• Journal of KIISE:Software and Applications
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• v.29 no.11
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• pp.837-850
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• 2002

In this paper, we propose an EEG-based response time prediction method during a yes/no cognitive decision task. In the experimental task, a subject goes through responding of visual stimulus, understanding the given problem, controlling hand motions, and hitting a key. Considering the subject's varying brain activities, we model subjects' mental states with defining CT (cut time), ST (selection time), and RP (repeated period). Based on the assumption between ST and RT in the mental model, we predict subjects' response time by detection of selection time. To recognize the subjects' selection time ST, we extract 3 types of feature from the filtered brain waves at frequency bands of $\alpha$, $\beta$, ${\gamma}$ waves in 4 electrode pairs combined by spatial relationships. From the extracted features, we construct specific rules for each subject and meta rules including common factors in all subjects. Applying the ST detection rules to 8 subjects gives 83% success rates and also shows that the subjects will hit a key in 0.73 seconds after ST detected. To validate the detection rules and parameters, we test the rules for 2 subjects among 8 and discuss about the experimental results. We expect that the proposed detection method can be a basic technology for brain-computer-interface by combining with left/right hand movement or yes/no discrimination methods.

• The Journal of the Korea Contents Association
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• v.14 no.3
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• pp.166-175
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• 2014

The negative influence by disaster on human's life could be so tremendous. I like to give attention to the disaster, considerable many cases, that disaster was used as stimulation or motivation for artist's creativity, especially in the film among various art activities. The reason I focus on disaster through art activities is disaster is closely related to human's daily life and also aesthetic consciousness. I like to look into the flood disasters' appearances described in the both films, and and the people's aesthetic consciousness expressed from the flood disasters. In the traditional education of the East. 'cultivation' has been used as the meaning of self education which develops mostly one's personality by doing self practice, and self insight meditation. And In the modern western education, cultivation has been identified as the meaning of unique mission, that each human being expresses one's own individuality, that is personality, progressively. I think 'the aesthetic ' already immanence in human's mind. Analysis for The beauty of Kant is also starts from special nature, delightfulness. The aesthetic doesn't appears in sight easely because it always exists in one's bottom of heart like mist. That's the reason we try to reach to the aesthetic through the medium, that's art. Human can achieve aesthetic cultivation which reaches to the aesthetic by having lot of events and experiences in the process.

• The Journal of the Acoustical Society of Korea
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• v.32 no.5
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• pp.423-429
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• 2013

The present study aimed to find the most sensitive placement of the skull to perceive speech through the bone vibrator in various protection methods while being exposed to noise. Twenty young normal-hearing adults (10 male and 10 female) participated in the study. As stimulus, Korean spondee words were presented via one of five skull locations (i.e., jaw angle, condyle, temple, mastoid, and vertex), while the participants wore one of four protection methods (i.e., ear form, ear plug, ear muff, and ear form and muff together) against white noise in one of four noise directions (i.e., 0, 90, 180, 270 degrees). The results showed: 1) there was a significant difference among the five skull locations with condyle being the most sensitive placement; 2) there was a significant difference among the four protection methods, with the ear form plus ear muff condition (or dual protection) providing the lowest threshold; 3) when exposed to noise from 90 degrees, the significantly lowest threshold was found; 4) there was no significant difference in results by gender. The pattern of results suggests that the communicative condition via the condyle bone conduction and the dual protection of the air conduction under any noise direction might be ideal for preventing noise-induced hearing loss, although further studies should be undertaken in this area.

• Journal of Digital Convergence
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• v.11 no.6
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• pp.11-21
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• 2013

Though adolescents have the skillful ability to use internet and use it extensively, they have experienced sexually less than adults and are hard to have the right viewpoint toward sexuality. Because of these adolescents' characteristics, internet pornography cause them serious troubles with their sexual behavior. Based on the viewpoint, this research explores structural relationship among their sexual orientations, exposure to internet pornography, the sexual drive and behavior with PLS path modeling analysis. In result, androcentric and pornography-friendly sexual orientation have an influence on the exposure to internet pornography, in turn, the exposure to internet pornography affect the sexual drive and behavior directly and sexual behavior indirectly mediated by the drive. The significance of this research is to identify fact that sexual orientations, reconceptionalized from previous researches's dependent variables, predict the exposure to internet pro-pornographic and is to identify a popular myth indirectly that the exposure to internet pornography stimulates sexual drive to cause behavior, in turn leads to sex crimes finally.

