• The Journal of the Convergence on Culture Technology
• /
• v.4 no.2
• /
• pp.161-169
• /
• 2018

This study aimed to evaluate seaweed polysaccharide extracts as a cosmetic material. To assess anti-microbial efficacy, Staphylococcus aureus (S. aureus) was treated with seaweed polysaccharide extracts and zones of inhibition were measured. In addition, the anti-inflammatory effect was confirmed in RAW 264.7cells, and seaweed polysaccharide extracts was applied to the dorsal skin of Sprague-Dawley (SD) rats to evaluate single-dose toxicity. As a results, seaweed polysaccharide extracts did not exhibit cytotoxicity at concentrations up to $1,000{\mu}g/mL$ in skin fibroblasts. Furthermore, when S. aureus was treated with 1% seaweed polysaccharide extracts, clear zones of $1.52{\pm}0.34cm$ formed, confirming sufficient anti-microbial activity. When RAW 264.7 cells were treated with seaweed polysaccharide extracts extract, nitric oxide (NO) production decreased in a concentration-dependent manner and the production of inflammation-related cytokines, such as interleukin 1 beta ($IL1{\beta}$), tumor necrosis factor alpha ($TNF{\alpha}$), and prostaglandin E2(PGE2), decreased. When seaweed polysaccharide extracts extract was applied at various concentrations to rats, symptoms did not change for more than 14 d, and there was no change in body or organ weights. In conclusion we found that seaweed polysaccharide extracts is not cytotoxic and has anti-microbial and anti-inflammatory effects. Therefore, it is suitable for use as a cosmetic material.

• Journal of the Korean Crystal Growth and Crystal Technology
• /
• v.25 no.6
• /
• pp.257-262
• /
• 2015

Recently the world wide efforts reduce occurrence of $CO_2$; global warming main reason. The aim of this study is to improve recycling rate of the fly ash (FA) and fused waste slag (FWS) from the power plant and to carbonate under supercritical condition ($40^{\circ}C$, $80kgf/cm^2$ pressure, 60 min) for $CO_2$ fixation. Specimens of mortar with various mixing ratios of FA, FWS (from 100:0 to 20:80 in 5 steps of 20 % reduction each time), distilled water and 3 M NaOH alkali activators were prepared. As a result, the proportion of weight change ratio increases with CaO content, to 12 % after carbonation under the supercritical condition. There is difference of compressive strength between the carbonated and the alkali activator mortar specimens. The stabilization of $CO_2$ fixation through carbonation which could confirm the applicability of the eco-friendly materials without loss of compressive strength.

• Journal of the Korea Concrete Institute
• /
• v.18 no.2 s.92
• /
• pp.275-282
• /
• 2006

Recently, Fiber Reinforced Polymers(FRP) has been emerged as an alternative material to solve the corrosion of steel reinforcement in reinforced concrete structures. FRP exhibits higher specific strength and lower weight compared to steel reinforcement. Moreover, good resistance to corrosion of the FRP may be useful in aggressive environments causing deterioration such as chloride environment. However, causes for higher initial cost of FRP than that of steel, little information on the long-term behavior of FRP, and brittle failure make the efforts to apply FRP in civil structures slow. Glass fiber among the fibers used to manufacture FRP can be seen as the most beneficial material with regard to initial costs. But its low elastic modulus, which attains barely a quarter of steel, nay thus lead to excessive deflections when used as reinforcement for flexural members. This research was carried out on the tensile properties of hybrid rods made with glass and carbon fibers to improve those of FRP rod made with glass fiber. Parameters were resin type and the arrangement of glass and carbon fibers. The tensile properties of hybrid rods were compared with those of rods manufactured with only glass or carbon fibers. The results indicated that the tensile properties of hybrid rod were good when the carbon fiber was arranged in the core.

