• Proceedings of the Korean Vacuum Society Conference
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• 2010.08a
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• pp.315-315
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• 2010

양성자 빔을 이용하여 두경부 암 치료를 South Africa의 iTHEMBA에서 시행하고 있다. 200 MeV의 양성자 빔라인으로부터 진공에서 대기로 인출하여 노즐을 통과하여 종양세포에 조사된다. 치료계획에 적합하게 빔에너지와 모양을 변환하고, 빔을 모니터링하는 기계적 장치들이 노즐에 구성된다. 빔라인에는 이온챔버, Steering Magnet, Multi-wire 이온챔버, Range trimmer plates, lead scattering plate, Double-wedge energy degrader, Multi-layer Faraday cup, Range modulator, Range monitor, occluding ring, Shielding collimators, Quadrant and monitor ionization chamber, Treatment collimator, 그리고 Wellhofer dosimetry tank로 구성되어 있다. 총길이는 6.6m이며 노즐 끝에서 환자의 isocenter 까지는 30cm 정도 아래에 위치한다. 상기의 배치를 갖는 시스템의 양성자 scattering system의 성능을 MCNPX v2.5.0 Monte Carlo simulation을 실시하였다. 또한 정확한 선량을 실시간으로 측정하는 방법인 투과형 검출기를 개발하여 치료와 빔 특성을 동시에 수행하는 기술개발연구가 보고되고 있다. 본 연구에서는 Multileaf Faraday Cup (MLPC) 검출기 설계구조와 데이터 측정방법에 관한 연구를 수행하고자 한다. 빔의 전송 방향으로 3개층의 $4{\times}4$ 배열의 구조로 48 channel의 전류값을 측정하여 입자빔의 분포를 실시간으로 관측하고, 측정된 전류는 ADC를 거쳐 치료계획에 의해 선택된 영역의 SOBP를 유지하도록 range modulation propeller를 조절하는 feed-back system을 갖춘 방사선치료빔 실시간 측정장치 개발에 관한 결과를 보고하고자 한다.

• Journal of Digestive Cancer Research
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• v.2 no.2
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• pp.78-81
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• 2014

Intraductal papillary neoplasm of the bile duct (IPN-B) is a rare disease characterized by multicentric proliferation of adenomatous epithelium within the bile ducts. It has better prognosis because of slow disease progression and high probability of early diagnosis, but also has potential for malignant transformation. Therefore early treatment such as surgical resection has been recommended. There are few reports about nature course of IPN-B without treatment. We report a case of papillary adenoma of intrahepatic duct that transformed into intrahepatic cholangiocarcinoma with 8 years of follow up.

• Journal of radiological science and technology
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• v.37 no.4
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• pp.331-339
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• 2014

To test feasibility of proton arc therapy (PAT) in the treatment of para-aortic lymph node tumor and compare its dosimetric properties with advanced radiotherapy techniques such as intensity modulated radiation therapy (IMRT) and conventional 3D conformal proton beam therapy (PBT). The treatment plans for para-aortic lymph node tumor were planned for 9 patients treated at our institution using IMRT, PBT, and PAT. Feasibility test and dosimetric evaluation were based on comparisons of dose volume histograms (DVHs) which reveal mean dose, $D_{30%}$, $D_{60%}$, $D_{90%}$, $V_{30%}$, $V_{60%}$, $V_{90%}$, organ equivalent doses (OEDs), normal tissue complication probability (NTCP), homogeneity index (HI) and conformity index (CI). The average doses delivered by PAT to the liver, kidney, small bowel, duodenum, stomach were 7.6%, 3%, 17.3%, 26.7%, and 14.4%, of the prescription dose (PD), respectively, which is higher than the doses delivered by IMRT (0.4%, 7.2%, 14.2%, 15.9%, and 12.8%, respectively) and PBT (4.9%, 0.5%, 14.12%, 16.1% 9.9%, respectively). The average homogeneity index and conformity index of tumor using PAT were 12.1 and 1.21, respectively which were much better than IMRT (21.5 and 1.47, respectively) and comparable to PBT (13.1 and 1.23, respectively). The result shows that both NTCP and OED of PAT are generally lower than IMRT and PBT. This study demonstrates that PAT is better in target conformity and homogeneity than IMRT and PBT but worse than IMRT and PBT for most of dosimetric factor which indicate that PAT is not recommended for the treatment of para-aortic lymph node tumor.

