• Title/Summary/Keyword: 안전성 평가지표

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Effect of Pu'er tea extract on C2C12 myoblast differentiation (보이차 열수 추출물의 근아세포 근분화에 미치는 영향)

  • Lee, Hyoseong;Choi, Sunkyung;Lee, Boyeong;Kim, Eunmi;Lee, Woonghee;Han, Hyosang;Kim, Keekwang
    • Journal of Digital Convergence
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    • v.18 no.12
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    • pp.585-594
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    • 2020
  • At present, aging-related degenerative muscle diseases are considered a serious problem. However, the drug effect on the treatment and prevention of sarcopenia has not been investigated. The purpose of this study was to evaluate the value of extract of Pu'er tea as a remedy to alleviate the symptoms of sarcopenia. Pu'er tea extracts showed excellent radical scavenging ability. The expression of Myh3 was promoted and myotube formation also was increased by treatment of Pu'er tea extracts. These results suggest that Pu'er tea is a natural substance that promotes myogenesis, and is valuable as a material for pharmaceutical research on the prevention and treatment of various muscle diseases, including sarcopenia. And It is necessary to confirm specific indicator substances of puer tea and further study on this.

Economic Evaluation System for Deteriorated Military Facilities (노후 군시설물의 경제성 평가 시스템)

  • Jang, Won-Suk;Lim, Tae-Kyung;Lee, Dong-Eun
    • Journal of the Korea Institute of Building Construction
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    • v.13 no.2
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    • pp.181-192
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    • 2013
  • Given both structural safety and economic benefits of aging facilities, remodelling of the existing facilities is preferable to reconstruction. This recognition provides an opportunity to reduce the commitment of resources and national budget. However, when a subordinate troop asks for remodeling or reconstruction of a deteriorated facility, it is difficult to ensure the consistency and objectivity in the process of decision making for the alternatives due to the absence of systematic and quantitative rating methodology. Their economic evaluation methodology only exists in a manual format. Thus, further research is required for converting the methodology into an automated system in view of practicality such as rapid and accurate data processing. The contributions of this study are as follows: 1) Literature review found out a representative economic evaluation model focused on military facilities, and comparative analysis with a similar study identified the strength and weakness. 2) this study presented how to convert the theoretical framework which enables to solve a specific subject matter into an automated system. 3) it developed a user friendly interfaces which consist of four functional modules by considering the usability and accessibility of the system user. 4) the developed system was verified by a case study in terms of four kinds of performance indicators.

Evaluation technique for efficiency of fishway based on hydraulic analysis (수리해석을 기반으로 어도 효율을 평가하는 기법)

  • Baek, Kyong Oh
    • Journal of Korea Water Resources Association
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    • v.52 no.spc2
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    • pp.855-863
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    • 2019
  • The efficiency of fishway installed in rivers can be directly evaluated by means of fish monitoring. On the other hand, when it is difficult to monitor the fish in certain conditions, or when planning a fishway, the efficiency can be evaluated indirectly through the hydraulic analysis. In this study, the hydraulic analysis technique for evaluating the efficiency of a fishway was presented. The River-2D model with the fish physical habitat module was used for the analysis of the attraction efficiency, and the weighted usable area was proposed as an index of the efficiency. In the analysis of passage efficiency, the three-dimensional model, Flow-3D, was used as an evaluation tool to describe the fluid behavior on a hydraulic structure with free surface. The ice-harbor type fishway at Baekgok weir in the Deokcheon River was selected as a test-site, and the efficiency was estimated using the hydraulic analysis. And then it was compared with fish monitoring data acquired from the river. As a result, it is difficult to replace the hydraulic analysis results with the efficiency quantitatively, but it can help to grasp the general tendency.

Studies on Anti-Wrinkle and Whitening Effects of Liposomes Containing Acerola Extract Mixture (아세로라 추출물 혼합 리포좀의 주름, 미백 효과에 대한 연구)

  • Kim, Su Jin;Oh, Won Jun;Kwon, Sung Pil;Nam, Gaewon
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.47 no.4
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    • pp.341-352
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    • 2021
  • Acerola is an excellent ingredient because of its high natural vitamin C content, but it is difficult to stabilize and has hardly been studied as a cosmetic material. Therefore, this study developed a mixed liposome preparation for stabilizing acerola extract. As a safety test, the skin irritation test was evaluated by BCOP assay and HET-CAM assay. We evaluated the inhibition of tyrosinase activity, the whitening effect of melanin production, and the wrinkle effect of prochloragentype-I C-peptide production, and confirmed the possibility of functional cosmetics. In addition, a cream of liposomes containing acerola extract mixture was developed to evaluate the clinical studies of skin wrinkles and whitening. BCOP assay, HET-CAM assay and human skin primary irritation test results of liposomes containing acerola extract mixture showed no irritation and were safe from skin and eye. The result of tyrosinase activity by 75.8% at 1,000 ㎍/mL. As a result of the melanogenesis inhibition test, liposome with acerola extract showed the melanin content by 46.2% at 1,000 ㎍/mL that does not effect the viability of the B16F10 cell line. The result of collagen production test using ELISA kit, liposomes containing acerola extract mixture showed collagen synthesis ability by 152.1% at 1,000 ㎍/mL that does not affect the viability of the HS68 cell line. But it did not showed any inhibition of collagenase (MMP-1) activity at all concentrations in the MMP-1 activity inhibition test in the HS68 cell line. We performed clinical studies for the whitening and skin-wrinkle activity of cream containing acerola extract mixes liposome, was showed that the melanin contents and wrinkle was statistically significant reduction. These results suggest that liposomes containing acerola extract mixture have safe natural material, and skin wrinkle, whitening effects allowing their application in cosmetics as a natural product.

