• 한국전산유체공학회:학술대회논문집
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• 1995.10a
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• pp.31-36
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• 1995

비유선형의 물체 주위의 유동은 정체유동, 경계층 박리 및 주기적 와열 생성 등의 복잡한 유동현상이 공존한다. 본 연구에서는 비교적 단순한 형상인 정사각주 주위의 비정상 난류 유동을 2-방정식 와점성 난류모델인 표준 $k-{\varepsilon}$ 모델과 RNG $k-{\varepsilon}$ 모델을 이용하여 예측할 수 있는지를 검증하였다. 정교하게 수행된 최근의 실험과 대와류모사(LES)의 결과를 검증을 위한 비교의 자료로 삼았다. 적절한 난류모델의 선정과 더불어 시간 정확도, 공간 정확도 및 대류항 처리법 등이 해석결과에 미치는 영향도 살펴보았다. 기존의 표준 $k-{\varepsilon}$모델은 정체점 부근에서 난류 운동에너지를 과도하게 생성하는 근본적인 문제점 때문에 실험 및 LES의 결과를 제대로 예측할 수 없었다. 난류운동에너지의 초과 예측에 따른 운동량의 과도한 혼합으로 인해, 항력계수 및 양력계수의 비정상성 뿐 아니라 평균 항력계수도 부정확하게 예측하였다. RNG $k-{\varepsilon}$ 모델을 사용한 경우에는 정체점 주위 유동현상의 예측이 상당히 향상되어 항력계수 및 양력계수의 평균치, 진폭 및 비정상성의 주기 등을 정확하게 예측하는 것이 가능하였다. 그러나 이 경우에도 예측의 정확도가 시간 증분과 격자의 크기 및 대류항 처리법등에 영향을 받으며, 특별히 대류항 처리법에 상당히 민감하게 변하는 것을 알 수 있었다. 향상된 유동예측은 RNG $k-{\varepsilon}$ 모델의 난류에너지 소산율 방정식의 개선된 항이 과도하게 생성된 난류에너지를 정체점 부근에서 제거하기 때문에 가능하다는 것을 알 수 있었다.의 20세 이하 골절 및 탈구가$30.3\%까지 감소하게되어 년도가 증가함에 따라 청장년 층에 비하여 소아골절 및 탈구가 전체적으로 감소하는 경향을 보였다. 스키골절의 부위별 발생빈도는 1990년 이전까지 하지골절 및 탈구가 많았으나 이후 점차 상지의 골절 탈구가 증가하였다 하지에서 가장 많은 골절은 경골 골절이었으며, 경골골절은 회전력에 의한 나선형골절이 $76.5\%로 가장 많았고 년도에 따른 변화는 보이지 않았다. 스키손상의 발생빈도는 초기에 비하여 점차 감소하는 경향을 보였으며, 손상의 특성도 부위별, 연령별로 다양한 변화를 나타내었다.해가능성을 가진 균이 상당수 검출되므로 원료의 수송, 김치의 제조 및 유통과정에서 병원균에 대한 오염방지에 유의하여야 할 것이다. 확인할 수 있었다. 이상의 결과에 의하면 고농도의 유기물이 함유된 음식물쓰레기는 Hybrid Anaerobic Reactor (HAR)를 이용하여 HRT 30일 정도에서 충분히 직접 혐기성처리가 가능하며, 이때 발생된 $CH_{4}$를 회수하여 이용하면 대체에너지원으로 활용 가치가 높은 것으로 판단된다./207), $99.2\%$(238/240), $98.5\%$(133/135) 및 $100\%$ (313)였다. 각각 두 개의 요골동맥과 우내흉동맥에서 부분협착이나 경쟁혈류가 관찰되었다. 결론: 동맥 도관만을 이용한 Off pump CABG를 시행하여 감염의 위험성을 증가시키지 않으면서 영구적인 신경학적 합병증을 일으키지 않았고 좋은 혈관 개존율을 보여주었다. 따라서 동맥 도관을 이용한 Off pump CABG는 관상동맥의 협착의 정도에 따라 효율적으로 시행