• Journal of the Korean Society of Radiology
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• v.79 no.6
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• pp.348-353
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• 2018

Hepatic pseudolymphoma is a rare benign liver mass that is characterized by proliferation of non-neoplastic lymphocytes extranodally. To the best of our knowledge, only 46 cases have been reported in the English literature. We described the case of a 75-year-old woman with hepatic pseudolymphoma mimicking a hypervascular tumor. After the histological confirmation of the rectal neuroendocrine tumor, CT scan revealed a 1.0 cm-sized, poorly-defined and low-density nodule in the liver. On MRI, the hepatic nodule showed an arterial enhancement and a low-signal intensity on the hepatobiliary phase. On diffusion-weighted imaging, the hepatic nodule showed a high signal intensity on a high b-value. On fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT, it revealed a high standardized uptake value nodule. The US showed the hypoechoic nodule and the US-guided biopsy confirmed the hepatic pseudolymphoma.

• YAKHAK HOEJI
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• v.17 no.2
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• pp.71-91
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• 1973

미생물의 대사산물은 극히 다양함으로 그중에는 암세포에 선택적으로 작용하여 증식을 억제하는 것이 있으리라는 예상하에서 종양을 이식한 동물을 사용하여 항암성 물질을 스크리-닝하기 시작한 것은 1951년경 부터였다. 그리하여 지난 20여년간에 200종 이상의 항종양성 물질이 보고되었고 그 화학구조는 가지 각색이다. 그간의 연구의 추세를 들이켜 본다면 초기에는 항종양작용에 중점을 두었기 때문에 독성이 강한 물질이 다소 보고되었으며 중기에는 조직배양을 이용했기 때문에 세포독 물질이 주축을 이루고 있다. 근래에는 독성이 낮은 물질, 특히, 고분자의 물질이 추구되고 있는 경향이다. 이미 보고된 200여종의 항종양성 항생물질중 실지로 쓰이고 있는 것은 10여종에 불과하다는 사실은 전신요법제로써의 항암제의 독어이 얼마나 중요한 가를 잘 증언해 주고 있다. 항종양성 항생물질은 화학구조, 생성하는 미생물, 작용기전 등에 분류할 수 있다. 그러나 화학구조가 다양하다는 점에서 또 생성하는 미생물은 대개 방성균류이라는 점에서 그리고 작용기전은 대개 핵산에 작용한다는 점에서 볼때 이러한 분류기준을 채택한다는 것이 특별히 유리한 점이 없는 것 같으므로 여기서는 편의상 발견된 연대순으로 나열하여 기재하기로 한다.

• The Korean Journal of Nuclear Medicine
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• v.34 no.3
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• pp.243-251
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• 2000

Purpose: This prospective study was performed to evaluate the usefulness of preoperative radioimmunoscintigraphy and intraoperative scintimetric examination (radioimmunoguided surgery: RIGS) using $^{99m}Tc-anti-CEA\;F(ab')_2$ fragment. Materials and Methods: Nineteen patients with rectal cancer underwent preoperative whole body planar scintigraphy at 4 hours after injection of $^{99m}Tc-anti-CEA\;F(ab')_2$ fragment and SPECT imaging at 18 hours. Surgical operation was performed at 24 hours after injection. During laparotomy, radioactivities from intraabdominal viscera were measured by gamma probe. The radioactivities from excised tumor and lymph nodes were also measured and compared with pathology. Results: All nineteen patients were confirmed to have adenocarcinomas in the rectum. Twenty-seven of 97 excised lymph node groups had metastasis and 2 patients had liver metastasis in pathology Preoperative radioimmunoscintigraphy detected primary tumors in 11 patients (sensitivity 55%) and it could not detect any lymph nodes or liver metastasis. All patients showed high radioactivity in the kidneys, liver, spleen, and major vessels in intraoperative measurement by gamma probe, and tumor activity was not discriminated from background activity However, radioactivity from excised tumor was higher than normal rectum (T/B ratio; $3.47{\pm}2.25$). When excised lymph node activity/background activity ratio >1.5 was considered as positive criteria of metastasis, sensitivity, specificity, positive and negative predictive values were 78.6%, 73.9%, 55.0% and 89.5%, respectively. Conclusion: Radioimmunoscintigraphy using $^{99m}Tc-anti-CEA\;F(ab')_2$ has no additional value for preoperative staging and use of early RIGS using $^{99m}Tc-anti-CEA\;F(ab')_2$ is inappropriate. For early RIGS using $^{99m}Tc$ labeled antibodies in rectal cancer patients, further development of more specific antibodies and methods to reduce background activity are needed.

