• Title/Summary/Keyword: 영상의학과

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Working Memory Deficits in Patients with Schizophrenia:fMRI Investigation (정신분열병 환자의 작동기억 이상에 대한 기능적 자기공명영상 연구)

  • Park, Yuh-Jin;Kim, Tae-Suk;Roh, Sa-Bong;Pae, Chi-Un;Kim, Jung-Jin;Lee, Soo-Jung;Lee, Chul;Paik, In-Ho;Lee, Chang-Uk
    • Korean Journal of Biological Psychiatry
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    • v.12 no.1
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    • pp.32-41
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    • 2005
  • Objective:Impaired processing of working memory is one of the cognitive deficits seen in patients with schizophrenia. This aimed at corroborating the differences in the brain activities involved in the process of working memory between patients with schizophrenia and the control subjects. Method:Fourteen patients with schizophrenia and 12 healthy volunteers were recruited in this study. Functional magnetic resonance imaging(fMRI) was used to assess cortical activities during the performance of a 2-back visual working memory paradigm using the Korean alphabet as mnemonic content. Results:Group analysis revealed that left lateral prefrontal cortex and right parietal lobule showed decreased cortical activities in the patient group. On the other hand, an increased activation in left superior and middle frontal gyrus, left middle temporal gyrus, right cuneus, both occipital lobes, right fusiform gyrus and right cingulate gyrus. The activation in left anterior lobe and both declive of cerebellum was also increased. Conclusions:This study showed a decreased activation in left lateral prefrontal and right parietal neural networks from the patient group and confirmed the earlier findings on the impaired working memory of patients with schizophrenia using fMRI investigation. The regions implicated in our study suggest an abnormal functioning of the fronto-parietal cortical areas that are critical to the information processing stream, which might be correspondent to common pathophysiology rather than a common etiology in schizophrenia.

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Quantitative Electroencephalographic Findings in Obsessive-Compulsive Disorder (강박 장애의 정량화 뇌파 소견)

  • Youn, Tak;Kwon, Jun Soo;Cho, Maeng-Je;Kim, Yong Sik;Rhi, Bou-Yong
    • Korean Journal of Biological Psychiatry
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    • v.3 no.2
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    • pp.216-221
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    • 1996
  • The quantitative EEGs of obsessive-compulsive disorder patients were analyzed using spectral analysis and compared to age and sex-matched controls. The subjects were 19 patients(men=15, women=4) suffering from obsessive-compulsive disorder(DSM-III-R). Absolute power, relative power and interhemispheric asymmetry of EEG were used to compare obsessive-compulsive disorder patients with controls. In order to fit the EEG data to a normal distribution, a log transformation of power values of every bandwidth in each deviation was calculated prior statistical analysis. The Wilcoxon rank test was performed to compare obsessive-compulsive group to the control group. In obsessive-compulsive disorder, abnormalities of quantitative EEGs are prominent in fronto-central. These results ore compatible with other brain imaging studies of obsessive-compulsive disorder and suggested that fronto-central area plays an important role in the pathophysiology of obsessive-compulsive disorder.

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Analysis for Correlation of Standardized Uptake Value in Fusion Imaging Scanner (융합영상장비의 표준섭취계수 상관관계 분석)

  • Kim, Jin-Eui;Kim, Jung-Soo;Choi, Nam-Gil;Han, Jae-Bok
    • Journal of the Korean Society of Radiology
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    • v.12 no.5
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    • pp.593-601
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    • 2018
  • Recently in nuclear medicine, to improve diagnostic value, SUV, semi-quantitative indicator used in PET-CT, is adopted in SPECT-CT. Therefore, this research analyzed correlation of $SUV_{max}$ of two scanners through phantom test, and evaluated possibility of clinical application. Radiopharmaceuticals ($^{18}F$, $^{99m}Tc$) were injected with the ratios of 8:1 and 4:1, considering background radioactivity, into the phantom manufactured with 6 globes of different sizes, and, based on clinical protocol, positive phases were acquired with PET-CT and SPECT-CT scanners, and interesting areas were divided into ROI and VOI, and $SUV_{max}$ of them were measured, and analyzed. Tests found out no statistically significant difference in $SUV_{max}$ measured with two scanners (P>0.05). Thus, $SUV_{max}$ of PET-CT and SPECT-CT had a certain correlation within significant levels, and were evaluated as the same. Accordingly, it seems that $SUV_{max}$ quantitative analysis using SPECT-CT can provide significant diagnostic information as the case of PET-CT.

