• 대한본초학회지
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• 제35권5호
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• pp.13-21
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• 2020

Objective : The genus Glycyrrhiza has been used in food and traditional herbal medicine. Many experimental studies reported that Glycyrrhiza species possess several pharmacological properties. Glycyrrhiza new varieties WONGAM and SINWONGAM have been developed by Korea Rural Development Administration doing research for registration on Ministry of Food and Drug Safety. During the evaluations about pharmacological effect of Glycyrrhiza new varieties WONGAM and SINWONGAM, we focused the anti-allergic effect in this study. Methods : We investigated the anti-allergic effect of WONGAM and SINWONGAM compared with Glycyrrhiza uralensis Fischer and G. glabra L. using anti-dinitrophenyl-immunoglobulin E (IgE)/human serum albumin-stimulated RBL-2H3 cells, phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated HMC-1 cells and compound 48/80-induced anaphylaxis mice model. We analyzed the effect on the expression of various cytokines, and IgE from mast cells and the underlying molecular mechanisms of WONGAM and SINWONGAM in presented models. Results : WONGAM and SINWONGAM showed the inhibitory effect on the histamine release from rat peritoneal mast cells or human mast cells without cytotoxicity. WONGAM and SINWONGAM blocked anaphylactic shock and decreased the IgE production. Furthermore, WONGAM and SINWONGAM inhibited the productions of TNF-α and IL-6 in compound 48/80-induced anaphylaxis mice model. Conclusion : These results indicated that WONGAM and SINWONGAM would have protect effect on allergic responses through the inhibition of allergic mediators and pro-inflammatory cytokines. This study may facilitate the development on Glycyrrhiza new varieties for allergy.

• Tuberculosis and Respiratory Diseases
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• 제47권4호
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• pp.538-542
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• 1999

von Recklinghausen 병을 진단 받았거나 임상적으로 의심되는 환자에서 외상력없이 갑자기 시작된 흉통을 주소로 내원하여 흉부 X-선 소견상 흉수 소견이 관찰될 때 동맥파열에 의한 자발성 혈흉의 가능성을 의심할 수 있다. 저자들은 von Recklinghausen 병에 드물게 동반되는 늑간동맥류 파열에 의한 자발성 혈흉 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• 한국지능시스템학회논문지
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• 제26권4호
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• pp.286-294
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• 2016

초기설계 단계에서 시스템의 성능을 고려한 형상의 최적화가 필요하다. 하지만, 일반적으로 공학시스템의 성능예측은 많은 계산 시간이 요구되는 작업이다. 시스템 형상의 최적화를 위해서는 다양한 설계대안에 대한 성능의 평가가 요구되므로 초기 설계과정에서 많은 어려움이 있다. 이러한 문제를 해결하기 위해, 많은 연구자들은 응답표면방법을 이용한 성능예측에 관한 다양한 연구를 시도하고 있다. 하지만, 이 방법은 비선형성이 강한 문제에서 예측오차가 비교적 크게 발생하는 단점이 있다. 따라서 본 연구의 최종목표는 초기설계과정에서 성능예측을 위한 적절한 근사모델을 제시하고, 해양시스템 성능예측문제(부유식 해상발전기 하부구조물 최적화 문제, 유조선의 선저외판 최적화 문제)에 적용하여 제시된 근사모델을 검증하는 것이다.

• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 2014년도 추계학술대회
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• pp.17-18
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• 2014

파력발전기의 유형은 진동수주형, 월파형, 가동물체형으로 나누어진다. 그 중 가동물체형은 파도에너지를 기계적 운동에너지로 전환하여 발전하기 때문에 가동물체의 운동량이 증가해야 발전량이 증가 할 수 있다. 본 논문에서는 가동물체형 파력발전기를 발전시스템이 있는 구조물 본체와 가동부유체로 구성하고 바 형태의 다리로 연결하였다. 다양한 정면파 조건에서 가동부유체와 구조물 본체 간 연결 방식 변화에 따른 운동 특성을 연구하고, 발전축의 모멘트와 각속도를 계산하였다. 이 연구는 가동물체형 파력발전기의 설계시 기초 자료로 사용 될 수 있다.

• 한국전기전자재료학회논문지
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• 제31권7호
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• pp.502-509
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• 2018

Epitaxial ZnO nanowires (NWs) were synthesized on sapphire (001) substrates using a hydrothermal process. The effects of the pH value of the precursor solution on the structural and optical properties of the resulting NWs was studied. The epitaxial relationship and the domain matching configuration between the sapphire (001) substrate and the as-grown ZnO NWs were determined using synchrotron X-ray diffraction measurements. The (002) plane of $w{\ddot{u}}rtzite$ ZnO NW grows in the surface normal direction parallel to the sapphire (001) direction. However, three types of in-plane domain matching configurations were observed, such as the on-position, $30^{\circ}$-rotated position, and ${\pm}8.5^{\circ}$-rotated position relative to the on-position, which might be attributed to inheriting the in-plane domain configuration of the ZnO seed layer.

