• Title/Summary/Keyword: 아키

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Evaluation of Antimicrobial Activity and Mutagenicity of Ozonized Olive Oil (오존화 올리브유의 항균성 및 변이원성 평가)

  • Jang, Il-Woong;Lee, Seung-Jae;Ahn, Jeung-Youb;Miura, Toshiaki;Jung, Mun-Yhung;Choi, Dong-Seong
    • Korean Journal of Food Science and Technology
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    • v.38 no.6
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    • pp.805-809
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    • 2006
  • Ozonized olive oil was tested for its mutagenic potential in a Salmonella/microsome assay. Additionally, antimicrobial activity was tested against Propionibacterium acnes, Staphylococcus epidermidis, Staphylococcus aureus and Pseudomonas aeruginosa, pathogenic strains related to acne, using the paper disk and agar dilution method. Ozonized olive oil showed antimicrobial activities against all the strains tested, with minimal inhibitory concentrations (MICs) values in a range of 2${\sim}$10 mg/mL. Mutagenicity of ozonized olive oil was evaluated with Salmonells typhimurium TA98, TA100 and Ta1535, with and without addition of S9 mixture. No increase in the number of $his^{+}$ revertants over the negative control (solvent and non-ozonized olive oil) values was observed with TA98 (1,000 ${\mu}g/plate$), TA100 (1,500 ${\mu}g/plate$) and TA1535 (1,500 ${\mu}g/plate$) strains. The results from this study suggested that ozonized olive oil does not show any mutagenic potential.

The Development of the Conceptual Model Visualization Program (개념모델 가시화 프로그램의 개발)

  • Choi, Hong-Seok;Okazaki, Akira
    • Science of Emotion and Sensibility
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    • v.13 no.3
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    • pp.573-580
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    • 2010
  • The earlier KANSEI evaluation had to choose not to overlap the opposite meaning of the words, had to choose that some figures are shown step by step and had to choose be prepared things in advance. However, The Study shows a method which visualizes the imprecise evaluations of human without choosing evaluation items which are not prepared figures. The program is used the way which is entered by hand-drawing that the subjects use the way to enter their subjective feelings about the evaluations presented by using the mouse or the graphics tablet. It is possible to express imprecise things about evaluations and the method of drawing is free. The program provides that we can express our thinking by drawing and there are a few limits and the prescribed standard. The area ratio of each circle is expressed as a pie chart and the area of circle what is drawn which is counted automatically at the same time. These things are possible not only to modify a transparency, a thickness of a line, a color and the area of circle what is drawn, but also to adjust the area of circle. The conceptual model is visualized that expresses something by hand-drawing such as a circle. The conceptual model has wide range of applications such as a personnel evaluation, a suffering evaluation and product evaluation. The program currently has been testing the effective of the program's possibilities which is used with the personnel appraisal tool of the nurses themselves who work in nurse support department where the St. Marianna University School of Medicine Hospital is. And also the program is proceeding with development to visualize the conceptual model by dynamic interfaces effectively and the program is applied such as KJ method and a program is used to express the kind of the patient's pain and its level.

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Effects of Cooling on Repeated Muscle Contractions and Tendon Structures in Human (냉각이 반복된 근수축과 사람의 건 구조에 미치는 영향)

  • Chae, Su-Dong;Jung, Myeong-Soo;Horii, Akira
    • The Journal of Korean Physical Therapy
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    • v.18 no.6
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    • pp.1-11
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    • 2006
  • Purpose: This study compared the effects of non-cold and cold conditions on the viscoelastic properties of tendon structures in vivo. Methods: Seven male subjects perfomed plantar flesion exercise with maximal isokinetic voluntary contraction, which consisted of muscle contraction for 6 see and relaxation for 60 secs, 10 times for 1 set, Totally 10 sets were repeated. Before and after each task, the elongation of the tendon and aponeurosis of the medial gastrocnemius muscle (MG) was directly measured by ultrasonography. (The relationship between the estimated tendon force and tendon elongation.) Tendon cross-sectional area and ankle joint moment arm were obtained from magnetic resonance imaging (MRI). The tendon force was calculated from the joint moments and the tendon moment arm and stress was obtained by dividing force by cross-sectional areas (CSA). The strain was measured from the displacements normalized to tendon length. Results: After cooling, the tendon force was larger in cold than non-cold. The value of the tendon stiffness of MVC were significantly higher under the cold condition than under the non-cold condition. The maximal strain and stress of $7.4{\pm}0.7%$ and $36.4{\pm}1.8$ MPa in non-cold and $7.8{\pm}8.5%,\;31.8{\pm}1.1$ MPa in cold (P<0.05). Conclusion: This study shows for the first time that the muscle endurance in cooling increases the stiffness and Young's modulus of human tendons. The improvement in muscle endurance with cooling was directly related to muscle and tendon.