The Comparison of Motion Correction Methods in Myocardial Perfusion SPECT (심근관류 SPECT에서 움직임 보정 방법들의 비교)

  • Park, Jang-Won;Nam, Ki-Pyo;Lee, Hoon-Dong;Kim, Sung-Hwan
    • The Korean Journal of Nuclear Medicine Technology
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    • v.18 no.2
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    • pp.28-32
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    • 2014
  • Purpose Patient motion during myocardial perfusion SPECT can produce images that show visual artifacts and perfusion defects. This artifacts and defects remain a significant source of unsatisfactory myocardial perfusion SPECT. Motion correction has been developed as a way to correct and detect the patient motion for reducing artifacts and defects, and each motion correction uses different algorithm. We corrected simulated motion patterns with several motion correction methods and compared those images. Materials and Methods Phantom study was performed. The anthropomorphic torso phantom was made with equal counts from patient's body and simulated defect was added in myocardium phantom for to observe the change in defect. Vertical motion was intentionally generated by moving phantom downward in a returning pattern and in a non-returning pattern throughout the acquisition. In addition, Lateral motion was generated by moving phantom upward in a returning pattern and in a non-returning pattern. The simulated motion patterns were detected and corrected similarly to no-motion pattern image and QPS score, after Motion Detection and Correction Method (MDC), stasis, Hopkins method were applied. Results In phantom study, Changes of perfusion defect were shown in the anterior wall by the simulated phantom motions, and inferior wall's defect was found in some situations. The changes derived from motion were corrected by motion correction methods, but Hopkins and Stasis method showed visual artifact, and this visual artifact did not affect to perfusion score. Conclusion It was confirmed that motion correction method is possible to reduce the motion artifact and artifactual perfusion defect, through the apply on the phantom tests. Motion Detection and Correction Method (MDC) performed better than other method with polar map image and perfusion score result.

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A Study on Availability about Positron Emission Mammography of Breast Cancer (유방암 환자의 Positron Emission Mammography에서의 유용성에 관한 연구)

  • Kim, Seung-Jeong;Kim, Jae-Il;Kim, Jin-Eui;Kim, Hyun-Joo
    • The Korean Journal of Nuclear Medicine Technology
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    • v.14 no.2
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    • pp.60-64
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    • 2010
  • Purpose: Until now the general study for breast cancer patient has been mammography, breast sonography for anatomic diagnostics and $^{18}F$-FDG whole body PET for functional one. But the PEM (Positron Emission Mammography) was developed to increase sensitivity, specificity and accuracy to improve the disadvantage of each study. Therefore this present study aims to describe availability of PEM for improving diagnosis of breast cancer. Materials and Methods: During 3 months from January in 2010, PEM was performed on 100 patients who had history of breast cancer. Using Naviscan's PEM Flex Solo II scanner, PEM images of breast were acquired. And then we evaluated sensitivity, specificity and accuracy of PEM data by comparing results of PEM images with postoperative pathologic finding. Results: On the 100 patients, it could reveal 89 true positive, 9 false positive, 7 false negative and 87 true negative. Thus the results of sensitivity, specificity and accuracy for PEM was evaluated 92.7%, 90.6% and 91.7%. Conclusion: The sensitivity, specificity and accuracy have been reported 83.7%, 68.5% and 77.1% in mammography, and that was 89.1%, 79.1% and 83.4% in breast sonography. However the results of PEM were more increased than others. Therefore the results of this study will be available that PEM used diagnosis with breast cancer, used preoperative operation plan and helps to discovery of a part recurrence.

