• Journal of Korean Biological Nursing Science
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• v.8 no.2
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• pp.5-12
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• 2006

목적 : 본 연구는 암환자 및 암의 유형에 따라 중요한 종양억제 조절인자로 알려져 있는 모노카인을 flowcytometry를 이용하여 분석, 비교하고자 하였다. 방법 : 연구대상은 고형종양(solid tumor)으로 진단받은 33세에서 76세 사이의 암환자 30명(유방암, 난소암, 폐암, 위암)을 대상으로 말초혈액 단구의 intracellular monokine 중 $TNF{\alpha}$, MIG, MIP를 분석한 유사실험설계 연구이다. 연구결과 : 암환자 군에서의 $TNF{\alpha}$, MIG, MIP 수치는 대조 군인 정상 군에 비해서 유의하게 증가되었으며 특히, 유방암과 난소암 환자 군에서의 $TNF{\alpha}$ 수치는 폐암과 위암의 대상자에 비해 의미 있는 차이를 보여주었다. 논의 : 본 연구에서 제시된 암환자 군에서의 모노카인 수치는 선행연구의 결과와 통일하게 종양 대상자의 면역에 중요한 역할을 하는 것으로 규명 되었으나, $TNF{\alpha}$는 고형종양 중에서도 여성생식기계 암환자 군에서 더 증가하였다. 이에 따라 종양 유형에 따른 모노카인의 역할과 호르몬과의 상호작용기전 규명에 대한 추후 연구가 필요하다.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.7
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• pp.281-290
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• 2019

This study analyzed the recognition types of the economic burden for cancer treatment and the characteristics of each recognition type by employing Q methodology. For this study, we determined the final 45 Q statements by conducting literature surveys, internet searches and in-depth interviews. The P samples are 35 people of cancer patients, their family members, and experts. The Q statements were classified according to the forced normal distribution method and the collected data was analyzed using the PC QUANL program. For the analysis results, we extracted four recognition types on the economic burden of cancer treatment, and we named them 'uncertain anxiety', 'acceptance by family burden', 'object to challenge with active response' and 'insurance preparation', depending on their characteristics. The results of this study can be used as a basis for preparing the clinical intervention plan and the policies for cancer patients and the families involved in the fields of medicine, nursing and social welfare.

• Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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• 2002.09a
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• pp.219-224
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• 2002

충북 청원군 미원면 금관-원룡리 일대를 따라 발달된 화전리층(상층)과 구룡산층 분포지역에서, 기반암에 따른 지하수 및 지표수의 수질특성의 차이를 규명하고자 하였다. 화전리층(상층)지역의 경우 Ca-(HCO$_3$+.CO$_3$) 유형을, 구룡산층 지역의 경우 (Ca,Mg)-SO$_4$ 및 (Ca,Mg)-HCO$_3$ 유형을 보였다. 지하수의 경우, 화전리층(상층) 지역은 주고 탄산염광물의 풍화에 의해, 구룡산층 지역은 주로 규산염광물의 풍화에 의해 수질특성이 결정됨을 보였으며, 이러한 차이는 통계분석 방법으로 확인할 수 있었다. 지표수의 경우, 한 지점을 제외하고는 대부분이 암반 기원으로 도시되어 기반암의 영향이 수질특성을 좌우하고 있음을 보였다. 본 연구의 결과는, 지하수ㆍ지표수 각각의 수질 특성이 지역적인 기반암 종류에 따름을 확인시켜주는 바, 국가적인 수질관리정책은 지역적인 지질매체의 차이를 고려하면서 수립 ㆍ시행되어야 함을 보여준다.

• Proceedings of the Korean Information Science Society Conference
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• 2005.11b
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• pp.262-264
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• 2005

인유두종 바이러스(Human Papillomavirus: HPV)는 사마귀로부터 생식기 및 배설기의 침윤성 암에 이르기까지 여러 질병과 연관되어 있음이 알려져 있다. 현재 200종 이상이 알려져 있고, 이 중 85개는 전체 유전자가 밝혀져 있다. HPV 감염 시 만들어지는 단백질 중 E6. E7 단백질은 암 억제 유전자(p53, pRb)에 결합하여 세포의 암 억제 기능을 저하시키고 이로 인해 암을 발생시킨다. 본 논문은 암 발생과 밀접한 관련이 있는 HPV의 E6 단백질 서열과 HPV 유형(HPV Type)을 가지고, PLSA (Probabilistic Latent Semantic Analysis) 방법을 이용하여 HPV를 클러스터링(clustering) 해 보았다. 실험 결과, 특정 클러스터는 질병과 밀접하게 연관되어 있으며, 이와 관련된 주요 서열 분석이 가능함을 보여주고 있다.