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Estimation of site amplification and S-wave velocity profiles in metropolitan Manila, the Philippines, from earthquake ground motion records (지진 관측 기록을 이용한 필리핀 마닐라의 현장 증폭 특성 및 S파 속도구조 추정)

  • Yamanaka, Hiroaki;Ohtawara, Kaoru;Grutas, Rhommel;Tiglao, Robert B.;Lasala, Melchor;Narag, Ishmael C.;Bautista, Bartlome C.
    • Geophysics and Geophysical Exploration
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    • v.14 no.1
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    • pp.69-79
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    • 2011
  • In this study, empirical site amplifications and S-wave velocity profiles for shallow and deep soils are estimated using earthquake ground motion records in metropolitan Manila, the Philippines. We first apply a spectral inversion technique to the earthquake records to estimate effects of source, path, and local site amplification. The earthquake data used were obtained during 36 moderate earthquakes at 10 strong-motion stations of an earthquake observation network in Manila. The estimated Q value of the propagation path is modelled as $54.6f^{1.1}$. Most of the source spectra can be approximated with the omega-square model. The site amplifications show characteristic features according to surface geological conditions. The amplifications at the sites in the coastal lowland and Marikina Valley shows predominant peaks at frequencies from 1 to 5 Hz, while those in the central plateau are characterised by no dominant peaks. These site amplifications are inverted to subsurface S-wave velocity. We, next, discuss the relationship between the amplifications and average S-wave velocity in the top 30m of the S-wave velocity profiles. The amplifications at low frequencies are well correlated with the averaged S-wave velocity. However, high-frequency amplifications cannot be sufficiently explained by the averaged S-wave velocity in the top 30 m. They are correlated more with the average of S-wave velocity over depths less than 30 m.

A Study on the Development of a BIM Design Tool for Hanok Windows and Doors (BIM을 활용한 한옥 창호 설계 도구 개발에 관한 연구)

  • Choi, Joong-Hyun
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.15 no.12
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    • pp.7331-7339
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    • 2014
  • As the Korean government initiates the Han-style campaign, the efforts and expectations for the modernization and industrialization of Hanok are growing. Accordingly, a major R&D project sponsored by the government is in progress for the development of related technologies, in which the development of a Hanok design support system based on Building Information Modeling(BIM) technology is included as one of the major subjects. However, the development of design tools for Hanok so far has not focused on the windows and doors, which is another major element of Korean traditional architecture. Therefore, this study developed a BIM-based design tool for Hanok windows and doors as an approach to the integrated design of various Hanok elements and their applications to modern buildings. To this end, the characteristics of Hanok windows and doors were analyzed first in terms of the location, opening method, style, components, and the over-all construction. A design tool was then developed with the parametric modeling functions of the $ArchiCAD^{(R)}$system. The applicability and efficiency of the developed tool were verified with design simulations. This is expected to contribute to not only the application of Hanok windows and doors to modern buildings but also to the further development of an integrated Hanok design system.

Applicability of UV and UV/$H_2O_2$ Processes in the Control of Pharmaceuticals and Personal Care Products and Microbiological Safety for Water Reuse (잔류 의약품류의 제거 및 미생물학적 안전성을 고려한 하수 재이용 기술로서의 UV 및 UV/$H_2O_2$ 공정의 적용성)

  • Kim, Il-Ho;Tanaka, Hiroaki
    • Journal of Korean Society of Environmental Engineers
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    • v.32 no.7
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    • pp.722-729
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    • 2010
  • Over the last decades, much consideration has been given to microbiological and chemical risks, especially when wastewater was reclaimed as water resources for urban water, irrigation water and recreational water etc. We investigated the performance of UV-based processes such as UV and UV/$H_2O_2$ for both the removal of pharmaceuticals and personal care products (PPCPs) as an emerging chemical and the inactivation of pathogen with bench-scale experimental study. 38 kinds of PPCPs including antibiotics and analgesics were detected from secondary effluent used as tested water. Bench-scale experimental study showed that UV process would require considerable UV dose for the effective PPCPs removal. Contrarily, PPCPs removal efficiency significantly improved by the combination of $H_2O_2$ with UV even at a lower UV dose and, moreover, their removal efficiency increased with the increased initial $H_2O_2$ concentration. Besides naproxen (>89%), concentrations of all the investigated PPCPs decreased by more than 90% of their initial concentrations under $923\;mJ/cm^3$ of UV dose and 6.2 mg/L of $H_2O_2$. Previous studies showed that this operational condition could get 4~5 log inactivation for Total coliform, indicating that UV/$H_2O_2$ process will be appropriate to comply with the criteria of California Title 22 for Total coliform.

