• Journal of Dental Rehabilitation and Applied Science
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• v.28 no.2
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• pp.171-178
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• 2012

Botulinum toxin type A (BoNT-A) has been applied successfully to treat chronic migraine, dystonia, spasticity and temporomandubular disorders(TMDs) as well as frontal wrinkle and glabella wrinkle. Recently it has been reported that BoNT-A, reversibly blocks presynaptic acetylcholine release, also inhibits the release of substance P, CGRP(calcitonin gene related peptide) and glutamate related to peripheral sensitization and neurogenic inflammation in sensory nerve, In this study we reviewed animal nerve injury model such as rat and rabbit and identify the analgesic effect and mechanism of nerve injury pain after dental treatment.

• Proceedings of the Korea Information Processing Society Conference
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• 2012.11a
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• pp.672-675
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• 2012

음성은 가장 익숙하고 편리한 의사 소통 수단으로 스마트폰과 같이 크기가 작은 모바일 기기의 입력 인터페이스로 적합하다. 서버 기반의 음성 인식은 서버를 방문하는 다양한 사용자들을 대상으로 음성 모델을 구축하기 때문에 음성 인식률을 높일 수 있고 상용화가 가능하다. 구글 음성인식, 아이폰의 시리(SiRi)가 대표적인 예이며 최근 스마트폰 사용자의 증가로 이에 대한 수요가 급증하고 있다. 서버 기반 음성 인식 기법에서 음성 인식은 스마트폰과 인터넷으로 연결되어 있는 원격지 서버에서 이루어진다. 따라서, 사용자는 스마트폰에 저장된 음성 데이터를 인터넷을 통하여 음성 인식 서버로 전달해야 된다[1, 2]. 음성 데이터는 사용자 고유 정보를 가지고 있으므로 개인 인증 및 식별을 위한 용도로 사용될 수 있으며 음성의 톤, 음성 신호의 피치, 빠르기 등을 통해서 사용자의 감정까지도 판단 할 수 있다[3]. 서버 기반 음성 인식에서 네트워크로 전송되는 사용자 음성 데이터는 제 3 자에게 쉽게 노출되기 때문에 화자의 신분 및 감정이 알려지게 되어 프라이버시 침해를 받게 된다. 본 논문에서는 화자의 프라이버시를 보호하기 위하여 사용자 음성 데이터로부터 개인의 고유 특징 및 현재 상태를 파악할 수 있는 감정 정보를 제거하는 기법을 설계 및 구현하였다.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 1999.11a
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• pp.177-183
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• 1999

In this paper, we analyze transmission characteristics of ultrashort laser pulses using the property of Raised-cosine pulse which are systematically obtained following Class-2 PRS model. The high-order pulses are easily derived front a modified PRS system model as Class-1 PRS model. This may be based on the fact that the spectra and bandwidths of the high-order pulses are beautifully related to their orders. And we make clear they are very useful to cover wider area and more accurate transmission characteristics of ultrashort pulses than Gaussian or Sech pulse approximations used conventionally. First modifying the generalized PRS system model, we propose a new model for deriving any type of high-order pulse. And we offer a novel analysis method of ultrashort pulse transmission which has any shape and FWHM, using the proposed model. In addition, by fixing the pulse range $\tau$=1(ps) and varying the order of the pulse from n=1 to n=100, we obtain spectra of ultrashort pulses with 1(ps)-100(fs) FWHM's, and width of FWHM in the Class-2 PRS model 50~100(fs) smaller than Class-1 PRS model. As a one-step further, we derive PSD's of their pulse trains when they are applied to Unipolar signaling scheme. These PSD's are derided in the range of possible pulse intervals. All of these results are not only coincided with some conventional experimental works but also will to applied to any pioneering ultrashort pulse in the future.

