectively. Relationships between their genotypes and economic traits were analyzed. We found specific genotypes associated with economic traits such as body weight at 12 weeks of age/body fat including abdominal and trimmed fat/shear force (P〈0.001), body weight of 30 weeks of age (P〈0.01) and body weight of 3 weeks of age/back fat thickness (P〈0.05). The DD (263/263) and DF (263/267) types were associated with body weight at 3, 5, 12 and 30 weeks of age. The DF (263/267) type showed a highly significant effect on back fat thickness and body fat including abdominal and trimmed fat. The DF (263/267) type showed positive effect on shear force, whereas the BB (259/259) and DD (263/263) types negatively affected on tenderness.

Geometry and Kinematics of the Yeongdeok Fault in the Cretaceous Gyeongsang Basin, SE Korea (한반도 동남부 백악기 경상분지 내 영덕단층의 기하와 운동학적 특성)

  • Seo, Kyunghan;Ha, Sangmin;Lee, Seongjun;Kang, Hee-Cheol;Son, Moon
    • The Journal of the Petrological Society of Korea
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    • v.28 no.3
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    • pp.171-193
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    • 2019
  • This study aims to identify the geometry and internal structures of the Yeongdeok Fault, a branch fault of the Yangsan Fault, by detailed mapping and to characterize its kinematics by analyzing the attitudes of sedimentary rocks adjacent to the fault, slip data on the fault surfaces, and anisotropy of magnetic susceptibility (AMS) of the fault gouges. The Yeongdeok Fault, which shows a total extension of 40 km on the digital elevation map, cuts the Triassic Yeongdeok Granite and the Cretaceous sedimentary and volcanic rocks with about 8.1 km of dextral strike-slip offset. The NNW- or N-S-striking Yeongdeok Fault runs as a single fault north of Hwacheon-ri, Yeongdeok-eup, but south of Hwacheon-ri it branches into two faults. The western one of these two faults shows a zigzag-shaped extension consisting of a series of NNE- to NE- and NNW-striking segments, while the eastern one is extended south-southeastward and then merged with the Yangsan Fault in Gangu-myeon, Yeongdeok-gun. The Yeongdeok Fault dips eastward with an angle of > $65^{\circ}$ at most outcrops and shows its fault cores and damage zones of 2~15 m and of up to 180 m wide, respectively. The fault cores derived from several different wall rocks, such as granites and sedimentary and volcanic rocks, show different deformation patterns. The fault cores derived from granites consist mainly of fault breccias with gouge zones less than 10 cm thick, in which shear deformation is concentrated. While the fault cores derived from sedimentary rocks consist of gouges and breccia zones, which anastomose and link up each other with greater widths than those derived from granites. The attitudes of sedimentary rocks adjacent to the fault become tilted at a high angle similar to that of the fault. The fault slip data and AMS of the fault gouges indicate two main events of the Yeongdeok Fault, (1) sinistral strike-slip under NW-SE compression and then (2) dextral strike-slip under NE-SW compression, and shows the overwhelming deformation feature recorded by the later dextral strike-slip. Comparing the deformation history and features of the Yeongdeok Fault in the study area with those of the Yangsan Fault of previous studies, it is interpreted that the two faults experienced the same sinistral and dextral strike-slip movements under the late Cretaceous NW-SE compression and the Paleogene NE-SW compression, respectively, despite the slight difference in strike of the two faults.

Development Strengths of High Strength Headed Bars of RC and SFRC Exterior Beam-Column Joint (RC 및 SFRC 외부 보-기둥 접합부에 대한 고강도 확대머리 철근의 정착강도)

  • Duck-Young Jang;Jae-Won Jeong;Kang-Seok Lee;Seung-Hun Kim
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.27 no.6
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    • pp.94-101
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    • 2023
  • In this study, the development performance of the head bars, which is SD700, was experimentally evaluated at the RC (reinforced concrete) or SFRC (steel fiber reinforced concrete external beam-column joint. A total of 10 specimens were tested, and variables such as steel fibers, length of settlement, effective depth of the beam, and stirrups of the column were planned. As a result of the experiment, the specimens showed side-face blowout, concrete breakout, and shear failure depending on the experimental variables. In the RC series experiments with development length as a variable, it was confirmed that the development strength increased by 26.5~42.2% as the development length increased by 25-80%, which was not proportional to the development length. JD-based experiments with twice the effective depth of beams showed concrete breakout failure, reducing the maximum strength by 31.5% to 62% compared to the reference experiment. The S-series experiment, in which the spacing of the shear reinforcement around the enlarged head reinforcement was 1/2 times that of the reference experiment, increased the maximum strength by 8.4 to 9.7%. The concrete compressive strength of SFRC was evaluated to be 29.3% smaller than the concrete compressive strength of RC, but the development strength of SFRC specimens increased by 7.3% to 12.2%. Accordingly it was confirmed that the development performance of the head bar was greatly improved by reinforcing the steel fiber. Considering the results of 92% and 99% of the experimental maximum strength of the experiment arranged with 92% and 110% of the KDS-based settlement length, it is judged that the safety rate needs to be considered even more. In addition, it is required to present a design formula that considers the effective depth of the beam compared to the development length.