• Journal of the Korea Society of Computer and Information
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• v.14 no.11
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• pp.1-12
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• 2009

Mobbing is going the rounds through a society rapidly and Military is not exception. Because mobbing of military is expressed not only psychology exclusion that is mobbing pattern of adult society but also sometimes psychologic and physical mobbing, is possible to join serious military discipline like a suicide and outrageous behavior. Specially military try to protect occurrence of victims that is public service through various rules and management plan but victims is going on happen. It means importance of grasp not only current mobbing victims but also potential mobbing victims better than preparation of various rules and management plans. Therefore this paper extracts seven factors and fifty attributes that are related to this matter mobbing. Next, by using Gunwoo's Social Network Service that is made for oneself and expressing extracting factors as '1' if they are related me or not '0'. And apply similarity function(Dice's coefficient) to attributes summation included in factors to calculate similarity between the users. Third, calculate optimizing weight choosing factors included attributes by applying neural network algorithm of SPSS Clementine and propose Mobbing Value(MV) Algorithm through this total summation. Finally through this algorithm which will contribute to efficient personnel management, we can grasp mobbing victims and tentative mobbing victims.

• The Korean Journal of Physiology
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• v.8 no.2
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• pp.49-53
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• 1974

A single dose of pilocarpine was subcutaneously injected into the rabbit in order to clarify the effects of cholinergic activities on the secretion of the pulmonary surfactant. The animal was sacrificed four hours after the injection, and the pressure-volume curve of the excised lung was obtained. The surfactant activities of the lung washings were also measured, and a comparison was made with the normal. The pressure-volume curve of the excised lung by the injection and ejection of air formed a loop (hysteresis) and the mean intra-alveolar pressure at 35 ml of air was 220 $mmH_20$ in the normal. The mean deflation curve of the pilocarpine treated rabbit lungs was shifted to the left compared with the normal. The surfactant activities were slightly increased than the normal. The above results suggest that pilocarpine stimulates the secretion of the pulmonary surfactant from the Type II alveolar epithelial cell.

• Applied Microscopy
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• v.34 no.1
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• pp.31-42
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• 2004

Acute respiratory distress syndrome (ARDS) is a kind of acute lung injury characterized by inflammatory disruption of alveolar-capillary barrier and notorious for its high mortality. Neutrophils cause cell damage through the production of free radicals, inflammatory mediators, and proteases in ARDS. $PLA_2$ might serve a primary regulatory role in the activation of neutrophils. This present study was performed to elucidate the effect of rutin known as $PLA_2$ inhibitor on ARDS induced by endotoxin. Endotoxin had increased lung myeloperoxidase (MPO) activity, BAL (bronchoalveolar lavage) protein content, numbers of neutrophils in BALF (bronchoalveolar lavage fluid) compared with those of control rat (p<0.001). In addition, histological evidence of lung injury was correlated with neutrophil influx into alveolar space and cerrous perhydroxide granules were found in lining of endothelial cell, alveolar type I, II cells. In contrast, pretreated group of rutin had significantly decreased all of the parameters (p<0.001). These data suggest that inhibition of $PLA_2$ is one step approach that block the process of ARDS. Accordingly, we conclude that rutin can be used as the prophylactic agent for ARDS on the bases of these experimental results.