Investigation of Microbial Contamination Levels between GAP and non-GAP Certified Farms of Lettuce and Cucumber (GAP 인증·미인증 상추 및 오이 농가의 미생물학적 오염도 평가)

  • Kim, Jeong-Sook;Chung, Duck-Hwa;Shim, Won-Bo
    • Journal of Food Hygiene and Safety
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    • v.31 no.6
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    • pp.414-419
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    • 2016
  • The aims of this study were to investigate microbial contamination levels and to survey sanitation management between Good Agricultural Practices (GAP) and non-GAP farms of lettuce and cucumber. The samples (lettuce, cucumber, soil, agricultural water, gloves, and packing plastic bag) were tested to analyze sanitary indicator bacteria (total aerobic bacteria, coliforms and Escherichia coli) and major pathogenic bacteria (Staphylococcus aureus, Bacillus cereus). In the lettuce farms, the contamination levels of total aerobic bacteria and coliforms in GAP farms were little lower than non-GAP farms or similar. Staphylococcus aureus and Bacillus cereus in soil and agricultural water of GAP farms were detected at higher levels than non-GAP farms in soil and agricultural water. In the case of cucumber farms, levels of total bacteria and Bacillus cereus in soil and total bacteria and coliform in gloves of GAP farms were higher than those of non-GAP farms, and other bacteria contamination levels in collected samples were similar. These results indicate that agricultural products produced from GAP farm still exhibited potential microbial risks. According to the field survey, a sanitation management in GAP farms was insufficient. These results could be useful as basic data to suggestion of plan for preventing microbial contamination and to improvement of GAP certification.

Drivers' Workloads through the Driving Vehicle Test at Intersections (교차로 실차주행 실험을 통한 운전자 부하요인에 관한 연구)

  • Seo, Im-Ki;Park, Je-Jin;Sung, Soo-Lyeon;NamGung, Moon
    • The Journal of The Korea Institute of Intelligent Transport Systems
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    • v.11 no.3
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    • pp.112-123
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    • 2012
  • Different from general roads, intersections are the points where roads having different geometric structure and traffic operation system are met, and thereby they have complicated road structure and environmental factors. Various changes in driving patterns such as collision between vehicles approaching from roads adjacent to intersections, sudden stop of vehicles upon stop sign, quick start upon green lights kept increasing traffic accidents. It is known that traffic accidents are mainly derived from human factors. This study, in order to find out factors affecting drivers' behaviors within intersections, measured physiological responses such as brain wave, sight, driving speed, and so on by using state-of-the-art measuring device. As to concentration brain wave at individual intersections, it was found out that brain wave of testes was higher at main Arterial and accident-prone intersections compared with that of subsidiary Arterial. In addition, it was detected that drivers' visual activity was widely distributed at accident-prone intersections, meaning that it enhanced cautious driving from nearby vehicles. As to major factors causing drivers' workloads, factors from nearby vehicles such as deceleration, acceleration, lane change of nearby vehicles appeared as direct factors causing drivers' workloads, clarifying that these factors were closely related to causes of traffic accidents at intersections. Results of this study are expected to be used as basic data for evaluation of safety at intersections in consideration of physiological response of drivers.

Fiber Optic Bragg Grating Sensor for Crack Growth Detection of Structures (구조물의 균열 진전 탐지를 위한 광섬유 브래그 격자 센서)

  • Kwon, Il-Bum;Seo, Dae-Cheol;Kim, Chi-Yeop;Yoon, Dong-Jin;Lee, Seung-Seok
    • Journal of the Korean Society for Nondestructive Testing
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    • v.27 no.4
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    • pp.299-304
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    • 2007
  • There are to be some cracks on the material degradation part or the stress concentration parts of the main members, which carry on over-loads, of structures. Because these cracks can be used to evaluate the structural health status, it is important to monitor the crack growth for maintaining the structural safety. In this study, the fiber Bragg grating sensor with a drop ball was developed as a sensor for crack growth detection of an existing crack. The crack growth detection sensor was constructed with three parts: a probe part, a wavelength controling light source and receiver part, and an impact part. The probe part was just formed with a fiber Bragg grating optical fiber The wavelength controling light source part was composed of a current supplying circuit, a DFB laser diode, and a TEC controling circuit for wavelength control. Also, the impact part was just implemented by dropping a steel ball. The performance of this sensor was confirmed by the experiments of the crack detection with an aluminum plate having one existing crack. According to these experiments, the difference of the sensor signal outputs was correlated with the crack length. So, it was confirmed that this sensor could be applied to monitor the crack growth.

