• Childhood Kidney Diseases
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• v.3 no.2
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• pp.130-144
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• 1999

Purpose : Long-term use of Cyclosporine(CsA) reduce renal blood flow by afferent arteriolar vasoconstriction and lead to chronic pathologic changes of CsA nephrotoxicity - 1) interstitial nephritis(IN); tubular atrophy (TA) and/or interstitial fibrosis(IF),2) arteriolopathy(AP). The Object of this study is to estimate the incidence of chronic pathologic CsA nephrotoxicity by duration of treatment and type of renal disease, relationship between histologic and clinical nephrotoxicity, and optimal duration of CsA therapy. Methods : 102 children with steroid resistant or dependent nephrotic syndrome confirmed by renal biopsy and treated with CsA from 1986 to 1997 were enrolled in this study(58 MCNS, 10 FSGS, 10 MGN, 15 $Henoch-Sch\"{o}nlein$ purpura nephritis with nephrotic syndrome (HSPN) and 9 IgA nephropathy with nephrotic syndrome(IgAN)). CsA was administered for 1yr, 1.5yr, 2yr in 24, 12, 22 MCNS patients and 2, 2, 6 FSGS patients respectively, 1yr, 2yr in MGN and 1yr in HSPN and IgAN. Sequential biopsies were done in all 102 patients after CsA treatment for evaluation of pathologic nephrotoxicity. Results : Complete remission rate was 92.2% (100% in MCNS and MGN, 80% in FSGS, 86.6% in HSPN and 55.5% in IgAN). Incidence of relapse during 6months after CsA treatment was significantly decreased compaed with relapsing spisodes during 6months before CsA treatment in MCNS(P<0.0001) and FSGS(P<0.0001). According to pathologic changes, 71 patients(69.6%) showed no pathological change, 24 patients(23.5%) showed IN and 7 patients(6.8%) showed AP. IN was 16.6%, 33.3%, 27.2% in 1, 1.5, 2 year of CsA treatment group in MCNS. AP was 0%, 16.6%, 9% in 1, 1.5, 2 year of CsA treatment group in MCNS. 14 out of 58 MCNS(24.1%) showed IN and 4 out of 58 MCNS(6.8%) showed AP. Incidence of pathologic change was significantly lower in CsA therapy of <1yr than >1yr(P=0.03). There were no significant difference of incidence of pathologic change in original renal disease, age and sex. Conclusion : Duration of CsA treatment was significant risk factor for nephrotoxicity and optimal duration seemed to be 1 year. Pathologic change due to nephrotoxicity did not correlate with deterioration of renal function and only detectable by renal biopsy.

• Journal of fish pathology
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• v.10 no.1
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• pp.53-63
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• 1997

In this study, poikilocyte rate and histopathological observation of flounder, Paralichthys olivaceus, treated with formalin, neutral-formalin(0, 50, 100, 150, 200, 300 ppm) at two different temperatures (15 and $25^{\circ}C$) were conducted to determine the time need for recovery. In all test chamber, formalin was more toxic than neutral-formalin and moderate lesions were not observed at low concentration of formalin and neutral-formalin(50~100 ppm). As expectedly, time need for recovery of gill and kidney tissues was lengthening as increasing chemical concentration and temperature. Treatments caused edema, winding of secondary gill lamella, seperation of epithelial layer and thrombosis of secondary gill lamella in the gill; edema, hydropic and hyaline droplet degeneration in the kidney. Representatively, recovery period of fish gill that had been exposed to 300 ppm formalin and neutral-formalin was about 120 and 72 hr($25^{\circ}C$). 72 and 48 hr($15^{\circ}C$). Recovery period of kidney was about 72 and 48 hr($25^{\circ}C$), 48 and 48 hr($15^{\circ}C$) respectively. Maximum value of poikilocyte rate(27.84%) was shown in formalin 300 ppm treated fish at $25^{\circ}C$. Tendency of decreasing poikilocyte rate was similiar to recovery of tissues in treated fish.