Experimental Study on Flexural Capacity of Precast Steel Mesh Reinforced Mortar Panel (프리캐스트 스틸메쉬 보강 모르타르 패널의 휨 성능에 대한 실험적 연구)

  • Yi, Na Hyun;Kim, Jang Ho Jay;Lee, Sang Won;Kim, Tae Gyun
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.17 no.3
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    • pp.10-19
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    • 2013
  • Recently, researches related to precast modular construction have been actively conducted for nuclear power plant, LNG gas tank, and small-medium PCCV as well as bridges and buildings. In this study, the precast panel cast with steel mesh reinforced mortar (SRM) which is similar reinforced ferrocement was developed for efficient precast construction, construction time reduction, and easy transportation. Mortar mixture with high strength and flowability was obtained from various case studies using silica fume and GGBS. Also, $1,200{\times}600{\times}150mm$ SRM and reinforced concrete (RC) panels were manufactured with reinforcing ratio of 2% and 4%. To verify structural performance of the SRM specimen, the basic material tests, free shrinkage test, and 3-point flexural test with a line loading were carried out. From the test results, it was determined that SRM specimens showed outstanding flexural capacity and ductility. However, the 4% reinforced SRM specimens must consider shear reinforcing to be used as a precast modular member.

Seismic Response Control of Cable-Stayed Bridge using Fuzzy Supervisory Control Technique (퍼지관리제어기법을 이용한 사장교의 지진응답제어)

  • Park, Kwan-Soon;Koh, Hyun-Moo;Ok, Seung-Yong;Seo, Chung-Won
    • Journal of the Earthquake Engineering Society of Korea
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    • v.8 no.4
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    • pp.51-62
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    • 2004
  • Fuzzy supervisory control technique for the seismic response control of cable-stayed bridges subject to earthquakes is studied. The proposed technique is a hybrid control method, which adopts a hierarchical structure consisting of several sub-controllers and a fuzzy supervisor. Sub-controllers are independently designed to reduced the responses to be controlled of a cable-stayed bridge, and a fuzzy supervisor achieves improved seismic control performance by tuning the pre-designed sub-controllers. It is realized by converting static gains of the sub-controllers into time-varying dynamic gains through the fuzzy inference mechanism. To evaluate the feasibility of the proposed technique, the benchmark control problem of cable-stayed bridge proposed by Dyke et al. is adopted. The control variables for the seismic response control of the cable-stayed bridge are determined to be t도 shear forces and bending moments at the base of the towers, the longitudinal displacements at the top of the towers, the relative displacements between the deck and the tower, and the tensions in the stay cables. Comparative results between the fuzzy supervisory controller and LQG controller demonstrate the effectiveness of the proposed control technique.

Case Study on the Instability of the Slopes in Unsaturated Residual Soils Considering the Rainfall Characteristics (강우특성을 고려한 불포화 잔적토 비탈면의 붕괴사례 연구)

  • Nam, Samheon;Lee, Younghuy;Oh, Seboong
    • Journal of the Korean GEO-environmental Society
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    • v.16 no.1
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    • pp.45-53
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    • 2015
  • This study has obtained Soil Water Retention Curve (SWRC) of the unsaturated soil from the volumetric pressure plate extractor test and the triaxial compression tests was also conducted. By using the rainfall data measured in the site the seepage analysis of unsteady flow was performed with the program of SEEP/W in Geostudio 2007 and stability of the slope was analyzed with SLOPE/W program. Results of analyses show that shear strength of the unsaturated soil increases with the increase of matric suction. And it was also found that the net volumetric stress and the apparent cohesion increased with the matric suction. The seepage analysis of rainfall represents that the increasing rate of negative pore pressure at the zone of large negative pore pressure is appeared to be high even though lower rainfall intensity, but this tendency declines with ground depth. The stability analysis of slope was carried out for the actual plane of failure with the data representing the field condition. The factor of safety thus calculated was about unity (1.0) or just below, which means that the adopted method of analysis is in good agreement with the field condition.