• Journal of Life Science
• /
• v.24 no.10
• /
• pp.1132-1136
• /
• 2014

A yellow-colored pigment is found in turmeric, or Curcuma longa L. (Zingiberaceae), a perennial herb distributed mainly throughout tropical and subtropical regions. C. longa has potent antiviral, antimutagenic, anti-inflammatory, anticancer, and antioxidant properties. However, pharmacological mechanisms of ethanol extract derived from C. longa remain poorly understood. The aim of this study was to investigate the potential acute toxicity of C. longa (Curcuma longa L.) extract in BALB/c mice administered a single oral dose of 0, 20, 200, and 2,000 mg/kg by gavage. After the administration of the agent, signs of toxicity were observed every hour for the first 6 hr and every day for 14 days. No mortality, abnormal clinical signs, or pathological changes were observed compared to a control group, and there were no differences in the body weights of the control and treatment groups. Biological serum activities were not significantly changed in the treatment group compared to the control group. These results indicate that a single oral administration of C. longa extract does not exert any toxic effects at a dose of 2,000 mg/kg body weight and that the $LD_{50}$ of C. longa extract is greater than 2,000 mg/kg body weight. Accordingly, C. longa appears to have potential in various functional agents or foods, without toxicity.

• The Korean Journal of Mycology
• /
• v.36 no.1
• /
• pp.66-74
• /
• 2008

Tremella aurantialba, one of edible and medicinal mushrooms belonging to Tremellaceae of Basidiomycota, has been known to have outstanding curing effects on coughing, tracheitis and hypertension of humans and antitumor activity on the sarcoma 180 and Erhrlich carcinoma of mice. Neutral saline soluble (0.9% NaCl), hot water soluble and methanol soluble substances (hereinafter referred to Fr. NaCl, Fr. HW and Fr. MeOH, respectively) were extracted from fruiting body of the mushroom. In vitro cytotoxicity tests showed that all crude polysaccharides extracted from the fruiting body were not cytotoxic against cancer cell lines such as RAW 309 CR.1 and Sarcoma 180 at the concentration of $2000\;{\mu}g/ml$. Intraperitoneal injection with crude polysaccharides exhibited life prolongation effect of $11.1{\sim}66.7%$ in mice inoculated with Sarcoma 180. Fr. MeOH improved the immunopotentiation activity of B lymphocyte by increasing the alkaline phosphatase activity by 1.16 folds at the concentration of $200\;{\mu}g/ml$. In case of Fr. HW, the numbers of peritoneal exudate cells and circulating leukocytes were increased by 1.42 and 2.87 folds, respectively.

• Journal of the Korean Society of Food Science and Nutrition
• /
• v.32 no.5
• /
• pp.710-714
• /
• 2003

This study was carried out to compare the effects of different plant oil sources on lipid metabolism of insulin dependent diabetic mice. Streptozotocin-induced (65 mg/kg B.W.) diabetic mice were fed four kinds of experimental diets with 20% lipid, which composed of 10% lard, and 10% soy bean oil (SBO), 10% rice germ oil (RGO), 10% rice brab oil (RBO) and 10% sesame oil (SSO) respectively, for 7 weeks. Diet intake, body weight, organs weights and lipids levels of serum, liver and feces were measured. There was no significant difference in diet intake and body weight among experimental groups. But the concentrations of serum triglyceride of RGO and RBO groups, and of serum total cholesterol of RGO and SSO groups were lower than those of the others. The hepatic total cholesterol level was the lowest in RGO group. The contents of total lipid and total cholesterol excreted in feces of RGO and RBO groups were higher than those of SBO and SSO groups. These results suggested that rice germ oil can effectively reduce serum triglyceride level and hepatic total cholesterol concentration of insulin dependent diabetic mice than rice bran oil, soy bean oil and sesame oil, and hypolipidemic effect of rice germ oil be due to increasing fecal lipid excretion. But we need to investigate the more detailed factors on lipid reducing effect in rice germ oil and rice bran oil.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.21 no.11
• /
• pp.201-208
• /
• 2020

