• Korean Journal of Biological Psychiatry
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• v.16 no.4
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• pp.266-270
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• 2009

Adverse drug reactions are very common in clinical practice, and skin is one of the most frequent organs for adverse drug reactions. We report a case of a 71-year-old male patient who developed skin eruptions after switching formulation of quetiapine immediate release(IR) to quetiapine extended release(XR). He had been taking quetiapine IR(400mg/day) for treatment of manic episode which was developed one year ago. The patient showed great improvement of symptoms after taking quetiapine IR for about one year, thus dosage of medication was reduced to 50mg/day on the average. Unfortunately dose reduction has tended to worsen symptoms, so dose of quetiapine was increased again to 200mg/day with formulation changes to XR. Two days after he took new formulation, erythematous papules were occurred over his anterior neck and ventral side of left wrist. As he stopped quetiapine XR, the skin lesions gradually subsided. And he was successfully treated with readministration of quetiapine IR without any skin lesions.

• 한국항공운항학회:학술대회논문집
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• 2016.05a
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• pp.249-254
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• 2016

저비용항공사들은 전세계적인 항공수요 증가 등으로 약진을 하기도 했지만, 2000년대 초반부터 세계 항공산업은 테러위험, 유가급등, 오일머니를 등에 업은 중동 항공사들의 급성장, 그리고 2008년부터 시작된 세계경제위기로 미국과 유럽, 일본 등 메이저 항공사들은 일단 최소한의 생존가능 임계규모를 갖추고자 뼈를 깎는 구조조정을 수반한 인수합병, 대외악재에 대한 대응능력 제고, 새로운 보조수익원 개발을 통해 위기를 헤쳐나갔다. 그러나 2013년 11월 단행된 중동 항공사들(Emirates, Qatar, Etihad)의 역사상 유례없는, 한화 약 170조원 규모의 항공기 구매계약에 미국과 유럽은 물론이고 아시아 메이저 항공업계까지 다시 한번 커다란 위기감에 휩싸이게 되었다. 이러한 상황하에서도 효율적 경영의 선구적 역할을 미국의 Southwest, 유럽의 LCC Ryan Air, 아시아의 LCC Air Asia 등 LCC산업은 극심한 경기침체를 겪으면서도 해당 산업의 규모는 지속적 성장을 거듭할 전망이다. 결론적으로, 이러한 상황에서, 비록 미국과 유럽 항공사들이 대규모 구조조정을 겪고 2012년 이후부터 점차 회복기미를 보이고 있긴 하지만, 중동 항공사들의 영향력에 대응하기 위해 향후에도 추가적인 구조조정은 물론 인수/합병 등 생존을 위한 메이저 항공사들 간의 빅딜이 이어질 전망이며, 일본처럼 내수시장이 넓지 않은 한국도 중국 등 성장잠재력이 높은 국가들과의 항공자유화 등을 적극적으로 추진하여 보다 넓은 시장을 확보하지 못한다면 머지않아 수익성에 큰 타격을 입을 수밖에 없다는 결론에 도달하였다.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 1998.10a
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• pp.497-504
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• 1998

In the nonlinear dynamic structural analysis, the given ground excitation as an input should be well defined. Because of the lack of recorded accelerograms in Korea, it is required to generate an artificial earthquake by a stochastic model of ground excitation with various dynamic properties rather than recorded accelerograms. It is well own that earthquake motions are generally non-stationary with time-varying intensity and frequency content. Many researchers have proposed non-stationary random process models. Yeh and Wen (1990) proposed a non-stationary stochastic process model which can be modeled as components with an intensity function, a frequency modulation function and a power spectral density function to describe such non-stationary characteristics. This model is based on the simulation for the strong-motion earthquakes with magnitude greater than approximately 5.0~6.0, because it will be not only expected to cause structural damage but also involved the characteristics of earthquake motions. Also, the recorded earthquake motion within this range are still very scarce in Korea. Thus, it is necessary to verify the model by the application of it to the mid-magnitude (approximately 4.0~6.0) earthquakes actually recorded in domestic or foreign area. The purpose of the paper is to generate an artificial earthquake using the model of Yeh and Wen in the area with low seismicity.