Analysis of copy number abnormality (CNA) and loss of heterozygosity (LOH) in the whole genome using single nucleotide polymorphism (SNP) genotyping arrays in tongue squamous cell carcinoma (설편평상피암에 있어서의 고밀도 SNP Genotyping 어레이를 이용한 전게놈북제수와 헤테로접합성 소실의 분석)

  • Kuroiwa, Tsukasa;Yamamoto, Nobuharu;Onda, Takeshi;Bessyo, Hiroki;Yakushiji, Takashi;Katakura, Akira;Takano, Nobuo;Shibahara, Takahiko
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.37 no.6
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    • pp.550-555
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    • 2011
  • Chromosomal loss of heterozygosity (LOH) is a common mechanism for the inactivation of tumor suppressor genes in human epithelial cancers. LOH patterns can be generated through allelotyping using polymorphic microsatellite markers; however, owing to the limited number of available microsatellite markers and the requirement for large amounts of DNA, only a modest number of microsatellite markers can be screened. Hybridization to single nucleotide polymorphism (SNP) arrays using Affymetarix GeneChip Mapping 10 K 2.0 Array is an efficient method to detect genome-wide cancer LOH. We determined the presence of LOH in oral SCCs using these arrays. DNA was extracted from tissue samples obtained from 10 patients with tongue SCCs who presented at the Hospital of Tokyo Dental College. We examined the presence of LOH in 3 of the 10 patients using these arrays. At the locus that had LOH, we examined the presence of LOH using microsatellite markers. LOH analysis using Affymetarix GeneChip Mapping 10K Array showed LOH in all patients at the 1q31.1. The LOH regions were detected and demarcated by the copy number 1 with the series of three SNP probes. LOH analysis of 1q31.1 using microsatellite markers (D1S1189, D1S2151, D1S2595) showed LOH in all 10 patients (100). Our data may suggest that a putative tumor suppressor gene is located at the 1q31.1 region. Inactivation of such a gene may play a role in tongue tumorigenesis.

Removal of pharmaceuticals in biologically treated sewage with $O_3$ and advanced oxidation processes (오존 및 고도산화처리에 의한 하수 2차 처리수중의 의약품류 제거)

  • Kim, Il-Ho;Tanaka, Hiroaki;Song, Ho-Myeon;Joo, Jin-Chul;Ahn, Chang-Hyuk
    • Proceedings of the Korea Water Resources Association Conference
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    • 2011.05a
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    • pp.137-137
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    • 2011
  • 급격한 세계인구의 증가에 의해 물 부족지역이 세계 각지로 확산되고 있다. 이에 따라, 건전한 수자원으로써 하수처리수의 재이용이 주목을 받고 있다. 하수처리수의 재이용시에는 특히, 재이용수의 미생물학적 안전성과 더불어 화학물질 등으로부터 기인할 수 있는 인체 및 생태계에의 리스크를 고려해야 한다. 미국 EPA는 병원성 미생물 뿐만 아니라 화학물질에 대한 안전성을 확보 차원에자외선/과산화수소 등의 고도산화처리법을 검토하였다. 1일 $10m^3$ 처리규모의 연속실험장치를 이용, 검토된 공정별 실제 하수 2차 처리수중에 존재하는 의약품류의 제거효과, 에너지 소비량 및 생태리스크 저감효과 등을 비교, 평가하였다. 에너지 소비량에 있어서는 공정별로 다소 차이가 있었으나, 본 실험동안 검출된 38종의 의약품류 제거에는 각 공정 모두 매우 효과적이었다. 에너지 소비측면에서는 오존 단독공정이 가장 적은 에너지 소비량에서 타 공정과 동일한 수준의 의약품류 서 막처리나 자외선 처리 등의 고도처리시설에 대한 정보를 재이용수 가이드라인에 제시하고 있는 반면, 우리나라에서는 재이용수중에 일정농도 이상의 염소가 잔류하도록 함으로써, 재이용수의 미생물학적 안전성 확보만을 고려하고 있다. 최근, 수환경분야에서는 의약품류라는 화학물질이 유럽, 미국 및 일본 등지를 중심으로 주목을 받아오고 있으며, 이들은 ng/L-${\mu}g$/L 수준으로 수환경중에서 검출되고 있다. 이들의 주요 발생원으로 하수처리시설이 지목되고 있으며, 따라서 하수처리수의 재이용시 잔류 의약품류에 의한 리스크 발생 가능성이 우려되고 있다. 이를 배경으로, 하수처리시설에서 의약품류를 효과적으로 제거할 수 있는 공정으로 오존 및 오존/자외선, 제거효과가 얻어졌다. 한편, 오존처리시 발암성 물질인 브로메이트($BrO_3^-$) 등과 같은 부생성물 생성 가능성을 고려하면, 오존 단독공정보다 상대적으로 많은 에너지를 소비하는 오존/자외선, 자외선/과산화수소 등의 고도산화처리법이 높은 적용성을 갖는 것으로 나타났다. 향후, 수자원 부족문제로 재이용수의 용도가 훨씬 다양해 질 것으로 예상된다. 그에 따라, 재이용수의 안전성 확보를 위해 보다 폭넓은 검토가 예상되지만, 현 단계에서는 오존을 포함, 다소 많은 에너지 소비가 예상되는 자외선을 이용한 고도산화처리법이 다양한 미량 화학물질의 제거에 유효한 공정으로 판단된다.

