• Journal of Applied Biological Chemistry
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• v.54 no.1
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• pp.56-62
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• 2011

Molecular docking of polyhydroxy substituted flavone analogues (1-25) as substrate molecules to the active site of tyrosinase (PDB ID: Deoxy-form (2ZMX) & Oxy-form (1WX2)) and Free-Wilson analysis were studied to understand the roles of hydroxyl substituents ($R_1-R_9$) in substrate molecules for the tyrosinase inhibitory activation. It is founded from Free-Wilson analysis that the $R_1$=hydroxyl among $R_1-R_9$ substituents had the strongest influence on the tyrosinase inhibitory activity. H-bonds between the hydroxyl substituents of substrate molecules and amino acid residues in the active site of tyrosinase were contributed to make a stable substrate-receptor complex compound. Particularly, it is proposed from the findings that the noncompetitive inhibitory activation would take place via H-bonding between peroxide oxygen (Per404) atom in the active site of tyrosinase and the hydroxyl substituents in substrate molecule.

• Proceedings of the KIEE Conference
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• 1999.07b
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• pp.794-796
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• 1999

본 논문에서는 3상 유도전동기의 속도를 제어하는데 기존 제어기의 문제점을 해결하고 최적화하기 위해서 유전자 알고리즘을 이용한 하이브리드 퍼지 -PID(HFPID) 제어기를 고안하고, 이에 대한 파라미터 설정 방법을 제안한다. 유도전동기의 제어는 지연시간이 길고, 비선형성이 강하며, 부하변동이 잦은 프로세스이기 때문에, 기존의 제어방식으로는 만족할만한 결과를 얻을 수 없다. 제안한 하이브리드 퍼지-PID 제어기는 PID 제어기의 장점인 과도기의 우수성과 퍼지 제어기의 장점인 정상기의 우수성을 퍼지 변수로 결합시켜 설계한다. 이 제어기에 유전자 알고리즘을 적용하여 최적의 퍼지 및 PID 파라미터를 설정하다. 그리고 이 제어기를 3상 유도전동기의 속도 제어에 응용한다. 또한 속도오차에 대한 룩업 표를 만들어 온라인 실시간 제어를 가능하게 한다. 이상의 과정을 3상 유도전동기에서 컴퓨터 시뮬레이션 하였다. 시뮬레이션 결과를 비교해 볼 때, 하이브리드 퍼지-PID 제어기는 기존의 제어기 보다 전동기의 속도 및 토크성분 전류 둥의 특성에서 우수한 성능을 보였다.

• Applied Biological Chemistry
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• v.51 no.3
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• pp.171-176
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• 2008

The comparative molecular similarity indices analysis (CoMSIA) models between 3${\beta}$-Hydroxy-12-oleanen-28-oic acid (1-30) analogues as substrate molecule and their inhibitory activities ($pI_{50}$) against protein tyrosine phosphatase (PTP)-1B were derived and discussed quantitatively. Listing in order, the CoMFA>CoMSIA${\geq}$HQSAR>2D-QSAR model, these QSAR models had the better statistical values. The optimized CoMSIA F1 model at grid 3.0${\AA}$ had the best predictability and fitness ($q^2$=0.754 and $r^2$=0.976) by field fit alignment. The order of contribution ratio (%) of CoMSIA fields concerning the inhibitory activities was a H-bond acceptor (48.9%), steric field (25.8%) and hydrophobic field (25.4%), respectively. Therefore, the inhibitory activities of substrate molecules against PTP-1B were dependent upon H-bond acceptor field (A) of $R_4$-group. From the analytical results of CoMSIA contour maps, oleanolic acid derivatives will have better inhibition activities if $R_1$ group has H-bond acceptor disfavor, $R_3$group has steric disfavor and $R_4$ group has steric, hydrophobic, H-bond favor.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.45 no.8
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• pp.28-34
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• 2008

A magnetic field detector as a potential MRI receiver is proposed. The proposed device is composed of SRR(split ring resonator) which is a kind of LC resonator first introduced as a negative permeability material and a simple loop antenna. The proposed device showed similar degree of performance to commercial one with a simpler circuit.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.41 no.2
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• pp.33-38
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• 2004

We have demonstrated a tunable Inter based on an asymmetric directional coupler made of a side-polished polarization maintaining fiber coupled with a polymer planar waveguide. The thermo-optic effects of the polymer planar waveguide induced by a micro-strip heater placed on the top layer of the device leads to shift of resonance wavelength of the coupler. The fabricated device exhibited wide tunable range exceeding 230 nm with 720 ㎽ of applied electrical power.