• Journal of radiological science and technology
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• v.36 no.4
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• pp.299-304
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• 2013

Whole body bone scan has been used to confirm bone metastasis and follow-up study with radio isotope. However, if the factors related to $^{99m}Tc$ uptake and waiting time for study are inappropriate, it would be image of low quality. The purpose of present study was to investigate correlation between the evaluation index of renal function and uptake of radiopharmaceuticals. The population for this retrospective study consisted of 387 patients who underwent whole body bone scan between June 2012 and December 2012. As a result of quantitative and qualitative analysis, we were able to confirm that GFR of less than normal range and creatinine levels in blood of more than average are more likely to be under the mean uptake rate. As a result of analysis on the indicator affecting soft-tissue and bone uptake, the correlation of all elements was somewhat low. Also there are no statistically significances due to the other parameters we did not deal with. Therefore, further research on additional factors is needed for exact study and improvement of the image quality.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.19 no.3
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• pp.249-256
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• 1986

The carp (Cyprinus carpio) used in the experiment were hatched in the spring this year and reared to 5.96g($4.84{\sim}6.55g$) in mean weight in a nursery pond at Daeyon fish farm, Pusan, Korea. The sample fish were exposed to different conditions of total ammonia (TA-N) concentrations 10, 20 and 30ppm and pH 6.5, 7.0, 7.5 and 8.0 at water temperatures 20, 25 and $30^{\circ}C$ for 24, 48 and 72 hours. After the procedure, the gill, liver and kidney of the fish were examined histopathologically. In this experiment, with the rise of water temperature, increase of pH and ammonia concentration, and the extension of exposure time the three organs showed the tendency of apparent abnormal changes such as hypertrophy and necrosis in their tissues. At $20^{\circ}C$ of water temperature gill tissue did not show any abnormality regardless of the change of pH at 10 ppm of ammonia concentration for 24 hours of exposure, but beyond the conditions given above, there occurred hypertrophy and the epithelium of gill lamellae was detached. The detach of gill lamellae epithelium initiated from the proximal part of the gill lamellae then gradually spread toward the uppermost tip. The heavier vacuolation of the liver was observed with the rise of water temperature and pH, and such morbid state in the liver was considered to be the result of edema in the liver tissue. The kidney showed no damage to the renal tubule epithelium at pH 6.5, but it was damaged at pH 8.0 when exposed to 30 ppm ammonia at $20^{\circ}C$ for 24 hours.

• The Korean Journal of Ecology
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• v.25 no.5
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• pp.335-339
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• 2002

Concentrations of Fe, Zn, Mn, Cd and Pb were determined in the tissues of sixty adult pigeons collected at six colonies in Korea, and examined correlations between elements, and between tissues in feral pigeons. As the results, we found many significant correlations between elements, and between tissues in them, A negative correlation between Cd and Fe concentrations was observed in the kidney, Cd depresses the absorption of Fe from the intestine and, in this way, affects the levels of Fe in particular tissues. This tendency could be expressed in terms of lower hemoglobin and hematocrit values because hematocrit is one of the most sensitive indicators of Cd intoxication. Zn concentrations are strongly associated with higher Cd levels in the kidney and liver. This is thought to be a reflection of the interaction known to occur between these two metals. Zn induction has been shown to antagonize a number of toxic effects of Cd. A positive correlation between Pb and Fe concentrations was detected in the livers at the Busan colony with relatively high Pb and Fe concentrations. Pb has been shown to co-accumulate with Fe in the liver by inhibiting the heme synthesis. Significant correlations, especially in toxic elements, Pb and Cd, were observed for many pairs of tissues. We suggest that these correlations between elements, and between tissues should be considered in biomonitoring for heavy metal pollution.

• Proceedings of the Korean Society of Dyers and Finishers Conference
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• 2011.03a
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• pp.49-49
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• 2011

최근 나일론 세섬 신축소재를 이용한 초경량 직물은 에 많이 사용되어지는 Nylon직물은 DTY 20~40d 소재를 이용한 rib조직과 이중조직 설계기술 및 염색가공기술에 의한 것으로 이들 제품은 조직의 한계점(이중조직, Rib), 신축특성의 저하, 품질 저하의 문제점이 대두되고 있어 아직까지 본격적으로는 상용화되지 못하고 있는 실정이다. 국내외적으로는 Polyester를 이용한 잠재권축 사는 일정수준으로 기술개발 진행 되어왔으나 아직까지 나일론 세섬사의 잠재권축 소재의 기술개발은 전무한 실정이다. 따라서 본 연구에서는 스포츠/레저용 초경량 Nylon 박지에 적합한 자발신장 개념인 Nylon6 잠재권축 소재를 개발하기 위하여 26D수준의 side by side형인 nylon6/Co-Nylon의 구조와 물성을 조사 검토하여 이를 실제 현장에 자료를 제공하는 것을 목적으로 하였다.

