• Pediatric Infection and Vaccine
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• v.19 no.3
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• pp.111-120
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• 2012

Purpose: The aim of this study is to investigate the colonization rate of Methicillin-resistant Staphylococcus aureus (MRSA) in neonates by different clinical characteristics, to presume the origin of MRSA acquisition, and to identify the risk factors associated with MRSA colonization. Methods: We retrospectively reviewed the medical records of 1,733 neonates admitted to Seoul Eulji hospital Neonatal Intensive Care Unit between January 2008 and December 2011. Nasal, inguinal and rectal swab specimens were obtained upon admission and each week until discharge. We classified the route of MRSA acquisition as; hospital associated (HA-MRSA) and community associated (CA-MRSA) according to the case definition. Results: Among 1,733 neonates, 415 (23.9%) were colonized with MRSA. Gestational age, birth weight, delivery type, maternal antibiotics usage before delivery, birth place and care place before admission were influencing factors in colonization of MRSA. The colonization rate was significantly high in neonates without maternal prophylactic antibiotics use before delivery than in the other group (relative risk 2.77, 95% CI 1.88-4.07; P<0.01), and outborns showed higher MRSA colonization rate compared to inborns (relative risk 2.28, 95% CI 1.17-4.42; P=0.015). Conclusion: We identified the neonatal MRSA colonization rate to be 23.9%. We estimated HA-MRSA colonization rate to be 10% (51/511) and CA-MRSA colonization rate to be 36% (309/858). We ascertained that risk factors in MRSA colonization in neonates were prophylactic use of antibiotics in mothers and the birth place.

• Journal of the Korean Society of Radiology
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• v.13 no.2
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• pp.291-296
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• 2019

Nuclear medicine have often used to diagnose cancers. The main absorbed dose from radiation to a radiation worker resulted from open radioisotopes. Methods for reducing the radiation dose to a radiation worker from radioisotopes injected to patients were studied. The shield device of 0.2 mmPb was manufactured as a size of $300mm{\times}500mm{\times}150mm$. By using dosimeters of Nanodot, the absorbed doses for thyroid, chest and genital organ were measured with and without a shielding device and with syringe shield and shielding device together. The highest absorbed dose of 0.908 mGy reduction of 20.8% as 0.719 mGy was in the genital organ by using the syringe shield and a shielding device together. A effective dose for a radiation worker during 1 year was expected to 1.223 mSv at the chest, which was decrease as 0.994 mSv by shielding device and syringe shield together. When open radioisotope is injected to a patient for examination, the only use of a shielding device results in the reduction of radiation dose to radiation workers.

• Journal of Life Science
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• v.23 no.10
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• pp.1280-1287
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• 2013

The current study investigated the effects of [6]-gingerol, a ginger phytochemical, on the expression of autophagy-related genes and the activation of antioxidative enzymes in the pancreas of mice with cerulein-induced acute pancreatitis. The following were studied: pancreatic edema, ${\alpha}$-amylase activity in serum, expression of autophagy genes, activities of antioxidative defense enzymes, such as superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and the production of lipid peroxidation (LPO). The results revealed that cerulein-induced edema in the pancreas and ${\alpha}$-amylase activity in the cerulein group significantly increased compared with that of the control. However, that of the [6]-gingerol pretreated group was significantly decreased compared with that of the cerulein-alone injected group (positive control). There was no significant difference compared with that of control. The expression of autophagy-related proteins, including Beclin-1 and cleaved microtubule-associated protein 1 light chain 3, were significantly increased in the positive control but significantly decreased in the [6]-gingerol-pretreated group. Furthermore, the activities of SOD and GSH-Px in the positive control were decreased compared with those of the control. However, those of the [6]-gingerol pretreated group were significantly increased compared with those of the cerulein-alone group. The mRNA levels and antioxidant enzyme activities were similar. The production of LPO in the cerulein with and without [6]-gingerol groups was increased by 133.1% and 26.3%, respectively, compared with that of the control, whereas that of the [6]-gingerol-pretreated group was significantly decreased by 48.5% compared with that of the positive control. Therefore, [6]-gingerol may be a strong candidate in reducing autophagy and LPO production and in enhancing antioxidative enzyme activities to help prevent acute and chronic pancreatitis.