Chloride Diffusion Coefficient Evaluation in 1 Year-Cured OPC Concrete under Loading Conditions and Cold Joint (하중조건과 콜드조인트를 고려한 1년 양생된 OPC 콘크리트의 염화물 확산계수 평가)

  • Oh, Kyeong-Seok;Kwon, Seung-Jun
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.21 no.5
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    • pp.21-29
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    • 2017
  • Cold joint caused by construction delay is vulnerable to shear stress and it allows more rapid chloride penetration and diffusion. In the paper, investigation of chloride diffusion coefficient is performed for 1-year cured concrete considering compressive and tensile loading level and cold joint. The results are compared with the previous results in 91-day cured concrete. In the 1-year cured concrete without loading, 10.7% and 10.5% of diffusion reduction are evaluated for those in 91-day cured concrete, respectively. The reduction ratios are almost similar however the result in cold joint concrete shows much higher values. The results in 1-year cured concrete under 30% and 60% of compressive loading show reduction of chloride diffusion by 10.9% and 5.8% compared with 91-day cured results, which is caused by steady hydration of cement particles, so called, time effect. In the case of tensile loading, the differences in results are not significant regardless of time effect and cold joint since micro cracks which is weak point of concrete is much dominant despite of long term curing.

도공층의 공극 구조와 인쇄후 잉크의 잔류 거동에 관한 연구(II)

  • ;;Douglas W. Bousfield
    • Proceedings of the Korea Technical Association of the Pulp and Paper Industry Conference
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    • 2001.11a
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    • pp.127-127
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    • 2001
  • 종이의 공극은 도공용 원지 또는 인쇄 용지로 사용될 때 도공액과 잉크 조성분의 침 투 거동에 영향을 미침으로써 여러 가지 물리적 성질에 변화를 가져온다. 도공 공정의 경우, 도공액에 포함되어 있는 물과 수용성 고분자 물질의 원지 침투는 도공 작업성과 도공층의 구조에 변화를 가져 올 수 있다. 이러한 변화는 물을 포함한 수용성 물질의 원지 침투가 빨라질 때 도공액의 고형화점 상승에 의한 원지 피복력 저하에 따른 도공 지의 평활성 감소를 가져온다. 또한 높은 전단력이 가해지는 블레이드 도공에서는 도피 직전 도공액의 수분 이탈이 급격하게 일어날 경우 블레이드에서 도공액의 유동성 저하 가 발생됨으로써 여러가지 문제점을 나타낸다고 보고 된 바 있다. 인쇄 공정의 경우에 는 도공층이 잉크의 직접적인 기질(substrate)로 작용되어 잉크 성분의 잔류 및 침투 거동에 영향을 미친다. 즉 지나치게’발달된공극 특성을 지닌 도공층에서는 잉크 안료가 적절한 결합력을 가지고 도공층에 정착되기 전에 잉크 속의 레진과 용제가 도공층의 공극으로 소실됨으로써 인쇄 완료 후 작은 외력에도 잉크 층이 파괴되는 효킹 ( (chalking) 현상이 일어난다. 그러나 과도한 바인더의 적용과 미세한 안료의 사용에 따 라 도공층의 공극이 폐쇄될 경우에는 인쇄 후 잉크의 건조가 늦어져 인쇄 작업성의 저 해 요인으로써 작용한다. 종이의 공극성과 인쇄적성은 주지하는 바와 같이 불가분의 관계에 있으며, 본 연구에 서는 피인쇄체로서 공극성을 달리한 세 종류의 도공지를 제조하고 실험실적으로 제조 된 잉크를 사용하여 각각의 특성에 따른 잉크의 잔류 특성에 대하여 고찰해 보고자 하 였다. 특히 인쇄 전 피인쇄체의 공극 특성에 따른 인쇄 전후의 공극율 변화와 주요 인 쇄 적성간의 관계에 대해 초점을 맞추었다.시아노에틸화한 PYA용액의 점탄성 평가를 위하여 storage modulus와 loss modulus 를 분석하였다. 일반적 유변특성 평가 결과 PYA용액은 shear-thinning, pseudoplastic 한 특성을 나타내어 표면사이즈 공정에서의 적용 가능성을 확인할 수 있었다. 사용하는 통계기법 중의 하나인 주성분회귀분석을 실시하였다. 주성분 분석은 여러 개의 반응변수에 대하여 얻어진 다변량 자료의 다차원적인 변 수들을 축소, 요약하는 차원의 단순화와 더불어 서로 상관되어있는 반응변수들 상호간 의 복잡한 구조를 분석하는 기법이다. 본 발표에서는 공정 자료를 활용하여 인공신경망 과 주성분분석을 통해 공정 트러블의 발생에 영향 하는 인자들을 보다 현실적으로 추 정하고, 그 대책을 모색함으로써 이를 최소화할 수 있는 방안을 소개하고자 한다.금 빛 용사 둥과 같은 표면처리를 할 경우임의 소재 표면에 도금 및 용 사에 용이한 재료를 오버레이용접시킨 후 표면처리를 함으로써 보다 고품질의 표면층을 얻기위한 시도가 이루어지고 있다. 따라서 국내, 외의 오버레이 용접기술의 적용현황 및 대표적인 적용사례, 오버레이 용접기술 및 용접재료의 개발현황 둥을 중심으로 살펴봄으로서 아직 국내에서는 널리 알려지지 않은 본 기 술의 활용을 넓이고자 한다. within minimum time from beginning of the shutdown.및 12.36%, $101{\sim}200$일의 경우 12.78% 및 12.44%, 201일 이상의 경우 13.17% 및 11.30%로 201일 이상의 유기의 경우에만 대조구와 삭제 구간에 유의적인(p<0.05) 차이를 나타내었다.는 담수(淡水)에서 10%o의 해수(海水)로 이주된지 14일(日) 이후에 신장(腎臟)에서 수축된 것으로

