• 건강소식
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• v.35 no.4
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• pp.30-31
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• 2011

살랑살랑 불어오는 봄바람은 아토피 피부염에는 가장 큰 적이다. 소아기의 아토피 피부염은 손이나 발목이 접히는 부위의 피부가 건조하고 두꺼워지는 것으로 나타나다. 그리고 눈주위의 홍반, 귀 주위의 피부 균열, 손이나 발의 습진도 흔하게 생긴다.

• 건강소식
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• v.29 no.12 s.325
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• pp.24-25
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• 2005

아토피 피부염이란? '아토피'란 말은 어원상 이상한 반응이라는 뜻을 가지고 있다. 아토피 피부염은 얼굴, 팔이 접히는 부위, 무릎 뒤 부위에 흔히 발생하는 습진성 질병이다. 대체로 전신의 피부가 건조하고 거칠게 느껴지며 심한 가려움증을 동반한다. 처음 발생하는 연령은 90% 이상이 2세 이하지만 최근 들어 정신적 스트레스의 영향인 듯 성인에게서도 나타나고 있다.

• Proceedings of the Korea Contents Association Conference
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• 2011.05a
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• pp.297-298
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• 2011

아토피 피부염(atopic dermatitis, AD)은 염증과 소양감을 동반하는 재발성 만성적인 피부질환으로서 심각성이 나날이 커지고 있는 대표적 건강문제이다. 본 연구의 목적은 아토피 피부염을 겪고 있는 대상자를 위하여, 한국전통 식품과 무 유선 인터넷 기반의 맞춤형 영양 관리 시스템을 개발하는 것이다. 신체계측 및 모발 무기질 수치를 입력하면 체질량지수(BMI) 및 내분비, 탄수화물 내응성 등 대사 관련 기능을 판정 받은 후, 이 평가를 기반으로 체내 기능 개선에 적합한 한국 전통 위주의 식품을 추천하며, 동시에 관련 정보, 식품 성분, 요리법 등을 제공하여 대상자 스스로 아토피를 관리할 수 있는 능력을 갖도록 하는 것이다. 결론적으로 본 연구를 통하여 개발된 시스템을 통하여 모바일 사용자들은 장소와 시간의 제약을 받지 않고 어디서나 효과적으로 한국 전통식품 토대의 아토피 피부염 개선을 위한 맞춤형 영양관리를 받을 수 있도록 하였다.

• Journal of the Korean Society of Fashion and Beauty
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• v.3 no.3 s.3
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• pp.41-47
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• 2005

This study was conducted with 60 adult males who visited the Atomi Cooperative Clinic(Atomi Dermatology/Pediatrics/Oriental Clinic) in Seoul between May 2003 and December 2004; they were divided into three groups, each of which consisted of 20 persons, according to the level of erythma and then each group was subdivided to consist of ten according to whether they received skin treatment and care. The standard care provided to two groups involved topical steroids and oriental medicines prescribed by a dermatologist and a oriental doctor, respectively. 5th-grade topical steroid ointment was applied to the face and 3rd-grade to the limbs; a oriental medicine was administered in a lukewarm state half an hour after meals three times a day. To determine how special and systematic skin treatment and care was helpful in treating atopy, a skin treatment system was applied to the experimental group while the control group was provided with standard care alone. By using Mexameter(MX18) manufactured by ck-mpa as a measuring tool, the inflammation level was observed at the right antecubital space during each visit to the clinic. In view of the re suits, introduction of the systemic skin care for A. D to legitimate treatment provided by a medical institution is expected to be an appropriate supplementary treatment for adult patients who suffer from frequent recurrence of atopic dermatitis.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.22 no.3
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• pp.237-245
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• 2009

Objective : It is well known that patients with atopic dermatitis are prone to cutaneous infections. Especially Staphylococcus aureus has been regarded as having an influence on atopic dermatitis. We observed and treated a case of an adult atopic dermatitis patient with sepsis by cooperation of east-west medicine. We present this case because there were no former reports of atopic dermatitis with sepsis treated by cooperation of east-west medicine. Method : We used herbal medication, acupuncture, herbal wet dressing combined with antibiotics and analgesics for 19 days. Atopic dermatitis grade was determined using SCORAD index. Result : The SCORAD index was lowered 32.3 at discharge than before of which the SCORAD index was 62.5 at admission. Other systemic inflammatory response such as fever, pus was also resolved. Conclusion : From this result, we suggest that herbal therapy associated with antibiotic therapy were shown to treat atopic dermatitis with secondary infection effectively.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.30 no.3 s.47
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• pp.345-352
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• 2004

There are two paradigms to explain the atopic dermatitis. The first is outside-inside paradigm and the second is inside-outside paradigm. According to the outside-inside paradigm the best way to treat the atopic dermatitis is recovery of skin barrier function. The barrier function is maintained by the specific structure of stratum corneum, which is constructed from corneocytes and intercellular lipids. In terms of lipid structures of SC in atopic dermatitis and lamellar ichthyosis, they contain more fluid hexagonal gel structures in SC and show deficiencies in free fatty acids, especially long chains and certain ceramides. With this reason, moisturizer which has the lamellar structure and restoring function of intrinsic intercellualr long periodicity phase can maintain and restore the lamellar structure of intercellular lipids in SC. The moisturizers containing ceramide or pseudoceramide also seem to be reasonable therapy for atopic dermatitis and several skin diseases, which interrelated with impaired skin harrier. By the way, according to the inside-outside paradigm, immune response including helper T cells, IgE, eosinophils is related. It is effective treatment of atopic dermititis to restore imbalance between Th1 and Th2 cells. Even though several kinds of immune-suppressor were introduced, these can affect the intrinsic immune function. SPC and S1P, metabolites of ceramide, would be interesting because they have the function of wound healing and immune modulating properties.