• Korea journal of population studies
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• v.19 no.1
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• pp.5-44
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• 1996

Wornen's lahor market participation as well as the policy concern for wider utilization of married women, have continuously grown up. However, research efforts on the determinants of women's labor market participation, in the context of the relationship hetween life courses and active entry into lahor market, has been far behind the growing interest in this field. This study has conducted an event histoiry analysis of women's labor market transition utilizing personal occupational history data collected by the Korea Institute for Women's Development in 1991. The analysis is divided into tow parts: First part introduces logit regression to analyze the determinants of women's labor market participation and exit. The second part employs Cox regression to see the variation of transition rate between employment and non-employment. The result shows that there is a wide variation in women's labor market participation according to age, cohort, and family formation. Special note is needed for the significantly negative effect of marriage and child birth on labor market participation. The transition pattern of lower class women with less education fits well to the prediction of neo-classical economics; but the tendency of highly educated women's regression to non-employment reveals the strong influence of the unfavorable labor market structure, which can be better explained by the neo-structuralist perspective. There is a strong trade-off between productive and reproductive labor of women, which can only be corrected by strong policy implementation, such as extended child care facilities, abolition of discriminatory employment practices, and expansion of flexible part-time employment.

• Science of Emotion and Sensibility
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• v.8 no.4
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• pp.423-433
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• 2005

The computer hardware development has provided many chances of emergence between art and technology. In many cases today's interactive artworks cannot be completed without audience's participation. The interactive production process with technical supplementation can be celled feedback. Mr. Nam Jun Paik showed 'Participant TV' that interacts with audience's response in real time. It means artwork changes with the constantly changing value from the data set from human visual perception. Dan Graham showed another feedback related work, which delays 5second playback in mirror that implies consequence of time. Today's media art has to sublimate coincidence, time ant audience into philosophical artwork through consonance that comes with video and sound as we can see from Bill Viola. Stelarc produced artworks. That use input data that is weak signals from brain, muscles. Through a terminal display with player, body expanded meaning of media. Jeffrey Shaw's 'Legible City' provided a fabrication of the reality with the interaction of bicycle's pedal speed and steering direction that is controlled by 4river. RE:MARK used microphone as input device as Edmond Couchot's 'Je same a la vent' and Nam Jun Paik's 'Participant TV' did. There is no communication without feedback between human being. The reality makes audience involved into artworks. That is the reason why feedback has to be natural. Through the feedback process, the originality of the idea is altered by audience. The feedback is not just part of flesh of artwork rather skeleton of it. Technological showoff cannot be art itself The perfection of technological application plan helps feedback that interacts with audience naturally in order that audience hoes not feel the feedback as artificial plan. Interactive media art has to be evolved into new media form with new integration feedback technology.

• Journal of Life Science
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• v.28 no.10
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• pp.1140-1146
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• 2018

Dual-specificity phosphatases (DUSPs) play a role in cell growth and differentiation by modulating mitogen-activated protein kinases. DUSPs are considered targets for drugs against cancers, diabetes, immune diseases, and neuronal diseases. Part of the DUSP family, DUSP19 modulates c-Jun N-terminal kinase activity and is involved in osteoarthritis pathogenesis. Here, we report screening of cavity-creating mutants and the crystal structure of a cavity-creating L75A mutant of DUSP19 which has significantly enhanced enzyme activity in comparison to the wild-type protein. The crystal structure reveals a well-formed cavity due to the absent Leu75 side chain and a rotation of the active site-bound sulfate ion. Despite the cavity creation, residues surrounding the cavity did not rearrange significantly. Instead, a tightened hydrophobic interaction by a remote tryptophan residue was observed, indicating that the protein folding of the L75A mutant is stabilized by global folding energy minimization, not by local rearrangements in the cavity region. Conformation of the rotated active site sulfate ion resembles that of the phosphor-tyrosine substrate, indicating that cavity creation induces an optimal active site conformation. The activity enhancement by an internal cavity and its structural information provide insight on allosteric modulation of DUSP19 activity and development of therapeutics.