• Korean Journal of Food Science and Technology
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• v.28 no.4
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• pp.684-688
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• 1996

In order to search for antithrombotic peptides from soybean paste, the inhibitory activity of water extract of soybean paste and its peptide fractions on ADP-induced aggregation of washed platelets was assayed. Soybean paste extract treated with ultrafiltration (M.W. cut off, 3,000 daltons) was found to have inhibitory activity of 90% at the dose of $96\;{\mu}g/ml$ by the method of turbidometric aggregometer. Soybean paste extract was fractionated to 19 fractions (No. B-18) by Dowex 50W X-2 ion exchange column chromatography and activity test was performed by the microplate method. All of the fractions had antithrombotic activity $(IC_{50},\;101,000\;{\mu}g/ml)$, and most fractions had higher activity than positive control, RGDS $(IC_{50}.\;205\;{\mu}g/ml)$. Especially, basic fractions No.16-18 showed higher activity than soybean paste extract $(IC_{50},\;30\;{\mu}g/ml)$. The fraction No.16 with the highest activity $(IC_{50},\;10\;{\mu}g/ml)$ was purified and analysed for amino acid composition. The results showed that histidine, arginine, and alanine were major residues in the peptide part of the fraction.

• Clinical and Experimental Reproductive Medicine
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• v.21 no.2
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• pp.183-190
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• 1994

Purpose of the present study was to find the optimal culture conditions for the maturation and fertilization of immature oocytes by the use human body fluids and gonadotropins (Gn) in the mouse model. Cumulus-enclosed mouse immature oocytes were incubated in the medium containing various human body fluids with or without Gn in vitro, and examined to confirm nuclear maturation (NM) and fertilization. Female ICR mice were stimulated with 7.5 IU pregnant mares' serum gonadotropin (PMSG). Cumulus-enclosed immature oocytes were isolated at 48-52 hr post PMSG injection and cultured in TCM 199 supplemented with various concentrations (20, 50, and 70%) of human body fluids such as fetal cord serum (hCS), follicular fluid (hFF), peritoneal fluid (hPF) and amniotic fluid (hAF) in the presence or absence of 10 IU/ml PMSG and 10 IU/ml human chorionic gonadotropin (hCG) for 18 hr. Fetal calf serum (FCS) was used as a control for the supplements. Matured oocytes were fertilized with sperm collected from the epididymis of male mice. Fertilization was conducted in T6 medium containing 15 mgl ml bovine serum albumin, and confirmed at 6 hr post-insemination. Evaluation of nucler maturation and fertilization was carried out by rapid staining using fuchin. There was no significant difference between the effects of human body fluids and FCS supplements on nuclear maturation of cumulus enclosed mouse immature oocytes. When maturation medium was supplemented with 20% hPF or 20% hAF, fertilization rates were significantly (P<0.01) lower than that of 20% FCS, hCS and hFF groups. However, higher concentrations of body fluids during IVM were not more beneficial on fertilizability of oocytes. The addition of Gn significantly increased the fertilization rates in hPF and hAF groups (hPF without Gn; 51.5%, compared with 85.1% for addition of Gn, and hAF without Gn; 30.1% compared with 85.8% for addition of Gn) at 20% concentration. These results suggest that human body fluids at 20% concentration and gonadotropins can be used as supplements for the maturation of mouse immature oocytes in vitro. When gonadotropins supplemented with the human body fluids in the maturation medium, fertilizability of mouse immature oocytes was increased in hPF and hAF groups. These results can be applied to maturation of human immature oocytes in vitro.

• Clinical and Experimental Reproductive Medicine
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• v.29 no.1
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• pp.45-56
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• 2002

Objectives: Recently, recombinant FSH (rFSH) has been manufactured using a Chinese hamster ovary cell line transfected with the gene encoding human FSH. Both rFSH and urinary gonadotropin (uFSH) could be used for controlled ovarian hyperstimulation (COH). However, uFSH implies a number of disadvantages, such as batch-to-batch inconsistency, no absolute source control, dependence on large amounts of urine, low specific activity, and low purity. The purpose of this study was to evaluate the efficacy of rFSH in human IVF-ET program. Materials and Methods: A total of 508 infertile women was enrolled in this study. They are classified into rFSH group (n=177) or uFSH group (n=331), and all of them were matched by age and cause of infertility in same period. The $Puregon^{(R)}$ (Organon, Holland) was used as rFSH, and the Metrodin-$HP^{(R)}$ (Serono, Switzeland) and $Humegon^{(R)}$ (Organon, Holland) was used as uFSH. We subdivided the patients into three age groups. The outcomes of IVF-ET program were analyzed using the statistical package for social sciences (SPSS). Results: There was no significant differences in the level of estradiol on hCG injection day, the numbers of retrieved oocytes, matured oocytes, fertilized oocytes, transferred embryos, frozen embryos between the two groups. The total dose (IU) of gonadotropin for COH was significantly lower in the rFSH group compared to uFSH group ($1339{\pm}5491.1$ vs $2527.8{\pm}1075.2$ IU, p<0.001). Clinical pregnancy rate per embryo transfer in the rFSH group showed increasing tendency, compared to the uFSH group, but there was no statistical significance (35.2% vs 29.3%). Our results demonstrated that the relative efficiency of rFSH compared with uFSH is higher in older patients. Conclusions: The ovarian stimulatory effect and clinical outcome of recombinant FSH was similar to that of the urinary gonadotropin. The IVF-ET cycles with significantly lower dose of gonadotropin in rFSH group showed comparable results. Therefore, we suggest that recombinant FSH is more potent and effective than urinary gonadotropin.