• Economic and Environmental Geology
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• v.30 no.6
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• pp.603-612
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• 1997

Cretaceous sedimentary-volcanoclastic formations of the Kyeongsang Supergroup were intruded by granitic rocks in the late Cretaceous and early Tertiary. In the Euiseong and Shinryeong area, these intrusives have various compositions including gabbro, diorite，biotite granite and feldspar porphyry. Associated volcanic rocks consist of two chemically distinct types: the bimodal suite of basalt and rhyolite in the Keumseongsan caldera, and the felsic suite of andesite and rhyolite in the Sunamsan-Hwasan calderas. Most rocks are subalkaline, and follow a typical differentiation path of the calc-alkaline magma. The granitic rocks can be distinguished chemically from the volcanics by high Zr/Y ratios. Differences in Zr/Y and K/Y ratios between the two volcanic suites can be accounted for by mantle source and fractionation. Chondrite-normalized trace element abundances of granitic rocks are depleted in Th and K, whereas those of the Keumseongsan rhyolites are depleted in Sr and Ti. Rb, La and Ce is enriched in rhyolites of the Sunamsan-Hwasan calderas. $Rb-SiO_2$ and Rb-Y+Nb discrimination diagrams suggest that the intrusives and volcanics have a volcanic arc setting. K-Ar ages indicate four plutonic episodes : diorite (89 Ma), granite (66~62 Ma), granite and porphyry (55~52 Ma) and gabbro (52~45 Ma), and two volcanisms : bimodal basaltic and rhyolitic volcanism (71~66 Ma) in the Keumseongsan caldera, and felsic andesitic and rhyolitic volcanism (61~54 Ma) in the Sunamsan-Hwasan calderas. Geochemical and age data thus suggest that the igneous rocks are related to several geologic episodes during the late Cretaceous to early Tertiary.

• Spatial Information Research
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• v.20 no.6
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• pp.23-32
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• 2012

This study applied an exploratory analysis based on Self Organizing Map and GIS to cause specific age-standardized regional death rates data related to ten types of male cancers to find meaning patterns in the data. Then the patterns revealed from the exploratory analysis was evaluated to investigate possible relationship between these patterns and regional socio-economic status represented by regional educational attainment levels of head of household. The results from this analysis show that SI-GUN-GUs in Korea can be clustered to eighteen unique clusters in the stand point of male cancer death rates and these clusters are also spatially clustered. Also, the results reveal that regions with higher socio-economic status show lower level of the death rates compared with the regions with lower socio-economic status. However, for some cancer types, the regions with higher socio-economic status show relatively higher death rates. These patterns imply that the prevention, detection, and treatment of male cancers might be strongly affected by regional factors such as socio-economic status, environmental factors, and cultures and norms in Korea. Especially, one of the eighteen clusters, which includes Gangnam-Gu and Seocho-Gu, shows lower death rates in many of male cancer types. This implies that socio-economic status may be one of the most influential factors for regional cancer control.

• The Journal of Korean Society for School & Community Health Education
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• v.25 no.2
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• pp.45-57
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• 2024

Objectives: The purpose of this study is to determine the impact of artificial menopause on the diagnosis of thyroid cancer, breast cancer, and cervical cancer, and to provide basic data for cancer prevention and early diagnosis in women. Methods: Analysis was conducted using raw data from the 2011-2020 National Health and Nutrition Examination Survey. Among the 79,262 people surveyed in the 2011-2020 National Health and Nutrition Examination Survey, 10,207 people were selected as the final research subjects, excluding men, those under 18 years old, those over 80 years old, those who did not participate in the health survey, those with missing data, and those who were not in menopause. Among them, 248 people were diagnosed with thyroid cancer (2.7%), 225 people were diagnosed with breast cancer (2.5%), and 143 people were diagnosed with cervical cancer (21.5%). Results: First, there appeared to be differences between the thyroid cancer diagnosed group and the non-diagnosed group depending on educational level, childbirth experience, and menopause type. Second, there appeared to be differences between the breast cancer diagnosis group and the non-diagnosis group depending on educational level, menopause age, pregnancy experience, childbirth experience, subjective health status, and menopause type. Third, there appeared to be differences between the cervical cancer diagnosis group and the non-diagnosis group depending on menopause age, subjective health status, and menopause type. Fourth, compared to natural menopause, in the case of artificial menopause, the diagnosis probability of women increased by 2.010 times for thyroid cancer, 3.872 times for breast cancer, and 14.902 times for cervical cancer. Conclusion: For thyroid cancer, breast cancer, and cervical cancer, the probability of cancer diagnosis increases in the case of artificial menopause compared to natural menopause, so it is considered important to avoid experiencing artificial menopause to prevent cancer.

