• Proceedings of the Korean Society for Cognitive Science Conference
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• 2005.05a
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• pp.212-215
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• 2005

연령의 증가에 따른 신경원의 활성화도 변화는 기억 및 집행기능 등의 인지기능에 영향을 미치는 것으로 알려져 왔다. 그러나 어떠한 뇌 영역의 기능적 저하가 연령증가에 따라 남자와 여자에서 차별적으로 인지기능의 변화를 가져오는지에 대해서는 거의 알려진 바가 없다. F-18 FDG PET을 이용하여 78명의 정상 성인 남녀를 대상으로 뇌 포도당 대사량을 조사하였다. 남녀가 공통적으로 연령증가에 따라 뇌 포도당 대사량의 저하를 보이는 영역은frontal lobe과 left insula, right anterior cingulate gyrus, bilateral caudate body, thalamus. right corpus callosum 이었다. 여성의 경우 남성과 달리 추가적으로 right caudate와 bilaterial thalamus에서 연령과 뇌 포도당대사량 간에 부적 상관을 보이고 있었다(P < 0.001 uncorrected). 남녀 모두에서 연령이 증가하면서 포도당 대사 저하를 보이는 right inferior frontal gyrus는 여자에게서만 포도당대사 감소비율이 유의하게 컸다. 남녀에서 보이는 이러한 노화 과정 동안의 뇌 포도당 대사의 저하율의 차이가 여성과 남성의 연령증가에 따른 인지적 기능의 차별적 저하에 대한 설명을 제시할 수 있을 것이라 생각한다.

• Sleep Medicine and Psychophysiology
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• v.21 no.1
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• pp.5-13
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• 2014

Objectives: Depression, sleep complaints and cognitive impairments are commonly observed in the elderly. Elderly subjects with depressive symptoms have been found to show both poor cognitive performances and sleep disturbances. However, the relationship between sleep complaints and cognitive dysfunction in elderly depression is not clear. The aim of this study is to identify the association between sleep disturbances and cognitive decline in late-life depression. Methods: A total of 282 elderly people who underwent nocturnal polysomnography in a sleep laboratory were enrolled in the study. The Korean version of the Neuropsychological Assessment Battery developed by the Consortium to Establish a Registry for Alzheimer's Disease (CERAD-K) was applied to evaluate cognitive function. Depressive symptoms were assessed with the geriatric depression scale (GDS) and subjective sleep quality was measured using the Pittsburg sleep quality index (PSQI). Results: The control group ($GDS{\leq}9$) when compared with mild ($10{\leq}GDS{\leq}16$) and severe ($17{\leq}GDS$) depression groups, had significantly different scores in the Trail making test part B (TMT-B), Benton visual retention test part A (BVRT-A), and Stroop color and word test (SCWT)(all tests p<0.05). The PSQI score, REM sleep duration, apnea-hypopnea index and oxygen desaturation index were significantly different across the three groups (all indices, p<0.05). A stepwise multiple regression model showed that educational level, age and GDS score were predictive for both TMT-B time (adjusted $R^2$=35.6%, p<0.001) and BVRT-A score (adjusted $R^2$=28.3%, p<0.001). SCWT score was predicted by educational level, age, apnea-hypopnea index (AHI) and GDS score (adjusted $R^2$=20.6%, p<0.001). Poor sleep quality and sleep structure alterations observed in depression did not have any significant effects on cognitive deterioration. Conclusion: Older adults with depressive symptoms showed mild sleep alterations and poor cognitive performances. However, we found no association between sleep disturbances (except sleep apnea) and cognitive difficulties in elderly subjects with depressive symptoms. It is possible that the impact of sleep disruptions on cognitive abilities was hindered by the confounding effect of age, education and depressive symptoms.

