• Title/Summary/Keyword: 인삼 추출물

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RESTORATION OF RADIATION INJURY BY GINSENG EXTRACT II (인삼에 의한 방사선 손상 회복효과)

  • Yonezawa M.;Takeda A.;Katoh N.
    • Proceedings of the Ginseng society Conference
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    • 1984.09a
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    • pp.133-140
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    • 1984
  • 인체가 방사선에 의해 손상을 받게 되면, 실제적으로 치료, 회복시킨 수 있는 물질은 아직 발견되지 않았다. 이에 저자는 720R의 X-선을 조사시킨 mice에 Oura 등의 방법에 따라 부분 정제한 인삼 추출물을 투여하여 X-선 손상으로부터의 회복능을 검정하였다. 주사한 인삼 추출물의 용량에 의존적으로 30일간의 생존율이 증가하였다. Saline을 주사한 대조군과 인삼 추출물을 주사한 실험군 사이의 생존율의 차이는, 동물 한 마리당 1.8mg을 투여한 실험에서 조차 통계학적으로 유의성을 보였다. (P<0.001) 550R의 X-선을 조사시킨 mice에 인삼 추출물을 투여하면 적혈구와 혈소판의 양적 회복이 촉진되었다. 또한 인삼 추출물중 열에 안정한 분획이 비장이 비대하여지는 것과 같은 부작용이 없어 방사선의 손상으로부터 보호 효과가 있음을 알았다. 이 분획은 mice뿐만 아니라, 반치사량의 X-선을 조사한 rat, guinea pig와 같은 실험동물에 있어서도 30일간의 생존율이 더 연장되므로서 현저한 효과를 보였다. 혈액상태 특히 혈소판의 양적 회복은 열에 안정한 이 분획에 의해서도 촉진되었다. 열에 안정한 분획을 투여한 mice에 있어서 X-선 조사에 의한 출혈이 방지되는데, 이를 매일 매일의 변에서 잠재혈액을 측정함으로써 정량적으로 관찰하였다. 결론적으로, 인삼 투여로 방사선에 의한 치사율이 감소되는데 이의 기전은 혈소판 생성을 촉진시키며, X-선에 의한 출혈을 감소시키기 때문이다.

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Antioxidant potential of root extracts of Panax ginseng and Panax notoginseng (인삼(Panax ginseng)과 전칠삼(Panax notoginseng) 뿌리 추출물의 항산화능)

  • In, Man Jin;Kim, Dong Chung
    • Journal of Applied Biological Chemistry
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    • v.64 no.4
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    • pp.407-411
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    • 2021
  • In vitro antioxidant potential of 30% (v/v) ethanolic extracts from Panax ginseng and Panax notoginseng roots was investigated. The polyphenol contents of Panax ginseng and Panax notoginseng extracts were 10.3±0.3 and 10.4±0.4 mg/g-extract, respectively. The extracts of Panax ginseng and Panax notoginseng possessed an antioxidant potential in a concentration-dependent manner. EC50 values of Panax ginseng and Panax notoginseng extracts for cation radical, reducing power, and nitrite were 4.76±0.12 and 6.24±0.14 mg/mL, 1.99±0.01 and 3.13±0.05 mg/mL, and 4.78±0.31 and 3.52±0.10 mg/mL, respectively.

Antioxidant and Antiaging Effect of Ginseng Berry Extract Fermented by Lactic Acid Bacteria (유산균 발효에 의한 인삼열매 추출물의 항산화 및 항노화 효과)

  • Jeon, Ji-Min;Choi, Sung-Kyu;Kim, Yun-Jeong;Jang, Su-Jin;Cheon, Jong-Woo;Lee, Hyun-Sang
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.37 no.1
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    • pp.75-81
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    • 2011
  • The effect of lactic acid bacteria.fermented ginseng berry extract (FGBE) on physiological activities was evaluated. The contents of ginsenosides Re, Rc, and Rb1 in ginseng berry extract (GBE) were increased after fermentation by lactic acid bacteria when analyzed by high performance liquid chromatography. Antioxidant activity of GBE and FGBE was also analyzed by DPPH radical scavenging activity assay and SOD.like activity assay. FGBE showed a 86.34 % inhibition of DPPH radical and a 76.82 % inhibition by SOD.like activity at a concentration of 1.00 %. GBE showed a 49.78 % inhibition of DPPH radical and a 40.80 % inhibition by SOD.like activity at the same concentration. Furthermore, procollagen type I (COL1A1) gene expression increased by 823.13 % and matrix metal-loproteinase(MMP)-1 and tumor necrosis factor (TNF)-${\alpha}$ gene expression decreased by 87.88 % and 99.92 %, respectively, in human fibroblast cultured with FGBE at a concentration of 0.50 %. These results suggest that FGBE could be used as an active ingredient for functional cosmetics.

