• Journal of Food Hygiene and Safety
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• v.36 no.1
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• pp.77-85
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• 2021

Glucosylceramides (GluCer) are known to play an important role in both water retention and epidermal permeability barrier function in the mammalian stratum corneum. In this study, we investigated the effects of pineapple fruit extract containing glucosylceramides (PFEG) on the maintenance and recovery of skin barrier function using atopic dermatitis-induced animal models. Five-week-old male Hos:HR-1 mice were divided into four groups fed on standard diet, unsaturated fatty acids-deficient (HR-AD) diet, and HR-AD diet supplemented with 0.01% or 0.1% pineapple-GluCer. Skin barrier function was evaluated by transepidermal water loss (TEWL), dermal moisture content, moisture content of the stratum corneum and wrinkle formation. The control group (HR-AD administration group) showed increased transepidermal water loss (TEWL), while the epidermal moisture content and the moisture content of the stratum corneum slowly decreased. However, in the PFEG groups (with 0.1% or 0.01% glucosylceramide), the TEWL levels were significantly reduced at 2 weeks. The PFEG also helped maintain skin moisturizing function by significantly suppressing the decrease of the epidermal moisture content and the moisture content of the stratum corneum. These results show that the PFEG is effective for maintaining and improving the function of the skin barrier. Therefore, this study suggests that PFEG is a potential candidate material for skin functional foods.

• Journal of Korean Tunnelling and Underground Space Association
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• v.21 no.1
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• pp.49-59
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• 2019

In this study, the durability of conical pick cutter was compared and analyzed by pre- and post-test visual inspection, measurement of weight loss and wear volume through field test on two types of conical pick cutters applied to rotary drum cutter. In the visual inspection, it was found that only 9 inserts were lost in the slim type conical pick cutter. This result show that the thickness of the head cover surrounding a insert was important to maintain the insert during excavation. The weight loss and wear volume of the heavy type conical pick cutter were less than half that of the slim type. From these results, it can be confirmed that heavy type is more useful than slim type in hard rock. It should be noted that, when determining the wear loss of the conical pick cutter, the mutual comparison of the weight measurement and the wear volume measurement results may be different due to the unit weight of the material and the spalling caused by excavation.

• Journal of the Korean Applied Science and Technology
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• v.40 no.3
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• pp.453-461
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• 2023

This study was to verify the skin safety of Coptis Japonica extract(CJE) -containing cosmetics by patching them on sensitive skin and checking its stimulating level. 32 subjects diagnosed with sensitive skin by the result of the lactic acid injury test, were subjected to 20 ㎕ of solubilized essence mixed with 2% CJE on the test subjects' back and closed patched for 24 hours. No stimulus reactions were found by bare eyes and scored 0 stimulus figure points after they were taken off in 30 minutes, 24 hours, and 48 hours. Coptis japonica's medical efficacies such as antioxidant, and anti-inflammatory are expectable to be used as functional cosmetics, and this research would be the foundation of further research into its cosmetical usage.

• Korean Journal of Food Science and Technology
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• v.32 no.3
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• pp.531-537
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• 2000

The simple microgel electrophoresis of single cells, a 'comet assay', on fruit seeds enabled the rapid identification of irradiated fruits by comparing the intact non-irradiated cells and the damaged cells of irradiated fruits. Grapes and plums were irradiated with 0.1, 0.5, 0.7, 1.0 kGy and strawberries, peaches, apples, and nectarines were irradiated with only 1.0 kGy. Seeds were isolated, crushed, and the suspended cells were embedded in an agarose layer. After lysis of the cells, they were subjected to microgel electrophoresis for 2 minutes, and then stained. The DNA radiation-induced fragmentation of all the fruits stretched and migrated out of the cells forming a tail toward the anode giving the appearance of a comet, while the undamaged cells appeared as intact nuclei without tails. Grape and plum seeds irradiated at 0.5 kGy and higher showed significant increases in tail length. With increasing the irradiation doses, longer extention of the DNA from the nucleus toward the anode was observed. Strawberry, peach, apple, and nectarine seeds irradiated with 1.0 kGy also showed the longer tails than non-irradiated ones. DNA comet assay as a rapid and inexpensive screening technique could be an officially validated method for the detection of irradiated fruits.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.6 no.1
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• pp.10-16
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• 2003

Purpose: To evaluate the risk of gastrointestinal bleeding associated with use of low-dose aspirin in children. Methods: Among about 250 children who received low-dose aspirin (5 mg/kg/day) under the diagnosis of Kawasaki disease, from March 1995 to May 2001, at Eul-Ji general hospital, 100 children were enrolled in this study. We reviewed the medical records and interviewed the children's parents over the phone to confirm the existence of gross gastrointestinal bleeding. Results: The age of the children at the beginning of medication ranged 4~118 months. About 75% of them was younger than 3 years old. The duration of medication ranged 0.5~17 months. About 70% of the children took the medicine for 2~3 months. Only 1 child (1%) had hematochezia during medication without any accompanying gastrointestinal symptom, and cimetidine for 1 week had cleared up the bleeding. The total duration of medication of 100 children was 341.5 months, and only 1 child had gastrointestinal bleeding. This translates into a rate of clinically significant gastrointestinal bleeding of 3.5 episodes/100 children/year. Conclusion: The long-term use of low-dose aspirin is safe, but, is associated with the risk of gastrointestinal bleeding in children. Careful follow-up and efforts to reduce the risk of gastrointestinal bleeding are necessary during long-term low-dose aspirin therapy in children.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.25 no.1
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• pp.23-36
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• 1999