• Journal of Mushroom
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• v.14 no.4
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• pp.220-224
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• 2016

Chronic inflammation, which results from continuous exposure to antigens, is one of major reasons for tissue damage and diseases such as rheumatoid arthritis and type 2 diabetes. In this study, we investigated the anti-inflammatory effects of extracts (hexane, $CHCl_3$, MeOH, $MeOH/H_2O$, and $H_2O$) from GW10-45, which is our new cultivar of an edible mushroom Pleurotus ferulae (ASI 2803 and ASI 2778), in RAW264.7 murine macrophages. None of the extracts showed cytotoxicity in RAW264.7 cells and the hexane, CHCl and H extracts reduced nitric oxide (NO) production, an important inflammatory marker, in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Particularly, the extract (CG45) inhibited NO production more than the other extracts did. To elucidate the effects of CG45 on molecular targets involved in pro-inflammatory responses, we performed western blot analysis. Expression of inducible nitric oxide (iNOS) significantly decreased in LPS and CG45 co-incubated cells compared to that in LPS only-treated cells. Additionally, another protein thatplays a critical role in inflammation, was down-regulated in cells treated with both LPS and CG45. In the nuclear factor $(NF)-{\kappa}B$ pathway, phosphorylation of $I{\kappa}B{\alpha}$ decreased in RAW264.7 cells treated with both LPS and CG45. Furthermore, CG45 inhibited the phosphorylation of $NF-{\kappa}B$ in LPS-stimulated RAW264.7 cells. Conclusively, CG45 could suppress pro-inflammatory responses in LPS-stimulated RAW264.7 cells by down-regulating not only the phosphorylation of $NF-{\kappa}B$ and $I{\kappa}B{\alpha}$ but also the expression of iNOS and COX-2 without any cytotoxicity.

• Journal of Life Science
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• v.31 no.8
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• pp.745-754
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• 2021

Deterioration of the immune function weakens the body's resistance to various infections, leading to a series of diseases. Immunomodulatory biomaterials have been used to reduce the side effects of immunosuppressants or to enhance immunity. Agarwood is the aromatic resinous portion of Aquilaria trees that has been traditionally used as a medicinal herb for the treatment of various diseases. Although previous studies have shown that agarwood can improve the body's immunity, evidence for this claim is still lacking. In this study, the immune-enhancing effects of the agarwood methanol extracts of Aquilaria malaccensis Lamk were evaluated in a RAW 264.7 macrophage model. Based on the results, the agarwood extracts markedly enhanced phagocytosis in the absence of cytotoxicity. The agarwood extract-treated RAW 264.7 cells exhibited the typical morphology of activated macrophages, which are spindle-shaped with elongated filopodia. Agarwood extract also significantly increased the production of nitric oxide (NO), which is associated with the increased expression of inducible NO synthase. Moreover, the secretion and expression levels of cytokines, such as tumor necrosis factor-α and interleukin (IL)-1β and IL-6, were increased by agarwood treatment. Notably, these are also associated with a mitogen-activated protein kinase signaling pathway. Taken together, our findings provide scientific evidence that agarwood has potential immune-enhancing effects in vitro.

• Korean journal of applied entomology
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• v.61 no.1
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• pp.109-115
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• 2022

Vitellogenesis is the process by which yolk accumulates in developing oocytes. The initiation of vitellogenesis represents an important control point in oogenesis. When females of the model insect Drosophila melanogaster molt to become adults, their ovaries lack mature vitellogenic oocytes, only producing them after reproductive maturation. After maturation, vitellogenesis stops until a mating signal re-activates it. Juvenile hormone (JH) from the endocrine organ known as the corpora allata (CA) is the major insect gonadotropin that stimulates vitellogenesis, and the seminal protein sex peptide (SP) has long been implicated as a mating signal that stimulates JH biosynthesis. In this review, we discuss our new findings that explain how the nervous system gates JH biosynthesis and vitellogenesis associated with reproductive maturation and the SP-induced post-mating response. Mated females exhibit diurnal rhythmicity in oogenesis. A subset of brain circadian pacemaker neurons produce Allatostatin C (AstC) to generate a circadian oogenesis rhythm by indirectly regulating JH and vitellogenesis through the brain insulin-producing cells. We also discuss genetic evidence that supports this model and future research directions.

