• Journal of the Korea Convergence Society
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• v.11 no.3
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• pp.135-143
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• 2020

Parkinson's Disease (PD) is one of the three major old-age onset neurodegenerative diseases, its incidence rate is increasing worldwide as being an aging society. The number of PD patients has increased from 3 million in 1990 to 6.2 million in 2015 and is expected to increase to 12.4 million by 2040. Although many therapeutic candidates have been under development, but not yet been suggested the therapeutics of PD. For analyzing the trends and the status of convergence of technologies in the PD therapeutics, we classified into six sub-categories using global patent information and analyzed the level of technical competitiveness and technology convergence according to year, country, applicant, and technical description. These results can be used as a fundamental understanding for the current technical trend and the status of convergence of PD therapeutics, and establish the direction and strategy of R&D.

• Journal of the Korea Convergence Society
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• v.13 no.1
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• pp.313-323
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• 2022

The purpose of this study was to explore ways a digital therapeutics-based community care plans for the rehabilitation in dysarthria in a situation where non-face-to-face services are expanding in the COVID-19 era. To this end, a qualitative study was conducted on experts working in hospitals, speech-language pathology centers, and social welfare centers, and as a result of the study, 3 topics, 9 sub-themes, and 18 content units were derived. Based on the analysis results, the digital therapeutics-based community care model consisted of 9 types: remote diagnosis, telepractice, rehabilitation training program, peer supporters, clinical support, communication, psychosocial intervention, and care plan services. This study will be able to provide basic data for health care & welfare services using digital therapeutics and guidelines for establishing shared care plans based on multidisciplinary cooperation.

• The Journal of the Convergence on Culture Technology
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• v.9 no.1
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• pp.581-586
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• 2023

Recently a drama that features a lawyer with autism spectrum disorder has attracted a lot of attention, raising interest in the difficulties faced by people with autism spectrum disorders. If the Autism spectrum gets detected early and proper education and treatment, the prognosis can be improved, so the development of the treatment is urgently needed. Drugs currently used to treat autism spectrum often have side effects, so Digital Therapeutics that have no side effects and can be supplied in large quantities are drawing attention. In this paper, we introduce 'AEmotion', an application and a Digital Therapeutic that provides emotion and facial expression learning for toddlers with an autism spectrum disorder. This system is developed as an application for smartphones to increase interest in training autistic children and to test easily. Using machine learning, this system consists of three main stages: an 'emotion learning' step to learn emotions with facial expression cards, an 'emotion identification' step to check if the user understood emotions and facial expressions properly, and an 'expression training' step to make appropriate facial expressions. Through this system, it is expected that it will help autistic toddlers who have difficulties with social interactions by having problems recognizing facial expressions and emotions.

• Journal of the Korea Convergence Society
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• v.10 no.11
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• pp.199-207
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• 2019

This study was a convergence study of pre- and post-treatment clinical outcomes and radiologic results of school aged flexible flat foot using insole inserted indoor sandal. Thirty five subjects were asked to wear insole inserted indoor sandals at least five times a week and at least four hours a day. Before and after the $4^{th}$ and $8^{th}$ week of the treatment, foot radiography and FAOS questionnaire were performed. Statistical analysis was performed using repeated measure ANOVA. The clinical results showed statistically significant improvement in FAOS symptom and pain category. Radiological results showed a tendency of improvement in the Anterioposterior Talo-$1^{st}$ Metatarsal angle, the Lateral Talo-$1^{st}$ Metatarsal angle, and the Talo-Horizontal angle, but no statistical significance was found. In this study, the use of insole inserted indoor sandal during the majority of the indoor life in school aged flexible flat foot patients is effective in alleviating symptoms and pain relief in the short term.

• The Journal of the Korean dental association
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• v.54 no.2
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• pp.142-148
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• 2016

본 연구의 목적은 특이한 C형 치근과 근관을 가지고 있는 상악 제 1대구치의 근관치료 증례를 콘빔단층촬영을 사용하여 진단 및 치료하였음을 보고하는 것이다. 본 증례에서는 특이적인 해부학적 근관 형태가 콘빔단층촬영을 사용하여 확인되었으며 비외과적 근관치료가 시행되었다. 촬영한 영상에서 모든 치근이 C 형태로 융합되어 있으며 독립적인 4개의 근관을 포함하고 있음이 관찰되었다. C형 근관계의 복잡성을 고려할 때 콘빔단층촬영이 적절한 근관계의 확인과 의원성 손상을 예방하기 위해 유용한 보조적 방법인 것으로 보여진다.

