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Acute Respiratory Distress Syndrome after Topotecan Therapy in a Patient with Small Cell Lung Cancer (소세포폐암 환자에서 토포테칸 투약 후 발생한 급성호흡곤란증후군)

  • Tae, Jung Hyun;Lee, Jin Hwa;Kim, Yoon Kyung;Sim, Yun Su;Lee, Kyung Jong;Noh, Young Wook;Park, Jae Jung;Ryu, Yon Ju;Chun, Eun Mi;Chang, Jung Hyun
    • Tuberculosis and Respiratory Diseases
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    • v.65 no.2
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    • pp.142-146
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    • 2008
  • Small cell lung cancer is characterized by an aggressive clinical course and a high tendency for early dissemination in spite of a good chemotherapy response. Topotecan is a topoisomerase I inhibitor, and it is used as second-line treatment for small cell lung cancer. The reported dose-limiting adverse reactions to topotecan are mainly hematologic. Yet pulmonary toxicity associated with topotecan is known to be rare. We report here on a case that showed the development of acute respiratory distress syndrome during the 3rd cycle of topotecan chemotherapy in a patient with small cell lung cancer. He developed dyspnea and respiratory failure, and the chest CT scan revealed diffuse ground-glass opacity that was probably due to chemotherapy-related pulmonary toxicity. He finally died of acute respiratory distress syndrome.

Prey Consumption and Suppression of Vegetable Aphids by Chrysopa pallens (Neuroptera: Chrysopidae) as a Predator (채소류 진딧물에 대한 칠성풀잠자리붙이의 포식량 및 밀도억제 효과)

  • 이건휘;이승찬;최남영;김두호
    • Korean journal of applied entomology
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    • v.39 no.4
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    • pp.251-258
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    • 2000
  • These studies were conducted to investigate the prey consumption and suppression of cotton aphid and green peach aphid by Chrysopa pallens Ramber as a predator. The 3$^{rd}$ instar of C. pallets fed on 29.8, 77.9, 133.6, and 155.7 individuals of apterous Aphis goussypii Glover a day at 17,22, 27, and 32$^{\circ}C$, respectively. A preovipositing female fed on 73.1 individuals, ovipositing female on 86.6 individuals, and adult male on 69.7 individuals of apterous Myzus persicae (Sulzer) a day at the 27$^{\circ}C$. The functional response curve of the larvae and adults of C. pallens to the densities of A. gossypii indicated Helling’s Type II: the consumption of prey by the C. pallens increased with the prey density but the consumption rate decreased. The attack rate of 3rd instar of C. pallens was the highest among the 2nd instar, 3$^{rd}$ instar, adult male and adult female, and handling time was the shortest. The critical ratio of the predator vs. the prey to effectively suppress the population of A. gossypii by releasing C. pallets eggs was 1 : 4 on red pepper and egg plant, and 1 : 3 on cucumber. Release of second larval stave of C. pallens at the ratio of 1 : 30 of the predator vs. the prey controlled satisfactorily A. gossypii on red pepper, and 1 : 20 on cucumber and tomato. The three-times introduction of the eggs of C. pallens was as effective as four applications of insecticides from mid-June to late September.r.

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Effect on Shoot Growth Inhibition by Prohexadion-Calcium in 'Sato Nishiki' Sweet Cherry (Prohexadion-Calcium이 체리 '좌등금'의 신초생장 억제에 미치는 영향)

  • Lee, Se-Uk;Nam, Eun-Young;Yun, Seok-Kyu;Shin, Yong-Uk;Jung, Jae-Hoon;Kang, Hee-Kyoung;Yoon, Ik-Koo
    • Journal of Bio-Environment Control
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    • v.19 no.4
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    • pp.387-391
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    • 2010
  • This research was conducted to get the basic information for improving production amount as well as fruit quality by using Prohaxadion-Calcium (Pro-Ca) used as 'Sato Nishiki', cherry cultivar, which is most frequently cultivated in Korea. In fruiting trees, we used Pro-ca and concentration of treatment selected 150, 200 and $250\;mg{\cdot}L^{-1}$. When treating Pro-Ca $200\;mg{\cdot}L^{-1}$, we could get the highest effect on inhibition of shoot growth. All treatments of Pro-Ca were increased chlorophyll a and b, respectively compared with control. Although treatments of Pro-Ca treatment showed the decreased effect on leaf area and there was no difference in fruit quality among treatments. Also, Pro-Ca $250\;mg{\cdot}L^{-1}$, sprayed 3 times, and pclobutrazol ($PP_{333}$) 500 and $1,000\;mg{\cdot}L^{-1}$, applicated soil, were treated to 1 year old plnted pot. Pro-Ca and $PP_{333}$ showed inhibition of shoot growth, especially, Pro-Ca showed the more effect than $pp_{333}$ on growth inhibition. Soil applications of $pp_{333}$ showed less effect to enlargement of tree trunk compared to Pro-Ca and control. Pro-Ca and $pp_{333}$ were not difference in number of inter-nodes when comparing to control, but they on decreased leaf area and increased chlorophyll.