• 한국응용곤충학회지
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• 제59권3호
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• pp.251-255
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• 2020

2019년 경남 진주시 배나무에서 석류가루이(신칭) Siphoninus phillyreae (Haliday, 1835) 가 발견되었다. 분포조사를 통하여, 부산, 창원, 진주, 광양, 순천, 고흥, 고성에서 발생을 확인하였고, 기주식물로 석류, 배, 모과, 매실, 산사, 비파, 홍가시, 피라칸타, 배롱나무, 꽃사과나무를 확인하였다. 이 해충의 피해 상황과 분류학적 특징을 기재한다.

• 척추신경추나의학회지
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• 제8권2호
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• pp.1-19
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• 2013

Objectives : The purpose of this study is to explore the trends of Chuna(manipulation) treatment on neck pain and cervical disc displacement. Methods : We set up the two searching strategies and investigated the latest clinical trials on Chuna(manipulation) therapy for Neck disorders and cervical disc herniation through PubMed search. The searched papers were analyzed and the year, journals, article types of literatures were examined. Of the articles, Randomized controlled trials(RCTs) are assessed by Jadad scale. Results : Studies on Chuna(manipulation) treatment to cervical disc herniation were very few. Articles on Chuna(manipulation) treatment to neck pain were relatively more than those of cervical disc herniation. The most frequently published journal was J Manipulative Physiol Ther. The main design of study was RCT. The limited quality assessment of RCT was conducted by Jadad scale and the average Jadad score was 1.73, which indicates low quality in terms of Jadad evaluation criteria. Conclusions : International trends of studies on Chuna therapy of cervical disease is increasingly reviewed. Although this review has several limitations, analyzing the latest trends of studies on Chuna(manipulation) treatment on neck pain and cervical disc displacement is necessary for further studies.

• 척추신경추나의학회지
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• 제8권2호
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• pp.131-139
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• 2013

Objectives : The purpose of this study is to investigate the efficacy of conservative treatment on Achondroplasia patient who has low back pain with radiation. Methods : The patient was treated by conservative treatment including acupuncture, pharmaco acupuncture, chu-na manipulation, herbal medicine. Numeric rating scale(NRS), Oswestry disability index(ODI) were used to evaluate pain reduction. Physical examination also used to compare with admission state and discharge state. Results : After 1 month admission treatment, NRS decreased 9 to 6, ODI dcreased 56 to 42, ROM improved as normal person. Conclusions : It was efficient that Achondroplasia patient who has low back pain with radiation treated as conservative treatment including acupuncture, pharmaco acupuncture, chu-na manipulation, herbal medicine. But It was just one case and treatments were carried out in Integrative Package. So further studies are required to compare that which treatment is efficient.

• 해양환경안전학회:학술대회논문집
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• 해양환경안전학회 2007년도 춘계학술발표회
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• pp.109-113
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• 2007

요트에서는 가벼운 선체에 비해 고성능의 엔진을 탑재하게 되므로 엔진에서 발생하는 소음이 승조원 및 여객에 미치는 영향은 매우 크다. 최근에는 국내에서도 크루즈요트의 생산이 시도되고 있지만, 선박의 성능과 함께 기관소음의 차단기술이 구매자의 요구에 부응하지 못하고 있는 실정이다. 이와 같이 선실의 소음이 구매를 결정하는 중요한 척도로 되고 있지만, 메인엔진의 소음을 차단하기 위한 대책 이 부족한 형편이다. 그러나 최근에 발전되고 있는 모니터링설비와 지능제어시스템을 이용하면, 주 엔진의 주변을 고효율의 흡음벽으로 차단하여 기관실의 소음을 개선할 수 있다. 본 연구에서는 소음을 흡수할 수 있는 흡음벽의 성능을 높이기 위해 헬름홀츠 공명기의 원리를 적용에 대하여 연구하였다.

• 약학회지
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• 제58권1호
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• pp.62-70
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• 2014

A 28-day repeated-dose oral toxicity test was performed to determine the no-observed-effect level (NOEL) and establish an optimum dose of the highly toxic Aconiti Ciliare Tuber (ACT) used as a folk remedy. Repeated oral doses of 1,250, 2,500, and 5,000 mg/kg/day of the hot water extract of ACT were administered to five male and five female Sprague-Dawley rats in each group for 4 weeks. The indicators for toxicity included results of examination of common symptoms and changes in weight and feed intake, eye test, urinalysis, hematological and serum biochemical analyses, and post-mortem weight measurement of organs, and visual inspections. All animals survived at the end of the experiment; in addition, we observed no specific test substance-mediated symptoms. We observed no test substance-mediated changes in body weight and feed intake. We observed statistically significant changes in male OB and pH levels (p<0.05). Further, the biochemical test showed statistically significant changes in the IP value of male rats and $CL^-$valueoffemalerats (p<0.05). However, all changes were within historical data. The post-mortem examinations showed no test substance-mediated changes. Moreover, statistically significant changes under the test conditions were confirmed to have been caused by factors other than the test substance. Thus, the maximum NOEL of ACT extract in rats was estimated to be 5,000 mg/kg/day.