• 대한핵의학회:학술대회논문집
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• 1998.11a
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• pp.27.2-27.2
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• 1998

• 대한생식의학회:학술대회논문집
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• 2001.06a
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• pp.45.1-45.1
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• 2001

• 대한생식의학회:학술대회논문집
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• 2002.11a
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• pp.67-68
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• 2002

• Clinical and Experimental Pediatrics
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• v.52 no.4
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• pp.441-445
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• 2009

Purpose : Some patients develop side effects from theophylline even at low serum concentrations. We designed a prospective study to evaluate the side effects of theophylline. Methods : A Prospective, controlled trial study was conducted. The low-dose group received an intravenous continuous aminophylline dose of 5 mg/kg/day on the first day and subsequently 10 mg/kg/day on the following two days. The usual-dose group received 10 mg/kg/day for three days and the control group received normal saline for three days. Heart rate, respiratory rate, serum concentration of theophylline, and four adverse events (irritability, sleep disturbance, jitter, and vomiting) were checked at the time of admission and at 2, 12, 24, 48, and 72 h after the start of aminophylline infusions. Results : Nine patients out of 37 in the low-dose group and six of 21 in the usual-dose group dropped out because of uncontrolled irritability. The serum concentrations of theophylline in dropouts ($3.68{\pm}1.93$ ig/mL) and participants ($4.47{\pm}2.45$ ig/mL) were not significantly different. Irritability was a more frequent side effect in the usual-dose group at 12 h, but there was no difference between the low-dose and usual-dose groups in terms of vomiting, sleep disturbance, and jitter. Most of the severe adverse effects were observed in children below two years of age. Conclusion : Some patients dropped out regardless of the initiating aminophylline dose, especially patients under the age of two years.

• Journal of the Korean Vacuum Society
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• v.12 no.3
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• pp.151-156
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• 2003

Two capacitance diaphragm gauges(CDG) and two resonance silicon gauges(RSG) were calibrated using an ultrasonic interferometer as a national low vacuum standard in KRISS. The CDG has superior pressure resolution and is rugged as well as resistant to over-pressure because of all-metal inner components. Meanwhile, the RSG is a new type of MEMS sensor that has excellent calibration stability and is resistant to mechanical shocks. The calibration uncertainties were analyzed according to the ISO procedures. Results showed that the maximum difference of the expanded uncertainties was $9\times10^{-3}$Pa at the generated pressure of 100 Pa for the two different types. It is remarkable that the RSG can be used as a transfer standard at low vacuum since their accuracies were found to be within 0.5 %.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1995.04a
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• pp.125-125
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• 1995

Quinolone계 항균제인 rufloxacin의 전임상시험의 일환으로 항원성 유발여부를 평가하기 여부를 평가하기 위하여 아나필락시스 쇼크 반응시험, 수동 피부 아나필락시스 반응시험 및 간접 적혈구 응집 반응시험을 실시하여 다음과 같은 결과를 얻었다. 1. 기니픽을 이용한 아나필락시스 쇼크 반응시험에서 rufloxacin의 저용량투여군(1mg/body, 추정임상용량), 고용량투여군(5mg/body), 고용량혼합투여군(5mg/body mixed with Freunds' complete or incomplete adjuvant) 및 단백결합혼합투여군(rufloxacin-BSA, 1mg/body)에 있어서 아나필락시스 쇼크 반응이 관찰되지 않았다. 2. 마우스-랫드를 이용한 수동 피부 아나필락시스 반응시험에서 저용량투여군, 고용량투여군, 오용량혼합투여군 및 bovine serum albumin(BSA)과 결합시킨 단백결합혼합투여군 모두에서 음성의 반응을 나타내었다. 3. 간접 적혈구 응집 반응시험 결과 저용량투여군, 고용량투여군, 고용량혼합투여군 및 단백결합혼합투여군에서는 각군당 1-4마리에서 16-32배에서 양성반응을 나타내었다. 그러나 음성대조군에서도 10마리 중 4마리에서 16-32배에서 양성반응을 나타낸 것으로 미루어 약물투여군에서의 미약란 양성반응이 약물특이적 반응은 아닌 것으로 사료된다. 이상의 실험결과로 미루어 rufloxacin은 항체 생성능은 가지지 않는 것으로 사료된다. 이상의 실험결과를 종합하여 볼 때 ndloxacin은 전반적인 항원성 potential은 없는 것으로 사료되며 또한 생체내에서 체내 단백과 결합하여 hapten으로 작용할 가능성은 없는 것으로 사료된다.

• The KIPS Transactions:PartA
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• v.13A no.2 s.99
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• pp.101-110
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• 2006

One of the most effective ways to improve cache performance is to exploit both temporal and spatial locality given by any program executional characteristics. This paper proposes a data cache with small space for low power but high performance on multimedia applications. The basic architecture is a split-cache consisting of a direct-mapped cache with small block sire and a fully-associative buffer with large block size. To overcome the disadvantage of small cache space, two mechanisms are enhanced by considering operational behaviors of multimedia applications: an adaptive multi-block prefetching to initiate various fetch sizes and an efficient block filtering to remove rarely reused data. The simulations on MediaBench show that the proposed 5KB-cache can provide equivalent performance and reduce energy consumption up to 40% as compared with 16KB 4-way set associative cache.

• Tuberculosis and Respiratory Diseases
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• v.53 no.6
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• pp.656-661
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• 2002

Amidarone is one of the most commonly prescribed anti-arrythmic agents for almost all arrythmias, whether atrial or ventricular in origin. There are several side effects associated with amiodarone therapy. These include corneal deposits, abnormal liver function tests, hyper and hypothyroidism, bluish discolorations of the skin, bone marrow suppression, coagulopathies, peripheral neuropathies, and pulmonary toxicity. Amiodarone-induced pulmonary toxicity(APT), which was first described in 1980, is potentially serious side effects that are believed to develop in 5% of patients. Doctors often assume that APT occurs only when high amiodarone doses are used for a long time, but in practice a low maintenance dose of amiodarone may also be toxic. In this report, a case of amiodarone-induced pulmonary toxicity after a long course of a low dose therapy for refractory supraventricular arrythmia is described.

• 월간산업보건
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• s.41
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• pp.60-60
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• 1991

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2007.11a
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• pp.252-255
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• 2007

Recently military industrial company, utilizing company funded R&D and goverment and industry contracts, has developed ACTS/DACS technology. This technology can be utilized to rapidly steer "smart" bullets, "smart" rounds, tactical missile, cruise missile and kill vehicles for both endo- and exoatmospheric applications. The ACTS/DACS typically consists of a Smart Bus Controller(SCB), a proprietary network firing bus, Smart Pyrotechnic Devices(SPD), rocket motors, and a structure. The SCB communicates with the SPDs over the propretary network firing bus. Each rocket motor contains an SPD which provides rocket motor ignition. Firing energy is stored locally in the SPD so surge currents do not occur in the system as rocket motors are fired. This approach allows multiple, truly simultaneous firings without the need for large, dedicated batteries. Each SPD also functions as a network tranceiver and high reliability fir set all in the space of a single-sided 10 millimeter diameter circuit. The present work develops a new means for igniting explosive materials. The volume of semiconductor bridge (SCB) is over 30 times smaller than a conventional hot wire. We believe that the present work has a potential for development of a new igniter such as smart pyrotechnic device.