In Vitro Antioxidant and Anticancer Potential of n-Hexane Extract from Ginseng Marc (인삼박 n-Hexane 추출물의 in vitro 항산화 및 항암 활성)

  • In, Man-Jin;Chae, Hee Jeong;Kim, Dong Chung
    • Journal of Applied Biological Chemistry
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    • v.57 no.3
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    • pp.247-250
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    • 2014
  • A lipid-soluble extract in ginseng marc was prepared by n-hexane extraction to evaluate its antioxidant and anticancer potential. A hexane extract of ginseng marc (HEGM) possessed a 2,2-diphenyl-1-picryl-hydrazyl free radical scavenging activity which was related to the amount of total phenolics. Also, HEGM showed a potent inhibitory activity on human non-small cell lung cancer (A549, $GI_{50}=34.0{\mu}g/mL$) and colon cancer (SNU-C4, $GI_{50}=45.2{\mu}g/mL$) cells proliferation in vitro in a concentration-dependent manner as did the hexane extract of ginseng with $GI_{50}$ values of $20.0{\mu}g/mL$ in A549 and $37.0{\mu}g/mL$ in SNU-C4. These results imply that HEGM can be utilized as an antioxidant and anticancer substance.

Variation of Effective Constituents Contents, Physical Properties and Color Intensities of Extracts from White Ginseng Roots of Different Cultivating Years. (년근별 인삼추출물의 사포닌함량, 물리성 및 색도의 변화)

  • Kim, Dong-Cheol;Chang, Sang-Moon;Choi, Jyung
    • Applied Biological Chemistry
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    • v.38 no.1
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    • pp.67-71
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    • 1995
  • For the quality management of ginseng root extracts and their products, the effective constituents contents, physical properties (pH, turbidity, viscosity, optical density) and color intenties of the extracts from white ginseng roots of different cultivating years. The sugar contents, lightness and yellow intensity of extracts from white ginseng roots increased with increased their cultivating years. The crude ash contents turbidity and optical density of extracts from white ginseng roots decreased with increased their cultivating years. Therefore, the extracts from white ginseng root of 5 or 6 cultivated years showed higher quality than the extracts from ginseng root of 4 cultivated years.

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Studies on the Antioxygenic Substances in Panax ginseng Roots -I. The Antioxidative Action of Various Solvent Extracts of Panax ginseng Roots- (인삼중의 항산화물질에 관한 연구 -제 1 보 : 인삼의 각종 용매 추출물의 항산화작용-)

  • Paik, Tai-Hong;Hong, Jeong-Tai;Hong, Soon-Yoog
    • Korean Journal of Food Science and Technology
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    • v.14 no.2
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    • pp.130-135
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    • 1982
  • The antioxidative action of petroleum ether, chloroform, chloroform-methamol (2 : 1, v/v), methanol and methanol-water extracts of Panax ginseng roots in the autoxidation of mixed methyl esters of unsaturated fatty acids (MEUFA) was investigated in vitro. All of the extracts of Panax ginseng roots possessed antioxidative activity and inhibited the formation of hydroperoxides in the autoxidation of mixed methyl esters of unsaturated fatty acids (MEUEA). The induction period in the autoxidation of MEUFA was extended by the addition of each extract. The antioxidative activity was more prominent with chloroform and chloroform-methanol (2 : 1, v/v) extracts than with other extracts. The antioxidative activity of each extract estimated by Olcott's oven test and the measurement of peroxide value (POV) showed a similar tendency. From the results obtained, it was conclude that extracts of Panax ginseng roots had remarkable antioxidative activity in the autoxidation of MEUFA in vitro.