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Assessment of Radiation Dose Due to X-Ray Simple Series Examinations (X-선 단순 Series 촬영 시 피폭 선량 평가)

  • Gang, Eunbo;Hwang, Incheol;Shin, Woonjae
    • Journal of the Korean Society of Radiology
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    • v.8 no.2
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    • pp.81-88
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    • 2014
  • In diagnostic radiology, each part is examined through serial radiography in most cases of general radiography. However, the reality is that, as for diagnostic reference level, measured values have been set up only for AP projection of each part and lateral projection. In the clinical setting, cumulative dose is incurred by serial radiography of patients, and this can make comparison of diagnostic reference level and cumulative exposure dose impossible or can lead to underestimation of diagnostic reference level. In this study, measurement of cumulative dose of serial radiography of each part revealed that when converting entrance surface dose to effective dose in case it is included in the exposure field, cumulative dose measured from a maximum of 38.06% to a minimum of 0.23% of individual dose limitation of the public. Also, when converting entrance surface dose of each part that is not included in the exposure field into effective dose, it measured from a maximum of 5% to a minimum of 0.04% of individual dose limitation of the public. Results of this study show entrance surface dose substantially increases in serial radiography of each part. Therefore, it is deemed that hospitals need to establish diagnostic reference level specifically, and subdivision of radiography orders for patients is also required in order to reduce unnecessary inspections. Moreover, the need of accurate exposure field is emphasized in case of inspection of several parts.

Usefulness Evaluation and Fabrication of the Radiation Shield Using 3D Printing Technology (3차원 프린팅 기술을 이용한 차폐체 제작 및 유용성 평가)

  • Jang, Hui-Min;Yoon, Joon
    • Journal of the Korean Society of Radiology
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    • v.13 no.7
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    • pp.1015-1024
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    • 2019
  • In the medical field, X-rays are essential in the diagnosis and treatment of diseases, and the use of X-rays continues to increase with the development of imaging technology, but X-rays have the disadvantage of radiation exposure. Although lead protection tools are used in clinical practice to protect against radiation exposure, lead is classified as a heavy metal and can cause harmful reactions such as lead poisoning. Therefore, the purpose of this study is to investigate the usefulness of the shield fabricated using materials of FDM (Fused Deposition Modeling) 3D printer. In order to confirm the filament's line attenuation factor, phantoms were fabricated using PLA, XT-CF20, Wood, Glow and Brass, and CT scan was performed. And the shielding sheet of 100 × 100 × 2 mm size was modeled, the dose and shielding rate was measured by using a diagnostic X-ray generator and irradiation dose meter, and the shielding rate with lead protection tools. As a result of the experiment, the CT number of the brass was measured to be the highest, and the shielding sheet was manufactured by using the brass. As a result of confirming with the diagnostic X-ray generator, the shielding rate was increased in the shielding sheet having a thickness of 6 mm upon X-ray irradiation under the condition of 100 kV and 40 mAs. It measured by 90% or more, and confirmed that the shielding rate is higher than apron 0.25 mmPb. As a result of this study, it was confirmed that the shield fabricated by 3D printing technology showed high shielding rate in the diagnostic X-ray region. there was.

Acute pyelonephritis and myositis after carboxytherapy : A case report (카르복시테라피 후 발생한 급성 신우신염 및 근육염 : 증례 보고)

  • Sun, KyungHoon;Heo, JunHo;Hwang, Yong
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.19 no.8
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    • pp.417-421
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    • 2018
  • Carboxytherapy is very similar to mesotherapy in terms of methods, conditions it treats, and outcomes. An important difference consider, however, is that carboxytherapy administers carbon dioxide gas into the subcutaneous layer, just underneath the skin, whereas mesotherapy administers a cocktail of vitamins, minerals, and drugs and into the mesoderm of the skin. There have been many previous case reports of complications of mesotherapy such as hematoma, granulomatous panniculitis, cellulitis, and abscesses. However, complications of carboxytherapy have rarely been reported because the carbon dioxide gas is absorbed within a week and is infused into the subcutaneous and superficial layers. A 27-year-old woman who had twice undergone carboxytherapy to reduce abdominal fat (3 days and 2 weeks ago) at an oriental medical clinic visited the emergency department due to high fever, myalgia, severe back pain, and subcutaneous emphysema from the buttocks to the lower chest wall area. A computed tomography (CT) scan was performed for diagnosis and treatment. We immediately started broad spectrum antibiotics and consulted with the department of radiology, which could not rule out acute peritonitis due to needle injury. A radiologist confirmed abdominal myositis and needle puncture induced acute pyelonephritis. Pyelonephritis can even lead to septicemia, which can have fatal consequences. Therefore, if the patient has costovertebral or back pain after undergoing needle puncture or acupuncture therapy, the emergency physcians need careful initial evaluation for diagnosis and treatment.