Medimin A is a derivative of vitamin A which has been developed by coupling retinoic acid with polyethylene glycol(PEG) to enhance skin permeability and stability. We carried out the collagen synthesis and clinical test to examine the reducing effect of wrinkles by Medimin A. In vitro collagen synthesis was evaluated by quantitative assay of ($^3$H)-proline incorporation into collagenase sensitive protein in fibroblast cultures. Clinical test was evaluated by image analysis of skin replica, visual observation and self-estimated response of volunteers for 10 weeks. Medimin A stimulated about 40% in collagen synthesis. The area of main deep wrinkle on the skin replica was reduced 38.4% with topical application of O/W emulsion containing 0.2% Medimin A. The wrinkles on the eye region was also reduced 25.4%-44.1% by the visual observation and 93% of all volunteers responded that topical application of the O/W emulsion was showed some reducing effect of wrinkles after 10 weeks. From these results, we suggest that Medimin A is a potent anti-wrinkle agent by objective evaluation methods(in vitro collagen synthesis and image analysis of skin replica) and subjective evaluation methods(visual observation and self-estimated response of volunteers).

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2012.05a
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• pp.137-138
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• 2012

본 연구에서는 가스터빈 압축기 로터용 제작 관통볼트의 건전성 검사가 수행됐다. 육안검사, 치수, 재질, 경도 및 피닝처리 등을 검사했으며 GE 볼트와 비교해 건전성을 판단하였다. 평가 결과 제작볼트는 기준범위 이하의 피닝강도로 처리되었다. 이에 숏피닝 강도를 향상시켜 다시 제작된 수정볼트를 재검사했고 모든 항목에서 기준범위에 포함됨을 확인했다. 궁극적으로 본 연구에서 수행된 가스터빈 압축기 로터용 관통볼트의 건전성 검사가 유효함을 확인하였다.

• 한국경영정보학회:학술대회논문집
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• 2007.06a
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• pp.1036-1042
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• 2007

현재 우리나라 상수도 시스템의 경우 대부분 각 가정집에 설치된 계량기의 측정값을 검침원이 육안으로 확인, 수기 기입 방법으로 수도 검침이 이루어지고 있다. 이러한 방법은 사생활 침해 및 범죄로 이어질 가능성이 있다. 본 논문에서는 상수도의 검침데이터를 무선주파수 및 코드분할다중접속방식을 사용하여 송수신 가능한 네트워크 망을 구축, 수신된 데이터 값을 활용하여 각 상수도 수용가의 사용량을 자동으로 검침하여 청구 내역서까지 작성해 주는 상수도 자동검침시스템을 소개한다. 상수도 자동검침시스템은 검침을 디지털화하고 이를 무선송신 가능한 검침기와 검침기의 검침데이터 값을 송수신 할 수 있는 중계기 및 집중기, 그리고 CDMA 망을 통한 검침데이터를 수신할 수 있는 애플리케이션 서버 등을 구축하여 지역 내 원격 검침 네트워크 망을 구축하는 것을 포함하고 있다. 본 연구의 시스템은 화재, 가스, 전기 등의 검침데이터를 통합으로 수집하여 데이터를 관리하는 통합 시스템으로 확대가 용이하며 이러한 상수도 자동검침시스템은 누수 및 독거노인 등의 생활보호대상자의 안전을 확인하는 기초 정보로도 활용할 수 있다.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2004.10a
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• pp.752-755
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• 2004

선박용 엔진의 제작에 있어 크랭크 샤프트 조립 시 1 회전의 상태에서 크랭크 스루 간의 디플렉션의 상대값이 정상오차 범위를 넘어서는지 확인한 후 조립상태를 보정하게 된다. 기존의 방법은 다이얼 게이지를 사용하여 측정 담당자가 베드 플레이트 내에 들어가 크랭크 샤프트 회전 시 따라 돌면서 직접 육안 확인을 통해 측정이 이루어졌다. 이 때, 측정의 불편함과 열악한 작업환경 하의 안전 문제가 야기된다. 이러한 문제점을 해결하기 위해 본 연구에서는 블루투스 통신을 이용하여 디지털 게이지를 사용한 측정장치 기구부의 신호를 무선으로 받아서 작업자는 베드 플레이트 외부에서 측정이 가능하도록 하는 시스템의 개발하였다. 이를 통해 작업의 편리성 및 안정성을 확보했으며, 디지털 측정을 통한 측정의 정확도를 향상시켰다.

• Proceedings of the Korean Information Science Society Conference
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• 2007.06c
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• pp.427-431
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• 2007

차세대 지뢰탐지 기술로는 NQR(Nuclear Quadrupole Resonance, 핵4중극자공명), GPR(Ground Penetrating Radar, 지상 침투 레이더)등 이 연구 및 개발 중 이다. 현재 우리나라에서도 이중 GPR을 차세대 지뢰탐지 기술로 연구중에 있다. 그렇지만 지금까지 개발된 GPR 기술을 적용한 지뢰탐지기는 얻어진 2차원 영상에 대해서 육안에 의한 식별만이 가능하여 지뢰 식별이 장시간 소요된다는 단점을 가지고 있다. 이에 본 논문에서는 그러한 문제를 해결하기 위해 주성분 분석법을 적용하여 해결하고, 제안된 시스템이 가능한지 확인하기 위해 유사한 실험 환경을 구성하고, 얻어진 영상을 학습시켜 실제로 얻어진 영상에 대한 분류가 가능한지를 확인하였다.