• Title/Summary/Keyword: 장기능

Search Result 378, Processing Time 0.033 seconds

Effect of Phyto-Extract Fermented Mixture (MP119) on the Sexual Functions and on the Toxicities of Cadmium (식물추출복합발효물(MP119)이 성기능에 미치는 영향 및 카드뮴 독성에 대한 효과)

  • Jang, Young-Sun;Jeong, Jong-Moon
    • Journal of the Korean Society of Food Science and Nutrition
    • /
    • v.38 no.12
    • /
    • pp.1724-1731
    • /
    • 2009
  • This study was aimed to investigate the effect of phyto-extract fermented mixture (MP119) on the male sexual functions. The MP119 was evaluated for anti-impotency and anti-hypertensive effects via ACE (angiotensin converting enzyme) or PDE (phosphodiesterase) inhibition assay. $IC_{50}$ values of MP119 against ACE and PDE were 241.3${\pm}$35.5 ppm and 372.2${\pm}$33.8 ppm, respectively. To investigate the effect of testosterone expression by MP119, we performed cell media test using mouse Leydig-derived TM3 cells. Production of testosterone in TM3 cell was increased by MP119. Also, NO (nitric oxide) production of HUVEC (human umbilical vein endothelial cell) was increased when MP119 was added to the cultures. Forty male ICR mice were divided into 4 groups. MP119 was orally intubated for 7 days to group 1 and 3, and same volume of vehicle to group 2 and 4 as controls. After that, group 3 and 4 were intraperitoneally injected cadmium chloride at a single dose of 2 mg/kg. On the 8th experimental day, weights of testis, epididymis and seminal vesicle, number of sperm, concentrations of serum testosterone and cGMP were determined. The number of sperm, the concentrations of testosterone and cGMP were significantly increased in two experimental groups (group 1, 3). These results suggest that MP119 enhanced the sexual function of male mice, and could protect the sexual organs from the cadmium chloride as one of the endocrine disrupters.

Effects of Nattokinase fibrinol supplementation on Fibrinolysis and Atherogenesis (Nattokinase fibrinol의 섭취가 혈전 용해능 및 동맥경화에 미치는 영향)

  • Noh, Kyung-Hee;Park, Chong-Mu;Jang, Ji-Hyun;Shin, Jin-Hyuk;Cho, Mi-Kyung;Kim, Jeong-Ok;Song, Young-Sun
    • Journal of Life Science
    • /
    • v.19 no.2
    • /
    • pp.289-298
    • /
    • 2009
  • Effects of Nattokinase fibrinol (NKF), defined as a fibrinolytic product, on fibrinolytic and atherogenetic markers were studied for healthy adults (20-31 years old), who is smoking more than 20 cigarettes per day. Subjects were divided into 29 for NKF group and 10 for placebo group in a short term study. They were given 2 tablets of NKF (4,000 unit) or placebo tablet and thereafter blood samples were collected at 0, 2, 4 hr prerid. For a 4-week long term study, 15 subjects for NFK group and 10 subjects for placebo group were supplemented one tablet of each NKF (2,000 unit) and placebo per day, respectively. Blood samples were collected at 0, 1, 2, 4 weeks later. The short-term experimental trial showed that NKF remarkably increased fibrinolytic activity at 2hr after consumption, which was maintained up to 4 hr, relative to that of placebo, while NKF reduced the euglobulin clot lysis time (ECLT) and retarded the activated partial thromboplastin time (aPTT), as compared to placebo group. NKF supplementation for 4 weeks elevated fibrinolytic activity, shortened ECLT and retarded aPTT. Furthermore, NKF supplementation increased anti-atherogenic index by decreasing triglyceride (TG) and elevating high-density lipiprotein (HDL)-cholesterol. These results indicate that NKF supplementation for short term or long term might have beneficial effects on preventing and treating cardiovascular disease by increasing fibrinolytic activity and improving atherogenic markers such as hyperlipidemia.