• Tuberculosis and Respiratory Diseases
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• v.48 no.2
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• pp.210-222
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• 2000

Background: Endothelin(ET) is the most potent vasoconstrictor and bronchoconstrictor. The plasma ET-1 level is elevated in patients with acute pulmonary thromboembolism(APTE). This finding suggest that ET-1 may be an important mediator in the cardiopulmonary derangement of APTE. But whether ET-1 is a pathogenic mediator or a simple marker of APTE is not known. The role of ET-1 in the pathogenesis of cardiopulmonary dysfunction in APTE(delete) was investigated through an evaluation of the effects of $ET_A$-receptor antagonist on APTE. The increase in local levels of preproET-1 mRNA and ET-1 peptide in the embolized lung was also demonstrated. Methods: In a canine autologous blood clot pulmonary embolism model, $ET_A$-receptor antagonist(10 mg/kg intravenously, n=6) was administered one hour after the onset of the embolism. Hemodynamic measurements, blood gas tensions and plasma levels of ET-1 immunoreactivity in this treatment group were compared with those in the control group(n=5). After the experiment., preproET-1 mRNA expression(using Northern blot analysis) and the distribution of ET-1(by immunohistochemical analysis) in the lung tissues were examined. Results: The increases in pulmonary arterial pressure and pulmonary vascular resistance of the treatment group were less than those of the control group. Decrease in cardiac output was also less in the treatment group. Complications such as systemic arterial hypotension and hypoxemia did not occur with the administration of $ET_A$-receptor antagonist The plasma level of ET-1 like(ED: what does 'like' mean?) immunoreactivity was increased after embolization in both groups but was significantly higher in the treatment group. The preproET-1 mRNA and ET-1 peptide expressions were increased in the embolized lung. Conclusion: ET-1 synthesis increases with embolization in the lung and may plays play an important role in the pathophysiology of cardiopulmonary derangement of APTE. Furthermore, $ET_A$-receptor antagonist attenuates cardiopulmonary alterations seen in APTE, suggesting a potential benefit of this therapy.

• The Korean Journal of Nuclear Medicine
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• v.30 no.1
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• pp.77-85
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• 1996

Radioiodine($^{131}I$) has been used for the treatment of Graves' hyperthyroidism since the late 1940's and is now generally regarded as the treatment of choice for Graves' hyperthyroidism who does not remit following a course of antithyroid drugs. But for the dose given, several different protocols have been described by different centers, each attempting to reduce the incidence of long-term hypothyroidism while maintaining an acceptable rate control of Graves' hyperthyroidism. Our goals were to evaluate effective half-life and predict absorbed dose in Graves' hyperthyroidism patients, therefore, to calculate and readminister radioiodine activity needed to achieve aimed radiation dose. Our data showed that the mean effective $^{131}I$ half-life for Graves' disease is 5.3 days(S.D=0.88) and mean biologic half-life is 21 days, range 9.5-67.2 days. The mean admininistered activity and the mean values of absorbed doses were 532 MBq(S.D.=254), 112 Gy (S.D.=50.9), respectively. The mean activity needed to achieve aimed radiation dose were 51MBq and marked differences of $^{131}I$ thyroidal uptake between tracer and therapy ocurred in our study. We are sure that the dose calculation method that uses 5 days thyroidal $^{131}I$ uptake measurements after tracer and therapy dose, provides sufficient data about the effective half-life and absorbed dose of $^{131}I$ in the thyroid and predict the effectiveness of $^{131}I$ treatment in Graves' hyperthyroidism.

• The Korean Journal of Nuclear Medicine
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• v.31 no.1
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• pp.9-18
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• 1997

