• Journal of the korean academy of Pediatric Dentistry
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• v.21 no.2
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• pp.439-455
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• 1994

The purpose of this study was to investigate the distribution of nerves in the periodontal ligament of a dog's primary teeth by each developing stage. The distribution of nerves in the periodontal ligament were investigated by means of immunohistochemistry for detection of neurofilament protein (NFP). The results were as follows: The NFP-immunoreactive nerve fibers were found to be densely distributed in the apical third of the periodontal ligament, while they were sparse in the coronal two third, in both primary and permanent teeth. In generally the density of distribution and degree of arborization of nerve fibers in periodontal ligament of primary teeth revealed a poor appearance compared with that of permanent teeth. Periodontal ligament in anterior teeth showed more abundant nerve innervation than posterior teeth, and the periodontal ligament of the bifurcation area in posterior teeth roots were not observed to have nerve fiber. The density of nerve distribution in the periodontal ligament of primary teeth was reduced according to the physiological root resorption and nerve fibers were not observed in the surrounding area on the root of the exfoliation stage in primary teeth. The distribution of nerve fibers in mucogingival tissue, was poor innervated according to the aging of the dogs. A more abundant distribution of nerve fiber was represented in the lingual mucogingival tissue than in the labial side. Most of the nerve endings in the periodontal ligament of primary teeth showed a tree-like appearance. However, the typical Ruffini-like nerve endings were not observed.

• The Journal of Dong Guk Oriental Medicine
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• v.7 no.2
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• pp.1-8
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• 1999

This paper documents a holistic study of the kidney and its symptom. To this end, the relationship between internal organs and its diseases have been studied from th e viewpoint of the connecting role of the kidney channel of foot-shaoyin. The results of this study are as follows; The function of the kidney has specific re lations with the liver, lung, heart, urinary bladder, throat, tongue, chest, sole of the foot, inside of the thigh and waist. These mutual relations reflect the pathological changes of the kidney. So physiological function and symptom of the kidney can be better understood throu gh the connecting role of the kidney channel of foot-shaoyin on the concept of the organism as a whole. This is the key of the clinical treatment based on the precept sof oriental medicine.

• Annals of Clinical Neurophysiology
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• v.4 no.1
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• pp.81-84
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• 2002

Tetanus is a disorder known to interfere with inhibitory modulation of the motor system in humans. In this report, we describe the characteristic neurophysiological findings in a 52-year-old patient with generalized tetanus. The cutaneous silent period was absent and the silent period evoked in distal upper limb muscles by transcranial magnetic stimulation was shortened. These findings can be interpreted as evidence of impaired inhibitory mechanisms at multiple levels of the nervous system.

• Science of Emotion and Sensibility
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• v.3 no.2
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• pp.41-55
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• 2000

경영활동에 있어서 직관력은 잘 알려진 인지능력이지만 효과적인 의사결정지원시스템의 개발 목적으로는 거의 고려되고 있지 않다. 본 연구는 의사결정자의 인지 유형에 따른 시계열 예측의 정확성과 뇌파의 차이를 통계적 검증, 인공신경망, 데이터 마이닝의 세 가지 접근방법으로 탐색하여 그 결과를 비교 분석함으로써 시계열 직관 예측에 영향을 주는 의사결정자의 인지적/생리적 특성을 도출함으로써 효과적인 의사결정환경을 조성하는데 공헌하고자 하였다. 실험결과 통계적 분석에서는 아무런 유의성을 찾을 수 없었으나, 인공신경망 분석에서는 인지유형과 감성유형이 모두 시계열 예측 정확도와 상관성이 있는 것으로 나타났으며, 데이터 마이닝 분석에서는 보다 의미 있는 상관관계를 찾아낼 수 있었다.

• Annals of Clinical Neurophysiology
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• v.17 no.2
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• pp.45-52
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• 2015

The paraproteinemia is a disorder in which a single clone of plasma cells (monoclonal gammopathy) is responsible for the proliferation of monoclonal proteins (M-proteins). Approximately 10% of patients with idiopathic peripheral neuropathy have monoclonal gammopathy. Some M-proteins have the properties of an antibody to the components of peripheral nerve myelin, but the pathophysiological relationship between the neuropathy and the M-protein is often obscure. The relationship between peripheral neuropathy and monoclonal gammopathy requires the appropriate neurological and hematological investigations for precise diagnosis and treatment. In this review, we provide an update on the causal associations between peripheral neuropathy and monoclonal gammopathy as well as characteristics of clinical and electrophysiologic features.

