• Proceedings of the Korean Society of Applied Pharmacology
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• 1993.04a
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• pp.103-103
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• 1993

목적: Estroge 결핍으로 나타나는 폐경기의 주요 증상을 경감 치료하기 위해, estrogen경구 투여시 위장장애, 위장에서의 대사, 간 초회효과, 자주 투여로 인한 환자의 불편 등의 단점이 있나, 이러한 점을 개선하기 위한 투여경로의 하나로 피부를 통해 일정약물을 장기간 일정속도로 송달시키는 경피 흡수 시스템의 개발이 필요하다. 따라서 (EE)의 장기제어방출을 위해 ethylene vinyl acetate (EVA)를 사용하여 장기 제어방출 및 경피 흡수의 최적화 조건을 설정하여 경피흡수 시스템을 위한 막의 개방을 목적으로 한다. 방법: VA 함량이 18-40％까지의 EVA를 사용하여 EE를 함유한 matrix를 casting 방법으로 제조하고 변형된 Keshary-Chien cell을 이용하여 방출실험을 실행하였다. 이때 방출에 미치는 여러 가지 인자로서 EVA 주의 VA함량, 막의 두께, receptor 중 PEG 400의 용량비율, 방출 매개체의 온도, loading 된 약물의 량 등에 대해 검토하였다. 그리고 점개한 mouse skin에 대한 투과 실험을 행하고 이에 미치는 PEG 400과 자질층의 역할을 검토하였다. 결과: EE의 용해도는 saline so PEG 400의 용량 비율이 증가함에 따라 지수 함수적으로 증가하였다. 그리고 VA 함량이 증가될수록, PEG 400의 용량비율, 방출 매개체의 온도, loading 된 약물의 양이 증가될수록 PEG 400의 용량비율, 방출 매개체의 온도, loading 된 약물의 양이 증가될수록 EE의 방출속도와 부과속도는 증가하였다. 또한 투과속도는 막두께의 역수와 직선상의 상관 관계를 보였다. 그리고 EVA matrix로부터 EE가 방출되는 양상은 diffusion-controlled model을 따랐으며 이때 단위면적당 방출된 총량은 T에 비례되었다. 절개한 mouse skin을 통한 EE의 permeation은 PEG 400의 첨가에 의해 상승되었다. 이와 같이 EVA 막이 EE의 부과 및 방출을 조절하는 것으로 보아 경피 흡수를 위해 사용될 수 있다고 사료된다.

• Proceedings of the Korea Water Resources Association Conference
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• 2004.05b
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• pp.246-250
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• 2004

국내 수자원의 지역적 불균형으로 가뭄 시 해안 지역은 제한급수지역의 대부분을 차지하였다(건교부, 2001). 또한 해안지역의 평균 상수도 보급률은 $40\%$대로서 전국 평균 $87.1\%$(환경부, 2001)의 절반 정도이다. 실제로 해안지역의 지하수 이용량은 전국 지하수 이용량 약 31억$m^3$/년(수자원공사, 2002)의 약 $21\%$를 차지하고 있지만, 1인당 지하수 이용량은 전국 평균 $65m^3$의 4배에 달하는 것으로 조사된 바가 있다(홍성훈, 2003). 즉, 용수공급원의 부족으로 해안지역에서는 지하수에 대한 의존도가 높으며, 이로 인해 해안 지역에서 무분별한 지하수 개발과 그로 인한 해수침입 등의 환경 장애와 더불어 폐공 발생수가 증가하고 있는 실정이다. 따라서, 이런 문제점들과 해안지역을 고려한 지하수의 지속적 확보가 절실히 필요하다. 국외 인구동향을 보면 밀도류나 해수침투와 같은 해안지역 특성을 고려한 지하수 최적개발 모델이 개랄 또는 적용되어지고 있다. 하지만 해안지역 지하수 개랄 및 관리에서 요구하는 다양한 충족조건 내신 하나의 목적함수(예를 들어 최적 양수량, 최적 비용 등)만을 고려하고 있다. 그렇지만 실제적인 문제에서는 어느 위치에서 얼마만큼 개발되어야 하는지를 고려해야만 한다. 따라서 본 연구에서는 관정의 최적 개발량과 치적 위치라는 두개의 최적해를 고려할 수 있는 최적 양수모델을 제시하고, 실험실 수리모형에서의 검증을 소개하고자 한다. 또한 해안 지하수의 지속적 확보를 위한 방안을 제시하고자 한다.