• Proceedings of the Korean Society of Postharvest Science and Technology of Agricultural Products Conference
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• 2003.10a
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• pp.225.2-226
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• 2003

본 연구에서는 현미로부터 tocoles 획분을 분리하여 고콜레스테롤 식이를 섭취한 흰쥐의 체내 지질대사에 미치는 영향을 조사하였다. 실험동물은 SD계 숫컷 5주령을 구입하여 정상군, 대조군 (1% cholesterol), rice oil 첨가군, tocoles 첨가군의 4군으로 나누어 AIN-76 diet 조성에 의거하여 식이를 조제하여 4주 동안 섭취시켰다. 실험기간이 끝난 후 복부 대동맥으로부터 채혈하고 각 조직을 적출하여 간, 신장, 비장 및 부고환지방 조직의 무게를 측정하였다. 또한 혈청 lipid profile과 TBARS 함량 및 ALT, AST 및 ALP 활성을 분석하였고 간장중 중성지방, 콜레스테롤 및 TBARS 함량과 G6PDH 및 malic enzyme을 분석하였다. 그 결과 간장 및 부고환지방의 무게가 대조군에서 유의적으로 증가하였으나, tocoles 첨가군은 정상군의 수준으로 감소하였다. 혈청 내의 중성지방과 총 콜레스테롤은 실험군 간에 유의적인 차이는 나타내지 않았으나 감소하는 경향을 보였다. 간장 조직 내 지질함량은 대조군에서 높게 나타났으며, tocoles 군에서 중성지방과 콜레스테롤 및 총 지방의 함량이 유의하게 감소하였다. 지질 과산화물 함량은 혈청과 간장 조직 모두 유의적으로 감소하였다.

• Korean Journal of Ecology and Environment
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• v.43 no.3
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• pp.377-384
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• 2010

Heavy metal accumulation levels of inhabitant fish, Hemibarbus labeo in Andong and Imha reservoirs were analyzed using an inductively coupled plasma spectrometer and atomic absorption spectrometer. Heavy metal contents of H. labeo from Andong reservoir were higher than those from Imha reservoir. Likewise, relative high contents of As, Cd and Hg were detected in the tissues from Andong reservoir. Among the heavy metals, Al, As and Fe were detected with high concentration in the gill tissues but not in the muscle tissues. Also, the average content of Zn was almost similar in all tissues. In addition, high accumulated level of Al, Cr, Cu and Mn were detected in gill and kidney tissues of H. labeo from Andong reservoir. As a result, the heavy metal contents from the inhabitant fishes, H. labeo, in Andong reservoir showed higher than those in Imha reservoir. We propose that heavy metal contamination in water and in inhabitated fishes is caused from various metals derived from water and sediments in water environment of Andong reservoir.

• The Journal of the Korean bone and joint tumor society
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• v.14 no.2
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• pp.192-197
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• 2008

It is well understood that liposarcoma is most common in soft tissue sarcomas. It usually develop proximally in the extremities and most patients are older than 50 years. We report a case of huge liposarcoma which develop on left thigh of 67-year-old man. There was no evidence of metastasis and the tumor was successfully removed by marginal resection. Patient's height is 153 cm and weight is 43 kg, but the tumor's size is $34{\times}20{\times}9\;cm$ and weight is 2.82 kg. The Mass is severely huge in compare with patient's height and weight. But, There are few reports regarding the correlation between tumor-size and pathologic differentiation. Pathological examination reveals a well differentiated liposarcoma. The patient is still asymptomatic at 6-months follow up.

• Journal of fish pathology
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• v.6 no.2
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• pp.143-161
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• 1993

1. For the induction of ceroidosis, the flounders were fed on the different Peroxidation Value(POV) diets for 6 months from April 1 to September 27, 1991. The growth of the flounder fed on the high POV diets, 90.4mEq/kg and 36.9mEq/kg, were markedly decreased after 3 months and 4 months respectively, compared to those fed on the two different low POV diets, 15.5mEq/kg or 15.2mEq/kg. 2. Histologically, it was hard to observe any pathological signs in the tissues of the control group with normal diets(POV 10.5mEq/kg). With the increasing of POV values of diets, severe ceroid accumulation and parenchymal degenerative lesions were found in the liver, spleen and kindeny. However, any abmormalities were not observed in muscle and intestine been in high POV diets fed flounder.