• The Journal of the Korea Contents Association
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• v.22 no.3
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• pp.529-537
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• 2022

The purpose of this study was to analyze the relationship between social participation activities, cognitive function, and depression of middle and old single-person households in consideration of social problems such as aging population and increasing single-person households. For the analysis, path analysis and multi-group analysis were conducted. As a result of the analysis, it was found that social participation activities of middle and old single-person households reduced depression through increased cognitive function, and the positive effects of social participation activities were stronger in groups of dementia. Based on these results, we discussed ways to promote social participation activities, implications for developing programs that can help cognitive function or mental health, and suggested the need for programs or treatment methods to promote social participation rather than isolated treatment in nursing facilities.

• Journal of the Korean Society of Radiology
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• v.85 no.1
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• pp.184-196
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• 2024

Purpose We investigated potentially promising imaging findings and their combinations in the evaluation of cognitive decline. Materials and Methods This retrospective study included 138 patients with subjective cognitive impairments, who underwent brain MRI. We classified the same group of patients into Alzheimer's disease (AD) and non-AD groups, based on the neuropsychiatric evaluation. We analyzed imaging findings, including white matter hyperintensity (WMH) and cerebral microbleeds (CMBs), using the Kruskal-Wallis test for group comparison, and receiver operating characteristic (ROC) curve analysis for assessing the diagnostic performance of imaging findings. Results CMBs in the lobar or deep locations demonstrated higher prevalence in the patients with AD compared to those in the non-AD group. The presence of lobar CMBs combined with periventricular WMH (area under the ROC curve [AUC] = 0.702 [95% confidence interval: 0.599-0.806], p < 0.001) showed the highest performance in differentiation of AD from non-AD group. Conclusion Combinations of imaging findings can serve as useful additive diagnostic tools in the assessment of cognitive decline.

• Proceedings of the Korea Information Processing Society Conference
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• 2019.10a
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• pp.1157-1159
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• 2019

치매환자는 인지기능 중 기억력이 가장 먼저 저하된 후 동시다발적으로 인지기능 저하를 보인다. 인지기능의 재활을 위해 다양한 방법들이 연구되고 있으며 콘텐츠도 개발되고 있다. 치매환자의 인지기능은 지속적인 재활이 중요하며 누구든 쉽게 접근할 할 수 있어야 한다. 본 논문에서는 이러한 문제해결을 제안하기 위해 스마트블록을 활용한 치매환자의 인지재활 콘텐츠를 개발하였다.

• The Journal of Korean society of community based occupational therapy
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• v.9 no.2
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• pp.13-22
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• 2019

Objective : The purpose of this technical research is to determine decline of episodic memory by normal aging focucing on object, spatial location, and temporal order memory. Methods : We allocated seventy-seven of healthy adults from twenty to eighty years old, and performed computer-based cognitive tasks which were consisted of the object, spatial location, and temporal order memory. We used OpenSesame(OpenSesame Inc, OR), put ten pictures people normally see in their daily life, and evaluated those aspects through asking the objects types, object spatial locations, and picture temporal orders from 10 sheets of the picture. Results : Object and spatial location memory were not affected by normal aging whereas, temporal order memory significantly decreased with normal aging. Specifically, temporal order memory for in their age of forty was significantly decreased compared with their age of twenty and object memory at their age of eighty was relatively high compared to spatial location and temporal order memory. We found out that temporal order memory worse fastest and object memory lasted longest. Conclusion : In this study, we confirmed characteristics of declines of episodic memory consisting of object, spatial location, and temporal order memory. Notably, we could specifically identify declines of spatial location and temporal order memory with normal aging previous studies investigated on a limited basis using conventional neuropsychological assessments. These findings would be helpful to screen impairment in episodic memory by normal aging and provide an evidence that cognitive intervention for healthy older adults needs to include spatial and temporal aspect of memory.