• Korean Journal of Optics and Photonics
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• v.15 no.2
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• pp.109-113
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• 2004

We have manufactured and characterized the fiber-to-Planar Waveguide Coupler for analysis of the photo-induced refractive index change of DM-BTE .(l,2-bis[2,5-dimethylthio-phen-3-yl]-hexafluorocyclopentene) When irradiated with ultraviolet light, the colorless diarylethene(DM-BTE)-crystal turned red while keeping the crystal shape. The red color was bleached by irradiation with visible light(λ＞450 nm). The resonant wavelength was shifted and recovered owing to the refractive index variation of the planar waveguide because of its photo-functional properties on exposure to UV and visible light. The wavelength responses of this switch by UV exposure were measured as 0.057 nm/sec with saturation time of 60 seconds. and when illuminated by visible light, resonance wavelength variations were measured as 0.028 nm/sec, with recovery time of 140 seconds.

• Journal of the Korean Magnetics Society
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• v.23 no.3
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• pp.110-116
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• 2013

This paper proposes a sampling-based sensitivity method for dealing with electromagnetic coupled design problems effectively. The black-box modeling technique is basically applied to obtain an optimum regardless of how strong the electromagnetic, thermal and structural analyses are coupled with each other. To achieve this, Kriging surrogate models are produced in a hyper-cubic local window with the center of a current design point. Then design sensitivity values are extracted from the differentiation of basis functions which consist of the models. The proposed method falls under a hybrid optimization method which takes advantages of the sampling-based and the sensitivity-based methods. Owing to the aforementioned feature, the method can be applied even to electromagnetic problems of which the material properties are strongly coupled with thermal or structural outputs. To examine the accuracy and validity of the proposed method, a strongly nonlinear mathematical example and a coil design problem for local induction heating are tested.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.35 no.4
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• pp.271-276
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• 2009

The 3-dimensional quantitative structure-activity relationships (3D-QSARs) models between the substituents with changing groups ($R_1$ & $R_2$) of 4-($R_1$)-benzyl alcohol and 4-($R_2$)-phenol derivatives as substrate molecule and their inhibitory activities against tyrosinase were derived and discussed quantitatively. The optimized CoMSIA 2 model have best predictability and fitness ($r^2\;=\;0.858$ & $q^2\;=\;0.951$). The contour maps of optimized CoMSIA 2 model showed that, the inhibitory activities of the analogues against tyrosinase were expected to increase when hydrophobic favor, negative charge favor, steric disfavor and hydrogen bond donor disfavor groups were substituted at the $R^2$ position. When the positive charge and the hydrogen bond donor favor groups were substituted at the $R_1$ position, it is predicted that the substituents will be able to increase the inhibitory activity. However, hydrogen bond acceptor did not affect inhibitory activities of tyrosinase.

• Applied Biological Chemistry
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• v.50 no.3
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• pp.187-191
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• 2007

Comparative molecular similarity indice analysis (CoMSIA) models on the fungicidal activities of N-phenyl substituents (X) in N-phenyl-O-phenylthionocarbamate derivatives against rice sheath blight (Rhizoctonia solani: RS) and phytophthora blight (Phytophthora capsici: PC) were derived. Also, the characterizations of H-bonds between substrates and ${\beta}-tubulin$ were discussed quantitatively. It was revealed that, from the contour maps of CoMSIA models, the H-bond acceptor field contributed the most highly to fungicidal activity for two fungi in common. It is predicted that the selectivity in the fungicidal activity between two fungi is caused by results from the roles of H-bond donor disfavor functional groups in RS and H-bond acceptor disfavor functional groups in PC when these two groups induced at meta- and para-position on the N-phenyl ring. And also, if the substituents (X) are steric disfavor group, negative charge favor groups are introduced at the metaposition in RS and H-bond acceptor group is introduced at the para-position in PC, the antifungal activity against two fungi will be likely able to be increased.

• Proceedings of the Korean Radioactive Waste Society Conference
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• 2004.06a
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• pp.236-236
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• 2004

삼중수소수 오염처리의 선행공정으로 적합한 전기분해-촉매교환 결합공정(CECE process)은 수소동위원소 산화물의 수소화 전환을 위한 전해셀과 다단 액상촉매 교환탑으로 이루어진 탈삼중수소 공정이다(그림 1). 촉매탑은 수소 흐름에 수증기를 동반하도록 하는 친수층과 수증기-수소간의 수소동위원소 교환반응을 유도하는 촉매층으로 구분되며, 탑 상부에는 수소의 산화 반응기 그리고 하부에는 물의 수소화 전해셀로 구성되어 있다(그림 2).(중략)