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A Study on the Landcover Classification using Band Ratioing Data of Landsat-TM (Landsat-TM의 밴드비 연산데이터를 이용한 토지피복분류에 관한 연구)

  • Kwon, Bong-Kyum;Yamada, Kiyoshi;Niren, Takaaki;Jo, Myung-Hee
    • Journal of the Korean Association of Geographic Information Studies
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    • v.6 no.2
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    • pp.80-91
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    • 2003
  • In this research, re-using band ratio data was proposed and examined as a method of raising the accuracy in landcover classification which is using satellite data.In order to determine the band which is used to calculation in the classified item, the six bands except the band 6 were combined with the band in which combination is possible and the landcover classification by MLC of supervised classification was carried out. In the result of landcover classification which is combined with forty nine combination, Two bands which were mostly used by band combination in the accuracy belonged inside the 10th place of a higher rank were selected and also calculated. landcover classification were performed again after the calculation result had been recombinated from the research. In addition, the new landcover classification result was compared and examined with the landcover classification using the old data. From the result of which was compared and examined the new landcover classification data recombinated calculation result with landcover classification using the original data, The classification accuracy of the new landcover classification data recombinated calculation result became low in ground but became improved in the all class. Specially The accuracy to urban area is very improved. therefore, it determined that reusing band ratio data is very useful when we need to analyze landcover classification and land information to urban area after that.

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Applicability Investigation of E.coli, RNA and DNA Bacteriophages for Possible Indicator Microorganisms Based on the Inactivation Effectiveness by UV (UV 불활성화 효과에 의거한 E.coli, RNA 및 DNA 박테리오파지의 대체 지표 미생물로서의 적용성 검토)

  • Kim, Il-Ho;Wahid, Marfiah AB;Tanaka, Hiroaki
    • Journal of Korean Society of Environmental Engineers
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    • v.32 no.11
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    • pp.1063-1068
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    • 2010
  • This study compared UV and UV/$H_2O_2$ inactivation of E.coli, a possible indicator microorganism for fecal contamination of water, and $Q{\ss}$ phage, an indicator for pathogenic viruses. UV inactivation of $Q{\ss}$, T4 and lambda phages in actual secondary effluent was investigated, too. As a result, similar inactivation efficiency between $Q{\ss}$ phage and E.coli was observed during UV treatment, while $Q{\ss}$ phage showed higher resistance to UV/$H_2O_2$ than E.coli. $Q{\ss}$ phage resistance to UV or UV/$H_2O_2$ does not reflect those of all pathogenic viruses. However, the result tells that the use of E.coli inactivation efficiency in evaluating microbiological safety of water could not always ensure the sufficient safety from pathogenic viruses. Meanwhile, $Q{\ss}$ phage showed less resistance to UV than T4 and lambda phages, indicating that the use of $Q{\ss}$ phage as an indicator virus may bring insufficient disinfection effectiveness by causing the introduction of lower UV dose than required. Consequently, it can be thought that T4 or lambda phages would be more desirable indicators in ensuring the sufficient disinfection effectiveness for various pathogenic viruses.