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The Effects of Magnesium Rich Sea Mineral Water on Atopic Dermatitis-like Skin Lesions in Hairless Mice  

Kim, Dong-Heui (Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University)
Lee, Kyu-Jae (Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University)
Qi, Xu-Feng (Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University)
Lee, Young-Mi (Biotech Research Institute. HDr Co. Ltd.)
Yoon, Yang-Suk (Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University)
Kim, Jeong-Lye (Department of Biomedical Laboratory Science, College of Health Science, Yonsei University)
Chang, Byung-Soo (Department of Cosmetology, Hanseo University)
Ryang, Yong-Suk (Department of Biomedical Laboratory Science, College of Health Science, Yonsei University)
Publication Information
Applied Microscopy / v.38, no.3, 2008 , pp. 167-174 More about this Journal
Abstract
Atopic dermatitis (AD) is a chronically relapsing inflammatory skin disease that often has asthma and allergic rhinitis. Magnesium salts, the important component of minerals in Dead Sea water, are known to exhibit beneficial effects in inflammatory disease. Favorable effects of magnesium ions and sea water treated to the skin of patients with contact dermatitis have been reported. But histological and immunological investigations are insufficient. This study was performed to examine the inhibitory effect of magnesium-rich sea mineral water on the development of AD-like skin lesions in hairless mice. AD-like skin lesions are induced by the repeated application of 2,4-dinitrochlorobenzene (DNCB). Local application of magnesium-rich sea mineral water on hairless mice skin applied with DNCB inhibited the development of AD-like skin lesions as exemplified by a significant increase in skin hydration (p<0.01), and a decrease in epidermal water loss (p<0.01). Serum IgE level was also significantly decreased (p<0.01). These results suggest that magnesium-rich sea mineral water inhibits the development of DNCB-induced AD-like skin lesions in hairless mice. These observations indicate that magnesium-rich sea mineral water may be alternative and assistant substances for the management of AD.
Keywords
Atopic dermatitis; Magnesium; Hairless mouse; Effect;
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