• Korean Journal of Ecology and Environment
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• v.52 no.2
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• pp.81-93
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• 2019

Phytoplankton is one of the important primary producers providing organic matter through photosynthesis in aquatic environments. In order to determine a temporal and spatial variation in primary productivity after weir construction in the Nakdong River, we investigated carbon uptake rates using in-situ $^{13}C$ labeling experiments and identified algal communities contributing to primary productivity using HPLC-CHEMTAX analysis from October to December, 2017. The primary productivity gradually decreased from fall to early winter season ($249{\sim}933mgC\;m^{-2}d^{-1}$ in October, $64{\sim}536mgC\;m^{-2}d^{-1}$ in November and $60{\sim}274mgC\;m^{-2}d^{-1}$ in December, respectively). This is attributed to the temporally declining light intensity and the decreasing biomass and physiological activity of phytoplankton in winter. The contribution of diatoms to the phytoplankton community in the Nakdong River was approximately 63% at all the sampling sites and seasons, while the contribution of cryptophytes increased from 9% in October to 32% in November and December. The temporal changes in the primary productivity and the dominant phytoplankton species in the mid and downstream weirs of the Nakdong River was investigated for the first time, after construction of the weirs, and major environmental factors controlling the temporal variation in primary productivity and phytoplankton communities were identified in this study. We suggest that seasonal field investigations will provide further information on the major environmental factors which affect the annual variation of primary productivity and phytoplankton communities.

• Korean Journal of Remote Sensing
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• v.38 no.5_1
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• pp.571-585
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• 2022

As the threat of natural disasters such as droughts, floods, forest fires, and landslides increases due to climate change, social demand for high-resolution soil moisture retrieval, such as Synthetic Aperture Radar (SAR), is also increasing. However, the domestic environment has a high proportion of mountainous topography, making it challenging to retrieve soil moisture from SAR data. This study evaluated the usability of Sentinel-1 SAR, which is applied with the Artificial Neural Network (ANN) technique, to retrieve soil moisture. It was confirmed that the backscattering coefficient obtained from Sentinel-1 significantly correlated with soil moisture behavior, and the possibility of stand-alone use to correct vegetation effects without using auxiliary data observed from other satellites or observatories. However, there was a large difference in the characteristics of each site and topographic group. In particular, when the model learned on the mountain and at flat land cross-applied, the soil moisture could not be properly simulated. In addition, when the number of learning points was increased to solve this problem, the soil moisture retrieval model was smoothed. As a result, the overall correlation coefficient of all sites improved, but errors at individual sites gradually increased. Therefore, systematic research must be conducted in order to widely apply high-resolution SAR soil moisture data. It is expected that it can be effectively used in various fields if the scope of learning sites and application targets are specifically limited.

• Journal of Life Science
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• v.33 no.4
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• pp.305-314
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• 2023

Ultraviolet B (UVB) irradiation causes skin diseases by inducing cellular oxidative stress, photoaging, and inflammation. This study aimed to investigate the protective effects of morin against UVB-induced oxidative stress in normal human dermal fibroblasts (NHDFs). Morin has been reported to be a potential therapeutic candidate for oxidative stress-mediated diseases, neurodegenerative diseases, and inflammation. Since morin has been identified as a potential antioxidant, we speculated that morin could alleviate UVB-induced apoptosis in NHDFs. Cell viability and intracellular reactive oxygen species (ROS) levels were measured using the MTT assay, H2DCFDA, and the DHE staining method, respectively. Lipid peroxidation and protein carbonyl formation were tested using ELISA kits. DNA fragmentation and comet assay were used to assess DNA damage. Apoptotic bodies were analyzed using Hoechst 33342 staining and TUNEL assay. The expression of apoptosis-related proteins was examined using Western blot analysis. Morin showed a cyto-protective effect by scavenging UVB-induced ROS, increasing the expression of antioxidant-related proteins and inhibiting UVB-induced oxidative alterations such as lipid peroxidation, protein carbonylation, and DNA damage. Morin protects against UVB-induced cell apoptosis by inhibiting Bcl-2-associated X protein, caspase-9, and caspase-3 expression, while increasing the expression of the anti-apoptotic protein Bcl-2. These effects of morin were conferred through decreased phosphorylation of p38 and c-Jun N-terminal kinase 1/2. The results demonstrated that morin may be developed as a preventive/therapeutic drug to be used to prevent UVB-induced skin damage.