• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.10
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• pp.3833-3838
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• 2010

Brainwave can be the most effective means of detecting the state of the brain that changes moment by moment. Since brain has closed relations with hormones which are a foundation of metabolism, it needs to examine closely the mutual relationship between brainwave and hormone. We examined the possibility to find out such information about metabolism by comparing brainwave with cortisol hormone. The major variables are anti-stress quotient of brainwave and cortisol density which give stress information of the working women, to measure from March 3 to May 28, 2007. To find out the relationship between them, we performed such statistical analysis about the before and after of brainwave training as t-test, correlational analysis and regression analysis. We obtained following results: First, considerable changes of variables is shown by brain-wave training. Second, there exist a correlation between variables. Third, according to regression analysis, influence between variables is verified. Thus, we found that stress information of hormone analytical level can be obtined only through brainwave analysis.

• Proceedings of the Korean Society of Developmental Biology Conference
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• 2001.02a
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• pp.14-18
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• 2001

현대의 우리들의 생활환경 중에는 약 10만 종류 이상의 아주 많은 화학물질이 존재하고 있으며 매년 약 1000종류의 새로운 화합물이 상품화되고 있다고 알려져 있다. 이들 중 일부는 우리의 일상생활에 편리한 기능을 가져다 주는 역할을 하고 있으나 최근 생태계 및 인체에 유해한 영향을 미치는 물질로 판명되는 사례가 증가하고 있다. 그들 중에는, 성호르몬과 유사한 구조를 가지기 때문에 호르몬 수용체에 잘못 결합하여 호르몬 활성을 異常히 높이는 등의 영향을 미치는 것이 알려져 있으며, 또, 약물대사 효소의 유도나 효소활성의 저해 등에 의한 물질대사의 교란, 면역계통의 저해, 발암작용 등의 영향에도 미치는 것이 알려져 있다. 이러한 일군의 물질은 내분비계 장애물질(Endocrine disruptors; 환경 호르몬)로 불리며, 최근의 여성에 있어서 유방암의 발생율의 상승이나 남성의 정자수의 감소, 혹은 어떤 종의 야생 생물에 있어서 생식기능 장해(악어 수컷 생식기의 퇴화, 수컷 잉어등의 암컷화, 일부 권패류의 임포섹스 등)는 이러한 내분비계 장애물질에 의하여 유발되고 있다고 하는 가능성이 지적되고 있다. 그렇지만, 이러한 내분비계 장애물질의 환경 중에서의 분포나 다양한 생물에의 영향에 관한 연구는 세계적으로도 아직 부족하고 내분비계 장애물질의 실태나 그 메카니즘 및 그것이 가지는 의미에 대하여는 아직 명확하게 규명되어 있지 않고 있어, 그것에 의한 생체영향의 평가를 총합적으로 검토하기까지에는 이르지 않고 있다. 이러한 물질에 관한 연구는 최근 선진국을 중심으로 활발한 연구가 수행되고 있으나, 우리 나라에 있어서의 연구는 지금까지는 아직 미미한 수준에 머물고 있다. 따라서, 이러한 내분비계 장애물질을 빠른 시기에 발견하여 그것들에 의한 영향을 평가하고, 그 영향을 미연에 방지하는 데에 필요한 대책을 강구하기 위한 많은 연구가 필요 불가결하다. 본고에서는 이러한 환경호르몬 물질 중 본 연구실에서 수행한 내용을 중심으로 유해화학물질 오염 및 대책에 대하여 간단히 발표하고자 한다. 발표내용은, 남해안을 중심으로 조사한 유기주석화합물 오염, 광양만에서의 PAHs(다환방향족탄화수소류) 및 Bisphenol A 오염에 관한 연구결과와 이러한 유해화학물질 오염을 평가하고 관리하는 하나의 유용한 방법으로서 위해성 평가에 대하여 실례를 중심으로 간단히 소개하고자 한다.