The Thermal Performance of Building Insulation Materials According to Long-Term Aging (건축용 단열재의 장기 경시변화에 따른 열성능 특성)

  • Choi, Bo-Hye;Kang, Jae-Sik
    • Korean Journal of Air-Conditioning and Refrigeration Engineering
    • /
    • v.25 no.11
    • /
    • pp.617-623
    • /
    • 2013
  • This study is to draw thermal property data during long-term aging, by testing the thermal conductivity of building insulation materials in Korea. The thermal resistance of extruded insulation within 3 days from manufacture performed well over the KS Standard. After 50 to 110 days, however, the thermal performance had deteriorated to the level of the KS standard. Eventually, after 4,000 days, the insulation performance had deteriorated to about 25.4~41.8% of the initial performance. Therefore, this research will be utilized as a reference for thermal properties during long-term aging, in order to improve standards and regulations related to building insulation materials.

Systematic Diagnosis and Long-term Care of Cardiopulmonary Disease (심폐기 질환의 체계적인 진단과 장기-치료 관찰)

  • 김재웅
    • The Korean Journal of Food And Nutrition
    • /
    • v.11 no.2
    • /
    • pp.171-178
    • /
    • 1998
  • K14 patient with chronic dyspnea, who is senile female, early had suffered from radical mastectomy, radiotherapy, autoplastic transplantation, and knee arthritis. Abnormalities of cardiopulmonary function such as obesita, hypertension, mild left ventricular hypertrophy, and chronic pulmonary disease were found from K14 patient's clinical datas, which based on medical history and diagnosis, as well as evaluation of blood pressure, obesity, clinical diagnosis, chest PA, electrocardiogram, ultrasonocardiograph, and spirometery test. Diagnostic results were exactly analyzed, also long-term cares of K14 patient were discussed with related to the clinical literatures.

  • PDF

Discharge Capacity of Prefabricated Vertical Drain Confined In-Clay Under Long-Term Conditions (연직배수재 타설 후 장기간 경과된 지반의 통수성능)

  • Jeong, Sang-Guk
    • Journal of the Korean Geosynthetics Society
    • /
    • v.17 no.4
    • /
    • pp.239-249
    • /
    • 2018
  • Typically, soft clay improvement is carried out using installation of PVD and surcharge method. According to circumstances, installed PVD has left for a long time due to the change in construction schedule. Therefore, for simulation of this kind of condition, discharge capacity tests were carried out under a series of temperature condition (30, 35, $40^{\circ}C$). The results indicated that under water confinement, the discharge capacities significantly reduced with elapsed time. And, the empirical equation by Miura and Chai (2000) was used for estimating the long-term in-clay discharge capacity. Based on the test results, it is recommended that in term of long-term discharge capacity, Miura and Chai's equation and reliability evaluation using discharge capacity tests under a series of temperature condition may be used.

Short and Long-Term Properties of High-Performance Concrete Containing Silica Fume for Bridge Deck Overlay (실리카퓸을 혼합한 교면 포장용 고성능 콘크리트의 단기 및 장기 성능 평가)

  • Won Jong-Pil;Seo Jung-Min;Lee Chang-Soo;Park Hae-Kyun;Lee Myeong-Sub
    • Journal of the Korea Concrete Institute
    • /
    • v.17 no.5 s.89
    • /
    • pp.743-750
    • /
    • 2005
  • High performance concrete containing silica fume for use in bridge deck overlay emerged as a viable type of bridge deck overlay that economic advantage in construction. They have gained acceptance in Europe, America and Canada in a relatively short time due to their low cost. In this study, high-performance concretes containing silica fume were tested and evaluated in the laboratory to assess their applicability for use in bridge deck overlay. It was conducted with experiments of mechanical and durability characteristics in compressive strength, flexural strength, chloride permeability, abrasion resistance, repeated freezing and thawing cycles and deicing salt scaling resistance. Laboratory test result describe that high-performance concrete containing silica fume for bridge deck overlay application shows most outstanding capacity.

