• Journal of Biomedical Engineering Research
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• v.20 no.5
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• pp.559-566
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• 1999

환자의 기능평가를 위하여 중요한 자세균형의 유지는 압력중심(COP) 의 동요 신호를 직접 연속적으로 계측함으로써 가능하다. COP 신호로부터 다양한 종류의 자세안정도지표를 산출할 수 있으나 임상적으로 유용한 최소한의 지표종류로는 규명된 바 없다. 이에 본 연구에서는 인체가 서있는 상태의 정적자세를 유지할 때 압력중심 신호로부터 자세안정도지표를 산출하여 분석함으로써 임상적 유용성이 가장 큰 지표의 종류를 결정하고자 하였다. 양발을 편안히 벌리거나 (FS), 모두 모으거나(FT), 한쪽발 만으로(RL, LL)서있는 자세에 대해서 양쪽 눈을 뜨거나(EO) 감은(EC)8가지 정적자세를 취하며 30초간 자세균형을 유지시켰다. 자세형태에 따른 안정도의 척도로서 신체가 지면을 차지하는 면적(S)을 사용하였다. 자세안정도지표로서 1)position deviation, 2) position turn 3) velocity의 3가지로 분류할 수 있는 18가지 지표를 설정하였다. 피검자는 20, 30, 40 ,50 대 정상인을 연령대 별로 각각 남·녀 5명씩 고르게 총 40명을 선정하여 실험하였다. 자세안정도지표 모두가 S와 비교적 높은 유의한 상관관계를 보인 바 인을 연령대 별로 각각 남·녀 5명씩 고르게 총 40명을 선정하여 실험하였다. 자세안정도지표 모두가 S와 비교적 높은 유의한 상관관계를 보인바 (상관계수=0.6∼0.8, P<0.0001), S가 자세형태를 정량화 할 수 있음을 입증하였다. 모든 지표들에 있어서 시각의 영향이 뚜렷하였으며 특히 자세가 불안해질수록 상대적으로 시각의 영향이 두드러졌다. 그러나 시각의 영향의 지표들간의 차이는 없었다. 반면 노화(연령증가)에 따른 안정도지표의 변화는 미미하였으며 위의 3가지 안정도지표분류 중 position deviation 지표만이 통계적으로 유의한(P<0.05) 상관관계를 보였다. 따라서 정적자세유지시 안정도지표로는 position deviation 지표들이 가장 예민함을 알 수 있었다. 그러나 position deviation 지표들과 연령과의 상관계수는 0.5이하로서 매우 느슨한 상관관계를 보였으며, 연령증가에 따른 자제불안정도의 증가도 매우 작아서 그 임상적 응용가능성은 의문시되었다. 또한 위에서 제시한 3가지의 분류의 지표중 position turn 과 velocity 지표의 의미에 관해서는 향후 심층적인 연구가 필요한 것으로 판단되었다.

• Journal of Dental Rehabilitation and Applied Science
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• v.28 no.1
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• pp.37-46
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• 2012

The ultimate goal of periodontal therapy is the regeneration of supporting tissues. It is recommended to avoid probing until 6~9 months following the regenerative therapy because the probing may jeopardize the newly formed tissues. We can measure tooth mobility objectively using Periotest. The purpose of this study is to investigate whether Periotest can be used to evaluate the treatment results alternatively, and whether there are the correlations between the changes of Periotest value (PTV) and other clinical parameters. Regenerative treatments have been performed on 29 teeth of twenty five patients, at Department of Periodontology, Pusan National University Hospital. We measured the tooth mobility by Periotest and other parameters at the baseline, 6 and 12 months after regenerative treatment. Compared to the baseline, there were the statistically significant improvements in all the parameters at 6 months and 12 months. There were statistically significant correlations among the probing depth, attachment level, gingival recession and PTV at baseline, 6 months, and 12 months. Also there was the correlation between changes in PTV and in the attachment level at each time of observation period. We may conclude that regenerative therapy would improve the clinical parameters and periodontal status and PTV would be an alternative index to evaluate the healing process after regenerative surgery.

• Journal of Hospice and Palliative Care
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• v.14 no.2
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• pp.101-109
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• 2011

Purpose: The Assessing Care Of Vulnerable Elders project has developed indicators for the quality of the end-of-life (EOL) care. However, family members of cancer patients may have a different view on the quality indicators (QIs) established by health care experts. We evaluated the QIs from the family members' perspective. Methods: The information used in this study was gathered by surveying family members of cancer patients who were admitted to the inpatient hospice ward in Korea. A cross-sectional anonymous questionnaire was distributed to 120 potential respondents from July to October 2009. We included 69 responses in this study (effective response rate, 57.5%). Statistical analysis was performed by using SPSS for Win ver. 14.0, with independent t-test and Pearson's chi-square test. Results: Among QIs for good hospice care, families agreed the most on "Medical examination by the palliative care team or specialist" (88.4%) and "Dying in the family's presence" (88.4%). They agreed the least on "Discussing cardiopulmonary resuscitation with patients" (15.9%). Among QIs for bad hospice care, "Occurrence of fall or pressure ulcer are undesirable" showed the highest agreement rate (94.2%). The lowest agreement rate was 11.6% on "Dying in the hospital is undesirable." In addition, women, patients who were aware of their prognoses, and people with a high socioeconomic status tended to agree more on the QIs. Conclusion: Patients' families did not agree on some of the QIs recommended by previous studies. Family members' characteristics were related to their opinions on QIs.