The therapeutic efficacy of antipsychotic drugs is generally attributed to their ability to block dopamine $D_2$ receptors. Classical $D_2$ antagonists are not effective to treat negative symptoms and produce extrapyramidal side effects On the other hand, atypical antipsychotic agents ameliorate negative symptoms without producing extra-pyramidal side effects, and it is reported to be associated with blockade of serotonin $5-HT_2$ receptors. The purpose of this study was to evaluate the effect of risperidone on neuroreceptors in the rat brain by Quantitative autoradiography method. In acute treatment group, risperidone was injected into Peritoneal cavity of male Wistar rats with dose of 0, 0.1, 0.25, 0.5, 1.0 and 2.0mg/kg in each group(5/group), and they were decapitated after 2 hours. In chronic treatment group, risperidone was injected with dose of 0, 0.1, and 1mg/kg(I.P.) for 21 days and decapitated after 24 hours following last treatment. The effect of risperodone on the binding of [$^3H$]spiperone to $5-HT_2$ and $D_2$ receptors were analysed in 4 discrete regions of the striatum, nucleus accumbens, and frontal cortex by quantitative autoradiography Acute treatment with risperidone reduced cortical $5-HT_2$ specific [$^3H$]spiperone binding to 32% of vehicle-treated control. Subcortical $5-HT_2$ specific [$^3H$]spiperone binding was not affected at all dose groups whereas a significant reduction (57%) in $D_2$ specific [$^3H$]spiperone binding was observed in risperidone treated group at doses of 1-2mg/kg. Chronic treatment with risperidone produced a decrease in the maximal number of cortical $5-HT_2$ receptors to 51% and 46% of control in 0.1mg/kg & 1mg/kg treated group respectively. In conclusion, risperidone is a cortical serotonin receptor antagonist with relatively weak antagonistic action on dopamine receptors. These effects oil neuroreceptors may explain the therapeutic effect of risperidone as a atypical antipsychotic agents.

• Proceedings of the Korean DIstribution Association Conference
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• 2001.11b
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• pp.125-141
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• 2001

In this paper, the current problems of logistics industry in Korea and their possible solutions were discussed. With Korea Telecoms KT-Logis, the supplier and demander of logistics service would not have to invest large sum of money into their computer system. All they need is just a computer with internet connected. What KT-Logis influence on the logistics industry are the following; 1. Many logistics service supplier and demander can do the business on the web with one computer system. 2. This web based computer system does not only work on the office but also apply on the field worker such as delivery personnel or even the forwarder with mobile phone. 3. KT-Logis is an integrated system which cover the broad arrange of logistics management from truck management to customer relations management. 4. Finally, KT-Logis is web based systems which suits for current e-business and mobile environment. In future, more studies should be done to develop more progressive integrated logistics information systems with enterprise resource planning(ERP) and supply chain management(SCM).

• The Journal of the Korea Contents Association
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• v.13 no.12
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• pp.860-868
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• 2013

The purpose of this study is to ensure safety by measuring External radiation dose ratio (ERDR) by traits of patients in many ways after administering radiopharmaceutical($^{18}F$-FDG) for PET Torso scan, and to decrease ERDR of those to RI technologist, caretakers, and those who frequently exposed to radiation by arousing attention to radiation dose. Radiopharmaceutical was administered to 80 patients who conducted PET Torso from January to June, 2013. Radiation dose emitted from the patients was measured according to body shape(BMI), water hydration, height, amount of radiation administration. From the moment immediately after the radiopharmaceutical was administered, ERDR was measured by personal traits of patients. The radiation dose increased in proportion to the administered amount of the radiopharmaceutical, and there was no significant difference depending on the body shape of the patients. When water was supplied and the height was normal, the radiation dose was lower compared with the cases where water was not supplied and height was not normal. There is a need for making efforts to minimize the working time through sufficient education and mock training before those who RI technologist with sources of radiation for complying the radiation safety management rule. And they should minimize the ERDR by wearing a protective gear.

• Journal of Veterinary Clinics
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• v.30 no.3
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• pp.159-165
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• 2013

The present study was conducted to evaluate the efficacy of Cinnamomum cassia Blume (CC) extract on the repair of damaged cartilage in a rat model of osteoarthritis (OA) by anterior cruciate ligament transection (ACLT) and medial meniscus resection (MMx). Forty-eight rats were assigned to six groups (n = 8 per group): sham as negative control (NC), positive control (PC), diclofenac sodium (DS, 2 mg/kg), CC 25 mg/kg, CC 50 mg/kg and CC 100 mg/kg groups. Treatments were 12 weeks from 7 days after ACLT + MMx. Loss of cartilage and joint instability were significantly reduced in response to treatment with CC or DS compared to the PC (p < 0.05). CC significantly ameliorated cartilage degradation in a dose-dependent manner as assessed by histological findings (p < 0.01). A reduction in the severity of structural changes and a dose-dependent increase in Safranin-O staining intensity were observed in CC treatments, indicating that cartilage degradation was inhibited. Although DS did not affect the increase in active caspase-3 and cleaved poly(ADP-ribose) polymerase-induced apoptosis during the progression of OA, cells reactive to these apoptotic markers were decreased significantly by CC (p < 0.05). However, treatments with CC or DS did not influence the uptake of 5-bromo-2'-deoxyuridine. The findings suggest that CC can exert a chondroprotective action on OA through anti-inflammatory and anti-apoptotic properties.