Thermal Performance Evaluation of a Test Cell Thru Short Term Measurements (TEST CELL에서 단기측정에 의한 열성능 평가)

  • Jeon, M.S.;Yoon, H.K.;Chun, W.G.;Jeon, H.S.
    • Solar Energy
    • /
    • v.10 no.2
    • /
    • pp.10-17
    • /
    • 1990
  • Short-term tests were conducted on a house at KIER, Daejon for its thermal performance evaluation. The test procedure and data analysis were made according to the PSTAR method. Each test period was 3 days during which the building was unoccupied. The data measured with 8 channels were used to renormalize an audit based simulation model of the house. The following are the key parameters obtained in the present analysis: 1) the building loss coefficient(skin conductance plus infiltration conductance during coheating period); 2) the effective building heat capacity; and 3) the effective solar gain. An estimation of total heat required to maintain a standard level of comfort during a typical winter season is also calculated on the basis of the renormalized simulation model and typical long term weather data.

  • PDF

Difference of Synoptic Characteristics according to the Persistence of Rainfall in Korea during the Changma Season (장마철 우리나라 강수의 지속성에 따른 종관 특성의 차이)

  • Park, Byong-Ik
    • Journal of the Korean Geographical Society
    • /
    • v.45 no.6
    • /
    • pp.748-765
    • /
    • 2010
  • This study aims to investigate the difference of synoptic characteristics over East Asia according to the persistence of rainfall in Korea during the Changma season (June and July). In the cases of consecutive rainfall which lasts four or more days, there are developed ridges in 850hPa level east of the Korean peninsula which introduce stagnation of the synoptic cyclone over Korea. An cold area in 850hPa level moves southward from the Northern China in one day before the beginning the rainfall day in Korea and it aids the development of the stationary front in East Asia. When rainfall lasts a day or two, cyclones pass over Korea in rainy day and the stationary front in East Asia is not intensified. In both cases the synoptic cyclones near the Korean peninsula shows a deep-baroclinic structure, while in the former cases over the southwestern part of Japan a subtropical frontal zone which has a shallow structure appears near Japan. In latter cases the frontal structures are same near Korea and Japan. So, this means that the Changma is not necessarily similar to the Baiu of Japan in all cases.

Aspalatone의 항염증작용

  • 한병훈;서대연;양현옥;이송진;김현표
    • Proceedings of the Korean Society of Applied Pharmacology
    • /
    • 1994.04a
    • /
    • pp.235-235
    • /
    • 1994
  • NSAID의 대표적인 유도체인 acetylsalicylic acid(aspirin)은 항혈전 작용이 있다고 밝혀졌고, 주기적인 aspirin의 투여는 심근경색을 예방할 수 있음이 보고되었다. 그러나, 위궤양등 부작용의 발현이 심각하여 위의 목적에 입각한 aspirin의 장기적인 사용에 제약이 되고 있다. 이에 더욱 안전한 유도체인 aspalatone을 합성하였고, 이 물질은 낮은 궤양 유발능을 보이는 유망한 유도체로 개발중에 있다. 본 연구는 aspalatone의 in vivo 항염증 활성을 밝히기 위하여 시행하였다.

  • PDF

A Study on correlation of PM10, PM2.5 and pulmonary function in old man (미세 먼지와 노인 폐기능과의 상관성에 관한 연구)

  • 김윤신;안진호;현연주;이종태;황순용
    • Proceedings of the Korea Air Pollution Research Association Conference
    • /
    • 2001.11a
    • /
    • pp.267-268
    • /
    • 2001
  • 현대는 고도의 산업발전의 결과 발생된 대기오염이 우려할 만한 수준에 이르렀으며, 대기 오염으로 야기되는 질병들은 환경 위생학상 중요한 문제로 다루어져 왔다. 이에 따라 대기오염물질이 인체에 미치는 영향에 관심이 집중되고있다. 최근 우리나라에서도 급속한 경제 발전과 더불어 환경오염은 점차 심각해져 선진국과 마찬가지로 인간의 생존을 위하여 해결해야 할 커다란 과제로 대두됨에 따라 여러 연구가 다각도로 진행되어왔다. 일반적으로 대기오염의 인체영향은 고농도에서 급성으로 나타날 수 있고 장기적으로 저농도에 노출되었을 경우는 만성호흡기질환을 초래할 수 있다. (중략)

  • PDF