• Journal of the Korean Society of Radiology
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• v.81 no.2
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• pp.418-422
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• 2020

Serous cystic neoplasms of the pancreas are usually benign, with a low malignant potential. Herein, we report a case of malignant serous cystic neoplasm of the pancreas treated with subtotal pancreatectomy, which progressed to local recurrence and metachronous hepatic metastasis during the regular follow-up period.

• Journal of the Korean Society of Radiology
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• v.18 no.4
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• pp.355-363
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• 2024

This study evaluated the clinical utility of Shear Wave Elastography(SWE) by analyzing the differences in elastic modulus and shear wave speed across various types of breast tissue and assessing inter-observer agreement. A breast phantom that included normal breast tissue, benign tumors, and malignant tumors was utilized, and ten radiologists participated, measuring the minimum, average, and maximum elastic modulus and shear wave speed for each tissue type. Analysis of differences between tissues was conducted using one-way ANOVA, and intra- and inter-observer agreement was assessed using the Intraclass Correlation Coefficient(ICC). The results demonstrated significant differences in the average values of elastic modulus and shear wave speed among the tissue types(p<0.001), with malignant tumor tissues showing the highest average values. Furthermore, the ICC analysis for elastic modulus ranged from 0.75 to 0.99 and for shear wave speed from 0.89 to 0.99, indicating high reproducibility and agreement. These findings suggest that SWE is a reliable tool with high reproducibility and specificity for the diagnosis of breast cancer.

• Proceedings of the Korea Contents Association Conference
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• 2015.05a
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• pp.173-174
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• 2015

간에서 발생하는 악성종양과 양성종양의 대표적 질환 으로는 간세포암(Hepatocelluar carci- noma, HCC)과 간혈관종(Hepatic hemangioma, HH)이다. CT검사를 이용한 진단에 있어서 두 질환은 시간변화에 따른 조영증강양상 차이가 나타난다. Liver 3-phase computed tomography검사를 시행하여 시간별 조영증강 양상을 알아보았다. 본 연구는 조영제 주입전, 동맥기(35sec), 문맥기(70sec), 지연기(180sec)에 대한 Enhan -cement Pattern 변화와 HU(Hounsfield unit)값 변화, pixel값 변화의 관찰로서 검증하였다. 실험결과 HU를 사용한 방법에서 의미있게 구분되었고 임상적용 시 판독에 도움을 줄 것으로 생각한다.

• The Journal of the Korean bone and joint tumor society
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• v.9 no.1
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• pp.84-92
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• 2003

Purpose: To report two cases of bone tumors other than osteoid osteoma in the proximal femur and treated with percutaneous high frequency radioablation method. Cases: We reviewed two cases with intracortical chondroma and enchondroma in the femoral head retrospectively. The patient with intracortical chondroma was a thirty one year old woman and had suffered right hip pain of 1 year duration. The lesion was located in the head of right femur and treated with CT guided percutaneous high frequency radioablation after needle biopsy under general anesthesia. The symptom was gone immediately after the procedure and was discharged postop. 1 day. 15 months has passed without symptom recurrence. Second case having enchondroma, was 56 year old woman complaining of gluteal area pain for 3 months. Radiologic evaluation showed osteolytic lesion with sclerotic rim on the inferior portion of the left femoral head. She received a same therapy with CT guided radiofrequency ablation following needle biopsy. She reported dramatic pain relief after the procedure and was discharged postop. 1 day. No symptom has occurred for 3 months until now. Conclusion: We present 2 cases of bone tumor occurred in the hip joint area other than osteoid osteoma which were treated with CT guided radiofrequency ablation.