• Proceedings of the Korean Information Science Society Conference
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• 2007.10b
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• pp.247-252
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• 2007

오늘날 컴퓨팅 환경은 점차 복잡해지고 있으며, 복잡한 환경을 관리하는 이 점차 중요해 지고 있다. 이러한 관리를 위해 어플리케이션의 내부 구조를 드러내지 않은 상태에서 환경에 적응하는 자가치유에 관한 연구가 중요한 이슈가 되고 있다. 우리의 이전 연구에서는 자가 적응 모듈의 성능 향상을 위해 스위치를 사용하여 컴포넌트의 동작 유무를 결정하였다. 그러나 바이러스와 같은 외부 상황에 의해 자가 적응 모듈이 정상적으로 동작하지 않을 수 있으며 다수의 파일을 전송할 때 스위치가 꺼진 컴포넌트들은 메모리와 같은 리소스를 낭비한다. 본 연구에서는 이전 연구인 성능 개선 자가 적응 모듈에서 발생할 수 있는 문제점을 해결하기 위한 방법을 제안한다. 1) 컴포넌트의 동작 여부를 결정하는 스위치를 확인하여 비정상 상태인 컴포넌트를 찾아 치유를 하고, 2) 현재 단계에서 사용하지 않는 컴포넌트를 다른 작업에서 재사용한다. 이러한 제안 방법론을 통해 파일 전송이 않은 상황에서도 전체 컴포넌트의 수를 줄일 수 있으며 자가 적응 제어 모듈을 안정적으로 작동할 수 있도록 한다. 본 논문에서는 명가를 위하여 비디오 회의 시스템 내의 파일 전송 모듈에 제안 방법론을 적용하여 이전 연구의 모듈과 제안 방법론을 적용한 모듈이 미리 정한 상황들에서 정상적으로 적응할 수 있는지를 비교한다. 또한 파일 전송이 많은 상황에서 제안 방법론을 적용하였을 때 이전 연구 방법론과의 컴포넌트 수를 비교한다. 이를 통해 이전 연구의 자가 적응 모듈의 비정상 상태를 찾아낼 수 있었고, 둘 이상의 파일 전송이 이루어 질 때 컴포넌트의 재사용을 통해 리소스의 사용을 줄일 수 있었다.위해 잡음과 그림자 영역을 제거한다. 잡음과 그림자 영역을 제거하면 구멍이 발생하거나 실루엣이 손상되는 문제가 발생한다. 손상된 정보는 근접한 픽셀이 유사하지 않을 때 낮은 비용을 할당하는 에너지 함수의 스무드(smooth) 항에 의해 에지 정보를 기반으로 채워진다. 결론적으로 제안된 방법은 스무드 항과 대략적으로 설정된 데이터 항으로 구성된 에너지 함수를 그래프 컷으로 전역적으로 최소화함으로써 더욱 정확하게 목적이 되는 영역을 추출할 수 있다.능적으로 우수한 기호성, 즉석에서 먹을 수 있는 간편성, 장기저장에 의한 식품 산패, 오염 및 변패 미생물의 생육 등이 발생하지 않는 우수한 생선가공, 저장방법, 저가 생선류의 부가가치 상승 등 여러 유익한 결과를 얻을 수 있는 효과적인 가공방법을 증명하였다.의 평균섭취량에도 미치지 못하는 매우 저조한 영양상태를 보여 경제력, 육체적 활동 및 건강상태 등이 매우 열악한 이들 집단에 대한 질 좋은 영양서비스의 제공이 국가적 차원에서 시급히 재고되어야 할 것이다. 연구대상자 특히 배달급식 대상자의 경우 모집의 어려움으로 인해 적은 수의 연구대상자의 결과를 보고한 것은 본 연구의 제한점이라 할 수 있다 따라서 본 연구결과를 바탕으로 좀 더 많은 대상자를 대상으로 한 조사 연구가 계속 이루어져 가정배달급식 프로그램의 개선을 위한 유용한 자료로 축적되어야 할 것이다.상범주로 회복함을 알수 있었고 실험결과 항암제 투여후 3 일째 피판 형성한 군에서 피판치유가 늦어진 것으로 관찰되어 인체에서 항암 투여후 수술시기는 인체면역계가 회복하는 시기를 3주이상 경과후 적어도 4주째 수술시기를 정하는 것이 유리하리라 생각되