• Journal of Sasang Constitutional Medicine
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• v.15 no.1
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• pp.118-122
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• 2003

In this study, it is experienced that Drug eruptions of Soyangin patient mistreated with Taeumin, The patient was 61 years old, female. She entered our hospital for Stroke and sicked Drug eruptions by mistreatment of Taeumin, After we prescribed Yanggyuksanhwatang(凉膈散火湯), had the general improvement of drug eruptions. Drug eruptions is related to Yangdokbalban(陽毒發斑) in Oriental medicine. The Yangdokbalban(陽毒發斑) of Soyangin is classed as Wisuyulliyulbyung(胃受熱裏熱病). This is a kind of dermatitis caused by Wiyul(胃熱). We classified this as Soyangin-Liyuuljeung(小陽人裏熱證) and prescribed Yangdokbaekhotang(陽毒白虎湯) and Yanggyuksanhwatang(凉膈散火湯). In the result, we had the general improvement of Yangdokbalban(陽毒發斑).

• Journal of the Computational Structural Engineering Institute of Korea
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• v.21 no.5
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• pp.451-458
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• 2008

In this study 3- and 6-story flat plate structures designed only for gravity load are retrofitted with steel plates and braces and their seismic performances are evaluated to verify the effect of seismic retrofit. According to the analysis results obtained from nonlinear static and dynamic analyses both the strength and stiffness are significantly enhanced as a result of the seismic retrofit. Especially the effect of column jacketing could be enhanced significantly when slabs were reinforced to prevent premature punching shear failure. When buckling-restrained braces are used instead of conventional braces, the structures showed more ductile behavior, especially in the 3-story structure.

• Journal of Korean Academy of Nursing
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• v.3 no.2
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• pp.67-80
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• 1973

발전이란 말은 한 국가나 사회가 교육적, 경제적, 사회문화적 및 정치적으로 안정된 기조를 확립하여 국민 전체가 생을 영위함에 있어서 경제적으로 부족함이 없이 윤택하고 각종 사회적 제도가 참 삶을 추구할 수 있는 방향으로 변천되어 가는 과정을 뜻한다. 본 연구는 발전과 번영을 위해 약진하고 있는 대한민국의 최근 20년간의 발전과정 (1950년부터 1970년까지)을 경제적측면과 교육적 측면에서 미국의 것과를 비교하기 위하여 유네스코 통계 연감에 의하여 그 자료를 분석 검토하였다. 본 연구에서 한국은 경제성장율이 늘어남에 따라서 교육비 투자가 증가되었고 따라서 초등교육과정은 1965년도에서부터 취학율이 100%를 상회하게 되었으나 중등교육은 1968년도에 취학율이 겨우 36%로 아직도 저조하며 여학생 취학율은 초등교육에서 는 남녀 의 차이 가 없으나 중등교육에서는 1/3선으로 떨어지고 있으며 특히 여선생님의 남선생님에 대한 비율은 중등교육과정에서 걱우 14%밖에 안되고 인구 10만당 대학졸업생수는 1968년을 기준으로 볼 때 계속 증가되어 왔으나 미국이 3,735명(그중 40%는 여학생임)인데 비하여 한국은 566명 (여학생은 26%)으로 고등교육의 혜택을 받는 율이 아직도 미국에 비해서 낮고 초등교육과정에서 학생과 선생님의 비율을 보면은 한국은 60 : 1 인데 비하여 미국은 26 : 1로써 미국보다 높고 따라서 한국은 교직원 부족과 시설미비, 농촌과 도시간의 차이 및 고등교육 혜택의 불균형 및 여성교육의 기회가 남성에 비해 낮고 해외 유학의 경우 본국 귀환율이 적어서 지도자 양성이 문제되고 있다. 그러나 한국은 1960년대에 급격한 경제성장과 함께 교육투자도 증가되었고 따라서 발전을 거듭하여 계속하고 있다.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.20 no.1 s.32
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• pp.256-264
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• 2007