• Journal of Dental Rehabilitation and Applied Science
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• v.37 no.4
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• pp.268-273
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• 2021

Paramolar tubercle is a rare developmental dental anomaly defined as an additional cusp occurring on the buccal or lingual surfaces of the molar. Permanent molar fused with paramolar tubercles can be a cause of difficulty in root canal treatment. Therefore, proper understanding of these variations is important in order to ensure successful endodontic treatment. Cone beam computed tomography (CBCT) can be helpful to understand anatomy of complicated cases. This case report describes nonsurgical endodontic treatment of maxillary second premolar fused with paramolar tubercle.

• Journal of Convergence for Information Technology
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• v.10 no.12
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• pp.226-235
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• 2020

This study aimed to identify the integral factors influencing the attitudes of nursing students toward withdrawal of life-sustaining treatments. Methods: 139 nursing students were selected from the school of nursing of a single university. Questionnaires were used as measurement tools to measure their good death recognition, attitude towards death & towards withdrawal of life-sustaining treatment. The degree of good death recognition, attitude towards death & towards withdrawal of life-sustaining treatment were analyzed using descriptive statistics. Correlation between variables was analyzed using Pearson's correlation coefficient and factors influencing the attitude towards withdrawal of life-sustaining treatment using multiple linear regression. Results: Attitude towards withdrawal of life-sustaining treatment was significantly positively correlated with good death recognition(r=.312, p=.000). As a result of multiple linear regression, good death recognition significantly influenced (β=.312, p=.000), accounting for 8.5% of the variance in attitude towards withdrawal of life-sustaining treatment. Conclusions: The results from this study can be contribute to develop educational programs to foster positive attitudes towards withdrawal of life-sustaining treatment.

• Trans-
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• v.12
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• pp.21-49
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• 2022

This study examines the possibility of chronic brain disease rehabilitation treatment using VR/AR technology and raises the research need for the development of digital therapeutics. In addition, by proposing a digital therapeutic research and development process this study intends to contribute to the development of VR/AR rehabilitation treatment. To this end, this study identified research trends of VR/AR technology, neurophysiology, and chronic brain disease and proposed a method for applying VR/AR technology to treat chronic brain disease patients in three stages. The first stage is to prepare a neurophysiological basis for rehabilitation treatment of brain disease patients using VR technology. The second stage is to provide a treatment method using VR/AR technology and systematize the contents characteristics. The third stage is to conduct clinical trails and validate that the treatment method and contents utilization is effective for the patient. It is hope that this study serves as a guide for developing media production base technology for treating patient with a chronic brain disease.

• Journal of the Korea Convergence Society
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• v.13 no.1
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• pp.161-166
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• 2022

HIF-2α is a transcription factor activated mainly in hypoxic condition known to play crucial roles in a wide variety of pathophysiological events including cancer, metabolic syndrome, arthritis etc. In this context, a number of N'-aryl isonicotinolyhydrazides, in which known pharmacophores are included, have been selected from commercial chemical library and tested for the inhibitory activities targeting HIF-2α in cultured HTB94 cell. HRE-luciferase and HIF-2α were introduced into the cell by transfection and adenoviri infection, respectively and the reporter gene assay discovered the potency of 2-hydroxy-1-naphthyl structure. Accordingly, the scaffold has been adjusted based on this structure and subjected to anti-HIF-2α activity test, identifying 2 compounds as HIF-2α inhibitors. The activities were confirmed by false positive test. This study has been performed via the convergence of biology and chemistry and the results may be useful for discovering novel inhibitors and HIF-2α biology studies, and contribute to the development of therapeutic agents.

• Food Science and Industry
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• v.53 no.1
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• pp.2-32
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• 2020

In recent years, significant importance has been given to chitooligosaccharides (COS) due to its potent notable biological applications. COS can be derived from chitosan which is commonly produced by partially hydrolyzed products from crustacean shells. In order to produce COS, there are several approaches including chemical and enzymatic methods which are the two most common choices. In this regard, several new methods were intended to be promoted which use the enzymatic hydrolysis with a lower cost and desired properties. Hence, the dual reactor system has gained more attention than other newly developed technologies. Enzymatic hydrolysis derived COS possesses important biological activities such as anticancer, antioxidant, anti-hypersentive, anti-dementia (Altzheimer's disease), anti-diabeties, anti-allergy, anti-inflammatory, etc. Results strongly suggest that properties of COS can be potential materials for nutraceutical, pharmaceutical, and cosmeceutical product development.