• Journal of Life Science
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• v.17 no.4 s.84
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• pp.503-509
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• 2007

The purpose of this study was to investigate the effect of Gi exercises and soybean milk supplement on the body composition and the physiological parameters including blood level of lipids and related hormones in middle-aged women. The Gi exercise program was composed of warming-up(10 min), main exercise(40 min) and cooling-down(10 min). The 40 middle-aged women between 40 and 60 years old were divided into four groups; the control group(12 women), the Gi exercise group(14 women), the soybean milk supplement group(11 women), and the Gi exercise group with soybean milk supplement(14 women). The Gi exercise program was applied three times a week and two packs of the soybean milk per day were given. The result of this study was as follows 1. The control group showed the increase of body weight, percent body fat, and fat mass than other groups. 2. The blood level of T-C was increased in the control group and the Gi exercise group and exercise with supplemented group were decreased 3. The blood level of HDL-C was significantly decreased in the control group than other groups. 4. The blood level of LDL-C was significantly increased in the control group than other groups. 5. The level of TG were not significantly changed in all groups 6. The follicular stimulating hormone (FSH) and luteinizing hormone (LH) hormone levels were not significantly changed in all study groups

• Journal of the Korean Applied Science and Technology
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• v.35 no.4
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• pp.1096-1107
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• 2018

The purpose of this study was to investigate the effects of combined exercise on blood inflammatory factors, DHEA-s and arterial stiffness in elderly women. The subjects were 42 elderly females volunteers, aged 70 to 85 years, composed of the combined exercise group (n=21) and control group (n=21). The 60 minute combined exercise program(aquarobics 1 time/week, strength exercise 2 times/week) was performed 3 times per week for 12 weeks, and the intensity was progressively increased every 4 weeks(1-4 weeks: RPE 12 to 13, 5-8 weeks: RPE 13 to 14, 9-12weeks: RPE 14 to 15). The test data were analyzed by two-way repeated measures ANOVA, paired t-test, independent t-test and the alpha level of .05 was set for all tests of significance. As a result, the combined exercise for 12 weeks reduced the inflammatory response of elderly women, and DHEA-s was found to have a positive effect on aging hormone. The arterial stiffness decreased the central arterial blood pressure (systolic and diastolic), prevented the increase of the pulse pressure and the wave increase index, and decreased the pulse wave velocity. These results suggest that regular and continuous combined exercise may be recommended for the healthy aging and longevity of elderly women by inducing anti-inflammation effect and improving the aging hormonal function and the vascular health.

• 대한치주과학회:학술대회논문집
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• 2005.11a
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• pp.77-77
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• 2005

• Proceedings of the KSCN Conference
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• 2004.05a
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• pp.406.1-406
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• 2004

유방암은 선진국형 질병으로 미국의 경우 가장 흔한 암으로 보고되고 있으며, 우리나라의 경우 과거에는 유방암 발생률이 낮았으나, 생활방식이 서구화되고 영양상태가 좋아지면서 점차 증가하고 있다. 유방암이 증가하는 이유는 명확히 밝혀지지는 않았지만, 서구화 되어가는 생활 패턴으로 초경 연령이 빨라지고, 폐경연령이 늦어지는 등 유방암 발생에 중요한 역할을 하는 여성호르몬에 노출되는 기간이 길면 길수록 유방암 발생이 증가하는 것으로 알려져 있다. 가족 중에 유방암이 있거나 출산하지 않을 경우 등에서도 유방암의 발생률이 다소 높다고 한다.(중략)

• Bulletin of Food Technology
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• v.14 no.3
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• pp.3-16
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• 2001

대두에 함유되어 있는 생리활성 성분에 대한 과학적 규명에 뒤이어 몇 년 전 부터 대두와 인체생리와 관련한 여러 임상 데이터들과 대사시험에 관한 연구가 최근 집중적으로 수행되고 있다. 대두의 이소플라본은 특히 여성의 유방암, 남성의 전립선 암 등 성호르몬 관련 질환에 탁월한 효과가 있고 폐경과 관련된 호르몬 치료요법의 대체 수단으로 활발한 연구가 진행되고 있다. 그중 본문에서는 식이요인이 질병예방에 매우 중요한 인자로 작용하는 분야인 체내 지질대사 개선 및 유방암 예방과 관련된 최근 연구내용을소개한다.