• Annals of Clinical Neurophysiology
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• v.10 no.2
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• pp.98-100
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• 2008

Restless legs syndrome (RLS) is a sensorimotor neurological disorder in which the primary symptom is a compelling urge to move the legs, accompanied by unpleasant and disturbing sensations in the legs. Although pathophysiologic mechanism of RLS is still unclear, several evidences suggest that RLS is related to dysfunction in central nervous system involving brain and spinal cord. L-DOPA, as the precursor of dopamine, as well as dopamine agonists, plays an essential role in the treatment of RLS leading to the assumption of a key role of dopamine function in the pathophysiology of RLS. Patients with RLS have lower levels of dopamine in the substantia nigra and respond to iron administration. Iron, as a cofactor in dopamine production, plays a central role in the etiology of RLS. Functional neuroimaging studies using PET and SPECT support a central striatal D2 receptor abnormality in the pathophysiology of RLS. Functional MRI suggested a central generator of periodic limb movements during sleep (PLMs) in RLS. However, to date, we have no direct evidence of pathogenic mechanisms of RLS.

• Annals of Clinical Neurophysiology
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• v.12 no.2
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• pp.35-46
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• 2010

Various electrophysiological tests have provided a large body of valuable information on neuronal responses to a presented stimulus. The special and general somatic sensory pathways are main targets of evoked potentials. Two types of evoked potentials, exogenous and endogenous, are commonly used. Exogenous evoked potentials of general and special somatic sensory systems will be reviewed. One of general somatic sensory functional pathways, proprioception, can be evaluated by general somatosensory evoked potentials with electrical stimulation on nerves. The special somatosensory functional pathways, including vision, and audition, can be evaluated by visual evoked potentials and auditory evoked potentials. Also laser-evoked potentials are newly developed for pain pathway, including lateral spinothalamic pathway, and vestibular myogenic evoked potentials for sacculocollic pathways. The evoked potentials of sensory system have maximal clinical utility in evaluating functional deficits along the sensory pathways. They are used for evaluating comatose patients, hysterical patients, premature infants, patients with suspected demyelinating diseases or neoplasms, and research. We discuss the neurophysiologic tests of sensory systems in views of practical points. The organized evaluation of sensory electrophysiologic tests can be helpful in detecting and estimating the abnormalities in neurological diseases.

• Journal of the Institute of Electronics and Information Engineers
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• v.50 no.4
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• pp.229-235
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• 2013

In this paper, we investigate several important issues on the implementation of a totally implantable microsystem for brain-machine interface that has been attracting a lot of attention recently. So far most of the scientific research has been focused on the high performance, low power electronics or systems such as neural signal amplifiers and wireless signal transmitters, but the real application of the implantable microsystem is affected significantly by a number of factors, ranging from design of the encapsulation structure to physiological and anatomical characteristics of the brain. In this work, we discuss on the thermal effect of the system, the detecting volume of the neural probes, wireless data transmission and power delivery, and physiological and anatomical factors that are critically important for the actual implementation of a totally brain implantable neural interface microsystem.

• Annals of Clinical Neurophysiology
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• v.8 no.2
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• pp.107-124
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• 2006

The basal ganglia are a group of nuclei located in the deep portion of the brain. Along with the cerebellum, the basal ganglia have a major role in controlling human voluntary movements, and their dysfunction is apparently responsible for various involuntary movements. Although the exact mechanism of how the basal ganglia control movements has yet to be clarified, the model of focused selection (through the direct pathway) and tonic inhibition (via the indirect pathway) is proposed to be a principal functional model of the basal ganglia. Parkinson's disease (PD) is classically characterized by bradykinesia, rigidity and tremor-at-rest. All features seem to be associated with dopamine depletion resulting from the degeneration of the nigrostriatal pathway, which produces reduced activity of the direct pathway and a concurrent enhancement of excitatory output from STN. This change may result in increased tonic background inhibition and reduced focused selection via the direct pathway, causing difficulties in performing voluntary movements selectively. However, it has not been possible to define a single underlying pathophysiologic mechanism that explains all parkinsonian symptoms. Here the data that give separate understanding to each of the three classic features are discussed.

• Journal of the KSME
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• v.54 no.9
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• pp.31-34
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• 2014

이 글은 내피세포(endothelial cell)의 생리 병리학적 중요성에 대해 알아보고, 미세혈관기반의 생체 외(in vitro)모델을 소개하며 그 연구 동향에 대해 소개하고자 한다.