Clinical Manifestation of Extrapulmonary Tuberculosis in Children : A Single Center Experience (단일기관에서 경험한 소아 폐외결핵의 임상적 고찰)

  • Seung, So Jin;Kwak, Ga Young;Lee, Soo Young;Kang, Jin Han
    • Pediatric Infection and Vaccine
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    • v.15 no.2
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    • pp.167-173
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    • 2008
  • Purpose : We evaluated the prevalence and clinical, microbiological features of extrapulmonary tuberculosis (EPT) in pediatric patients. Methods : We retrospectively reviewed medical records of pediatric patients diagnosed with EPT at The Catholic University of Korea, Incheon St. Mary's Hospital between 2000 and 2007. Results : Of 109 patients diagnosed with tuberculosis (TB), 12 patients (11%) were admitted with EPT. At 2006-2007, the proportion of patients with EPT among patients with TB was the highest (20%) comparing with last 6 years. The ratio of male to female patients was 1.4:1 and the mean age was 9.2 years (range, 3 months-15 years). The involved sites were pleura in 5 (41.6%), central nervous system in 3 (25%), miliary TB in 2 (16.7%), gastrointestinal tract in 1 (8.3%) and bone and joint in 1 (8.3%). The most common symptom at admission was fever (91.6%) and mean duration of fever was 15.8 days (range, 0-47 days) in spite of the proper treatment. Confirmed rate for acid fast bacillus stain, culture, and polymerase chain reaction were 33.3%, 41.6% and 41.6%. Of 5 culture proven cases, 4 (80%) were resistant to more than one antituberculosis drugs. Eleven patients recovered without complication and 1 patient died. Conclusion : Total incidence of TB decreased steadily according to the nationwide survey. However, our results suggest that the proportion of diagnosis with EPT among diagnosis with TB in children has increased. Microbiological diagnosis of EPT in children was more difficult than that of pulmonary TB. And drug resistance rate has increased.

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Meaning of Anti Hepatitis C Virus Antibody Detection in Patients Treated with Intravenous Immunoglobulin (인민역 글로불린 제재를 투여받은 환아에서 C형 간염바이러스 항체(anti-HCV) 검출의 의의)

  • Lee, Myong-Gyun;Lee, Young-Hwan;Shin, Son-Moon;Hah, Jeong-Ok
    • Journal of Yeungnam Medical Science
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    • v.10 no.2
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    • pp.306-312
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    • 1993
  • To evaluate the meaning of anti-HCV detection in patients treated with IVIG, serum levels of aspartate aminotranstferase(AST), alanine aminotransterase(ALT), HCV Ab titer were measured after treatment with IVIG in 36 patients diagnised of Kawasaki disease or neonatal sepsis. Also polymerase chain reaction (PCR) for the detection of HCV was done in 8 patients with persistent HCV Ab positivity at 3 months after IVIG treatment. The results were as follows 1) HCV Ab was positive in all 36 patients at 1 week after IVIG treatment, but in only 8 cases it was positive at 3 months after IVIG treatment. 2) AST, ALT were elevated in 9 cases at 1 week after IVIG treatment, but they were normalized in all cases at 3 months after IVIG treatment. 3) PCR for the detection of HCV was done in 8 patients with persistent HCV Ab positivity at 3 months after IVIG treatment, but HCV was not isolated in any cases. These results suggested that detection of anti-HCV was merely transitory phenominon of HCV Ab transmission, did not show any evidence of HCV infection due to HCV transmission.

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Herbicidal Efficacy and Diffusibility of 500g Great Granule for Remote-Controlled Aerial Application in Paddy Rice (농용 무인항공방제용 500g 대립제의 잡초방제효과와 확산성)

  • Yoon, Cheol-Su;Lee, Sheong-Chun;Kim, Kyung-Hyun;Lee, Kye-Hwan;Seok, Chang-Soo;Kim, Hyun-Jae;Cho, Tae-Kyoung;Hwang, In-Cheon
    • Korean Journal of Weed Science
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    • v.30 no.4
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    • pp.445-453
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    • 2010
  • This study was conducted to investigate herbicidal efficacy and diffusibility of halosulfuron-methyl+mefenacet in water treated with 500 g great granule (GG) and 3 kg granule (GR). The 500 g GG was been spreading on the surface of the water within 6 minutes, 53 seconds, and it's active ingredient was diffused in the water bath of $10m^2$ size between 30 and 60 minutes. In addition, the diffusion of 500 g GG was influenced by moisture contents, so it have to immediately use 500 g GG in paddy fields when it was been unpacked. The herbicidal efficacy of the 500 g GG and 3 kg GR of halosulfuron-methyl+mefenacet was excellent to most weed species, but showed different efficacy for the control of Aneilema keisak and Scirpus juncoides, that was may be distribution pattern of active ingredient as different formulation.