This study examined the anti-obesity effect of krill oil (KO) by regulating adipokines in a high-fat diet (HFD)-induced obese mouse model. The mice were fed a 60 kcal% HFD for 16 weeks, and KO was then administered at an oral dose of 100, 200, and 500 mg/kg/day for four weeks before the end of the experiment. The administration of KO at concentrations of 200 and 500 mg/kg/day decreased body weight gain significantly compared with the HFD-fed control group. In addition, the HFD-fed control group showed the abnormal release of adipokines by an increase in leptin and decrease in adiponectin, compared to the normal diet-fed normal group. On the other hand, KO (500 mg/kg/day)-administered group attenuated the abnormal release of adipokines by the down-regulation of leptin and the up-regulation of adiponectin. Therefore, KO could be a promising therapeutic agent for obesity by the regulation of adipokines.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
• /
• v.15 no.2
• /
• pp.125-133
• /
• 2017

KAERI is conducting research on spent cladding hulls and additive metals to generate a solidification host matrix for the noble metal fission product waste in anode sludge from the electro-refining process to minimize the volume of waste that needs to be disposed of. In this study, alloy compositions Zr-17Cr, Zr-22Cr, and Zr-27Cr were prepared with or without eight noble metals representing fuel waste using induction melting. The microstructures of the resulting alloys were characterized and electrochemical corrosion tests were conducted to evaluate their corrosion characteristics. All the compositions had better corrosion characteristics than other Zr-based alloys that were evaluated for comparison. Analysis of the leach solution after the corrosion test of the Zr-22Cr-8NM specimen indicated that the noble metals were not leached during corrosion under 500 mV imposed voltage, which simulates a highly oxidizing disposal environment. The results of this study confirm that Zr-Cr based compositions will likely serve as chemically stable waste forms.

• Korean Journal of Food Science and Technology
• /
• v.39 no.3
• /
• pp.323-329
• /
• 2007

We investigated the immunomodulatory actions of water extract from Acanthopanax senticosus in male ICR mice. The mice were treated with fermented milk containing three added doses of freeze dried extract: 3 mg/kg (A), 9 mg/kg (B), and 27 mg/kg (C) of body weight with Acanthopanax senticosus: Codonopsis lanceolata (8:2) for 7 and 10 weeks, respectively. Organ weights, plaque-forming cell tests, agglutination tests, IgG tests, differential white cell counts, and histological tests were performed at the 7th and 10th weeks of dietary treatment. There were no significant differences in body weight and organ weight. The spleen indices of group B at 7 weeks and group C at 10 weeks were significantly higher than those of the control group (p<0.05). For the plaque-forming cell test, groups B and C at 7 weeks, and group C at 10 weeks, showed significant increases over the control group (p<0.05). The agglutination test decreased with an extended experimental period. Groups A, B, and C at 7 weeks, and groups B and C at 10 weeks, had greater antibody responses to sheep red blood cells (SRBC) than the control group. The IgG antibody production of group C at 7 weeks and groups B and C at 10 weeks were significantly higher than the control group (p<0.05). In groups B and C, lymphocyte percentage was higher than the control group, and their spleen and thymus tissues showed active immune reactions.

• Geophysics and Geophysical Exploration
• /
• v.20 no.1
• /
• pp.43-48
• /
• 2017

The applicability of refraction survey has been tested using a wave glider widely used in long-term ocean observations around the world. To record seismic refractions, a single channel streamer with metal weight and a seismic recording system were mounted on the wave glider. We used GPS precise time synchronization signal and radio frequency (RF) communication to synchronize shot and recorder triggers and to control acquired data quality in real time. When the wave glider is positioned close to the set point, a 2,000 J sparker is exploded along the designed track at 2 second intervals. Through the test survey, we were able to successfully acquire refractions from the subsurface.