• Journal of the Korean Society of Food Science and Nutrition
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• v.26 no.2
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• pp.319-326
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• 1997

This study was conducted to investigate the effects of methionine(Met) and selenium(Se) levels on alcohol metabolic enzyme system in rats. Sprague-Dawley male rats were fed on diets containing one of the three levels of Met(0, 3, 9g/kg diet) with or without Se(0.45mg/kg diet). Alcohol was administrated with 25%(v/v) ethanol orally at the same time once a day in alcohol group and isocaloric sucrose was administrated to the control group. The rats were sacrificed after 5 and 10 week of feeding periods. Alcohol dehydrogenase(ADH) and microsomal ethanol oxidizing system(MEOS) activities of hepatic tissuedom were increased more in alcohol treated groups than control group. Increment of activities preinated in simultaneous deficiency of dietary Met and Se(LMet-Se+EtOH) group. Aldehyde dehydrogenase (AIDH) activity was decreased more in alcohol treated groups than control group and significantly decreased in Met and Se supplemented(NMet+Se+EtOH) group. Hepatic cytochrome P-450 content and xanthine oxidase(XO) activity were significantly increased in alcohol treated groups Compared to control group and predominated in Met deficiency(LMet) group and excessive Met administration (HMet) group. Superoxide dismutase(SOD), catalase, glutathione S-transferase(GST) activities tended to increase by alcohol administration, the degree of increase predominated in 10 week. The activity of glutathione peroxidase(GSH-Px) was decreased in alcohol groups and tended to increase in proportion to the level of dietary Met.

• The Journal of the Korea Contents Association
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• v.9 no.6
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• pp.237-246
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• 2009

This study was carried out to investigate of the associations of Alcoholic & Nonalcoholic fatty liver disease(AFLD & NAFLD) with metabolic syndrome(MS) defined by IDF criteria. We conducted a cross-sectional study of 799 adult males with alcohol consumption underwent laboratory investigation(control 297, alcoholic 206, nonalcoholic 296). The ultrasound scan of the liver was performed to determine the presence and the severity of FLD. We analyzed the association between the severity of AFLD & NAFLD and MS by logistic regression analysis. The distribution of metabolic syndrome was 7.4%, 48.8%, 34.9% in control, AFLD & NAFLD. The association of blood pressure, glucose, triglycerides, obesity were risk factor in AFLD & NAFLD. According to the severity of FLD, AFLD was significantly increased with MS, Obesity, low HDL-cholesterol. MS, High triglycerides was increased significantly in NAFLD(p<0.05). The prevalence of AFLD & NAFLD was increased with increasing the number of features of metabolic syndrome. This study shows that AFLD & NAFLD was closely associated with MS and its components. The patients of AFLD & NAFLD should managed and monitored to prevent metabolic abnormalities.

• Applied Biological Chemistry
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• v.42 no.2
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• pp.162-165
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• 1999

Effects of compounds isolated from Ainsliaea acerifolia on alcohol metabolism in rats were examined and the results were as follows: Apigenin $7-O-{\beta}-D-glucoside$, after a single oral administration to rats, was found to cause a significant decrease in the serum ethanol concentration as well as enhancement of liver cytosolic alcohol dehydrogenase(ADH) activity.

• Korean Journal of Food Science and Technology
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• v.41 no.6
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• pp.706-711
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• 2009

Hepatoprotective effects of corn gluten hydrolysates (CGH) were investigated in rats orally treated with ethanol (30%(v/v), 3 g/kg body weight/day) for 4 weeks. Six-week old Sprague-Dawley male rats were divided into four dietary groups: normal diet (N), alcohol diet (E), E+CGH 1% diet (CGH-1%), and E+CGH 3% diet (CGH-3%). Body weights and liver indices were not significantly different among the four groups. However, food intakes were lower in the CGH groups than in the normal group (p<0.05). The administration of CGH significantly reduced serum alkaline phosphatase activity by 30% compared to the alcohol diet group. Among the antioxidative enzymes assessed, catalase activity was significantly decreased by 79% in the CGH diet groups compared to the alcohol diet group. In comparison to the alcohol-treated group, aldehyde dehydrogenase activity was increased by 20%, while microsomal ethanol oxidizing system activity was decreased by 20% in the CGH-treated groups. Furthermore, the area under the curve of the blood acetaldehyde concentration versus time profile after the administration of ethanol was significantly lower for the CGH rats than for the ethanol or asparaginic acid treated groups. Thus, CGH seems to offer beneficial effects by protecting against ethanol-induced hepatotoxicity by improving the acetaldehyde-related metabolizing system.