• Environmental and Resource Economics Review
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• v.12 no.2
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• pp.327-346
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• 2003

Unlike previous studies on the causal relationship between energy consumption and economic growth, this paper analyses the dynamic causal relationship between these variables using the dynamic vector using Johansen's multiple cointegration procedure, dynamic vector error-correction model and impulse response function. The empirical results show that while the energy consumption to a shock in income responds positively, the income responds positively to the shocks in energy consumption in the first place and then the responses become negative. We also find that the impact of energy consumption shock on the income is short-lived and causes higher inflationary pressure.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2018.10a
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• pp.101-102
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• 2018

Users who using computer may experience fatigue or sickness on their wrists if they use the keyboard and mouse for a long time. People with physical disabilities will find it difficult to work with the keyboard and mouse. There is a problem in that the substitute product for solving this is limited in function or expensive. In this paper, we development a system for controlling a personal computer with voice commands using the Amazon Echo and Amazon Web Services lambda functions. The implemented system processes the user's voice commands from the Amazon web server and sends them to the personal computer. The personal computer processes the received command and uses it to operate the application program.

• The KIPS Transactions:PartA
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• v.12A no.1 s.91
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• pp.53-58
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• 2005

The use of computers for control and monitoring of industrial process has expanded greatly in recent years. The computer used in such applications is shared between a certain number of time-critical control and monitor function and non time-critical batch processing job stream. Embedded systems encompass a variety of hardware and software components which perform specific function in host computer. Many embedded system must respond to external events under certain timing constraints. Failure to respond to certain events on time may either seriously degrade system performance or even result in a catastrophe. In the design of real-time embedded system, decisions made at the architectural design phase greatly affect the final implementation and performance of the system. Flexibility indicates how well a particular system architecture can tolerate with respect to satisfying real-time requirements. The degree of flexibility of real-time system architecture indicates the capability of the system to tolerate perturbations in timing related specifications. Given degree of flexibility, one may compare and rank different implementations. A system with a higher degree of flexibility is more desirable. Flexibility is also an important factor in the trade-off studies between cost and performance. In this paper, it is identified the need for flexibility function and shows that the existing real-time analysis result can be effective. This paper motivated the need for a flexibility for the efficient analysis of potential design candidates in the architectural design exploration or real time embedded system.

• Korean Journal of Construction Engineering and Management
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• v.13 no.6
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• pp.143-152
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• 2012

As the Public Procurement Service announced the compulsory of BIM adaption in every public construction from 2016, the importance of BIM is increasing. Besides, automatic code checking takes significance in terms of the quality control for BIM based design. In this study, rule-sets were defined for Act on the Promotion and Guarantee of Access for the Disabled, the Aged, and Pregnant Women to Facilities and Information. Three analytic steps were suggested to shortlist the objective clauses from the entire code; the frequency analysis using project reviews for architectural code compliance, the clause analysis on quantifiability, and the analysis for model checking possibilities. The shortlisted clauses were transformed into the machine readable rule-set definition. A case study was conducted to verify the adaptiveness and consistency of rule-set definitions. In future study, it is required the methodologies of selecting objective clauses to be specified and its indicators to be quantified. Also case studies should be performed to determine the pre-conditions in modeling and to check interoperability issues and other possible errors in models.