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Secondary Acute Myeloid Leukemia after Chemotherapy in an Osteosarcoma Patient - A Case Report - (골육종 환자에서 항암화학요법후 발생한 이차성 급성 골수성 백혈병 - 증례 보고 -)

  • Kim, Jae-Do;Kim, Seong-Dae;Son, Jung-Hwan
    • The Journal of the Korean bone and joint tumor society
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    • v.6 no.2
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    • pp.98-105
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    • 2000
  • In the case of osteosarcoma, secondary acute myeloid leukemia which occurs as the consequences of the complication of chemotherapy, is rare. We are reporting the case that we have recently experienced in the laboratory. A case of secondary acute myeloid leukemia have been occurred to among 77 patients who have been diagnosed as osteosarcoma and received chemotherapy from 1995 to 1999. This case was compared with the cases of other reports for the analysis of its cause and results. A 17-year-old man was diagnosed as a osteosarcoma in the distal part of femur, and recieved chemotherapy. Within 28months, the hematological analysis of the case indicated the severe increase in the number of the white cell (over 200,000) and the profound decrease in the number of platelets. A test of bone marrow needle aspiration and peripheral blood smear showed a tremendous increase in the number of the monocytoid immature cell, which mostly are blasts and promonocytes. Due to this clinical results, the case was diagnosed as the secondary acute myeloid leukemia after the chemotherapy. The frequency of occurrence of secondary acute myeloid leukemia after chemotherapy is quite phenomenal. But the disease could be fatal leading to a high rate of morbidity and mortality without early diagnosis and treatment. Hence, an enough recognition of the possibility of its development, the periodical observation and inspection after chemotherapy and an immediate treatment in the case of occurrence are essential.

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Joining High-Strength Steel and Al6061 Sheet Using Hole Clinching Process (Hole 클린칭을 이용한 고장력강판과 Al6061 이종소재의 접합)

  • Ahn, Nam-Sik;Lee, Chan-Joo;Lee, Jung-Min;Ko, Dae-Cheol;Lee, Seon-Bong;Kim, Byung-Min
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.36 no.6
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    • pp.691-698
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    • 2012
  • The joining of aluminum and HSS (high-strength steel) by the conventional clinching process is limited by the low formability of HSS. Defects in the clinching joint, such as necking of the upper sheet, cracks, and lack of interlocking, are produced by the different ductility properties of HSS and aluminum. In this study, we propose the hole clinching process for joining Al6061 and SPFC440, in which deformation of SPFC440 is avoided by drilling a hole in the SPFC440. The dimensions of the interlocking in the hole-clinched joint necessary to provide the required joint strength were determined. Based on the volume constant of the hole clinching process, the shapes of the tools were designed by finite element (FE)-analysis. A hole clinching experiment was performed to verify the proposed process. A cross-section of the joint showed good agreement with the results of the FE-analysis. The lap shear strength was found to be 2.56 kN, which is higher than required joint strength.