• Applied Microscopy
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• v.38 no.3
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• pp.167-174
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• 2008

Atopic dermatitis (AD) is a chronically relapsing inflammatory skin disease that often has asthma and allergic rhinitis. Magnesium salts, the important component of minerals in Dead Sea water, are known to exhibit beneficial effects in inflammatory disease. Favorable effects of magnesium ions and sea water treated to the skin of patients with contact dermatitis have been reported. But histological and immunological investigations are insufficient. This study was performed to examine the inhibitory effect of magnesium-rich sea mineral water on the development of AD-like skin lesions in hairless mice. AD-like skin lesions are induced by the repeated application of 2,4-dinitrochlorobenzene (DNCB). Local application of magnesium-rich sea mineral water on hairless mice skin applied with DNCB inhibited the development of AD-like skin lesions as exemplified by a significant increase in skin hydration (p<0.01), and a decrease in epidermal water loss (p<0.01). Serum IgE level was also significantly decreased (p<0.01). These results suggest that magnesium-rich sea mineral water inhibits the development of DNCB-induced AD-like skin lesions in hairless mice. These observations indicate that magnesium-rich sea mineral water may be alternative and assistant substances for the management of AD.

• Product Safety
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• s.195
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• pp.62-65
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• 2010

최근 오염된 공기 때문에 아토피 같은 피부 질환과, 비염과 천식 등의 호흡기 질환을 앓는 사람들이 많아지고 있다. 그래서 집안 공기나 위생을 관리할 수 있는 건강 가전제품인 가습기나 공기청정기의 판매량이 급증하고 있다고 한다. 건강을 위해 사용하는 공기청정기는 사용하게 되면 위생관리에 각별히 신경을 써야 한다. 건강과 직결되는 만큼 올바른 공기청정기 사용법을 알아두어 공기 청정기 내에서 세균 번식을 막아 '청정기'의 제 기능을 다할 수 있도록 하여야 한다. 가족들이 맘 편히 청정한 공기를 마실 수 있도록 올바른 공기청정기 사용 방법을 알아보도록 하자.

• KSBB Journal
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• v.25 no.4
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• pp.387-394
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• 2010

This study was conducted to investigate effect of complex extract of various mushrooms and sharp toothed eel on the skin conditions with atopic dermatitis and acne symptoms. The total phenol concentration was increased in order of hot water> ethanol> ethyl acetate> petroleum ether> chloroform extract. Especially, when the hot water extract was used, it was about 2-3 fold higher than that of ethyl acetate, petroleumether, and chloroform extract. When the complex extract concentration was increased from 1.0 to 50 mg/L, the DPPH scavenging rate increased from 10.1 to 81.4%. The reduction power was sharply increased from 0.05 to 0.27 (700 nm) when the complex extract concentration was increased from 25 to 75 mg/L. However, above 100 mg/L, it was not decreased. In the case of SOD-like activity, it was 45.7% at 100 mg/L. Total numbers of patients with atopic dermatitis were 15 and 5 patients with severe acne symptoms. According to photos taken before and after the treatment and questionnaire results, considerable improvements in skin conditions are observed in the patients with atopic dermatitis and acne. For atopic patients, erythema and edema have been improved but the degree of effect was dependent on the individual's constitution. Concerning acne, the effect of coating of the extracts was prominent for first week and the degree decreased with time till 4 weeks. The complex extracts wereefficient in soothing rash and maturation. Side effects such as a scar were not detected during the application and treatment.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.34 no.1
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• pp.1-8
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• 2008

Epidermis is one of the most dynamic organs in the human body. Multiple layers of keratinocytes in the epidermis continuously undergo proliferation, differentiation, and desquamation cycles, which is the bases of maintaining the epidermal homeostasis. Epidermal homeostasis eventually leads to establish and maintain permeability barrier homeostasis, the most important function of the epidermis. The permeability barrier is located in the stratum corneum. Tightly coordinated regulations are required for the sustained normal barrier function. Extensive studies have established that several nuclear hormone liposensors, including peroxisome proliferator-activated receptor a PPARa, PPARb/d, PPARg and LXRs are expressed in keratinocyte. Activation of PPARs and LXRs could provide a mechanism to coordinate the formation of the corneocytes and extracellular lipid membranes that constitute the stratum corneum. Topical application of PPAR/LXR ligands to murine skin results in the increased expression of keratinocyte differentiation-related proteins, such as involucrin, loricrin, profilaggrin, and trans-glutaminase 1, which would stimulate cornified envelope formation. In conclusion, topical application of ligands or activators of PPAR/LXR as an epidermotherapy would be a promising option to deal dry skin conditions such as atopy.