• The Transactions of the Korea Information Processing Society
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• v.7 no.9
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• pp.2948-2957
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• 2000

A broadband access network in B- ISDN subscriber network, plays a role of concentration or multiplexing of various subscribers into a service node. To establish an end-to-end ATM connection, interworking functions between \'B5.2 interface's connection protocol and the signalling protocol, are perfonned at the service node. A sequential interworking model and a parallel interworking model were proposed for these interworking functions. The sequential interworking model proceeds the signalling protocol of network node after the response of VB5.2 interface protocol. On the other hand, the parallel interworking model proceeds the signalling protocol and the VB5.2 interface protocol simultaneously. In this paper, we analyze and simulate above two interworking models in tenns of a connection setup delay and completion ratio, when call requests with eBR and VBR transfer capability arrive at the service node. We observed that the completion ratios of the two interworking models are quite closed. However the connection setup delay of parallel interworking model is improved by about 33% compared with that of the sequential interworking model.

• Journal of the Korean Electrochemical Society
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• v.14 no.3
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• pp.138-144
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• 2011

The transport phenomena of electron and ion around the electrode have been analyzed, herein the computational program to simulate the electrochemical signal of cyclic voltammetry has been implemented. For the dominant mass-transfer system, the governing equation and its boundary conditions are confined to the semi-infinite diffusion model and the reversible reaction at the electrode. In order to obtain the numerical solutions of cyclic voltammetry, MATLAB was used for the explicit finite difference method. Experimental results from the cyclic voltammetry of electrochemical system(10 mM $K_3Fe(CN)_6$ and 0.1M KCl) upon the ITO glass substrate were compared with the numerical solutions. Present program explains the experimental results fairly well, where they approached the simulated ones closely with deceasing the scan rate. Furthermore, the effects of electrode area, electrochemical reaction constants and transfering coefficients in the cyclic voltammetry were discussed quantitatively.

• Horticultural Science & Technology
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• v.32 no.5
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• pp.684-693
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• 2014

Abiotic stress conditions such as cold, drought, and salinity trigger physiological and morphological changes and yield loss in plants. Hence, plants adapt to adverse environments by developing tolerance through complex regulation of genes related to various metabolic processes. This study was conducted to construct a coexpression network for multidirectional analysis of salt-stress response genes in Brassica rapa (Chinese cabbage). To construct the coexpression network, we collected KBGP-24K microarray data from the B. rapa EST and microarray database (BrEMD) and performed time-based expression analyses of B. rapa plants. The constructed coexpression network model showed 1,853 nodes, 5,740 edges, and 142 connected components (correlation coefficient > 0.85). On the basis of the significantly expressed genes in the network, we concluded that the development of salt tolerance is closely related to the activation of $Na^+$ transport by reactive oxygen species signaling and the accumulation of proline in Chinese cabbage.

• Korean Journal of Remote Sensing
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• v.39 no.6_1
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• pp.1273-1281
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• 2023

Absolute radiometric calibration is a crucial process in converting the electromagnetic signals obtained from satellite sensors into physical quantities. It is performed to enhance the accuracy of satellite data, facilitate comparison and integration with other satellite datasets, and address changes in sensor characteristics over time or due to environmental conditions. In this study, field campaigns were conducted to perform vicarious calibration for the multispectral channels of the CAS500-1. Two valid field observations were obtained under clear-sky conditions, and the top-of-atmosphere (TOA) radiance was simulated using the MODerate resolution atmospheric TRANsmission 6 (MODTRAN 6) radiative transfer model. While a linear relationship was observed between the simulated TOA radiance of tarps and CAS500-1 digital numbers(DN), challenges such as a wide field of view and saturation in CAS500-1 imagery suggest the need for future refinement of the calibration coefficients. Nevertheless, this study represents the first attempt at absolute radiometric calibration for CAS500-1. Despite the challenges, it provides valuable insights for future research aiming to determine reliable coefficients for enhanced accuracy in CAS500-1's absolute radiometric calibration.