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http://dx.doi.org/10.5762/KAIS.2020.21.11.201

Anti-Obesity Effect of Krill Oil by Regulation of Adipokines in High Fat Diet-Induced Mouse Model  

Kim, Ji Hyun (Department of Food Science, Gyeongnam National University of Technology and Science)
He, Mei Tong (Department of Food Science and Nutrition, Pusan National University)
Seo, Hyo Jeong (Department of Food Science and Nutrition, Pusan National University)
Lee, Dongjun (NZ Origin Ltd.)
Cho, Eun Ju (Department of Food Science and Nutrition, Pusan National University)
Publication Information
Journal of the Korea Academia-Industrial cooperation Society / v.21, no.11, 2020 , pp. 201-208 More about this Journal
Abstract
This study examined the anti-obesity effect of krill oil (KO) by regulating adipokines in a high-fat diet (HFD)-induced obese mouse model. The mice were fed a 60 kcal% HFD for 16 weeks, and KO was then administered at an oral dose of 100, 200, and 500 mg/kg/day for four weeks before the end of the experiment. The administration of KO at concentrations of 200 and 500 mg/kg/day decreased body weight gain significantly compared with the HFD-fed control group. In addition, the HFD-fed control group showed the abnormal release of adipokines by an increase in leptin and decrease in adiponectin, compared to the normal diet-fed normal group. On the other hand, KO (500 mg/kg/day)-administered group attenuated the abnormal release of adipokines by the down-regulation of leptin and the up-regulation of adiponectin. Therefore, KO could be a promising therapeutic agent for obesity by the regulation of adipokines.
Keywords
Adiponectin; Adipokine; Leptin; Krill oil; Obesity;
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