Browse > Article
http://dx.doi.org/10.3746/jkfn.2008.37.3.396

Effects of Paecilomyces tenuipes Water Extract on the Alcohol Metabolism of Rats  

Kim, Ji-Myung (Dept. of Food and Nutritional Sciences, Hanbuk University)
Park, Jae-Hwan (Food Convergence Technology Division, Korea Food Research Institute)
Kim, Mi-Kyung (Dept. of Food and Nutritional Science, Ewha Womans University)
Chun, Hyang-Sook (Food Convergence Technology Division, Korea Food Research Institute)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.37, no.3, 2008 , pp. 396-400 More about this Journal
Abstract
The effect of Paecilomyces tenuipes water extract (PTWE) on the alcohol metabolism was examined on rats. PTWE of 0, 30, 100 mg/kg body weight was administrated orally to the rats 30 min before oral treatment of 3 g/kg body weight of alcohol. Blood alcohol and acetaldehyde concentrations were measured 0.5, 1, 3, 6, 9 hr after alcohol treatment. Hepatic alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ADH), microsomal ethanol oxidizing system (MEOS) activities were measured 9 hr after alcohol treatment. There were no differences in blood alcohol concentrations and area under the curve (AUC) of alcohol. PTWE decreased acetaldehyde concentration and there were significant differences after 6 hr in 30 mg/kg PTWE and after 3 and 9 hr in 100 mg/kg PTWE, respectively. In particular, 100 mg/kg PTWE decreased AUC of acetaldehyde by 44%. However, there were no changes in the hepatic ADH, ALDH, and MEOS activities.
Keywords
Paecilomyces tenuipes water extract (PTWE); alcohol; acetaldehyde; area under the curve (AUC);
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
Times Cited By SCOPUS : 0
연도 인용수 순위
1 Umulis DM, Gurmen NM, Singh P, Fogler HS. 2005. A physiologically based model for ethanol and acetaldehyde metabolism in human beings. Alcohol 35: 3-12   DOI   ScienceOn
2 Zakhari S. 2006. Overview: how is alcohol metabolized by the body? Alcohol Res Health 29: 245-254
3 Kim TW, Song OK, Han SY, Cao QR, Park MJ, Kang SH, Sin KW, Cui JH, Lee BJ. 2005. Bioavailability of cefaclor capsules using an improved analytical method of cefaclor in human plasma. J Kor Pharm Sci 35: 117-122   과학기술학회마을   DOI   ScienceOn
4 Cho JY, Kim AR, Yeon JD, Lim SW, Lee JH, Yoo ES, Yu YH, Park MH. 1997. Effects of combined preparation (DWP715) containing Alaska pollack extract, maltol, ascorbic acid and nicotinamide on decreasing of blood alcohol concentration, anti-fatigue and anti-oxidation. Korean J Food Sci Technol 29: 167-172   과학기술학회마을
5 Castro GD, de Castro CR, Maciel ME, Fanelli SL. 2006. Ethanol-induced oxidative stress and acetaldehyde formation in rat mammary tissue: Potential factors involved in alcohol drinking promotion of breast cancer. Toxicology 219: 208-219   DOI   ScienceOn
6 Cho SY. 1999. Cultivation and distribution of silkworm-dongchunghacho (Paecilomyces japonica). Paper presented at 1st International Symposium on Cordyceps. The Korean Society Sericultural Science and the Korean Society of Life Science, Seoul, Korea. p 73-82
7 Kim CI. 1999. Cause and effect of hangover. Food Ind Nutr 4: 26-30   과학기술학회마을
8 Shim JY, Lee YS, Lim SS, Shin KH, Hyun JE, Kim SY, Lee EB. 2000. Pharmacological activities of Paecilomyces japonica, a new type Cordyceps sp. Kor J Pharmacogn 31: 163-167   과학기술학회마을
9 Helander A, Tottmar O. 1988. Effect of acute ethanol administration on human blood aldehyde dehydrogenase activity. Alcohol Clin Exp Res 12: 643-646   DOI   ScienceOn
10 Bergmeyer HU. 1974. Alcohol dehydrogenase. In Methods of Enzymatic Analysis. Academic Press, New York. Vol 2, p 428-429
11 Tottmar SO, Petterson H, Kiessling KH. 1973. The subcellular distribution and properties of aldehyde dehydrogenase in rat liver. Biochem J 135: 577-586   DOI
12 Bae JW. 1999. Effects of red-ginseng extract on pharmacokinetics of ethanol. J Ginseng Res 23: 172-175   과학기술학회마을
13 Shim JS, Min EG, Han YH. 2000. Cytotoxicity against human cancer cell lines by Paecilomyces tenuipes DUGM 32001. Kor J Microbiol 36: 312-315   과학기술학회마을
14 Kwon SH, Woo HJ, Han DS, Kim MK. 2001. Effect of dried powders and water extracts of Paecilomyces tenuipes and Cordyceps militaris on lipid metabolism, antioxidative capacity and immune status in rats. Kor J Nutr 34: 271-284   과학기술학회마을
15 Jornvall H, Hoog JO, Bahr-Lindstrom H, Johanson J, Kaiser R, Person R. 1988. Alcohol dehydrogenase and aldehyde dehydrogenase. Biochem Soc Trans 16: 223-227   DOI
16 Lieber CS. 1994. Alcohol and the liver: 1994 Update. Gastroenterol 106: 1085-1105   DOI
17 Ramchandani VA, Bosron WF, Li TK. 2001. Research advances in ethanol metabolism. Pathol Biol 49: 676-682   DOI   ScienceOn
18 Park SC. 1993. Ethanol oxidation is accelerated by augmentation of malate-aspartate shuttle with aspartate. Kor J Biochem 25: 137-143