Objective : This study describes a case of urticarial drug eruption assumed to be caused by non-steroidal anti- inflammatory drugs (NSAIDs) treated with oriental medicine and acupuncture. Methods : We studied the case of 20-years-old drug eruption patient. The patient complained of urticaria, angioedema, itching and burning sensation after taking NSAIDs. The indications for NSAIDs prescribed were common cold symptom and sore throat. For diagnosis, blood test and urinalysis were done. For treatment, acupuncture and herbal-medicine treatment were applied. Results : The patient of this report were examined for 13 days. The radiological finding was within normal limits. The WBC, neutrophil, lymphocyte and eosinophil level normalized during admission. After 3 days, itching and wheal reaction of whole body disappeared except facial symptom. The angioedema, itching and wheal reaction in the face was almost improved in the 4th day after discharge. Conclusions : We may expect that the oriental medical therapy improves the urticarial drug eruption caused by NSAIDs.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.25 no.3
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• pp.175-183
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• 2012

Objectives : The purpose of this report is to know the effect of Younkyopaedok-san(連翹敗毒散), Sammulhwanggum-tang(三物黃芩湯) on eczema worsened by drug eruption and Gungguigyoae-tang(芎歸膠艾湯) on chronic eczema. Methods : We experienced one case of eczema treated with Younkyopaedok-san, Sammulhwanggum-tang and Gungguigyoae-tang. We used visual analogue scale(VAS). Results : After the treatment the grade of VAS was decreased and clinical symptoms were gradually disappeared. Conclusion : Younkyopaedok-san, Sammulhwanggum-tang and Gungguigyoae-tang had improved the signs and symptoms of eczema. 1. Younkyopaedok-san and Sammulhwanggum-tang were effective on the treatment of inflammatory eczema. 2. Gungguigyoae-tang was effective on the treatment of chronic eczema.

• Journal of the Korean Geotechnical Society
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• v.19 no.2
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• pp.123-133
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• 2003

A practical statistical approach that can be used to model various sources of uncertainty systematically is presented in the context of reliability analysis of slope stability. New expressions for probabilistic characterization of soil properties incorporate sampling and measurement errors, as well as spatial variability and its reduced variance due to spatial averaging. The stochastic nature of seismic loading is studied by generating a large series of hazard-compatible artificial motions, and by using them in subsequent response analyses. The analyses indicate that in a seismically less active region such as the Korean Peninsular, a moderate variability in soil properties has an effect as large as the characterization of earthquake hazard on the computed risk of slope failure and excessive slope deformations.

• The Journal of Internal Korean Medicine
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• v.43 no.6
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• pp.1075-1088
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• 2022

Objectives: The aim of this study is to analyze cancer research trends in traditional Korean medical journals indexed in the Korea Citation Index since 2000. Methods: Cancer research papers published in traditional Korean medical journals were searched in databases from inception to October 2022. The numbers of publications by journal and by year were descriptively assessed. After natural language processing, topic modeling (based on Latent Dirichlet allocation) and keyword network analysis were conducted. Results: This research trend analysis involved 1,265 papers. Six topics were identified by topic modeling: case reports on symptom management, literature reviews, experiments on apoptosis, herbal extract treatments of breast carcinoma cell lines, anti-proliferative effects of herbal extracts, and anti-tumor effects. Keyword network analysis found that the effects of herbal medicine were assessed in clinical and experimental studies, while acupuncture was mainly mentioned in clinical reports. Conclusions: Cancer research papers in traditional Korean medical journals have contributed to evidence-based medicine. Further experimental studies are needed to elucidate the effects of on different hallmarks of cancer. Rigorous clinical studies are needed to support clinical guidelines.