• Journal of the Korean Chemical Society
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• v.34 no.3
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• pp.239-247
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• 1990

The gas-phase S_N2$ reactions can be classified into neutral bimolecular, solvated, and ionic reactions; the neutral bimolecular reaction proceeds via retention mechanism whereas the ionic reaction produces inversion products. In the reaction of solvated nucleophile with one solvent molecule, a six-center transition state (TS) is formed and the two processes i.e., retention and inversion, are found to compete with a favored path depending on the electronic effect of the nucleophile and substituents in the substrate and on the steric requirement. In the ionic reaction, the difference in the energy barrier between the two processes reduces to a small value when the substrate methyl group is made bulky, leaving ability of the leaving group is improved and at the same time the negative charge of the nucleophile is dispersed. When the reaction center atom in the $S_N2$ reaction is changed to a larger sized second row elements, the activation barrier decreases since the steric crowding in the penta-coordinated TS is relieved. However within the same row, the barrier was found to increase as the atomic size decreased. For the boron, B, the barrier height was the least since in addition to the relatively large atomic size compared to C and N, it forms tetra-coordinated TS so that the steric crowding becomes nearly negligible.

• Journal of the Institute of Electronics and Information Engineers
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• v.49 no.12
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• pp.256-264
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• 2012

The directional algebraic reconstruction technique (DART) using the trigonometric current pattern is one of the image reconstruction algorithms in electrical impedance tomography (EIT). This method needs to compute resistances between electrode pairs as using relation between the injected currents and measured voltages for the reconstruction of the inner image. The delay time is incurred in this process. Therefore this paper proposes modified directional algebraic reconstruction technique (mDART) using the adjacent current pattern instead of the trigonometric current pattern to solve the delay time for initial resistance values. The proposed method uses measured voltages instead of computed resistances in the reconstruction algorithm. Hence this method can eliminate the delay time because it does not use the resistances. In conclusion, the proposed method improves image quality and image reconstruction time by using the adjacent current pattern. To prove performance of the proposed method, we carried on computer simulation of various cases.

• Journal of Preventive Medicine and Public Health
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• v.31 no.1 s.60
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• pp.91-103
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• 1998

Under experimental conditions, UVB radiation, a type of ultra violet radiation, has shown to .elate with the occurrence of skin erythema (sun-burn) in human and skin cancer in experimental animal. Cumulative exposure to UVB is also believed to be at least partly responsible for the 'aging' process of the skin in human. It has also been observed to have an effect of altering DNA (deoxyribonucleic acid). UVB radiation is both an initiator and a promoter of non-melanoma skin cancer. Meta-analysis is a new discipline that critically reviews and statistically combines the results of previous researches. A recent review of meta-analysis in the field of public health emphasized its growing importance. Using a meta-analysis in this study, we explored more reliable dose-response relationships between UVB radiation and skin cancer incidence. We estimated skin cancer incidence using measured UVB radiation dose at a local area of Seoul (Shin chou-dong). The studies showing the dose-response relationships between UVB radiation and non-melanoma skin cancer incidence were searched and selected for a meta-analysis. The data for 7 reported epidemiological studies of three counties (USA, England, Australia) were pooled to estimated the risk. We estimated rate of incidence change of skin cancer using pooled data by meta-analysis method, and exponential and power models. Using either model, the regression coefficients for UVB did not differ significantly by gender and age. In each analysis of variance, non-melanoma skin cancer incidence after removing the gender and age and UVB effects was significant (p>0.01). The coefficients for UVB dose were estimated $2.07\times10^{-6}$ by the exponential model and 2.49 by the power model. At a local area of Seoul (Shinchon-Dong), BAF value were estimated 1.90 and 2.51 by the exponential and power model, respectively. The estimated BAP value were increased statistical power than that of primary studies that using a meta-analysis method.

• Journal of KIISE:Information Networking
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• v.31 no.4
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• pp.384-392
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• 2004

Mobile contents service providers have some difficulties to timely and proper service deployment due to rapid development cycle of diverse portable devices with different capabilities. A way to resolve the problem is to introduce a mobile contents service paltform that can adapt original mobile contents to diverse devices dynamically and automatically. In this paper, we propose a mobile contents service platform based on active network mechanisms, called Mobile Content Adaptation Network(MobiCAN). The MobiCAN node provides effective service deployment, execution, and maintenance features and accommodates service layering and service customization capabilities for easy deployment. The basic functional units of the MobiCAN node are micro services with well-defined service interfaces and service layering features. For reliable services among the MobiCAN nodes, we design new distributed and robust Overlay Management Protocols(OMPs). As an example of practical MobiCAN applications, we finally describe Dynamic Contents Customization Proxy(DCCP) service.