The Size of Injection Wound, Tree Diameter, and Injection Wound Healing of a Tree - Response to Pospam Injection Wound - (흉고직경별 약제 수간주입구멍의 크기에 따른 주입구멍의 치유도 - 포스팜 수간주입구멍에 대한 반응 -)

  • Cha, Byeong Jin;Yun, Jeong Koo
    • Journal of Korean Society of Forest Science
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    • v.84 no.1
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    • pp.22-30
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    • 1995
  • Responses of Pospam-injected chestnut and pine trees to drill wound were examined. Pospam was injected into the stem by just filling up the drill wound in September 10, 1993. The diameter of the injection wound were 0.5 and 1cm. DBH of chestnut trees and pine trees injected were 10, 15, 20 and 10, 20, 30cm, respectively. The results of tree response were examined in June, 1994. None of them showed any symptom of decay by the time. However, sapwood under the bark was remarkably discolored. The discoloration was more severe in 1cm-injection wound than in 0.5cm one. The severity of discoloration was not differed between species and among DBH applied. The sapwood split was longer in 1cm-injection wounded trees than in 0.5cm trees and longer in chestnut trees than in pine trees. From the split, callus grew out and almost closed the splits. In the trunk injection tested, the damage was mare severe in 1cm injection wound of chestnut trees than in any other combination.

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Interaction of Herbicide Mixtures for Effective Control of Annual and Perennial Paddy Weeds (1년생(一年生) 및 다년생(多年生) 답잡초(沓雜草)의 방제(防除)를 위한 혼합제초제(混合除草劑)의 상호작용(相互作用))

  • Shim, I.S.;Oh, Y.B.;Bae, S.H.;Pyon, J.Y.
    • Korean Journal of Weed Science
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    • v.4 no.2
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    • pp.188-193
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    • 1984
  • Interactions of herbicide mixtures were assessed for effective control of annual and perennial paddy weeds by isobole method(90% control) using Echinochloa crusgalli Beauv. var. oryzicola Ohwi, Scirpus hotarui Ohwi, Sagittaria pygrnaea Miquel, and Cyperus serotinus Rottb which are dominated in the paddy field of Korea. Mixture of butachlor and pyrazolate showed additive effect for control of E. crusgalli Beauv. var. oryzicola Ohwi, S. hotarui Ohwi and C. serotinus Rottb, but synergistic effect for control of S. pygmaea Miquel. Interaction of bifenox and bromobutamide showed synergistic effect to E. crusgalli Beauv. var oryzicola Ohwi and C. Serotinus Rottb, but slightly antagonistic effect to S. pygmaeo Miquel.

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Alternative Herbicides to Control Herbicide-Resistant and Troublesome Weeds in Paddy Fields (제초제 저항성 및 난방제 잡초 방제를 위한 제초제 선발)

  • Park, Tae-Seon;Lee, In-Yong;Seong, Ki-Yeong;Cho, Hyun-Suk;Kim, Mi-Hyang;Yang, Woon-Ho;Seo, Myung-Chul;Kang, Hang-Won
    • Weed & Turfgrass Science
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    • v.2 no.3
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    • pp.248-253
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    • 2013
  • This study was conducted to select alternative herbicides to control herbicide-resistant and - troublesome weeds in rice fields, Korea. The resistant Echinochloa oryzicola to ACCase inhibitor was tested by herbicides registered to control Echinochloa oryzicola. And the resistant and troublesome weeds to sulfonylurea (SU) herbicides, ALS inhibitors, were tested by widely using herbicides to control the resistant weeds in Korea. The oxadiazon, pyrazolate, pretilachlor and benzobicyclone+thiobencarb effectively controlled resistant Echinochloa oryzicola to ACCase and ALS inhibitors at 0.5 leaf stage of the, Herbicides containing mefenacet or fentrazamide controlled effectively by the 2 leaf stage. In controlling other SU resistant weeds including Sagittaria trifolia and Ludwigia prostrate, benzobicyclon and mesotrione performed well all tested weeds, and carfentrazone and pytazolate were effective to broadleaf weeds. Sagittaria trifolia and Ludwigia prostrate, which were suspected to be resistance to SU herbicides, were well controlled by carfentrazone and pytazolate.

Isolation and Characteristics of Soil Microorganisms Degrading Herbicide Napropamide (제초제(除草劑) Napropamide의 분해미생물(分解微生物)의 분리(分離) 및 분해특성(分解特性))

  • Han, S.S.
    • Korean Journal of Weed Science
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    • v.15 no.1
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    • pp.63-72
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    • 1995
  • This study was carried out to isolate the soil bacteria degrading herbicide napropamide [N,N-diethyl-2-(1-naphthoxy)-propionamide] from the clayey loam soil tested and to clarify the characteristics of the napropamide-degrading bacteria. Twenty strains of the gram-positive and the gram-negative bacteria were isolated and identified from the clayey loam soil tested. Most of them were vigorously proliferated at 100ppm of napropamide and two strains of Staphylococcus spp., Corynebacterium spp. II and Other spp. II were very tolerated to napropamide even at the concentration of 1500ppm. Staphylococcus spp. II and Actinobacillus spp. II of the isolated bacteria degraded more than 20% of the treated napropamide. These two strains could not utilize napropamide as sole nitrogen sources, but could use this compound as sole carbon sources. Napropamide was rapidly decomposed by Staphylococcus spp. II at one-time application and at three-time application of napropamide, but wasn't at two-time application of napropamide.

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