• Development and Reproduction
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• v.5 no.1
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• pp.73-79
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• 2001

Recently many studies have reported that total and bioavailable androgens reduced in male and female athletes and that physical exercise reduces the body weight and increases the reproductive abnormalities such as oligomenorrhea, anovulation, inadequate luteal phase, and delayed puberty in women by the inhibition of the hypothalamic-pituitary-gonadal (HPG) axis . In addition, high mileage endurance 겨nning, psychological stress, and military endurance training in men also reduce the secretion of reproductive hormones. To investigate the efffcts of physical endurance exercise on the secretion of reproductive hormones in men, androgenic hormones from adrenal glands and testis were measured in serum by the conventional radioimmunoassays after long-term (more than3 months), short-term (1 week), and acute (1${sim}$2 hours) physical exercises. Androgenic hormones from adrenal glands and testis such as total testosterone (TT), free testosterone (fT), dehydroepiandrosterone (DHEA), and androstenedione (A) decreased after thesestrenuous endurance trainings, whereas ACTH, cortisol, and dehydroepiandrosterone sulfetes (DHEAS) increased. Conadotropins (LH and FSH) were not idluenced by the physical exercises. Based upon the present results, we assume that the decrease in adrenal and testicular androgens by physical endurance exercises might be associated with the reproductive abnormalities in athletes by unknown factor(s) in addition to the HPG axis disturbance.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.30 no.1
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• pp.15-22
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• 2004

Anti-wrinkle Effect of safflower (Carthamus tinctorius L.) seed extract (CTSE) was evaluated by determination of the anti-oxidation, collagen synthesis and elastase inhibition in normal human fibroblast. CTSE showed anti-oxidation and collagen synthesis ability as much as or greater than other phytoestrogenic compounds such as genistein or resveratrol. Consistent with collagen synthesis promotion, CTSE also showed inhibitory effect on elastase activity. In the human skin irritation test, 0.2％ CTSE did not show any adverse effect. These results demonstrate that CTSE can be useful as an anti-wrinkle cosmetic ingredient.

• Women's Health Nursing
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• v.8 no.2
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• pp.151-164
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• 2002

PURPOSE: Estrogen replacement therapy is indicated for the relief of hot flushes and urogenital atrophy, the prevention of osteoporosis and the reduction in risk of cardiovascular disease. The present study assessed by blood pressure, heart rate variability, and climacteric symptoms in menopausal women before treatment and at 1 month during estrogen replacement therapy. METHODS: The study sample consisted of 16 healthy menopausal women (range 49 to 59 years, mean : 53.4 years) attending menopausal clinics for the complaint of climateric symptoms at S. hospital in Chunchoen. They were all non-smokers and no patient had symptoms or evidence of cardiovascular disease. They took estrogen replacement therapy (conjugated estrogen 0.625 mg with or without medroxy progesteron 2.5mg) for 1 month. Blood pressure, heart rate variability(heart period and vagal tone) through ECG, and climacteric symptom were measured in all subjects before treatment and at 1 month during treatment. Climacteric symptom questionnaire which was developed by Neugarten et al.(1963) was modified with 20 items of question(Cronbach's alpha = 88 -.89). The data was collected from Sept. 1. 2000 to July. 30. 2001. RESULTS: There was no significant difference in mean systolic and diastolic pressure between the baseline and at 1 month during treatment. The mean heart period and vagal tone were slightly increased, but difference of mean heart period and vagal tone were not statistically significant between the baseline and at 1 month during treatment. The score of climacteric symptoms decreased significantly from the baseline after treatment. CONCLUSIONS: Even though, this study did not show that estrogen replacement therapy led decrease of blood pressure and increase heart rate variability, climacteric symptoms reduced much in all subjects after taking drugs. These results suggest that there is need to repeat study with long term period.