Target Reliability Index of Single Gravel Compaction Piles for Limit State Design (한계상태설계를 위한 단일 쇄석다짐말뚝의 목표신뢰도지수)

  • You, Youngkwon;Lim, Heuidae;Park, Joonmo
    • Journal of the Korean GEO-environmental Society
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    • v.15 no.2
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    • pp.5-15
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    • 2014
  • Target reliability index in the limit state design indicated the safety margin and it is important to determine the partial factor. To determine the target reliability index which is needed in the limit state design, the six design and construction case histories of gravel compaction piles (GCP) were investigated. The limit state functions were defined by bulging failure for the major failure mode of GCP. The reliability analysis were performed using the first order reliability method (FORM) and the reliability index was calculated for each ultimate bearing capacity formulation. The reliability index of GCP tended to be penportional to the safety factor of allowable stress design and average value was ${\beta}$=2.30. Reliability level that was assessed by reliability analysis and target reliability index for existing structure foundations were compared and analyzed. As a result, The GCP was required a relatively low level of safety compared with deep and shallow foundations and the currd t reliability level were similar to the target reliability in the reinforced earth retaining-wall and soil-nailing. Therefore the target reliability index of GCP suggested as ${\beta}_T$=2.33 by various literatures together with the computed reliability level in this study.

A study on the quality change of fish cakes by storage conditions to set the use by date of fish cakes (어묵의 소비기한 설정을 위한 보관방법 별 어묵의 품질변화 연구)

  • Sun Hye, Hwang;Min Joo, Kim;Ji Yeon, Choi;Yong Sun, Cho
    • Analytical Science and Technology
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    • v.35 no.6
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    • pp.267-273
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    • 2022
  • In this study, a quality evaluation was conducted to change the sell-by date of fish cakes to the use-by date. For product quality evaluation, storage conditions were set at 5, 10, and 15 ℃, and five tests of pH, acid value, volatile basic nitrogen, bacterial count, and coliform group were performed. As a result of the experiment, the quality safety limit period of fish cakes stored at 5 ℃ was 43 days, that of fish cakes stored at 10 ℃ were 30 days, and that of fish cakes stored at 15 ℃ was 7 days. Among the five test items used for quality evaluation, the quality-limit indicators were acid value, number of bacteria, and coliform groups. The index that determined the quality safety-limit period under the three storage conditions was the bacterial count. The sell-by date of the fish cake used in this experiment was 10 days. However, through quality evaluation, the use-by date at 10 ℃ was 28.5 days, which was calculated by multiplying the 30 days; the quality limit period, by a safety factor of 0.95. However, this study conducted a quality study on one item of fish cakes from a single company, and it was difficult to use the quality safety-limit period and use-by date set in this study universally. To change the sell-by date to the use-by date, extensive quality research on various products will be required. If this system is well established, it can help reduce food waste through proper consumption of food, and consumers will be able to consume food with confidence.

Recharge Potential Assessment of Artificial Recharge System for Agricultural Drought Adaptation (농업가뭄대응을 위한 인공함양 시스템의 함양능력 평가)

  • Lee, Jae Young;Kim, Gyoo Bum
    • Journal of Korean Society of Disaster and Security
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    • v.14 no.1
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    • pp.61-72
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    • 2021
  • There is an increasing need for water supply plan using sustainable groundwater to resolve water shortage problem caused by drought due to climate change and artificial aquifer recharge has recently emerged as an alternative. This study deals with recharge potential assessment for artificial recharge system and quantitative assessment for securing stable water and efficient agricultural water supply adapt to drought finding optimal operating condition by numerical modeling to reflect recharge scenarios considering climate condition, target water intake, injection rate, and injection duration. In order to assess recharge potential of injection well, numerical simulation was performed to predict groundwater level changes in injection and observation well respect to injection scenarios (Case 1~4) for a given total injection rate (10,000 m3). The results indicate that groundwater levels for each case are maintained for 25~42 days and optimal injection rate is 50 m3/day for Case 3 resulted in groundwater level rise less than 1 m below surface. The results also show that influential area of groundwater level rise due to injection was estimated at 113.5 m and groundwater storage and elapsed time were respectively increased by 6 times and 4 times after installation of low permeable barrier. The proposed assessment method can be contributed to sustainable agricultural water supply and stable water security for drought adaptation.