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Immunological Studies of Ginseng (인삼의 면역학적 연구)

  • Soldati Fabio
    • Proceedings of the Ginseng society Conference
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    • 1988.08a
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    • pp.108-114
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    • 1988
  • One of the major effects of Panax ginseng the best known traditional medicine in the Far East. is the enhancement of host resistance against infections. which could depend on an influence from the immune system. The studies presented have been carried out with extracts from Korean ginseng roots which were examined for immunological activity in vitro and in vivo. The results obtained in a double-blind clinical study with humans confirmed results obtained in vitro with human granulocytes and in vivo with mice. The ginseng extracts showed a significant stimulatory action on the immune response.

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Effect of Fermented Ginseng Extract by Mushroom Mycelia on Antiproliferation of Cancer Cells (버섯균사체로 발효시킨 인삼 추출물의 암세포 증식억제 효과)

  • Kim, Hyun-Young;Joung, Eun-Mi;Hwang, In-Guk;Jeong, Jae-Hyun;Yu, Kwang-Won;Lee, Jun-Soo;Jeong, Heon-Sang
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.39 no.1
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    • pp.36-41
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    • 2010
  • This study was conducted to investigate the effects of fermented ginseng extract by mushroom mycelia on antiproliferation of cancer cells. Phellinus linteus, Ganoderma lucidum, and Hericium erinaceum mycelia were inoculated to ginseng. The effects of fermented ginseng extract on antiproliferation of stomach (MKN-45), colon (HCT116), mammary (MCF-7), lung (NCIH460), prostate (PC-3), and liver (HepG2) cancer cells were investigated by MTT assay. Fermented ginseng extract showed significant antiproliferation effects compared with fresh ginseng extract. Fermented ginseng extract by P. linteus, G. lucidum, and H. erinaceum mycelia showed growth-inhibitory effect of 44.50, 17.75 and 43.98% viability at 1.5 mg/mL on the MKN-45 cell line, 62.86, 3.73, and 54.55% at 1.5 mg/mL on the HCT116 cell line, 41.81, 7.01, and 37.84% at 1.5 mg/mL on the MCF-7 cell line, 53.52, 5.31, and 35.27% at 1.5 mg/mL on the NCIH460 cell line, 35.05, 3.07, and 44.29% at 1.5 mg/mL on the PC-3 cell line, and 59.57, 6.34, and 4.97% at 1.5 mg/mL on the HepG2 cell line, respectively. These results indicated that fermented ginseng by G. lucidum mycelium showed the highest antiproliferation effect against various cancer cells.

일미생물에 의한 인삼에 관한 연구(제1보)-인삼추출물이 미생물 생육에 미치는 영향

  • 이정치;양한철;양한춘
    • Proceedings of the Korean Society for Applied Microbiology Conference
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    • 1975.12a
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    • pp.181.5-182
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    • 1975
  • 인삼의 성분 및 약이학적 연구에 관하여 많은 보고가 있으나 인삼성분이 미생물의 생육에 미치는 영향에 관하여는 거의 보고되어 있지 않다. 본 실험에서는 인삼추출물이 유산균, 효모의 생육에 미치는 영향을 검토한 결과 다음과 같은 결과를 얻었다.(중략)

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Difference between Steaming and Decocting Ginseng (인삼을 찌는 것과 삶는 것의 차이)

  • Park, Seo-Young;Jung, Ill;Kang, Tak-Lim;Park, Man-Ki
    • Journal of Ginseng Research
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    • v.25 no.1
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    • pp.37-40
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    • 2001
  • Two kinds of ginseng extracts were prepared and their brown color and radical scavenging activity were evaluated. The extract prepared by decoction after steaming exhibited deeper brown color and stronger radical scavenging activity than the extract prepared by decoction only. The difference in color and radical scavenging activity was greater in white ginseng than in fresh ginseng. Steaming white ginseng for 3 h was equivalent to 45 h of decoction in its brown color and radical scavenging activity. Consequently, we believe steaming process is better method than decoction to increase the biological activity of ginseng.

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