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http://dx.doi.org/10.3839/jabc.2014.039

In Vitro Antioxidant and Anticancer Potential of n-Hexane Extract from Ginseng Marc  

In, Man-Jin (Department of Human Nutrition and Food Science, Chungwoon University)
Chae, Hee Jeong (Department of Food Science and Technology, Hoseo University)
Kim, Dong Chung (Department of Human Nutrition and Food Science, Chungwoon University)
Publication Information
Journal of Applied Biological Chemistry / v.57, no.3, 2014 , pp. 247-250 More about this Journal
Abstract
A lipid-soluble extract in ginseng marc was prepared by n-hexane extraction to evaluate its antioxidant and anticancer potential. A hexane extract of ginseng marc (HEGM) possessed a 2,2-diphenyl-1-picryl-hydrazyl free radical scavenging activity which was related to the amount of total phenolics. Also, HEGM showed a potent inhibitory activity on human non-small cell lung cancer (A549, $GI_{50}=34.0{\mu}g/mL$) and colon cancer (SNU-C4, $GI_{50}=45.2{\mu}g/mL$) cells proliferation in vitro in a concentration-dependent manner as did the hexane extract of ginseng with $GI_{50}$ values of $20.0{\mu}g/mL$ in A549 and $37.0{\mu}g/mL$ in SNU-C4. These results imply that HEGM can be utilized as an antioxidant and anticancer substance.
Keywords
anticancer activity; antioxidant activity; ginseng marc; lipid-soluble extract;
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Times Cited By KSCI : 6  (Citation Analysis)
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