• Proceedings of the Korea Contents Association Conference
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• 2019.05a
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• pp.71-72
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• 2019

의학 기술의 발달로 인해 현 사회의 노령 인구가 급증하는 가운데 노화로 인한 노인들의 신체능력 및 인지능력의 저하가 전 세계의 사회적 문제로 자리 잡았다. 인지능력의 저하는 치매로까지 연결될 수 있어 초기에 관리를 하는 것이 매우 중요하며, 인지능력 향상을 목적으로 다양한 콘텐츠가 제작되고 있다. 최근 다양한 분야에서 콘텐츠들이 디지털화를 통해 효용을 높이고 있으나 노인을 위한 콘텐츠는 사용자의 특성상 디지털 콘텐츠로의 전환 및 활성화가 쉽지 않아 아날로그 콘텐츠가 현재까지도 일상 및 병원 치료활동에 주로 활용되고 있는 실정이다. 이에 현재 사용 중인 아날로그 콘텐츠의 사례분석을 통해 노인 콘텐츠의 특성을 파악하고 한계점을 도출해 노인 인지능력 향상을 위한 콘텐츠가 제공해야 하는 특성과 발전해나가야 할 방향성을 제시하고자 하였다. 본 연구는 노인 경도인지장애 개선을 위한 서비스디자인 가이드라인 개발을 위한 선행연구로 수행되었다.

• Journal of Digital Convergence
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• v.12 no.2
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• pp.587-594
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• 2014

This study was carried out to look into the cognitive function of the elderly in community and investigate the factors affecting their cognitive decline provide preliminary data so as to help develop a program to maintain and promote cognitive function. With 481 senior citizens aged over 65 in J. city, a survey was conducted on their demographic characteristics, health-related characteristics and depression using structured questionnaires from September 1 through 7, 2011. The collected data were analyzed by descriptive statistics, Chi-square test and logistic regression analysis using IBM SPSS Statistics V. 20. As a result of this study, 40.1% of the subjects showed cognitive decline and the factors related to their cognitive decline turned out to be the level of education (p<.001), age (p=.000), depression and exercise (p<.05). Therefore, intervention programs on depression or exercise should be implemented intensively and in particular, various programs and educations should be provided considering individual differences according to the level of education and age.

• Korean Journal of Psychosomatic Medicine
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• v.29 no.1
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• pp.17-25
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• 2021

Objectives : This study aimed to investigate quality of life, severity of depression, suicidality, subjective health and subjective stress of depression with subjective cognitive decline in Korean adults. Methods : We used the 7th KNHANES data to enroll 415 participants with a score of 10 or higher on Patient Health Questionnaire-9 (PHQ-9), aged 20-64. Depression was divided into two groups based on the presence/absence of subjective cognitive decline. Demographic and psychological characteristics were compared between two groups. Correlation analysis of subjective cognitive decline, quality of life, depression, suicidal idea was carried out. To detect which variables influenced quality of life, a multiple regression analysis was carried out. Results : Among the 415 participants, 98 had depression with subjective cognitive decline. We identified significant differences in age, marital status, education, employment between the two groups. After adjusting for these variables, depression with subjective cognitive decline had lower EuroQol-5D index scores, more severe depressive symptoms without cognition and worse subjective health than depression without cognitive decline. There was a significant correlation between subjective cognitive decline and quality of life (r=-0.236, p<0.001), suicidal idea (r=0.182, p<0.001), depression score without cognition (r=0.108, p=0.028). Through multiple regression analysis, subjective cognitive decline was predictor of reduced quality of life (β=-0.178, p<0.001). Conclusions : Depression with subjective cognitive decline has poor quality of life and severe depression. Cognitive decline should be considered to improve treatment result in depression.

• Journal of radiological science and technology
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• v.33 no.4
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• pp.313-320
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• 2010

The purpose of this study is to investigate the relationships between job role and exhausting metal status of radiologic technologists. The results showed as follows: First, job demand(role conflict, recognition demend, work demend) of radiologic technologist highly correlated to its exhausting mental status. Second, emotional intelligence moderated the relation between on the relationship between job demand(recognition demend) and burn-out(decline of success). We concluded that radiologic technologist's intervention for burn-out have positive effect on improving organizational performance. Further studies are needed to develop and test the effect of intervention programs for emotional intelligence and burn-out control.