• Proceedings of the Korean Information Science Society Conference
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• 2012.06c
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• pp.19-21
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• 2012

모든 암 세포는 체세포 변이를 동반한다. 따라서 암 유전체 변이 분석에 의하여 암을 발생시키는 유전자 및 진단/치료법을 찾아낼 수 있다. 본 연구에서는 차세대 시퀀싱 데이터를 이용하여 암 특이적 단이 반복 변이(copy number variation, CNV) 유형을 밝히는 새로운 알고리즘을 제안한다. 제안하는 방식은 암 환자의 정상 세포와 암세포로부터 얻어진 정상 유전체와 암 유전체를 동시 분석하여 각각 CNV 후보 영역을 추출하며, 통계적 유의성 분석을 통하여 암 특이적 CNV 후보 영역을 선별하고, 다음 후처리 과정에서 참조 표준 서열(reference sequence)에 존재하는 오류 영역 보정 작업을 수행하여 정확한 암 특이적 CNV 영역을 추출해 낸다. 또한 다수의 대용량 유전체 데이터 동시 분석을 위하여 맵리듀스(MapReduce) 기법을 기반으로 하는 병렬 수행 알고리즘을 제안한다.

• The Journal of Engineering Geology
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• v.33 no.3
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• pp.427-438
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• 2023

We carried out a geological survey to classify the types of mass movement in Danyang Geopark (where various rock types are distributed) and analyzed the mechanical and hydraulic characteristics of landslide materials using a series of laboratory tests. Debris flows occurred in areas of limestone/marble, shale, and porphyroblastic gneiss, and limestone/marble landslides were distinguished from the others through the presence of karren topography. Soil tests showed that soil derived from weathered gneiss, which has a higher proportion of coarse grains, has a higher friction angle, lower cohesion, and larger hydraulic conductivity than soils from areas of limestone/marble, and shale. Rock failure mass movements occurred in areas of phyllite, sandstone, and conglomerate and were subdivided into plane failure, block-fall, and boulder-fall types in areas of phyllite, sandstone, and conglomerate, respectively. The shear strength of phyllite is much lower than that of the other types of rock, which have similar rock quality. The slake durability index of the conglomerate is similar to that of the other rock types, which have similar degrees of weathering, but differential weathering of the matrix and clasts was clearly observed when comparing the samples before and after the test. This study can help establish appropriate reinforcement and disaster prevention measures, which depend on the type of mass movement expected given the geological characteristics of an area.

• The Journal of the Convergence on Culture Technology
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• v.6 no.4
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• pp.643-653
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• 2020

This study is a descriptive research study to identify the relationship between cancer fatigue, quality of sleep, environmental sleep disturbance, and comfort perceived by hospitalized cancer patients. Data were collected with structured questionnaires from 113 cancer patients from a university hospital in J city, Gyengnam, from September 17 to November 5, 2019, and analyzed using SPSS 21.0, using independent t-test, one-way ANOVA, Scheffé test, Pearson's correlation coefficient, and stepwise multiple regression. The subjects' Comfort is significantly different depending on education level, Cancerous type, Radiation treatment status, Usual exercise status. The result showed that comfort was negatively correlated with cancer fatigue(r=-.609, p<.001), quality of sleep(r=-.478, p<.001), and environmental sleep disturbance(r=-.297, p=.001). The variables that had a significant effect on comfort were cancer fatigue(β=-.42, p<.001), subjective quality of sleep(β=-.30, p=.001), and cancer type(β=-.18, p<.015), and the explanatory power was 46.1%(F=27.24, p<.001). Based on these results, it is necessary to develop a program to improve the quality of sleep and to reduce the cancer fatigue by cooperating with medical and nursing staff in multidisciplinary ways to enhance the comfort of hospitalized cancer patients.