• The Journal of the Korea Contents Association
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• v.11 no.1
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• pp.350-356
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• 2011

The purpose of this study is to empirically examine how much the electronic clinical trial data management system actually enhances its efficiency. While the development of clinical trial markets highlights the significance of data management with increasing rate of adoption of electronic systems, its effects have not been fully supported with rigorous evidences. Particularly, the adoption rate of electronic clinical trial systems is low in domestic clinical trials markets. This study attempts to analyze the effect of the systems for reminding the importance of e-data management in clinical trials. The measurement indicator is experimented with the time related data collected from a multi-center clinical trial case. The result showed that the speed of the electronic clinical trial processes can be improved. The implication of this study lies in its first attempt to empirically analyze the effect of electronic clinical data management systems. Furthermore, application of the indicator in conjunction with electronic clinical trial processes is expected to facilitate strategic data management.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 2009.05a
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• pp.15-15
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• 2009

• Korean Journal of Psychosomatic Medicine
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• v.28 no.1
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• pp.81-88
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• 2020

Objectives : This study aimed to compare autonomic nervous system (ANS) dysregulation and differential relationships with clinical severities between anxiety disorder, depressive disorder, and trauma·stressor related disorder using heart rate variability (HRV) parameters. Methods : We conducted a retrospective chart review of outpatients from 2017 to 2018 in Stress Clinic of National Center for Mental Health. Total 473 patients were included; 166 anxiety disorder; 184 depressive disorder ; 123 trauma·stressor related disorder. Parameters of 5-min analysis of HRV were compared in three groups. Additionally, we investigated the differential association of each parameters with Clinical Global Impression-Severity Scale (CGI-S) across each group. Results : No significant differences were found in all HRV parameters between the three groups. However, significant group interactions by CGI-S were found in standard deviation of all RR intervals (SDNN) and the square root of the mean squared differences of successive normal-to-normal intervals (RMSSD) (SDNN, p=0.017 ; RMSSD, p=0.034). A negative relationship between CGI-S and SDNN, RMSSD has been found in anxiety disorder and depressive disorder. However, a positive relationship between CGI-S and SDNN, RMSSD has been found in trauma·stressor related disorder. Conclusions : Despite of no significant differences of each HRV parameter, our findings suggested the differential associations of HRV parameters with clinical severity among anxiety disorder, depressive disorder and trauma·stressor related disorder. In trauma·stressor related disorder, the clinical severity and degree of ANS dysregulation may differ, so more aggressive treatment is suggested.

• Korean Journal of Clinical Laboratory Science
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• v.51 no.2
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• pp.185-190
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• 2019

Compression stockings are widely used for prevention of varicose vein. Depending on manufacture, there are diverse types of compression stockings available. Most common type of compression stocking might be the one cover calf of a lower leg which has 20~30 mmHg pressure. Despite being widely used, possible side effects that may occur by wearing compression stockings have not been studied much. We analyzed for a long wearing effect of compression stocking. Participants wore the compression stocking over one leg for 7 days. During the period, all the participants did their ordinary works wearing the compression stocking. Electrocardiogram (ECG), ankle-brachial index (ABI), blood pressure (BP), and electromyogram (EMG) were measured at 0 day, 3rd day and 7th day. There was no effect of wearing compression stockings from ECG, ABI or BP. Only EMG that was measured on the covered muscle increased proportionally to the wearing time. Interestingly, EMG from the opposite leg that had never been covered by compression stocking decreased in proportion to the wearing date. These results suggest wearing a compression stocking for varicose vein may cause unintentional increase or decrease of EMG from the wearing or non-wearing legs, respectively.

• Proceeding of EDISON Challenge
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• 2017.03a
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• pp.628-630
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• 2017

관상동맥의 협착 병변의 위험성을 치료 및 예방하기 위하여 FFR(Fractional flow reserve)이라는 지표를 사용한다. 기존의 임상에서 FFR을 측정하기 위하여 침습적인 방법을 이용하여 진행하였다. 이러한 침습적 방법은 부작용의 위험성을 가지고 있기 때문에 컴퓨터 시뮬레이션을 통해 계산하면 위험성을 해소할 수 있다. 하지만 현재 컴퓨터 시뮬레이션은 CT image를 이용하기 때문에 칼슘을 정확히 구별하거나 지질의 위치 등을 확인하는 것이 어렵기 때문에 FFR 결과에 오류를 발생시킬 수도 있고, 또한 전체 관상동맥을 해석하기 때문에 많은 계산량이 필요하다. 본 연구에서는 최근 높은 해상도를 가진 OCT(Optical Coherence Tomography)를 이용하여 이러한 한계점을 극복하고자 하고, 임상에서 측정한 FFR과 OCT에서 측정된 FFR은 비교하는 것이 목적이다.

• 한국임상약학회:학술대회논문집
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• 2007.12a
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• pp.179-179
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• 2007

• KCID journal
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• v.9 no.1
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• pp.123-127
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• 2002