Diagnosis of Ictal Hyperperfusion Using Subtraction Image of Ictal and Interictal Brain Perfusion SPECT (발작기와 발작간기 뇌 관류 SPECT 감산영상을 이용한 간질원인 병소 진단)

  • Lee, Dong Soo;Seo, Jong-Mo;Lee, Jae Sung;Lee, Sang-Kun;Kim, Hyun Jip;Chung, June-Key;Lee, Myung Chul;Koh, Chang-Soon
    • The Korean Journal of Nuclear Medicine
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    • v.32 no.1
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    • pp.20-31
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    • 1998
  • A robust algorithm to disclose and display the difference of ictal and interictal perfusion may facilitate the detection of ictal hyperfusion foci. Diagnostic performance of localizing epileptogenic zones with subtracted SPECT images was compared with the visual diagnosis using ictal and interictal SPECT, MR, or PET. Ietal and interictal Tc-99m-HMPAO cerebral perfusion SPECT images of 48 patients(pts) were processed to get parametric subtracted images. Epileptogenic foci of all pts were diagnosed by seizure free state after resection of epileptogenic zones. In subtraction SPECT, we used normalized difference ratio of pixel counts(ictal-interictal)/interictal ${\times}100%$) after correcting coordinates of ictal and interictal SPECT in semi-automatized 3-dimensional fashion. We found epileptogenic zones in subtraction SPECT and compared the performance with visual diagnosis of ictal and interictal SPECT, MR and PET using post-surgical diagnosis as gold standard. The concordance of subtraction SPECT and ictal-interictal SPECT was moderately good(kappa=0.49). The sensitivity of ictal-interictal SPECT was 73% and that of subtraction SPECT 58%. Positive predictive value of ictal-interictal SPECT was 76% and that of subtraction SPECT was 64%. There was no statistical difference between sensitivity or positive predictive values of subtraction SPECT and ictal-interictal SPECT, MR or PET. Such was also the case when we divided patients into temporal lobe epilepsy and neocortical epilepsy. We conclude that subtraction SPECT we produced had equivalent diagnostic performance compared with ictal-interictal SPECT in localizing epileptogenic zones. Additional value of these subtraction SPECT in clinical interpretation of ictal and interictal SPECT should be further evaluated.

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Development of Bladder Phantom and Image Evaluation of Lesion in the Vicinity according to Filling and Empty Bladder (방광 팬텀 제작을 통한 충만여부에 따른 방광 주변 병변에 대한 영상 평가)

  • Park, Chan-Rok;Kim, Jae-Il;Lee, Hong-Jae;Kim, Jin-Eui
    • The Korean Journal of Nuclear Medicine Technology
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    • v.20 no.1
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    • pp.24-27
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    • 2016
  • Purpose In this study, we evaluated image quality of lesion in the vicinity according filling and empty bladder developing bladder phantom. Materials and Methods Bladder phantom was developed by modifying NEMA IEC body phantom. Air-balloon was described as bladder and 6 insert were set as lesion in the vicinity bladder according to distance. The images were evaluated in terms of % BV, comparison of SUV and peak count rate (Single, Random and True count). Results % BV was decreased far away from bladder. There were different for SUV about $7.8{\pm}3.8%$ between filling and empty bladder. True count rate was decreased about 38 %. Single and random count were increased about 44, 61%. Conclusion When the lesion is close to bladder, noise is increased. That's why prior to PET-CT scan, It is important to urinate. and It helps patient to get the accurate result.

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