• Food preservation and processing industry
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• v.3 no.1
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• pp.81-87
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• 2004

• Journal of the Korean Society of Food Science and Nutrition
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• v.31 no.1
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• pp.92-97
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• 2002

The effects of Pueraria flos (PF) and Pueraria radix (PR) water extract on the hepatic alcohol metabolic enzyme activities were examined in rats that were orally administered ethanol (25% v/v, 5g/kg body weight/day) for 5 weeks. The PF and PR water extract were supplemented in a diet, based on 1.2 g or 2.4 g of raw PF or PR/kg body weight/body. Alcohol administration without the PF or PR supplementation significantly decreased net weight gain, feed intake and feed efficiency ratio. However. both dose of the PF of PR supplementation resulted in significant enhancement of growth and suppression of increased relative weight of liver, brain and heart by alcohol administration. Activities of hepatic alcohol dehydrogenase and microsomal ethanol oxidizing system were higher in the alcohol treated group than in the normal group, while aldehyde dehydrogenase activity was significantly lowered in the alcohol treated group. The hepatic metabolic enzyme activities altered by alcohol administration were normalized by both doses of PF or PR supplement. Hepatic monoamine oxidase activity and hydrogen peroxide, which were significantly higher in the alcohol treated group than in the normal group, were also decreased by the supplementation with either PF or PR. These results indicate that low-or high-supplementation of either water extract PF or PR may alleviate ethanol-induced hepatotoxicity by altering alcohol metabolic enzyme activities.

• Journal of the Korean Society of Food Science and Nutrition
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• v.37 no.3
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• pp.396-400
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• 2008

The effect of Paecilomyces tenuipes water extract (PTWE) on the alcohol metabolism was examined on rats. PTWE of 0, 30, 100 mg/kg body weight was administrated orally to the rats 30 min before oral treatment of 3 g/kg body weight of alcohol. Blood alcohol and acetaldehyde concentrations were measured 0.5, 1, 3, 6, 9 hr after alcohol treatment. Hepatic alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ADH), microsomal ethanol oxidizing system (MEOS) activities were measured 9 hr after alcohol treatment. There were no differences in blood alcohol concentrations and area under the curve (AUC) of alcohol. PTWE decreased acetaldehyde concentration and there were significant differences after 6 hr in 30 mg/kg PTWE and after 3 and 9 hr in 100 mg/kg PTWE, respectively. In particular, 100 mg/kg PTWE decreased AUC of acetaldehyde by 44%. However, there were no changes in the hepatic ADH, ALDH, and MEOS activities.

• Journal of the Korean Society of Food Science and Nutrition
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• v.38 no.10
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• pp.1342-1346
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• 2009

This study was conducted to investigate the effect of Pepino extract on alcohol metabolism in male Sprague-Dawley rats. When the rats were given Pepino extract 30 min before 60% alcohol (4 g/kg B.W) administration, alcohol concentration in blood was significantly reduced, but acetaldehyde concentration was not significantly different, compared with the control group after 3 hrs of alcohol administration. When the rats were given Pepino extract ($1^{\circ},\;5^{\circ},\;10^{\circ},\;&\;15^{\circ}$ Brix) 30 min before 60% alcohol administration, alcohol concentration in blood with $1^{\circ}$ Brix Pepino extract was 44% after 3 hrs of alcohol administration, compared with the control group. When the rats were given with $1^{\circ}$ Brix Pepino extract at 30 min before 60% alcohol administration, alcohol concentration in blood was significantly reduced after one hour and acetaldehyde concentration was reduced by 19% after 5 hrs of alcohol administration, compared with the control group. Glutamate-oxaloacetate transaminase and glutamate-pyruvate transaminase activities were not significantly different in all experimental groups, compared with the control group. These results suggest that Pepino extract can be effective in alcohol metabolism in the alcohol-treated rats.

• Applied Biological Chemistry
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• v.41 no.6
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• pp.447-450
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• 1998

Effects of organic solvents fraction from Ainsliaea acerifolia ethanol extract on alcohol metabolism in rats were examined and the results were as follows: Ethanol souble fraction, after a single oral administration to rats, was found to cause a significant decrease in the serum ethanol concentration as well as enhancement of liver cytosolic alcohol dehydrogenase(ADH) activity, on the other hand, the fraction insouble in ethanol was found to cause an increase ethanol concentration in the blood and inhibit ADH activity.

• Journal of the Korean Society of Food Science and Nutrition
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• v.37 no.4
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• pp.422-427
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• 2008

The effect of plum wine on lipid metabolism and lipid peroxidation in rats with chronic ethanol consumption was evaluated. Sprague-Dawley rats were randomly divided into the following 4 groups; water (NC), alcohol control (AC), low concentration plum wine (LP) and plum wine (P). The alcohol content of experimental drinking water of AC, LP and P were 6%, 6% and 12%, respectively. Animals were fed AIN-76 diet and experimental drinking water for 4 weeks. LP group showed significantly decreased liver weight per 100 g body weight, the levels of total cholesterol and atherogenic index in plasma whereas the ratio of HDL-cholesterol to total cholesterol was significantly increased in comparison to that of AC group. LP and P groups showed significantly decreased total lipid, total cholesterol in liver tissue, AST and ALT activities of plasma as compared with that of AC group. LP and P groups showed a significant decrease in the level of plasma lipid peroxidation products and LP group showed a significant decrease in the level of liver lipid peroxidation products as compared with that of AC group. These results suggest that supplementation of low concentration plum wine may exert more beneficial effects than pure alcohol beverage on lipid metabolism and lipid peroxidation products in chronically alcohol-treated animals by improving lipid profiles in plasma and liver tissues and decreasing plasma and hepatic lipid peroxidation product.