• 한국사회복지학회:학술대회논문집
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• 2002.04a
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• pp.497-531
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• 2002

It is very important for rehabilitation to deal with psychological aspects of persons with disabilities, as well as efforts improving the institutional and environmental conditions. A majority of persons with severe disabilities in the situation of Korea have difficulty in having and maintaining a job. Work should and would be a source of self-respect and material well-being in this modern society. Therefore, Vocational rehabilitation services are measures in restoration of family functions and social participation of persons with disabilities. This study aims at investigating linguistic characteristics and the validity of constructional concepts of picture interest test Inventories that have been utilized for the segregated groups of people such as persons with developmental disabilities. Picture interest test inventories seemed to be valid for measuring psychological traits and characteristics of people with mental retardation, and this finding can be extended to the group of other developmental disabilities, such as learning disabilities and mild/moderate behavioral deficits. The Holland classification system seemed to be best fitted for developing a comprehensive and accurate vocational interest inventory.

• Journal of Yeungnam Medical Science
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• v.8 no.2
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• pp.138-149
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• 1991

This study was aimed at investigation of the stimulatory innervations on the rat urinary bladder. Detrusor muscle strips of 15 mm long were suspended in isolated muscle chambers containing 1 ml of PSS maintained at $37^{\circ}C$ and aerated with 95% $O_2/5%CO_2$. Isometric myography was perfomed, and the results were as followings : Muscle strips showed "on-contraction" by electric field stimulation (EFS) frequency-dependently. The EFS-induced contraction was not affected by hexamethonium, a ganglion blocker, but abolished, by tetrodotoxin, a nerve conduction blocker. Physostigmine, a cholinesterase inhibitor enhanced the EFS-induced contraction which was inhibited by hemicholinium, an inhibitor of choline uptake at the cholinergic nerve ending. Such an EFS-induced contraction was antagonized by atropine only partially, and the atropine-resistant portion was completely abolished by the desensitization of purinergic receptors by prolonged incubatin of the strips in the presence of high concentratin of ATP. Bethanechol, a cholinergic agonist, elicited concentration-dependent contraction. Adenosine triphosphate (ATP), a purinergic agonist, induced a weak but concentration-dependent contraction of short duration. Bethanechol-induced contraction was not affected by ATP-desensitization, and ATP-induced contraction was not affected by tetrodotoxin. These results suggest that there are at least two main stimulatory components of innervations in the detrusor muscle, cholinergic muscarinic and purinergic ; and those receptors are independent each other.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.12
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• pp.503-511
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• 2017

This study was conducted to evaluate the anti-inflammatory activity and clinical efficacy of a sample (A.C.C. extracts) obtained by distillation extraction of 14 herbal medicines including Phellodendron bark. To confirm this, the amount of nitric oxide (NO) produced by the cells in RAW 264.7 cells stimulated by lipopolysaccharide (LPS) and the changes in the production of inflammatory cytokines such as tumor necrosis factor (TNF)-${\alpha}$, interleukin(IL)-$1{\beta}$ and IL-6 were determined. The results showed that A.C.C. extracts strongly inhibited the production of NO and inflammatory cytokines increased by LPS without cytotoxicity. In addition, A.C.C. extracts showed strong bacterial reduction rates of 99.9% in Pseudomonas aeruginosa, Staphylococcus aureus, MRSA (Methicillin-resistant Staphylococcus aureus), Candida albicans and Streptococcus mutans. These findings indicate that A.C.C. extracts are effective ingredients with a strong antimicrobial effect together with an anti-inflammatory effect. In addition, when A.C.C. extracts were applied to infants and toddlers who were suffering from diaper rash, itching, and perspiration symptoms, symptoms of rash, atopy, rash, itching, and heat rash were improved. After the lapse of time, it was visually confirmed that it was considerably relaxed. These findings confirm that A.C.C. extracts comprise a clinically effective anti-inflammatory and anti-bacterial agent that alleviates symptoms such as diaper rash and fever and may therefore be an effective alternative to inflammatory diseases.